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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Traditional medicines use among Indonesian young population: a Theory of Planned Behaviour study Widayati, Aris; Rahajeng, Bangunawati; Wulandari, Erna Tri; Abadi, Barnabas Bagus Aditya
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57953

Abstract

Adolescents are a group that is very intensively exposed to changes from the Internet of Things, resulting in reduced exploration of nature, including medicinal plants. This study explores behavioral factors related to the use of herbals among Indonesian adolescents by applying the theory of planned behavior (TPB). The study was an analytic with a cross-sectional design. The independent variables were attitude, subjective norm, and perceived behavioral control. The dependent variable was behavioral intention. The samples were adolescents aged 10 to 19 years, determined from 200 samples in each of Indonesia's five major island groups, so 1,000 respondents were recruited. The instrument was a validated questionnaire that refers to the TPB constructs. Data were analyzed with a chi-square test and regression. 931 respondents participated in the research; the response rate was 93.1%. Approximately 85.1% of the participants expressed an intention to use traditional medicine. There is a statistically significant association between attitude, subjective norms, perceived behavioral control, and the purpose of using traditional medicine. The combined effect of the three constructs accounts for 25.9% of adolescents' propensity for using traditional medicines. All the factors contributed partially, with the subjective norm being the most significant contributor.
Development and Validation of Analytical Method for Piperine in Phytopharmaceutical Product Containing Cabe Jawa Fructus by HPLC Galih, Wening; Permana, Benny; Damayanti, Sophi
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46348

Abstract

Cabe Jawa fruit (Retrofractii fructus) has empirically known to have effects such as anti-inflammatory and analgesic due to the presence of piperine. The maximum daily dose for piperine is 0.300–0.540 mg/kg/person/day. A reliable analytical method is required to ensure that phytopharmaceutical preparation is safe. This study developed and validated a piperine analysis method using phytopharmaceutical samples containing Cabe Jawa. A Shimadzu prominence HPLC SIL-20A Prominence autosampler and an X-Bridge C18 column (5 m x 250 mm x 4.6 mm) were used in the research devices. The OFAT method optimised the mobile phase, instrument systems, and sample preparation. The instrument system was optimized for acetonitrile:1% glacial acetic acid (48:52), 40°C, and a 1 mL/min flow rate. Each solid and liquid sample was prepared using the multilevel methanol dilution and water-dichloromethane liquid-liquid extraction (LLE) method. The results of validating the analytical procedures for solid and liquid samples were LOD and LOQ of 1.290 g/mL and 4.300 g/mL, 1.310 g/mL and 4 g/mL, respectively. Precision: 0.157% and 1.174%. Accuracy for three different concentrations were 94.232±1.050%, 95.387%±0.176%, and 96.272±1.043%; 88.801±0.428%, 89.473 ±0.252%, and 89.338 ±0.052% respectively. The analysis of the sample's piperine revealed that this method met the criteria for the validation parameters.
Lawsonia inermis: Review of Its Anti-inflammatory Properties and Therapeutic Potential Hidayat, Nafisa Nurfatia; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.58785

Abstract

Lawsonia inermis often referred to as henna has been utilized for millennia in many parts of the world in traditional medicine including antibacterial, antifungal, antioxidant, anticancer and immunomodulatory effects and also to treat various inflammatory conditions. This review aims to comprehensively evaluate the anti-inflammatory effects of L. inermis and its potential therapeutic applications. Primary methods included literature searches in scientific databases like PubMed, Scopus, Springer that analyzed the bioactive compounds and their effects on inflammation. L. inermis contains active compounds like lawsone, alkaloids, flavonoids, and tannins, which have been shown to reduce inflammation in various experimental settings by inhibiting the production of pro-inflammatory such as cytokines and enzymes. Studies conducted in vivo and in vitro have shown that effectivity of Lawsonia inermis is effective in lowering edema, healing wounds, and both acute and chronic inflammation which involve regulatory mechanism and mediators of inflammation signalling pathways. Promising outcomes in the treatment of contact dermatitis, wound healing, reduce symptoms and pain management have also been seen in clinical studies. L. inermis shows promise as a natural anti-inflammatory agent. However, further research is needed to fully understand its mechanisms of action and optimize its therapeutic applications, including investigating its potential interactions with other medications and identifying the optimal dosage and administration routes.
Formulation and Characterization Sunscreen Emulgel Containing Cinnamon Bark Oil (Cinnamomum Burmannii Nees Ex Blume) Priani, Sani Ega
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46573

Abstract

Cinnamon bark oil is known to contain high levels of cinnamaldehyde (>50%). Cinnamaldehyde is an aromatic compound that is conjugated with a carbonyl group and potential to have photoprotective activity. The purpose of this study was to develop an emulgel preparation containing cinnamon bark oil and to evaluate the  emulgel in terms of its physical properties, stability, and sunscreen activity. Cinnamon bark oil was characterized based on SNI 06-3734-2006. Cinnamon bark oil at concentrations of 0.5 and 1 % was formulated into an emulgel using a combination of stearic acid and triethanolamine as an emulsifier and viscolam mac 10 as a gelling agent. The preparation was evaluated for its physical characteristics and stability. The sunscreen activity test was carried out in vitro by determining the Sun Protection Factor's values (SPF), % erythema, and % pigmentation.  The results showed that cinnamon oil met the SNI standards of cinnamaldehyde concentration (53.33 %). Cinnamon oil emulgel preparation has good physical properties in terms of organoleptic, pH, viscosity, rheology, spreadability, and stability based on centrifugation and freeze-thaw tests. The addition of 0.5 and 1% of cinnamon oil significantly increased the sunscreen activity of the emulgel based on the SPF, % erythema, and % pigmentation values with the extra protection category. An emulgel containing cinnamon bark oil has been successfully developed which has good physical properties and stability and has sunscreen activity based on the value of FPS, % erythema, and % pigmentation. 
Nanoparticle Technology for Development of Immunostimulant Drugs Using Natural Product : Narrative Review Seran, Yuvina
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53217

Abstract

The field of nanotechnology focuses on systems at the nanometer scale. Nanotechnology is used in the medical field for drug development, medical imaging, and gene therapy. One application of nanotechnology is nanoparticles. Nanoparticles have sizes in the nanometer range, with a scale of 1 to 100 nm. Nanoparticles can be designed to stimulate the immune system and improve the immune response. Literature study using research articles from national and international journals the application Publish or Perish 8 based on the keywords "Immunostimulants, Nanotechnology, nanoparticle, gold nanoparticle, and silver nanoparticle." Based on searching various literature studies, it is proven that nanoparticle preparations can increase immunostimulants with various testing instruments that are often found, namely FTIR (Fourier Transform Infrared), WHICH (Scanning Electron Microscopy), XRD (X-ray Diffraction), HE HAS (Transmission Electron Microscopy), particle size, zeta potential, and spectroscopy UV-visible. Nanoparticles can be an effective drug delivery system and can help maintain the immune system in the body.
The Comparative Antioxidant Efficacy from Different Fractions of Clinacanthus nutans Leaves Anggraeni, Amaliyah Dina; Sadatiyah, Sadatiyah; Lestari, Nadia A.; Afifah, Salmahikaru; Paramitha, Alfina I.
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.57433

Abstract

Indonesia is a tropical country whose population is potentially exposed to ultraviolet (UV) radiation. Continuous exposure to UV radiation triggers the formation of free radicals that cause damage at the cell, tissue and organ levels. Dandang gendis (Clinacanthus nutans) is known for its diverse pharmacological activities, including its role as a source of antioxidants. This study aims to evaluate the antioxidant activity of specific fractions of dandang gendis plant through experimental methods. The fractionation process was carried out by stepwise maceration method. Antioxidant activity test was conducted using DPPH (2,2-diphenyl-1-picrylhydrazyl) method, which measures the ability of the extract to capture DPPH free radicals. The results obtained were IC50 values for vitamin C control at 1.25 μg/mL, ethanol fraction at 36.63 μg/mL, ethyl acetate fraction at 5.07 μg/mL, and n-hexane fraction at 40.19 μg/mL. These findings indicate that the ethyl acetate fraction of Dandang gendis has very strong antioxidant activity. Therefore, it can be concluded that the ethyl acetate fraction of Clinacanthus nutans leaves shows very strong potential antioxidant activity, with the lowest IC50 value compared to the ethanol fraction and the n-hexane fraction, so it has a great opportunity to be utilized as an external antioxidant.
Matoa Leaf Serum (Pometia pinnata Forst) : Physical Characteristics and Antioxidant Activity Khairunnisa, Amalia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49154

Abstract

Matoa Leaf (Pometia pinnata Forst) has antioxidant activity that inhibits free radicals. This research aims to determine the physical characteristic and antioxidant activity of facial serum Matoa leaves (P. pinnata Forst.) with concentrations of the ethanol extract F1 (1%), F2 (3%), and F3 (5%). The physical characteristics tested included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesivity. Antioxidant activity was determined by the DPPH method. The organoleptic results showed that the serum had a yellowish-brown to greenish-brown color, a distinctive aroma of extract, a slightly viscous liquid, and homogeneity. pH test results in F1, F2, and F3 were 6.93±0.02, 5.66±0.02, and 5.05±0.01. Viscosity test results in F1, F2, and F3 were 2983.3±76.3 cP, 3200±50 cP, and 3950.0±50.0 cP. Spreadability test results in F1, F2, and F3 were 5.33±0.05 cm, 5.06±0.05 cm, and 5.03±0.05 cm. Adhesivity test results in F1, F2, and F3 were 1.3±0.04 seconds, 1.89±0.07 seconds, and 2.43±0.09 seconds. Antioxidant activity values in F1, F2, and F3 were 206,445±2,900 ppm (very weak), 149,464±4,025 ppm (moderate), and 49,204±0.383 ppm (very strong). This research concludes that increasing the concentration of the extract increases color and aroma intensity, viscosity, and adhesivity, and decreases the pH value, spreadability, and IC50 value of facial serum.
Formulation Sunscreen Spray Gel of Vetiveria zizanioides (L.) Nash Root Infusion Damarwati, Vella Lailli; Fajarani, Rizky Anita; Sabeta, Meilidya Vani; Kurniawan, Muhammad Fariez; Winanta, Aji
Indonesian Journal of Pharmaceutical Science and Technology 2025: Vol. 12 Suppl. 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s1.59024

Abstract

Vetiveria zizanioides (L.) Nash is one of the plants with high flavonoid compound content with antioxidant activity. This study aims to formulate a spray gel of the root of Vetiveria zizanioides (L.) Nash infusion determines UV protection and observes the level of irritation caused by the application.  This study used formulas at variations concentrations FI 1%, FII 5%, and FIII 10%. The formulas observed flavonoid content, sun protection factor (SPF) value, and irritation index. Flavonoid content was tested using the Willstatter method. The SPF value was determined in vitro using UV-spectrophotometer, while the irritation test was conducted using the Draize test method. The SPF value test results showed that Formula 0 (F0), FI, FII, FIII, and the commercial preparation had SPF values of 0.355, 2.856, 5.324, 6.634, and 13.438, respectively. Meanwhile, the irritation test obtained an irritation infection of 0.3 in the commercial preparation and 0.6 in F3. Therefore, FII has the potential to be UV-protected and have a minimal irritating effect.  
The Effect of BHA as an Antioxidant to the Accelerated Stability Test of Snakehead Fish and Kelulut Honey Ointment Taurina, Wintari; Andrie, Mohamad; Mukkaromah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.37776

Abstract

The ointment of snakehead fish extract and kelulut honey has a synergistic potential to boost the wound recuperation process. This ointment is formulated for topical use to be easily applied to the wound area. The ointment base used in this preparation is adeps lanae. Adeps lanae is an easily oxidized substance that can cause the preparation to become unstable. The addition of antioxidants is one way to prevent the oxidation process in the preparation. This has a look at aims to decide the impact of the addition of BHA as an antioxidant in the ointments of snakehead fish extract (Channa striata) and kelulut honey (Heterotrigona itama) at 28 days of storage with an accelerated stability test method with a temperature 40 ± 20C and RH 75 ± 5%. The ointment was made with various concentrations of BHA 0.005% (F1), 0.01% (F2), and 0.02% (F3) then tested the physical properties of the ointment and analyzed by SPSS. Results of spreadability test analysis showed an increase of the spread and significant differences between F1, F2, and F3 to F0. The adhesion test analysis results showed a decrease in the stickiness of time bonding strength and a significant difference. The test results showed a decrease in acid number on the acid number F2 and F3. Results of the organoleptic test, homogeneity, and power protection showed that all formulas have good stability. F2 is the best formula to prevent oxidization of the dosage indicated by the smallest value of the acid number.
Exploration of Anti-FABP3 Aptamer Conformation Using Coarse-Grained Molecular Dynamics Simulation Aathirah, A Sayyidatina; Hardianto, Ari; Gaffar, Shabarni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.58912

Abstract

Aptamers have been extensively utilized in the development of diagnostic and therapeutic methodologies for a variety of diseases. Aptamer N13, obtained through the SELEX process in previous research, has been identified as an anti-FABP3 ssDNA aptamer to enhance diagnostic techniques for myocardial infarction. This study provides an in-depth examination of the conformation and structural dynamics of aptamer N13 using in-silico methods. These include secondary structure prediction via DNA-fold, 3D structures modeling through RNA-Composer, and coarse-grained molecular dynamics (MD) simulations with SIRAH AMBER. The 83 μs MD simulation results reveal that the predicted conformation generally struggles to maintain stability, as indicated by the RMSD values and their fluctuations. However, residues 1-50 demonstrate relatively stable conformations, particularly beyond the 40 μs point in the simulation. In contrast, residues 51-90, constituting the free end, exhibit persistent conformational instability. This instability is likely attributable to their single-stranded and free nature compared to the other regions characterized by loops that confer greater stability. Our findings suggest that the predicted conformation from existing tools does not yet provide the most stable reference structure, necessitating further exploration through extended molecular dynamics simulations. While current simulations offer a relatively stable conformational reference, additional simulations are warranted to determine the most stable configuration of the free-end region, thereby elucidating its role in the aptamer’s affinity and specificity

Page 44 of 50 | Total Record : 494

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