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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Arjuna Subject : -
Articles 382 Documents
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The Effects of N-Acetylcysteine as Adjuvant Therapy To Reduce TNF-Α Level And Increase SPO2/FIO2 Ratio In Improving Hypoxemia In COVID-19 Patients Ramadhan, Fitratul; Putra, Ngakan Putu Parsama; Setyawan, Ungky Agus; Djajalaksana, Susanthy; Listyoko, Aditya Sri; Al Rasyid, Harun
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.30874

Abstract

Tumor Necrosis Factor Alpha (TNF-α) is a pro-inflammatory cytokine that plays a crucial role in COVID-19 disease progression. N-acetylcysteine (NAC) works throughout several GSH-mediated mechanisms and is known to eliminate oxidative stress in acute respiratory distress syndrome (ARDS) in COVID-19. This study aims to analyze the effect of the N-Acetylcysteine as Adjuvant Therapy to reduce TNF-α levels and Increase SpO2/FiO2 ratio in Improving hypoxemia in COVID-19 Patients. This is a quasi-experimental, non-equivalent control group design study. There were 91 subjects selected using non-random sampling, which consisted of 75 patients in the NAC group and 16 patients in the control group. The TNF-α level was measured using the ELISA method, and SpO2/FiO2 ratio was calculated on day 1 (on admission) and day eight after NAC 5000mg/ 72 hours was given. Statistical analysis was conducted using Wilcoxon and Mann-Whitney U Test. There is a significant decrease in TNF-α level in the treatment group (median 1.49±5.22) (p=0.016) compared with the control group (median 1.64±1.99) (p=0.005). The Median SpO2/FiO2 ratio on day 1 is 163.70±69.64 in the control group and 121.49±40.41 in the treatment group (p=0.005). The Median SpO2/FiO2 ratio on day 8 is 249.69±132.26 in the control group and 151.29±59.18 in the treatment group (p=0.001). There is a positive correlation between serum TNF-α level and SpO2/FiO2 ratio after administration of adjuvant therapy NAC (r=0.240, p=0.038). There is a positive correlation and significant decrease of serum TNF-α and SpO2/FiO2 ratio after adjuvant NAC therapy, which improves hypoxemia in COVID-19 patients.
Convalescent Plasma Therapy: The Early Use in Moderate to Severe COVID-19 Patients in Hospitals with Limited Resources Mahdi, Bagus Aulia; Suryantoro, Satriyo Dwi; Romadhon, Pradana Zaky; Windradi, Choirina; Widiyastuti, Krisnina Nurul; Novendrianto, Dwiki; Widiasi, Etha Dini; Agustin, Esthiningrum Dewi; Firdausa, Sarah; Alkaff, Firas Farisi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.29113

Abstract

COVID-19 cases in Indonesia in the period of June-July 2021 showed a catastrophic spike. During this period, a recently discovered variant, the delta variant, appeared to be one of the sources of COVID-19 infection. Treatment modalities are limited due to reduced stock of drugs. A case of a 63-year-old man has been reported, with a history of having been vaccinated with two doses of Sinovac, experiencing moderate-to-severe symptoms of COVID-19 infection then given convalescent plasma therapy since his initial admission to the hospital. Three days after being given convalescent plasma therapy, the improvement was noticeable. Shortness of breath, cough, fever, and weakness were less complained. On the seventh day the patient fully recovered and got discharged. Convalescent plasma therapy was e ective in early stage and was able to improve outcomes. Indonesia needs sucient stocks of convalescent plasma as a therapy to overcome the limitations of medicines.
Evaluation of Epidemiological Investigation 1 -2-5 Implementation Program in Sukabumi Prasetyowati, Heni; Widawati, Mutiara; Fuadzy, Hubullah; Fuadiyah, M. Ezza Azmi; Ginanjar, Aryo; Nurindra, Rohmansyah W; Ridwan, Wawan; Hodijah, Dewi Nur; Sulaeman, Rizal Pratama
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.29599

Abstract

Epidemiological investigations as part of the malaria surveillance system in Indonesia are carried out through the 1-2-5 method. Assessing the 1-2-5 strategy compliance level at the district level is the first step towards determining whether the surveillance and response strategy is working as planned or not. This study was conducted in order to determine whether PE 1-2-5 had been implemented in health centers (puskesmas) in malaria receptive areas according to the technical guidelines issued by the Indonesian Ministry of Health. Health centers were determined through purposive sampling technique. The sampling is determined by selecting health centers that have been doing malaria vector control service in 2018 and 2019. Ten Puskesmas in malaria receptive areas in Sukabumi District were selected. The informants in this study were the key players in the malaria program at the health centers: the head of the health centers, the manager of the malaria program, and the village malaria officer (JMD) who were involved in the vector control process in 2018 and 2019 at the selected health centers. Data collection was conducted through in-depth interviews done by researcher with informants. The interview showed that the malaria program personnel in Sukabumi are doing the strategy as best as possible in order to achieve malaria elimination. 1-2-5 surveillance program in Sukabumi district has been implemented even though the implementation is not as ideal as the technical guidelines suggested by the Indonesian Ministry of Health, Sukabumi district still applied the strategy based on it by adjusting various aspects (resource situation and the availability of facilities) to the suitable condition in Sukabumi.
Analysis of HIV/AIDS Health Problems in Pacitan District East Java 2020 Famil, Mohamad
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 3 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i3.29362

Abstract

The implementation of health problem analysis is carried out to increase the eff ectiveness and effi ciency of solving health problems through the selection of health problems that become priority problems in a region. The purpose of this study was to analyze the problem and determine the priority of health problems in the work area of the Pacitan District Health Office, East Java Province. This research is a descriptive observational study conducted at the Pacitan District Health Office in January 2020. The type of data used is secondary data obtained from the 2016-2019 Pacitan District Health Profile and primary data obtained through interviews with related parties, namely the head of the fi eld. , section head and program holder. Prioritization of health problems is carried out using the USG method based on the criteria of Urgency, Seriousness, Growth and fi nding the root of the problem using the fi shbone diagram method. The increase in HIV/AIDS cases with an USG score of 128 has become a top priority health problem in Pacitan District. An increase over the last  4 years with the highest number of cases in 2019, which was 39 cases. The fishbine diagram shows the root of the HIV/AIDS problem, namely the lack of public knowledge about HIV/AIDS, the lack of public knowledge about HIV/AIDS, the lack of awareness of people at risk for conducting an HIV test, this makes the community less aware of information about HIV/AIDS, causing public stigma. which results in people being closed / unwilling to check themselves at the puskesmas orhospital. The increase in HIV/AIDS cases is one of the problems in Pacitan district. To reduce the incidence, health workers need to optimize the dissemination of information about HIV/AIDS, especially risk factors, causes, prevention, symptoms and treatment. Increase the understanding of health workers and public awareness in conducting early detection.
An Overview of COVID-19 Patients in RSUD Bhakti Dharma Husada Surabaya from September 2020 to June 2021 Trisnawati, Yunika; Firman Suryadi Rahman
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.29377

Abstract

The COVID-19 pandemic has been lasting more than a year. Until now, research on the analysis of an overview of COVID-19patients has not been carried out at RSUD Bhakti Dharma Husada Surabaya. This study aims to describe the COVID-19 cases in RSUD Bhakti Dharma Husada Surabaya about the gender of patients, highest number of patients, the most recovered patient, the highest death rate occurred, and Case Fatality rate (CFR). This study is a descriptive observational study with a case series approach. The data used in this study were COVID-19 data from the application of online Hospital ditjen yankes from September 2020 to June 2021. The majority of COVID-19 cases occured in women (53.04 %). The COVID-19 patients mostly came to the hospital in June 2021, about 241. The most recovered patients in Oktober were 255 patients. The highest death rates occurred in June 2021 ware 47 patients. Case Fatality rate (CFR) is at 5.79 % because in June 2021 the health facilities were full, and cause patients did not get help quickly. Many patients have been forced to self-isolate at home so that they have worsened and fi nally died. Most COVID-19 patients who were treated at the RSUD Bhakti Dharma Husada Surabaya from 2020 to June 2021 occurred in women and the most patients who were admitted was in June 2021.
Analysis of COVID-19 Surveillance System at Makassar City Health Office 2020 Fatmasari; Syahrul, Fariani; Darajat , Zakiah; Kusuma, Eva Flourentina
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 2 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i2.29378

Abstract

One of the infectious diseases that emerged in Indonesia in 2020 has been designated as a COVID-19 pandemic since March 11, 2020, and until now, the pandemic has not been completed. Surveillance has a role in providing information on targeted disease control activities; analyzed the COVID-19 surveillance system based on the current system approach at the Makassar City Health Office. Methods This research is a descriptive observational study conducted in September-October 2020. Data collection was carried out using in-depth interviews with people who were key informants of COVID-19 surveillance activities. There are four informants in this study. In addition, secondary data was obtained from the P2P field regarding COVID-19 cases. In general, the Input component has not been fulfilled; HR has multiple tasks, the job desk is irregular, and several important forms are not used in the methods section. The process component has been running but has not been maximized because there are still incomplete data, no reports based on the PE form, the All-Record TC-19 information system has not been used, and data analysis is still incomplete, data analysis is not equipped with data interpretation. In the Output component, the success rate for public health surveillance criteria has not been evaluated, and the dissemination of information has been carried out well across sectors. The implementation of COVID-19 surveillance at the Makassar City Health Office has been carried out well, but some things are still not optimal.
Clostridium difficile Infection (CDI) by Hypervirulent BI/NAP1/027 Strain: a Comprehensive Review of Toxigenicity, Pathogenesis, Risk Factors, and Preventative Measures Budayanti, Ni Nyoman Sri; Aryana, I Gusti Putu Suka; Wedari, Ni Luh Putu Harta
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.31030

Abstract

Clostridium difficile is an anaerobic bacil gram-positive bacteria, able to form spores and toxin, that is transmitted among humans through the fecal–oral route. Clostridium difficile infection (CDI), a typical nosocomial infection has been contributed to a signifi cant proportion of morbidity and mortality among in-patients with a case-fatality rate of 14% within 30 days after diagnosis. Profound culture and toxin examination for C. difficile are still minimal in many hospitals in various Asian countries. Consequently, C. difficile reports in Asia remain rare. Highly virulent form of C. difficile caused greater fatality and epidemics severity. Elderly age, hospitalization, exposure to antibiotics e.g., cephalosporins, fluoroquinolones, clindamycin, and penicillin contributed as main risk factors. Hypervirulent strain BI/NAP1/027 demonstrated to carry CdtLoc gene locus encodes CD196 ADP-ribosyltransferase (CDT) or known as binary toxin. Virulence factors are TcdA, TcdB, CDTa CDTb in which hypersporulation and mutation of TcD gene by hypervirulent strain led to toxin hyperexpression. Early cases detection, building management team to evaluate patient positive with all C. difficile toxins, hand hygiene improvement, continuation of contact precautions after diarrhea resolution, audit of infection control, and restriction of antimicrobials should be implemented as preventative measures. Focus measures also should emphasize on development of vaccine of C. difficile to boost immune state of elderly people. This review aims to describe severity of disease caused by hypervirulent BI/NAP1/027 C. difficile strain, its mechanism or pathogenesis, risk factors, current treatment options available, along with proposed preventative measures and infection control.
Correlation Between Risk of Febrile Neutropenia Based on Rondinelli Score with Clinical Outcomes in Acute Lymphoblastic Leukemia Patients Alifadiningrat, Dianira Hanum Febia; Puspitasari, Dwiyanti; Hernaningsih, Yetti
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.31916

Abstract

Febrile neutropenia (FN) is the most severe complication in patients with blood cancer and chemotherapy. Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children and the most common cause of febrile neutropenia. The low number of neutrophils in ALL patients due to lymphoblast cancer cells and the toxicity of chemotherapy makes patients susceptible to infection which, if not treated immediately, can lead to death. Early risk assessment for infectious complications in FN patients is needed to increase clinician awareness in high-risk patients and eliminate unnecessary therapy for low-risk patients. The Rondinelli scoring system is a reasonably good instrument for predicting severe infectious complications in pediatric patients with ALL who have febrile neutropenia. This study aims to determine the relationship between the risk category for febrile neutropenia (FN) based on the Rondinelli score with clinical outcomes in FN patients with acute lymphoblastic leukemia (ALL) in the Hematology-Oncology division of the child health department of RSUD Dr. Soetomo. This analytic observational study used secondary data FN patients with acute lymphoblastic leukemia (ALL) implementing a total sampling. From 30 samples of pediatric ALL patients with febrile neutropenia at Dr. Soetomo Hospital for June 2018-June 2020 it was found 17 patients (56.7%) had a moderate risk score category, and 13 others were in a low-risk category (43.3 %). Patients were dominated by moderate and severe severity of neutropenia respectively, 43.3%, had neutropenia for 1-7 days (50%), fever less than seven days (66.7%), had a length of stay of 8-14 days, and 15-30 days 33.3% each. Conclusion from this research is that there was a signifi cant relationship between the Rondinelli score category in pediatric ALL patients with FN with the severity of neutropenia p=0.037; R=0.383), duration of neutropenia (p=0.021; R=0.420), duration of fever (p=0.000; R=0.618), and length of stay (p-value 0.005; R=0.496).
Cat's Liver Disease Detection with SGOT and SGPT Evaluation as a Gold Standard Diagnosis Kurnia Desiandura; Asih Rahayu; Freshinta Jellia Wibisono
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.32087

Abstract

SGOT and SGPT are two enzymes found in the liver in large amounts. Therefore, elevated levels of these two enzymes in the blood indicate liver disease. This study aims to identify liver disease in cats in Surabaya through the levels of SGOT and SGPT in the blood as the gold standard of diagnosis. Samples came from stray cats and domesticated cats of random age, breed, and sex. The blood samples collected were 62 samples, consisting of 33 domestic cats and 29 samples from stray cats. This study showed that from 33 samples of domesticated cats, 19 samples had higher than normal levels of SGOT, and from 29 samples of stray cats, 27 samples had higher than normal levels of SGOT. For SGPT levels, from 33 samples of domesticated cats, six samples had higher than normal levels of SGPT, and from 29 samples of stray cats, six samples had higher levels of SGPT than average. Data analysis used an independent sample t-test with SPSS for Windows with a signifi cance level of 0.05. The data analysis results showed no signifi cant diff erence, which means that the high levels of cat SGOT and SGPT enzymes did not signifi cantly aff ect the origin of the cat. Therefore, it can be concluded that high levels of SGOT and SGPT as the gold standard for detecting liver diseases can occur in all cats, including stray cats and domesticated cats.
Novel Potential Immune Response Biomarkers to Multidrug-Resistant Tuberculosis in the Last Five Years Unicha, Mutiara Shinta Noviar; Wayan Tunas Artama; Niken Irfa Nastiti
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 1 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i1.32119

Abstract

Rapid and accurate detection performs an important role in the control of raising MDR-TB. Currently, studies on biomarkers as targets for TB diagnostic tests using immune response products to indicate the presence, mycobacterial load, early markers, and activity, diff erentiation, and progression markers of TB infection are rapidly available. This systematic review aims to summarize the last fi ve years of potential biomarkers studies from the immune response for MDR-TB rapid diagnostic development. The authors performed a literature search on four databases as ProQuest, EBSCO Academic Search, Universitas Gadjah Mada Online Library Journal Database, and Google Scholar, retrieved from January 2016 to December 2021. In total, 18,288 articles were identifi ed and three tudies met the inclusion criteria. Several promising biomarkers were found for MDR-TB diagnosis purposes, such as sCD14, PGLYRP2, FGA, Indoleamine 2, 3- dioxygenase (IDO), and Complement Receptor 2 (CR2). A combination of sCD14, PGLYRP2, and FGA were bringing a diagnostic design with a higher sensitivity (94.7%) and specifi city (80%) than the design of a single protein. Higher IDO activity towards the MDR-TB group than in the DS-TB group with a sensitivity of 87.50 %, specifi city of 72.22 %. CR2 was the main focus due to its association with IL-6. After induction of CR2 peptide in a dose-dependent manner, the expression level of IL-6 was decreased signifi cantly. It might because of CR2 peptide regulating the macrophages proinfl ammatory cytokines secretion to decrease the local infl ammation of the immune response. These biomarkers are strong candidates for MDR-TB diagnosis due to their important role as the pathogenesis marker of MDR-TB. There is a need of further research to investigate those immune response products and their role to eliminate infection of Mycobacterium tuberculosis directly.

Page 30 of 39 | Total Record : 382

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