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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Determinants of Medication Adherence Among Elderly Patients: A Multivariate Study at PKU Muhammadiyah Gamping Yogyakarta Octavia, Mega; Susana, Yolanda Putri; Rahajeng, Bangunawati
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57919

Abstract

Adherence to medication in elderly patients is crucial to support their health, as many suffer from chronic non-communicable diseases requiring long-term treatment. The complexity and volume of medications can lead to patient fatigue. Identifying factors that affect adherence is key to addressing these challenges. This study aims to identify the factors influencing medication compliance among elderly patients at PKU Muhammadiyah Gamping Hospital’s outpatient clinic. This quantitative, cross-sectional study involved 80 elderly patients at the internal medicine clinic, selected through accidental sampling. Data was collected using the MMAS-8 (Modified Morisky Adherence Scale-8) and additional questionnaires to determine the factors influencing therapy adherence, analyzed through multiple linear regression. Results showed that compliance was low in 21.3% of patients, moderate in 43.8%, and high in 35.0%. Statistical analysis found significant influences from education level (p<0.05), illness duration (p<0.05), knowledge level (p<0.05), health service access (p<0.05), family support (p<0.05), healthcare workers’ role (p=0.029), and treatment motivation (p<0.05). Compliance among elderly patients at PKU Muhammadiyah Gamping Hospital falls in the moderate category, with these factors explaining 75.6% of adherence levels.
Isolation of Chitosan Biopolymer from Nacre (Pinctada maxima) as Bone Scaffold Candidate Taufik S, Ahmad; Alawiyah, Geby; Rahayu, Susi; Kurniawidi, Dian W; Handayana, I Gusti Ngurah Yudi; Cahyawati, Triyana Dyah; Purnaning, Dyah; Amin, Muhamad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.44794

Abstract

The rising incidence of bone injuries necessitates researching and developing safe bone replacement materials. Chitosan biopolymer is one of the available materials. Because it is non-toxic, biocompatible, and biodegradable, chitosan can be employed as a bone scaffold material. According to the European Pharmacopeia 6.0 (Eur: Ph 6.0), chitosan, with a deacetylation level of more than 70%, is safe for medicinal usage. The purpose of this research was to analyze the  characteristics of chitosan isolated from nacre and the influence of nacre powder mass  on the degree of deacetylation of  chitosan. Chitosan was extracted by the processes of deproteination, demineralization, and deacetylation. Organoleptic tests, yield calculations for each stage, examination of the degree of deacetylation, creation of functional groups, and vibrational modes based on Fourier Transform Infrared (FTIR) data were performed on the isolated chitosan. The produced chitosan exhibited the properties of being beige color, odorless, and in powder form. The yield of insulation results obtained by the mass of chitosan. 3.7 % of the mass of nacre powder. The resultant chitosan has the formation of hydroxyl (OH) and amine (NH2) groups and vibrational stretching and bending modes. The variation in nacre powder mass throughout the isolation procedure altered the degree of deacetylation of the resultant chitosan and the wave number spectra of the hydroxyl (OH) and amine (NH2) groups. Chitosan, with a mass of 80 grams of nacre powder and a value of 76.94%, exhibited the highest degree of deacetylation. Considering that the functional groups generated in chitosan are comparable to those in bone, chitosan is a potential material for bone scaffolds.
Evaluation of Sidr Leaf Ethanol (Ziziphus mauritiana Lam.) Extract-Based Tablets as Antihypercholesterolemia Orbayinah, Salmah; Dewi, Yunita P.; Kurniawan, Fariez; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57926

Abstract

Sidr leaf extract (Ziziphus mauritiana Lam.) is effective against hypercholesterolemia by blocking the HMG-CoA reductase. This study seeks to identify the characteristics of tablets formulated from the ethanol extract of Sidr leaf and their efficacy in lowering total blood cholesterol levels. The tablets were produced using the wet granulation method and processed into three formulations, F1, F2, and F3, with differing dosages of 100, 150, and 250 mg, along with placebo. The granules produced were evaluated for their physical characteristics. The tablets were evaluated for their physical characteristics and tested for effectiveness in lowering cholesterol levels. The efficacy of tablet-form sidr leaf ethanol extract was assessed by analyzing cholesterol levels in mouse serum samples compared to simvastatin. The data were statistically analyzed using one-way ANOVA and post-hoc Tukey HSD test. In the disintegration time test, F1 and F2 tablets satisfied the criteria. However, F3 exceeded the limit of 60 minutes. Among the three tablet doses, the F2 tablet (150 mg) demonstrated superior efficacy in lowering total cholesterol levels relative to the F1 and F3 tablets. Consequently, tablets containing Sidr leaf extract demonstrate potential for hypercholesterolemia management at an effective dosage of 150 mg, warranting further investigation through clinical trials.
Functional beverage formulation of faloak (Sterculia quadrifida R.Br) stem bark kombucha with the addition of lontar palm sugar Lalong, Paulus Risan F; Naben, Maria Novalina; Laynurak, Yoseph M
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.52821

Abstract

Local potential and alternative substrates have been widely utilized to make kombucha with the aim of increasing its compound content and potential functional properties. In general, kombucha is made of black or green tea fermented using white cane sugar. On the other hand, the making of kombucha using faloak (Sterculia quadrifida R.Br) stem bark fermented using lontar palm sugar is relatively new. Therefore, the development of the optimum formula needs to be explored to confirm its functional properties. This study aims to determine the optimum formulation of lontar palm sugar concentration and fermentation time in terms of the chemical characteristics and antioxidant activity of faloak stem bark kombucha. The Response Surface Methodology (RSM) was employed in this study with two research factors, i.e., lontar palm sugar concentration and fermentation time. The results reveal the optimum formulation of palm sugar concentration of 15% and fermentation time of 15.18 days which can cause significant changes in properties, showing pH value of 2.72, total acid of 1.264%, total sugar of 6.451%, total phenol of 452.783 mg GAE/L, and antioxidant activity (IC50 value) of 70.877 ppm. In conclusion, the use of 15% lontar palm sugar fermented for 15.18 days can produce faloak stem bark kombucha with potential as a functional beverage.
In-Silico Study of N-Hydroxysuccinimide Folate and GAPDH as Targeting Agents for Tuberculosis Treatment Marhaendra, Laurentius Ivan Ageng; Muchtaridi, Muchtaridi; Rosandi, Yudi; Gazzali, Amirah Mohd
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59597

Abstract

Tuberculosis remains a major public health concern due to emerging cases of drug resistance. To overcome this issue, the effectiveness of antitubercular medications must be reinforced. One of the methods that can be used is using active targeting, which involves small molecules that bind to a specific receptor. In this research, we study the potential of N-hydroxysuccinimide (NHS) folate to be used as the targeting agent against the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) cell-surface receptor, a common virulence factor found on many pathogenic bacteria, including Mycobacterium tuberculosis. We conducted this research using computational methods, specifically molecular docking and molecular dynamics simulation. Based on the evaluation of molecular docking and molecular dynamics simulation results, NHS-folate is predicted to have a huge potential to be an active targeting agent against the GAPDH receptor of Mycobacterium tuberculosis.
Immunomodulatory Activity of Parijoto Fruit (Medinilla speciosa) on Macrophage Phagocytosis, Lymphocyte Proliferation, and IgG Production Jannah, Asni F.; Winanta, Aji; Anggreani, Ira; Krisridwany, Annisa
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57948

Abstract

Parijoto fruit (Medinilla speciosa) contains flavonoid compounds that are potentially immunomodulators because they increase macrophage phagocytosis activity and lymphocyte proliferation in vitro. This study aims to determine the phytochemical compound content of parijoto fruit and its potential as an immunomodulatory agent in vivo. Parijoto fruit was extracted using 70% ethanol solvent. The ethanol extract of parijoto fruit (EEPF) was qualitatively identified by phytochemical screening. The immunomodulatory activity test in vivo was conducted using BALB/c mice, which were separated into five groups: untreated, Phyllanthus niruri L. (PN) extract (positive control), and test groups (125mg/KgBW; 250mg/KgBW and 375mg/KgBW). The treatment duration was 18 days, with the induction of the hepatitis B vaccine on days 7 and 14. An immunomodulatory activity test was conducted on the 19th day, which included a macrophage phagocytosis activity test, lymphocyte proliferation, and measurement of IgG levels. The identification results showed that EEPF contains flavonoids, tannins, and saponins. Macrophage phagocytosis activity showed that EEPF increased macrophages' phagocytosis capacity (PC) and phagocytosis index (PI). EEPF increased lymphocyte proliferation activity and IgG levels, significantly different from control and not substantially different from positive control. Collectively, EEPF increases immunomodulatory activity in vivo.
The Optimization of Porang starch-lactose as a co-processed excipient of Bajakah (Spatholobus littoralis Hassk) root dried extract's effervescent tablet Ermawati, Dian Eka; Andini, Bimar Putri; Damayanti, Avina Kusuma
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46521

Abstract

Bajakah root has stronger antioxidant activity than vitamin C. The Dayak people use it to maintain health. Bajakah root infusion has an unpleasant taste and aroma, also unstable, so effervescent tablets are developed to resolve that problem. Effervescent tablets are prepared by direct compression method. The starch of porang tuber is a food that can act as fillers and tablet binders. The co-processed excipient can produce tablet fillers for the directly compressed method. Co-processed excipients of lactose-porang starch have excellent flow properties, improve tablet hardness, have good compatibility, and are cheaper. In this study, the proportions of porang starch and lactose as co-processed excipients were determined using the Simplex Lattice Design method, and then tested the flow properties and granule repose angle. The physical properties of the tablets include weight uniformity, hardness, brittleness, dissolution time, and antioxidant activity test. Test data were analyzed using the One Sample T-test. The results showed that effervescent tablets with co-processed excipient porang starch-lactose 64: 36% provide good physical stability, granule flow time of 10.45 ± 0.29 gram/second, granule repose angle of 27.52 ± 0.95°; tablet weight uniformity with a CV value of 1.021%; tablet hardness 5.74 ± 0.07 Kg, tablet friability of 0.549 ± 0.03%; tablet disintegration time 86 ± 4 seconds. The bajakah root has antioxidant activity of 0.155 mg/mL.
Aktivitas Ekstrak Etanol Daun Kate Mas (Euphorbia heterophylla Desf.) pada Tikus Putih Jantan Galur Wistar yang Resistensi Insulin Susilawati, Elis; Syihabbudin, Nazar; Kaniawati, Marita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59555

Abstract

Euphorbia heterophylla. Desf (kate mas) menunjukkan aktivitas penurunan glukosa darah, serta memiliki sifat antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mengeksplorasi potensi ekstrak etanol daun Euphorbia heterophylla Desf (EEH) sebagai anti resistensi insulin dalam pengelolaan diabetes mellitus tipe 2 (DMT2). Tujuan penelitian ini untuk mengetahui efek dan dosis efektif Ekstrak Etanol Daun Kate Mas (Euphorbia heterophylla Desf), disingkat EEH, terhadap tikus yang diinduksi makanan tinggi karbohidrat, lemak, dan fruktosa 30%. Metode penelitian dilakukan secara in vivo menggunakan 24 tikus jantan putih galur wistar yang dibagi menjadi 6 kelompok, yaitu kelompok kontrol normal, kontrol negatif, kontrol positif, EEH 50 mg/KgBB, 100 mg/KgBB, dan 200 mg/Kg BB dengan melakukan tes  kadar glukosa darah (KGD), pengukuran konstanta tes toleransi insulin (KTTI) dan histopatologi sel pankreas. Hasil penelitian menunjukkan bahwa EEH pada semua kelompok dapat menurunkan KGD (92,25 mg/dL±7,04 untuk 50 mg/KgBB; 99,75 mg/dL±13,57 untuk 100 mg/Kg BB; 117,00 mg/dL ±0,85 untuk 200 mg/Kg BB; dan 89,00 mg/dL ±5,34 untuk metformin) dibandingkan dengan kelompok kontrol negatif (132,00 mg/dL ±7,16). EEH 50 mg/Kg BB secara signifikan dapat meningkatkan sensitivitas insulin (3,95±0,53) dibandingkan dengan kelompok negatif (1,24±0,98). Hasil histologi pankreas menunjukan EEH pada semua kelompok uji dapat menurunkan jumlah nekrosis sel pankreas dibandingkan dengan kelompok kontrol negatif.  Kesimpulannya, EEH memiliki potensi untuk dieksplorasi lebih lanjut untuk aktivitas dalam meningkatkan sensitivitas insulin.
A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Abstract

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.
Acute Toxicity of Petai Cina (Leucaena leucocephala (Lam.) de Wit) Leaf Extract to the Hepar of Balb/c Mice Wulandari, Ririn Lispita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49645

Abstract

Daun petai cina memiliki banyak efek farmakologi namun belum diketahui profil keamanannya sebagai obat tradisional. Penelitian ini bertujuan untuk menguji efek toksik akut ekstrak daun petai cina (EEDPC) terhadap hepar mencit Balb/C dan menentukan nilai LD50. Pemeriksaan yang dilakukan meliputi gejala toksik, jumlah  hewan mati, berat badan, makroskopis hepar, dan kadar SGPT SGOT. Penelitian ini merupakan penelitian eksperimental. Ekstrak daun petai cina diperoleh dengan cara maserasi. Uji toksisitas akut dilakukan menggunakan metode fixed dose melalui uji pendahuluan dan utama. Berdasarkan uji pendahuluan ditetapkan dosis 2000 mg/kg BB sebagai dosis awal uji utama. Hewan uji dibagi menjadi 2 kelompok, masing-masing diberi CMC Na 1% (kontrol) dan EEDPC 2000 mg/kg BB. Gejala toksik dan kematian diamati selama 14 hari untuk menentukan kisaran nilai LD50. Pada hari ke-15 dilakukan pemeriksaan makroskopis dan SGPT SGOT hepar. Gejala toksik dan makroskopis hepar dianalisis deskriptif, sedangkan berat badan dan kadar SGOT SGPT dianalisis statistik. Hasil penelitian menunjukkan bahwa EEDPC memiliki kisaran nilai LD50>2000 mg/kg BB dan menurunkan berat badan tidak signifikan. Kondisi hepar secara makroskopis dan rata-rata kadar SGPT SGOT tergolong normal, meskipun kadar SGPT berbeda signifikan dengan kontrol, dan kadar SGOT berbeda tidak signifikan dengan kontrol.

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