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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
Arjuna Subject : -
Articles 382 Documents
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Antibiotic Sensitivity Against Klebsiella spp. in the Post Debridement Culture an Open Fracture in Emergency Department of dr. Soebandi Hospital Jember Agustina, Dini; Cahyaningrum, Endiningtyas; Komariah, Cicih; Semita, I Nyoman; Putra, Yudha Ananta Khaerul
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.18978

Abstract

Surgical site infection (SSI) in open fracture is often caused by bacterial contamination in the management of open fracture. Because of that, one of the most important thing in handling open fracture is debridement. Prophylactic antibiotics given are Cephalosporin and Aminoglycosides. Post-debridement culture is important in predicting the incidence of infection. One of the bacteria that is often found in post-debridement culture is Klebsiella spp. which can produce ESBL to fight β-lactam class of antibiotics. The purpose of this study was to determine antibiotic sensitivity against Klebsiella spp. in the post-debridement culture of cases of open fractures in the emergency department of dr. Soebandi hospital Jember. This study uses a laboratory exploratory research design. The sample of this study was the isolate of Klebsiella spp. which amounts to 5 from post debridement culture of open fracture patients in the emergency department of dr. Soebandi hospital Jember from March to May 2019.The method used is diffusion (Kirby Baurer) by matching using the CLSI standard table to determine sensitive, intermediate, or resistant. The results of this study showed that most antibiotics had resistance to Klebsiella spp., including β-lactam antibiotics, such as Amoxicillin, Ceftriaxone, Cefixime, Penicilin, Meropenem, and Cefadroxil. Vancomycin antibiotics are still sensitive to Klebsiella spp. in all patients. Gentamicin, Ciprofloxacin, Tetracycline, and Chloramphenicol antibiotics were sensitive in 1 patient. Erythromycin intermediates antibiotics against Klebsiella spp.. The conclusion of this study is that all β-lactam group antibiotics are resistant to Klebsiella spp while the most sensitive antibiotic is Vancomycin.
Relationship between Knowledge and Preventive Behavior of Leptospirosis in Berbah District Sleman Regency Yogyakarta in 2021 Murwani, Arita; Ashar, Hadi; Apriningtyas Budiyati, Gani
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.33076

Abstract

Public Health is the resultant from an balance of individual, agent, and environment problems. Individual knowledge and the ability to adapt to the environment vary greatly. The individual awareness and sensibility towards surroundings will contribute to the public health status. Environmental factor in the raining season with high intensity of rainfall cause some risks such as flood. It can be a disaster and destroy the facilities in the area. This can be a transmission media, a new habitat of insects for certain disease, one of them is Leptospirosis. The condition after flood with low level of clean water facilities can make these bacteria live and reproduce, with warm temperatures, neutral pH of water, humidity and also high rainfall. Leptospirosis cases in Indonesia are sufficiently high which in 2019, there are 845 cases with mortality rate for 16.26%. Some factors may affect the number of the case. This research is aimed to know the factors related to the preventive behavior of leptospirosis. It was held in Public Health Center Berbah Yogyakarta. The method of research is quantitative research with design survey method, quasi experiment. The population is the clients visiting to Public Health Center Berbah, with the average number of clients coming are 200 clients/day. The sample is taken by accidental sampling to the clients with the number of daily visits (50 persons). The result shows, that of five analyzed factors, knowledge is the factor related to the preventive behavior of leptospirosis.
Characteristics of Leptospirosis Cases in Pacitan District, East Java Province Prasetio, Firman Aji; Isfandiari, Muhammad Atoillah; Nugroho, Agung
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.34740

Abstract

Leptospirosis is a disease that is still a public health problem in the world, however, these cases are rarely reported due to the difficulty of distinguishing clinical symptoms from other endemic diseases and the lack of appropriate laboratory diagnostic services. Pacitan district is one of the districts in East Java that reported Leptospirosis cases for 3 consecutive years from 2017 to 2019. There were total 92 Leptospirosis cases with Case Fatality Rate (CFR) of 15.22% in Pacitan. This study is a descriptive study with a Cross Sectional design that aims to describe the distribution of characteristics of Leptospirosis cases in Pacitan district based on person, place, and time. This study used secondary data from the Pacitan district Health Office, East Java province. The population in this study was all cases with Leptospirosis cases as many as 92 cases recorded in the Pacitan district Health Office data for 2017–2019. The sample of this study were all cases with Leptospirosis as many as 92 cases.The results of the study obtained  Leptospirosis cases in Pacitan district in 2017–2019 based on person occured most in the age group of 40–49 years old by 20.45%, in the male sex by 68.48%, and in the population who worked as farmers by 73.58%. Based on the place where the most occured in Tulakan sub district by 52.75%, while based on time, most occured in February, March and April, this is because February to April is the rainy season. Therefore, based on the results of the study, it is necessary to educate the public, especially at risk groups, about the risk factors and Prevention of Leptospirosis.
Prolonged Use of Protective Masks Induced Facial Skin Injury in Primary Healthcare Workers during COVID-19 Pandemic: A Systematic Review Yapanto, Alvian Mohamad; Isnaeni, Aulia Rahma; Lestari, Khairani Ayu; Satyarsa, Agung Bagus Sista
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.34898

Abstract

COVID-19 transmission necessitates health workers to use personal protective equipment (PPE), especially protective masks when delivering medical services. Long-term use of protective masks might cause facial skin injuries. Our study aims to provide a systematic review to explore the phenomenon and incidence of protective masks induced facial skin injuries in primary healthcare workers. This systematic review was created by obtaining articles from the PubMed database and the Cochrane library from 2020 to 2021, using the keywords "Face skin injury," "Wearing protective masks for a long time," and "Wearing protective masks and facial skin disorders." Inclusion criteria were studies that fully report the phenomenon of wearing protective masks and the incidence of facial skin injuries. One hundred and sixty-eight studies were obtained, but only 14 articles matched the inclusion criteria with more than 10,430 participants from different countries that covered various characteristics of facial skin injuries in primary healthcare workers. The findings obtained dominant characteristics of health workers who experienced facial skin injuries: women, N95 masks, and daily N95 coverage for more than 6 hours (p<0.05). Facial skin injuries are often seen after using protective face masks, as it is used for an extended period as part of a defensive effort during work. Therefore, measures that protect health workers from COVID-19 and prevent health workers from potential injuries of protective masks must be taken into account.
Long-term Consequences, Chances of Re-infection, and Outcomes among Cases Recovered with Severe COVID-19 at a Tertiary Care Centre in Central India Saad, Talha; Mishra, Satyendra; Rai, Hindeshwari; Rawat, Sumit Kumar
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.35072

Abstract

COVID-19 has a wide disease spectrum. Different presentations may be seen in different people, with uncertain long-term fate. The amount and longevity of immunity provided among the infected also vary from person to person which might in turn affect the chances of re-infection. Current study tries to uncover the incidence, disease severity and outcomes amongst those who have been previously hospitalized for COVID-19. A prospective cohort study where all patients admitted to intensive care facility at the tertiary care center were followed up for any occurrences of re-infection for more than one year. All cases were followed up telephonically and at scheduled visits to the hospital by trained personnel. A total of 410 cases with a mean age of 59.8 years, including 310 (75.6%) males and 100 (24.4%) females. Among these 410 patients 287 remained alive till the end of study period. Re-infection rates among recovered ICU admitted seriously ill patients were 1.4% whereas the rate of ICU re-admission due to COVID-19 re-infection was only 0.7%. Re-infection among female was 1.1% whereas in male was 1.5%. ICU readmission rate among female was 1.1% while in male was 0.5% only. The chances of re-infection in female were seen less than that in males, but the severity of re-infection in females was found to be higher. COVID-19 re-infection in previously severely infected COVID-19 patient is not so common. The chances of a severe disease among such cases are even rarer.
The Curative Innovation of Novel Triple-Drug Compared to Double-Drug Regimen in Lymphatic Filariasis: A Systematic Review Ruby, Rivaldi; Arifin, Erlangga Saputra; Charens
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.35162

Abstract

The World Health Organization has established a global program for the elimination of lymphatic filariasis by 2020; recent data has shown an impracticable result accomplishing it. Therefore, this study aims to identify the efficacy and safety between triple-drugs (DEC, ALB, IVM) and double-drugs (DEC & ALB/IVM & ALB) for lymphatic filariasis treatment. A systematic review was conducted with Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement guidelines. The literature search was done using five databases: PubMed, ProQuest, ScienceDirect, EBSCO, and CENTRAL until December 3, 2020 without any publication date range imposed. Data collection was done by three independent reviewers and entered into a predesigned data extraction form. Cochrane risk of bias tool 2.0 was utilized in the quality assessment of the studies. Search strategies identified 209 studies. Three relevant full-text articles met our inclusion criteria. Overall studies had low risk of bias. The main findings are as follows: (a) Administration of single dose of triple-drug regimen resulted in a total elimination of microfilaria 12 months after treatment whilst 91% participants given with double-drug remained microfilaremic (p=0.002); (b) In larger samples (n=182), triple drug cleared microfilaria in 96% of the participants and only 32% of the participants receiving double-drug regimen after 12 months observation; (c) Statistically, the triple-drug safety has a lower degree than the double-drug regimen (p=0.02). The triple-drug treatment has a better efficacy compared to the double-drug regimen in treating lymphatic filariasis. Furthermore, both regimens are proven safe with no serious adverse events elicited.
A Prototype N95 Sterilizer: An Alternative Solution during Personal Protective Equipment Crisis Azhar, Muh. Aprizal; Natzir, Rosdiana; Sjahril, Rizalinda; Palantei, Elyas; Katu, Sudirman; Hidayah, Najdah; Massi, Muhammad Nasrum
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.37427

Abstract

The high demand for N95 masks, especially during the COVID (Coronavirus disease)-19 pandemic, has caused shortages worldwide. This study aimed to examine the sterilization ability of the portable sterilizer prototype for N95 masks and its effect on the filtration ability and changes in air resistance on the N95 mask in order to thrift personal protective equipment (PPE) use during a shortage. The sample used was an N95 mask type 1860. The mask was contaminated with 0.6-0.8 MFU Staphylococcus aureus and Escherichia coli. The sterilization methods used were Ultraviolet Germicidal Irradiation (UVGI), Heat at 75°C, and a combination of both from 1 to 120 minutes. Next, the masks were cultured in a nutrient agar medium. For aerosol penetration and air resistance tests, masks were tested before and after the sterilization process, lasting from 5 to 60 minutes. This prototype sterilizer with Heat effectively killed E. coli and S. aureus starting from 3 minutes. The filtration ability of the N95 mask was maintained at >95% even after the sterilization process with 75°C heat, UVC, or a combination of both for up to 60 minutes. There was also no significant difference in air resistance between new masks and masks that had been sterilized using a portable sterilizer. This prototype sterilizer with Heat at 75°C can effectively sterilize against both gram-positive and negative bacteria in the N95 mask without reducing the aerosol filtration ability and changing the air resistance of the N95 mask.
Epidemiology of Escherichia coli as a Critical Pathogen of Bloodstream Infection Patients in Tertiary Referral Hospital Endraswari, Pepy; Mertaniasih, Ni Made; Setiawan, Firman; Paramita, Ayu Lidya
Indonesian Journal of Tropical and Infectious Disease Vol. 10 No. 3 (2022)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v10i3.39494

Abstract

Bloodstream infections (BSI), caused primarily by multidrug-resistant Escherichia coli, are a significant cause of morbidity and mortality worldwide. This study aims to evaluate the epidemiology of E. coli as a critical pathogen in patients with bloodstream infections in a tertiary referral hospital. This is a retrospective study using a  descriptive observational research design. This study used a medical record instrument for bloodstream patients in Dr. Soetomo Hospital's inpatient ward with Gram-negative bacteria results of blood cultures in the Clinical Microbiology Laboratory from April 2021 to September 2021. The observed variables include; antimicrobial sensitivity, patient clinical characteristics, demographic data, clinical diagnosis, and clinical outcome. In 6 months, 276 Gram-negative bloodstream infection patients were treated at Dr. Soetomo Hospital. The proportion of E. coli was 17 %.  The main characteristics of patients were over 60 years old (28%), and 54% were female. 63% of E. coli were ESBL, and 9% were carbapenem-resistant microorganisms. High antimicrobial resistance was found in quinolones (100%), ampicillin (93%), piperacillin (74%), tetracycline (72%), ceftriaxone (66%), cefotaxime (65%), ceftazidime (60%), cefazolin (65%), and trimethoprim-sulfamethoxazole (65%). The most common potential determinant profile discovered was linked to immunocompromised status due to malignancy.  The high number of antimicrobial-resistant bacteria showed the importance of strict infection control and updated epidemiology data as a guide for empirical antimicrobial therapy.
Germ Tube Induction Test Comparing Total of Six Liquid and Three Solid Media in Candida albicans Ruby, Rivaldi; Arifin, Erlangga Saputra; Kurniawan, Sandy Vitria; Surja, Sem Samuel
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.34097

Abstract

Invasive candidiasis (IC) has a high mortality rate of 70%, thus diagnosis should be established without delay. Given its fast result, serological test such as β-d-glucan (BDG) test is one alternative diagnosis modalities. However, it lacks specificity. Candida albicans germ tube antibody (CAGTA) test is an alternative serological test which has a high sensitivity of 76.2% and specificity of 80.3%.  Manufacturing CAGTA serological test requires provision of specific germ tube antigen. In this study, various culture media were tested to find the best media for germ tube induction. This study was an experimental in vitro study. The number and length of the germ tube were recorded in two- and three-hour incubation periods. A total of six samples containing one C. albicans ATCC 90028, four C. albicans wild type strains, and one C. krusei wild type strain were used. Nine media were tested to induce germ   tube formation: human and sheep serum, fetal bovine serum, mueller hinton agar and broth, tryptic soy agar and broth, brain heart infusion agar and broth. At both incubation periods, the medium with the highest number of germ tube was human serum (p=0.001 and p=0). The longest germ tube was found in sheep serum at two-hour incubation period (p=0.005). Mueller hinton broth (MHB) showed comparable results with human and sheep serum (p>0.05). Human serum is a superior inducer of morphogenesis. However, the use of MHB is recommended in this study, since provision of fresh human and sheep serum on a regular basis is impractical.
Electronic Nose (E-Nose) for Quality Detection of Tuna (Thunnus thynnus) Contaminated Bacteria Astuti, Suryani Dyah; Muhamad, Alfian Baggraf; Rahmatillah, Akif; Yaqubi, Ahmad Khalil; Susilo, Yunus; Aji , Angger Krisna
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.39206

Abstract

Tuna (Thunnus thynnus) is a food that is often consumed raw to support raw food diet activities, so it has the potential to be contaminated with Salmonella typhi bacteria. Fish can be contaminated by bacteria due to their high water and protein content. Indonesia is the world's main tuna producer. Salmonella typhi detection in fresh tuna in Indonesia must be negative for Salmonella microbial contamination in order to meet food safety requirements. Microbial testing has drawbacks, such as long delays. An electronic nose was used to detect Salmonella typhi bacteria in tuna fish. The sample used consisted of 3 kinds of samples: Salmonella typhi bacteria, tuna, and tuna with Salmonella typhi contamination. The research was conducted with a shelf life of 48 hours and a sensing period every 6 hours with a sensor array of 8 sensors. The sensor output data is processed using the PCA (Principal Component Analysis) method. Through the PCA method, each variation of bacterial treatment can be classified. The result of the cumulative percentage variance of the two main components (PC) in the classification test between Salmonella typhi, tuna, and tuna with Salmonella typhi bacteria contamination was 90.5%. The most influential sensors in this study are TGS 825 for PC1 with a loading value of 0.625 and TGS 826 for PC2 with a loading value of -0.753. Therefore, it can be concluded that an electronic nose can classify between pure tuna and tuna contaminated with Salmonella typhi bacteria.

Page 32 of 39 | Total Record : 382

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