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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Potential of Quercetin Compound from Guava Leaves (Psidium guajava L.) as a Inhibitor COVID-19 Sengka, Rani; Rompegading, Andi Badli; Irfandi, Rizal; Nur, Muhammad; Arafah, Muhammad; Yani, Ahmad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.49666

Abstract

This research is a computer-based experimental study using the molecular docking method of quercetin compounds in the leaves of the guava plant (Psidium guajava L.) against the target protein (receptor), namely Mpro SARS-CoV-2 (PDB ID: 6M2N) using various softwares. consists of Chem Draw Ultra version 7.0, Marvin Sketch, PLANTS, Yasara, Discovery Studio Visualizer 2021, and pkCSM online tool and, protox online tool. This study aims to find out how the potential  of the quercetin compound from the leaves of the guava plant (Psidium guajava L.) has on its ability to inhibit the spread of Covid-19 by molecular docking. Data analysis in this study was carried out based on data obtained from the analysis of pharmacokinetic profiles, physicochemical properties, molecular docking, and predictions of toxicity to compounds that have potential as drug ingredients. Based on the results of molecular docking, it was shown that the quercetin compound has the potential to act as an inhibitor of the Mpro receptor (PDB ID: 6M2N) as evidenced by the docking score obtained which is smaller than the docking score obtained by the original ligand of the target receptor.
In Silico Study of Flavonoid from Caesalpinia sappan L. against HMG-CoA Reductase as Antihypercholesterolemia Luhung, Aditya; Shefelin, Kinar; Adiputri, Nurqisthi Iqlima; Deliyana, Alifa Nisa; Colin, Michelle Natasha; Claudina, Nur Shelly Ester; Nuwarda, Rina Fajri
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.56077

Abstract

Hypercholesterolemia is a severe condition characterized by elevated blood cholesterol levels exceeding 240 mg/dL, contributing to over 18.5 million deaths since 2019. Simvastatin, a widely used cholesterol-lowering therapy, inhibits the enzyme HMG-CoA reductase. However, despite its efficacy, statin-based drugs can cause adverse effects such as hepatotoxicity, malaise, rhabdomyolysis, and myopathy. Sappan wood (Caesalpinia sappan L.) is a potential alternative known for its antihypercholesterolemic properties, attributed to its main compounds: sappanone B, brazilin, and hematoxylin. This study aimed to evaluate the potential of flavonoids in sappan wood as HMG-CoA reductase inhibitors using molecular docking analysis. The results revealed that sappanone B exhibited the lowest binding energy (-7.71 kcal/mol) and an inhibition constant of 2.22 μM, followed by brazilin (-7.34 kcal/mol, 4.17 μM) and hematoxylin (-7.00 kcal/mol, 7.45 μM). These findings suggest that sappanone B, brazilin, and hematoxylin possess significant potential as competitive HMG-CoA reductase inhibitors, providing a promising natural alternative for hypercholesterolemia treatment with potentially fewer side effects.
Purity Analysis of Sesame Oil Extracted from Sesamum indicum L. Using the ATR-FTIR Method Mahendra, Muhammad Reza; Salamah, Nina; Guntarti, Any
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.50102

Abstract

Sesame seeds (Sesamum indicum L.) are a plant that produces the most important and oldest oil known to man. Apart from being rich in nutrients, sesame consists of important functional components such as sesamin, sesamolin, sesamol, sesaminol, sesamolin phenol, and other lignan-like active ingredients and can trigger the motive to produce sesame oil by adulteration in order to achieve market desires. The aim of this research is to identify the purity of sesame oil and analyze it using the ATR-FTIR method to detect and prevent counterfeiting. Testing the characteristics of sesame oil can be adjusted to the quality requirements that have been set, one of which is the Indonesian National Standard (SNI) so that the quality of sesame oil circulating on the market is guaranteed. This research is non-experimental research. Sesame seed oil resulting from pressing is based on the test requirements of SNI 01-4468-1998 including the physico-chemical properties test. The results of the sesame seed oil profile are that the sesame seed oil extraction yield is 29.265%, the sesame oil is bright yellow in color, has a distinctive smell, specific gravity (20oC) 0.9237± 0.0057, refractive index 1.4702 ± 0.0005, peroxide value 2 ± 0.0577 meqO2/Kg, iodine value 107.1 ± 0.5773, and acid number 0.224 ± 0.0577. Based on the research results, it can be concluded that the pressed sesame seed oil has met the requirements of the SNI 01-4468-1998 test, and from the functional groups that appear in the ATR-FTIR it can be concluded that the pressed sesame oil contains methyl ester group compounds.
Evaluasi Antibodi dan Kejadian Ikutan Pasca Imunisasi (KIPI) Vaksin COVID-19 AstraZeneca Dosis Lengkap di Sentra Vaksin UTA'45 Jakarta Lukas, Stefanus
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.54268

Abstract

Latar Belakang: AstraZeneca merupakan vaksin vektor virus. Vaksin adalah alat penting untuk membatasi kesehatan pandemi COVID -19. Vaksin ini memiliki metode yang lebih canggih yaitu menggunakan virus yang dimodifikasi untuk memicu antibodi guna menciptakan kekebalan kelompok (herd immunity) pada masyarakat. Tujuan : Mengevaluasi hubungan pemberian vaksin AstraZeneca terhadap nilai titer antibodi dan KIPI. Metode : Penelitian ini menggunakan metode  retrospektif dan prospektif kohort Responden yang telah memenuhi kriteria inklusi dan ekslusi akan dijadikan sebagai responden dalam penelitian. Sebanyak 113 responden melakukan vaksinasi COVID-19 AstraZaneca dosis lengkap di Pusat Vaksin UTA’45 Jakarta. Setelah 7 hari pasca-vaksinasi, dilakukan pengukuran kadar titer antibodi dan gejala lokal dan sistemik KIPI selama 7 hari. Hasil: Jumlah responden yang pernah terpapar COVI-19 signfikan secara statistik terjadi pada jenis kelamin laki-laki, umur dibawah 35 tahun, disertai dengan penyakit penyerta (komorbid), aktif berolahraga, merokok dan tidak meminum alkohol. Sebanyak 38 (88.4%) orang dari 43 (38,05%) responden memiliki titer antibodi tinggi dan 5 orang (11,63%)  dengan titer antibodi rendah. Tingginya kadar titer antibodi setelah vaksin COVID-19 berhubungan dengan munculnya gejala atau reaksi sistemik KIPI. Kesimpulan: Terdapat hubungan kadar titer antibodi COVID-19 dengan KIPI pasca vaksinasi
Cellulose Nata de Sago-Hyaluronic Acid Microneedle for Pneumococcal Conjugate Vaccine Saranani, Selpirahmawati; Laugi, Putri S.; K., Intan N.A.; Lakapu, Sonia M.; Syian, Alfiyani; Jayanti, Seftika
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.54045

Abstract

The use of syringe-administered vaccines has significantly increased immunization coverage among children. Still, pneumonia remains the leading cause of death in children under five worldwide, accounting for over 70% of fatalities in this age group. To address challenges such as needle phobia, transdermal drug delivery systems offer a promising, minimally invasive alternative for both local and systemic medication administration. This study focuses on developing and evaluating a nata de sago-hyaluronic acid cellulose microneedle formulation for the transdermal delivery of pneumonia vaccines in children. The study consisted of preparing nata de sago, cellulose suspension, microneedle fabrication, and subsequent characterization and effectiveness testing. Results showed that the microneedle reached swelling equilibrium with a swelling degree of 1. Diffusion tests revealed a drug release rate of 1.173% within 90 minutes, successfully penetrating the stratum corneum. Scanning Electron Microscopy (SEM) analysis confirmed an average microneedle length of 763.6 μm and a width of 191.7 μm for Pin 12, demonstrating its suitability for transdermal application. These findings highlight the nata de sago-hyaluronic acid microneedle as a well-designed and effective platform for pneumococcal vaccine delivery, offering a novel solution to improve pediatric immunization and address key challenges in child healthcare.
OPTIMASI DAN VALIDASI METODE KLT-DENSITOMETRI FASE TERBALIK UNTUK ANALISIS OKSIBENZON DALAM LOSION TABIR SURYA Andayani, Regina; Andira, Retno Permata; Armin, Fithriani
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.43555

Abstract

 AbstractSunscreen is useful for protecting the skin against sun exposure.  Oxybenzone is one of the active ingredients in sunscreen which can cause skin allergies, redness, dryness, and acne. This study aims to optimize and validate the reverse phase densitometry thin layer chromatography (TLC) method for the analysis of oxybenzone in sunscreen lotions. The TLC silica gel 60 RP-18 F254 was used as the stationary phase, the mobile phase was acetonitrile: aquabidest (18:3). The Rf values of oxybenzone in lotion A and B were 0.63. The resolution of oxybenzone in lotions A and B were 2.53 and 3.2, respectively. The correlation coefficient (r) of oxybenzone was 0.999 in the range of 50 – 250 μg/mL, the limit of detection was 16.37 μg/mL and the limit of quantitation was 49.39 μg/mL. The precision of lotions A and B was ≤ 2%. The % recovery of oxybenzone in lotion A and lotion B was  99.33-99.63%. The results showed that the levels of oxybenzone lotion A and B were 3.4% and 2.59% successively.  The reverse phase TLC-Densitometry method is a valid method for the analysis of oxybenzone in sunscreen lotions.Keywords: Oxybenzone, sunscreen, validation, thin layer chromatography-densitometry, reversed-phase. OPTIMASI DAN VALIDASI METODE KLT-DENSITOMETRI FASE TERBALIK UNTUK ANALISIS OKSIBENZON DALAM LOSION TABIR SURYA Abstrak Tabir surya berguna untuk melindungi kulit dari paparan sinar matahari. Oxybenzone merupakan salah satu bahan aktif tabir surya yang dapat menyebabkan alergi kulit, kemerahan, kering dan berjerawat. Penelitian ini bertujuan untuk mengoptimalkan dan memvalidasi metode kromatografi lapis tipis (KLT) densitometri fase terbalik untuk analisis oksibenzon dalam lotion tabir surya. Silika gel TLC 60 RP-18 F254 digunakan sebagai fase diam, fase geraknya adalah asetonitril: akuabides (18:3). Nilai Rf oxybenzone pada lotion A dan B adalah 0,63. Resolusi oxybenzone pada lotion A dan B berturut-turut adalah 2,53 dan 3,2. Koefisien korelasi (r) oxybenzone adalah 0,999 dalam kisaran 50 – 250 μg/mL, batas deteksi adalah 16,37 μg/mL dan batas kuantitasi adalah 49,39 μg/mL. Nilai presisis lotion A dan lotion B adalah ≤ 2%. Persentase perolehan kembali oxybenzone pada lotion A dan lotion B adalah 99,33-99,63%. Hasil penelitian menunjukkan bahwa kadar oxybenzone lotion A dan B berturut-turut adalah 3,4% dan 2,59%. Metode TLC-Densitometry fase terbalik adalah metode yang valid untuk analisis oxybenzone dalam lotion tabir surya.Kata kunci: Oxybenzone, tabir surya, validasi, kromatografi lapis tipis-densitometri, fase terbalik.
Formulation and Antioxidant Activity Test of Purple Button Herb Ethanol Extract Peel-Off Mask Ifaya, Mus; Baco, Juliana; Lolok, Nikeherpianti; Hasanuddin, Silviana; Rama, Wa; Fitriani, Rezky D.
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.54210

Abstract

Purple button herb (Borreria laevis Lamk) contains secondary metabolites, including flavonoids, saponins, phenolics, tannins, and steroids, which have antioxidant activity. Facial masks include pharmaceutical preparations for cleaning, maintaining, and increasing attractiveness. This study aims to formulate a peel-off facial mask preparation from purple button herb extract (Borreria laevis Lamk), which is good and stable as an antioxidant. Ethanol extract from purple button herb was used as an active ingredient in the manufacture of peel-off gel masks with concentrations of 5% (F1), 10% (F2), and 15% (F3) with several physical evaluations including homogeneity, organoleptic (odor, color, shape), pH, drying time, viscosity and antioxidant activity tests carried out using the DPPH method. The results of the antioxidant activity test showed that the peel-off gel mask formula of ethanol extract of purple button herb at concentrations of 5%, 10%, and 15% met the requirements of a good and stable preparation with an IC50 value at a concentration of 5% (F1) of 149.82 µg/mL in the moderate category for antioxidant activity. Based on the test results, the purple button herb can be an antioxidant formulated for peel-off facial masks.
Modulation of membrane transporter expression and activity by mangiferin, epigallocatechin-3-gallate (EGCG), quercetin, and kaempferol: A review Nazihah, Maryam; Estuningtyas, Ari
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.47068

Abstract

Membrane transporters are one of the important factors in drug pharmacokinetics. These proteins mediate drug transport in and out of cells; efflux transporters export the drug from inside the cell, while influx transporters facilitate the entry of it into the cell. Thus, the presence of these membrane proteins influences drug levels in cells, which then determines the drug efficacy and safety profile. Many studies have shown that various exogenous compounds can modulate the activity and/or expression of membrane transporters, including bioactive molecules. Flavonoids are secondary plant metabolites that are very abundant and widely used in diets, supplement products, and traditional medicine. Apart from their medical benefits, flavonoids have been reported to interact with membrane transporters involved in drug absorption and drug resistance. These interactions can be beneficial in multidrug resistance conditions or awareness of drug toxicity. This article collects studies that have been conducted on four widely consumed plant-derived compounds: mangiferin, epigallocatechin-3-gallate (EGCG), quercetin, and kaempferol, and their effects on membrane transporters. The effects can be a consideration when administering these flavonoids together with medication.
Assessment of Total Phenolic and Flavonoid Content from Nine Different Families of Herbal Medicines Originated from West Java, Indonesia Hasanah, Aliya Nur
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53533

Abstract

Indonesia is known as a country with abundant natural resources, one of which is herbal plants. These herbal plants contain secondary metabolites such as polyphenol and flavonoid that have some health advantages. The amounts of these two chemicals can be measured using the UV-visible spectrophotometric method, with gallic acid for polyphenols and quercetin for flavonoids as reference standards. In this study, 18 herbal plants from 9 different families were used to calculate the total phenolic content calculated as gallic acid and the total flavonoid content calculated as quercetin. Quantitative analysis was calculated using a UV-Visible spectrophotometry instrument. Meanwhile, qualitative analysis was observed using thin layer chromatography (TLC). The result shown that five plant extracts from Lauraceae, Fabaceae, Myrtaceae, and Melastomataceae family were obtained which had the highest total phenolic content, namely cinnamon cortex (Cinnamomum burmannii), angsana leaves (Pterocarpus indicus Willd.), bay leaves (Syzygium polyanthum (Wight.) Walp.), harendong bulu leaves (Clidemia hirta (L.) D. Don), and clove leaves (Syzygium aromaticum L.) with respective levels of 2120.00; 2056.19 ; 2049.52 ; 1989.52 and 1837.14 mgGAE/g. Meanwhile, the five plant extracts from Zingiberaceae, Fabaceae, and Lamiaceae family that had the highest total flavonoid levels were red ginger (Zingiber officinale cv rubra), temu ireng (Curcuma aeruginosa), temu giring (Curcuma heyneana), gayam leaves (Inocarpus fagiferus Fosb.), and nilam leaves (Pogostemon cablin Benth.) with respective levels of 130.47; 125.74; 107.91 ; 82.89 and 79.25 mgQE/g
Hypoglycaemic Properties of The Combination of Roselle Calyx (Hibiscus sabdariffa Linn.) and Stevia Leaves (Stevia rebaudiana B.) in Alloxan-Induced White Rats Febriyanti, Raden Maya; Putri, Refitha Nurul; Diantini, Ajeng; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59646

Abstract

Roselle (Hibiscus sabdariffa L.) and stevia (Stevia rebaudiana Bertoni) are known to contain phenolic compounds and flavonoids that act as antioxidants and are beneficial in lowering blood sugar levels. This study aimed to determine the phytochemical content and evaluate the hypoglycemic effects of a combined aqueous extract of H. sabdariffa and S. rebaudiana in a 3:1 ratio on diabetic rats. Aqueous extracts were prepared and analyzed for total phenolic and flavonoid contents using the Folin-Ciocalteu and aluminum chloride methods. Diabetes was induced in male Wistar rats by intraperitoneal injection of alloxan (235 mg/kgBW). Rats in the test groups received 500 or 1000 mg/kgBW of the combination, with blood glucose levels measured on the 0th, 7th, and 14th days post-treatment using a glucometer. H. sabdariffa, S. rebaudiana, and their combination contained total phenolic contents of 102.75, 188.053, and 118.856 mgGAE/g, respectively, and flavonoid contents of 3.099, 6.987, and 4.791 mgQE/g, subsequently. Administration of the combination extract at 1000 mg/kgBW showed the highest hypoglycemic effect, reducing blood glucose levels by 35.98% on the 14th day compared to the negative control (p<0.05). The combination of H. sabdariffa and S. rebaudiana extracts demonstrates significant hypoglycemic activity, attributed to their phenolic and flavonoid content.

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