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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Cardioprotective activity of Apples Juice on Isoproterenol-Induced Myocardial Infarction in Rat Kurniati, Neng Fisheri; Nadhirah, Yuthika Raihan
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 3 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i3.41445

Abstract

Myocardial infarction was local necrosis of heart tissue due to reduced oxygen supply because of theocclusion of coronary arteries. Fruits could reduce the risk of developing obesity and CVDs. Severalstudies have shown that apples had a strong cardioprotective effect. This study aimed to understandthe cardioprotective activity of two variants of apples, e.g., Fuji and Malang, on isoproterenol-inducedmale Wistar rats. The cardioprotective activity test was carried out for 14 days, all testing group exceptnegative control, was induced by isoproterenol. The results of testing cardioprotective activity showedthat Fuji Apple juice and Apel Malang juice had the same capability to inhibit increasing cardiacbiomarkers value (CK and CK-MB) with the highest inhibition was 79.56% and 73.08% for FujiApples, respectively, while for Apel Malang was 69.18% and 43.04%, respectively. The result of thecardiac histopathology examination showed that both Apples could prevent cardiac tissue damage. Alljuice Apple doses had the same cardioprotective activity.
Sansevieria trifasciata Prain. : A Review on Its Phytochemicals and Pharmacological Potential Sida, Nurramadhani A; Kasmawati, Henny; Ruslin, Ruslin
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52626

Abstract

Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciataPrain. is a potential herb as medicine to treat various diseases based on its chemical compounds.Sansevieria trifasciata Prain is known to contain phytochemical compounds and has the potential to treat various diseases. A systematic review was conducted by searching articles on Google Scholar, PubMed, NCBI, and Science Direct to gather information on identified chemical compounds and the pharmacological test results of S. trifasciata Prain leaves, both in vitro, in vivo, and in silico. The result showed that phytochemicals were derivatives of the flavonoids, alkaloids, steroids, saponins, glycosides, polyphenols, and fatty acids groups. These phytochemicals exhibit pharmacological properties, including antidiabetic, antibacterial, anticancer, antihelminthic, antimalarial, antifungal, antioxidant, antiwound healing, antianalgesic, and antiallergic properties. Acute toxicity tests indicate that S. trifasciata Prain. is safe for use, with an LC50 value exceeding 2000 mg/kgBW. We can conclude that Sansevieria trifasciata Prain. is a potential herb as medicine to treat various diseases based on its chemical compounds.
Antiviral Activity of Various Glycoside Compounds Al Azzahra, Yunita; Muchtaridi, Muchtaridi; Yusuf, muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.44496

Abstract

Glycoside compounds consist of several groups of important compounds, such as flavonoids and alkaloids. Sometimes the glycosidic residues in glycoside compounds have an important role in their activity, but some can only increase their pharmacokinetic parameters. However, recent developments in molecular glycobiology have gained a greater understanding of the activity of aglycones vs. glycosides. Several glycoside compounds, such as flavonoid glycosides and Cardiac glycosides, have been known to have antiviral activity, including against Herpes Simplex Virus, Influenza, and Human Immunodeficiency Virus. Still, until now, the potential for various Glycoside compounds as antivirals have not been widely studied, although many biologically active compounds are in the form of glycosides. Further studies regarding the antiviral activity of this glycoside compound are needed to determine the possibility of this compound as an alternative for treating diseases caused by viruses.Keyword : flavonoid glikosida, cardiac glikosida, HSV, Influenza, HIV
Professionality Study of Pharmacist for Pharmaceutical Care in Community Pharmacy at Samarinda City Nur, Muhammad Ramadhan Ramadhan
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53853

Abstract

Services related to pharmaceutical preparations that a pharmacist offers to patients directly and ethically with the goal of improving patient health are referred to as pharmaceutical services. In order to allow pharmacists to provide pharmaceutical services in a professional manner, the government has taken steps to enable them, as stated in Minister of Health Regulation Number 35 of 2014 about Pharmaceutical Service Standards in Pharmacies. Using Minister of Health Regulation Number 35 of 2014 as a guide, this study aims to describe the pharmaceutical service practices that pharmacists in Samarinda City pharmacies perform. This study employs a qualitative descriptive research design. Data was gathered by looking at questionnaire answers, conducting interviews, and observing pharmacists in action. There were fifty-one pharmacists from the Samarinda City Pharmacy who answered the survey. According to the study's findings, pharmacists in Samarinda City pharmacies manage 80.93% of pharmaceutical supplies, medical equipment, and consumable medical materials in addition to 81.1% of clinical pharmacy services. All practical services performed comply with Minister of Health Regulation Number 35 of 2014 standards.
Determination of Gamma Oryzanol from Ethanolic Extract of Indonesian Rice Bran (Oryza sativa) Vardhani, Afifah; Perdanastuti, Hidayah Sunar
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.46297

Abstract

Rice bran contains gamma oryzanol, a chemical compound mostly consisted of complex ester trans-ferulate with phytosterols1. Gamma oryzanol has a strong antioxidant activity, explained by the free radical scavenging activity. This study was aimed to determine gamma oryzanol from ethanolic extract of rice bran. Quantitative analysis was conducted using HPLC analysis with mixture of methanol:acetonitrile:isopropanol (50%:40%:10%) as mobile phase and Inertsil ODS-3 5 μm as stationary phase. The UV detector wavelength was set to 327 nm, and the flow rate was set to 1 mL/min2. Gamma oryzanol standard and rice bran ethanolic extract 96% was injected into HPLC system. Ethanolic extract of rice bran (Oryza sativa) sample showed four major peaks as those of gamma oryzanol standard and contained 105,981 ppm of gamma oryzanol. As the conclusion, ethanolic extract of rice bran (Oryza sativa) contains gamma oryzanol
Formulasi Cookies dari Labu Kuning (Cucurbita moschata) dan Tepung Kulit Pisang Kepok (Musa acuminata x Musa balbisiana) untuk Penderita DM Tipe 2 Haerunnisa, Rima; Sinthary, Venna; Kuncoro, Hadi; Narsa, Angga Cipta
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53425

Abstract

Diabetes mellitus (DM) merupakan penyakit yang ditandai dengan tingginya kadar gula dalam darah. Pemberian makanan yang tinggi serat diketahui dapat mengontrol kadar gula darah pada penderita diabetes mellitus. Buah labu kuning dan kulit pisang kepok merupakan salah satu pangan pilihan dengan kandungan serat tinggi sehingga bisa menjadi alternatif makanan selingan bagi penderita diabetes mellitus melalui olahan cookies. Penelitian ini bertujuan untuk mengetahui formulasi cookies yang optimal serta mengetahui evaluasi yakni kadar air, kadar abu, kadar serat, organoleptik dan hedonik. Hasil yang diperoleh yaitu didapatkan 3 formulasi yang berbeda FI (0,5:1,5 labu kuning:kulit pisang kepok); F2 (1:1 labu kuning:kulit pisang kepok); F3 (1,5:0,5 labu kuning:kulit pisang kepok) dengan nilai kadar air berturut-turut yaitu 0,289%; 0,375 dan 0,306%. Nilai kadar abu berturut-turut yaitu 1,974%; 1,990% dan 1,965%. Nilai Kadar serat berturut-turut yaitu 33,8%; 35,08% dan 50,525%. Nilai uji hedonik terbaik yaitu pada F2 dengan persentase nilai yaitu 72,67% dengan karakteristik organoleptik berwarna coklat, sedikit beraroma kulit pisang dan sedikit beraroma labu kuning, berasa manis dan memiliki tekstur renyah. Hal ini menunjukkan bahwa formula cookies yang dibuat dapat menjadi makanan selingan karena memenuhi nilai kadar serat dan nilai uji hedonik (kesukaan).
AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT BERBAGAI BAGIAN TANAMAN KESAMBI (Schleichera oleosa L.) DENGAN METODE DPPH Nursamsiar, Nursamsiar; Khairuddin, Khairuddin; Marwati, Marwati; Nur, Syamsu
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38871

Abstract

Kesambi (Schleichera oleosa) merupakan salah tanaman asli Indonesia yang berpotensi sebagai obat dan memiliki senyawa aktif yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui potensi berbagai bagian tanaman sebagai antioksidan dengan metode DPPH. Simplisia diekstraksi dengan metode maserasi menggunakan pelarut etil astetat. Identifikasi golongan senyawa dilakukan dengan skrining fitokimia menggunakan reagen kimia sedangkan pengujian aktivitas antioksidan dilakukan dengan metode peredaman radikal DPPH menggunakan spektrofotometer pada panjang gelombang 515 nm. Hasil skrining fitokimia menunjukkan bahwa semua ekstrak etil asetat dari berbagai bagian tanaman mengandung senyawa flavonoid, fenolik dan tannin. Pengujian aktivitas menunjukkan ekstrak etil asetat daun kesambi memiliki aktivitas antioksidan paling baik dengan nilai IC50 5,4952 μg/mL, dibandingkan dengan kulit batang (14,3621 μg/mL), akar (43,4159 μg/mL), kulit buah (159,8782 μg/mL) dan daging buah (167,2912 μg/mL). Ekstrak etil asetat berbagai bagian tanaman kesambi memiliki aktivitas antioksidan dengan urutan paling baik yaitu daun, kulit batang, akar, kulit buah, dan daging buah. Adanya profil bioaktivitas tersebut dapat memberikan informasi tambahan terhadap kekuatan atioksidan pada berbagai bagian tanaman kesambi yang belum dilaporkan pada penelitian sebelumnya sehingga dapat dikembangkan untuk penelitian lebih lanjut.
Formulasi dan Evaluasi emulgel Celecoxib dengan Tween 80 dan Lesitin untuk Penghantaran Obat Transdermal Wibowo, Danang Novianto; Prihantini, Malinda; Aini, Rakhmatul; Yudianti, Husna S.
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.48498

Abstract

Celecoxib merupakan senyawa yang termasuk kategori BCS (Biopharmaceutics Classification System) kelas II yang memiliki kelarutan rendah dengan permeabilitas tinggi dan berdampak pada penurunan bioavailabilitas. Tujuan penelitian ini adalah untuk mengetahui pengaruh variasi konsentasi surfaktan lesitin terhadap karakteristik fisik sediaan emulgel celecoxib dan untuk mengetahui permeasi secara in vitro sediaan emulgel celecoxib dengan variasi konsentrasi lesitin sebagai surfaktan.Sediaan emulgel celecoxib dibuat dalam enam formula dengan masing-masing variasi konsentrasi surfaktan lesitin pada formula 1 (3%), formula 2 (5%), dan formula 3 (7%) dan variasi konsentrasi surfaktan tween 80 pada formula 4 (5%), formula 5 (10%), dan formula 6 (15%). Sediaan emulgel dievaluasi karakteristik fisiknya meliputi organoleptis, homogenitas, penentuan tipe emulsi, pH, viskositas, daya lekat, daya sebar, dan dilakukan uji permeasi in vitro menggunakan metode sel difusi Franz. Data hasil uji organoleptis, homogenitas, dan penentuan tipe emulsi dianalisis secara deskriptif. Sedangkan untuk pH, viskositas, daya sebar, dan daya lekat dari setiap formula dianalisis menggunakan regresi linier, untuk data hasil uji permeasi in vitro dianalisis secara statistik menggunakan uji ANOVA.Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi surfaktan lesitin maka semakin tinggi pula nilai pH, viskositas, dan daya lekat emulgel. Peningkatan konsentrasi lesitin sebagai surfaktan meningkatkan jumlah celecoxib terpenetrasi per satuan luas area difusi dan laju penetrasi celecoxib.Kata kunci: Celecoxib, emulgel, surfaktan, lesitin.
The Potency Mucoadhesive Granules of Ethanol Extract Green Grass Jelly (Premna oblongifolia MERR.) as Peptic Ulcer Treatment Agent NOFIANTI, TITA
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.50688

Abstract

Cincau hijau (Premna oblongifolia Merr) banyak tumbuh di Indonesia dan merupakan makanan tradisional Indonesia yang kaya akan serat dan memiliki aktivitas antioksidan. Tujuan penelitian adalah untuk mengetahui pengaruh ekstrak etanol daun cincau terhadap penyembuhan maag. dan komposisi butiran mukoadhesif yang optimal. Tikus dikelompokkan menjadi kontrol negatif, kontrol positif, dan 3 kelompok dosis uji. Pengobatan diberikan selama tiga hari, tukak gastrointestinal diberi skor berdasarkan kuantitas dan tingkat keparahan tukak, dan statistik dibandingkan antar kelompok perlakuan menggunakan uji ANOVA satu arah. Hasil penelitian menunjukkan bahwa uji dosis ketiga memiliki aktivitas dalam penyembuhan tukak lambung dibandingkan dengan kelompok kontrol negatif, dengan proporsi penyembuhan luka pada dosis 1 sebesar (12,13%; p. 0,024), dosis 2 sebesar (20,93%; p. 0,004). ), dan dosis 3 menjadi (24,47%; p. 0,000). Oleh karena itu, dapat disimpulkan bahwa ekstrak etanol daun cincau hijau dosis ketiga dipilih sebagai dosis optimal untuk pengobatan tukak lambung. Formulasi terbaik terdapat pada formula 3.
Formulasi Sediaan Spray Gel Minyak Atsiri Daun Lintut (Strobilanthes kalimantanensis) sebagai Antibakteri Ramadhan, Adam M
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53554

Abstract

Tanaman Lintut (Strobilanthes kalimantanensis) merupakan tumbuhan terna yang tumbuh di tanah lembek dan berair. Terdapat minyak atsiri kuat yang terkandung di dalam tanaman lintut yang memiliki aktivitas sebagai antimikroba. Peneltian ini dilakukan untuk mengetahui formulasi dan sifat fisik sediaan spray gel minyak atsiri daun lintut serta efektivitas sediaan sebagai antiseptik tangan. Evaluasi sediaan spray gel dalam penelitian ini ialah pemeriksaan organoleptis, homogenitas, daya lekat, pH, viskositas dan pola penyemprotan serta uji stabilitas menggunakan metode freeze thaw. Minyak atsiri daun lintut mengandung senyawa terpenoid. Formula sediaan spray gel menggunakan gelling agent karbopol 0,35%. Hasil pengujian efektivitas antibakteri yang baik adalah formula 4 dengan konsentrasi minyak atsiri daun lintut sebesar 6% menurunkan mikroorganisme sebesar 88,19%. Hasil evaluasi sifat fisik sediaan spray gel menunjukan organoleptis, homogenitas, daya lekat, pH, viskositas dan pola penyemprotan yang memenuhi persyaratan dan hasil uji stabilitas menunjukan hasil yang stabil. Sediaan spray gel mampu membunuh bakteri e. coli.

Page 36 of 50 | Total Record : 494

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