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Majalah Obat Tradisional

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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 564 Documents

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Histopathological Changes of Egg Cells in the Uterine of Ascaridia galli after Treatment with Extract of Veitchia merrillii Nuts Ummu Balqis; Muslina Muslina; Muhammad Hambal; Farida Athaillah; Muttaqien Muttaqien; Azhar Azhar; Ismail Ismail; Rastina Rastina; Eliawardani Eliawardani; Abdul Harris; Abdullah Hamzah; Henni Vanda; Darmawi Darmawi
Majalah Obat Tradisional Vol 22, No 3 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The aim of the study was to observe the histopathological changes of the entire egg cells in the uterine of Ascaridia galli worms treated with crude ethanolic extract of Veitchia merrillii nuts. Histopathological changes of the entire egg cells were observed to describe that the activity of extract V. merrillii nuts interfered the reproduction process could decrease the quantity and quality of A. galli eggs. The experiments consisted of 16 head A. galli female adult worms divided into four groups, contained four worms of each, and maintained in 0.9% phosphate buffered saline (PBS). First group, a negative control experiment consisted of A. galli in 0.9% PBS. Second group, concentration of 15 mg/mL albendazole was used as a positive control. Third group and fourth group, in vitro exposure of the worms to the crude ethanolic extract V. merrillii nuts at a concentration of 25 mg/mL and 75 mg/mL, respectively. The histopathological changes of egg cells in the uterine region of stained worms was evaluated by light microscopic examination at 40x magnification. The results showed that shrinkage and disintegration of the entire egg cells in the breakage of uterus. The results indicate that the possible use of the plant as a potential anthelmintic against A. galli, the intestinal nematode parasite of domestic fowl.

AKTIVITAS SITOTOKSIK FRAKSI n-HEKSANA : KLOROFORM DARI EKSTRAK METANOL KULIT BATANG MANGROVE (Rhizopora mucronata) PADA SEL KANKER MYELOMA Harwoko Harwoko; Esti Dyah Utami
Majalah Obat Tradisional Vol 15, No 2 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The Mangrove plants have been long used for traditional medicine to cure gastroenteritis and cancer theraphy. Rhizopora mucronata, one species of Mangrove, is still rare studied that have potention as anti cancer. This research goals was to fractination bioactive compound of R. mucronata with various organic solvent and cytotoxicity test of those fraction n-heksana : chloroform to cancer cell myeloma. The extract from R. mucronata stem barks was made by maseration with methanol. The extracts was partitioned with chloroform, etil acetate, and methanol. The fraction of chloroform was fractination with n-heksana : chloroform (3 : 2). The fraction respectively was examined their cytotoxicity on Myeloma cell-line by MTT methods. Result showed that fraction n-heksana : chloroform from methanolic extract of R. mucronata stem barks was toxic on Myeloma cell, with the IC50 value was 15 µg/mLand phytochemical study showed that the active fractions contained flavonoid and terpenoid.

PENGARUH JUS BUAH DURIAN (Durio zibethinus Murr.) TERHADAP PROFIL FARMAKOKINETIK PARASETAMOL PADA TIKUS PUTIH (Rattus norvegicus L.) JANTAN GALUR WISTAR Pinondang Simaremare; Mohamad Andrie; Bambang Wijianto
Majalah Obat Tradisional Vol 18, No 3 (2013)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Paracetamol is widely used as analgesic and antipyretic agent in treatment of pain and fever. Paracetamol has interaction with carbohydrates and alcohol. Durian is the fruit native of Indonesia, that contain carbohydrates and alcohol. The aims of this research were to study the influence of durian fruit juice to the absorption and elimination kinetics of paracetamol and to know the dose of durian fruit juice that influence the absorption and elimination kinetics of paracetamol. The study was conducted using 16 rats, divided into 4 groups (n=4 per group). Each group was treated the following treatment : control paracetamol (paracetamol 9 mg/200 gBW), dose 1 group (paracetamol 9 mg/200 gBW and 0.675 g/200 gBW of durian fruit juice), dose 2 group (paracetamol 9 mg/200 gBW and 1.350 g/200 gBW of durian fruit juice) and dose 3 group (paracetamol 9 mg/200 gBW and 2.700 g/200 gBW of durian fruit juice). Blood sampling is done from the vein of rat’s tail at minutes 10, 20, 30, 40, 60, 90, 120, 180, 240, 300 and 360. The quantitation of paracetamol in plasma was determined by UV spectrophotometer at 243 nm. Result showed that durian fruit juice changed the absorption kinetics of paracetamol, durian fruit juice decreased Ka, Cpmaks and increased Tmaks parameter of paracetamol. Durian fruit juice also changed the elimination kinetics of paracetamol, its decreased Vd, Ke, Cl and increased the value of AUC and T1/2 paracetamol. All doses of durian fruit juice can influence the absorption and elimination kinetics of paracetamol includes Ka, Cpmaks, Tmaks, Vd, Cl, Ke, T1/2 and AUC parameters on wistar male rats (Rattus norvegicus L.).

In Vitro α-Glucosidase Inhibitory Activity of Ethanol Extract of Buas-buas (Premna serratifolia Linn) Dini Hadiarti
Majalah Obat Tradisional Vol 22, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

In 2008, diabetics in Indonesia has reached 8,5 million of 11,1 % prevalence in West Kalimantan. It was estimated to reach 14,1 million in 2035. The treatment of diabetes may occur adverse reactions such as hypoglycemia, lipoatrophy, lipohypertrophy, lactic acidosis, gastrointestinal disturbances, allergic reactions, and obesity. Therefore, it is necessary to find an alternative medicine to overcome this problem. Buas-buas (Premna serratifolia Linn) could supposedly be an anti diabetic by inhibiting the α-glucosidase enzyme, due to the compositions of secondary metabolites, cardioprotective activity and it has a similar genus with Premna serratifolia Linn. The soxhlet extraction result from Premna serrtifolia Linn leaf powders produced of 34,1 % yield. Meanwhile, the activity of α-glucosidase in vitroinhibition test with amicroplate reader in various concentrations of samples of 0,125, 0,5, 1, 1,5, 2, dan 2,5 2% (b/v) were obtained the absorptions of 37,95, 74,77, 86,15, 91,03 and 91,69 %, respectively. The extraction of Premna serratifolia Linn leaf revealed that the concentration of 2 % of sample inhibited in vitro α-glucosidase with a percentage of 91,03 %. The extraction of Premna serratifolia Linn leafinhibited α-glucosidase of 97 % from the percentage of Acarboseinhibition.

UJI ANTIINFLAMASI EKSTRAK METANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav ) PADA TIKUS PUTIH Atik Fitriyani; Lina Winarti; Siti Muslichah; Nuri Nuri
Majalah Obat Tradisional Vol 16, No 1 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Inflammation is a natural respon for tissue damage. To reduce inflammation, people used a NSAID (Non Steroid Antiinflammatory Drugs). This agent caused many side effects. One of medicinal plant empirically used for traditional medicine is Piper Crocatum Ruiz & Pav. This plant is potential to be developed as medicine for anti-inflammatory because its contains flavonoid, saponin, tannin, and alkaloid. The aim of this study was to investigate the anti-inflammatory effect of the P.Crocatum extract using carrageenan-induced rat oedema test. For the anti-inflammatory activity measurement, five different groups were established and piper extract was administered in three different doses : 25, 50 and 100 mg/kgBW. Acetosal was used as a reference agent. It was found that reduction in the flammation was 77.58% for acetosal, 72.37% for 25 mg/kg extract, 85.60% for 50mg/kg, and 81.02% mg/kg for 100mg/kg extract. Extract of P. Crocatum at 50 mg/kg showed the strongest anti-inflammatory activity among the doses used. The results showed that P. Crocatum extract posseses promising anti-inflammatory effect.

PENGARUH KOMBINASI EKSTRAK TERPURIFIKASI HERBA SAMBILOTO (Andrographis paniculata (Burm.f.) Nees) DAN HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP TRANSLOKASI PROTEIN GLUT-4 PADA TIKUS DIABETES MELLITUS TIPE 2 RESISTEN INSULIN Novena Yety Lindawati; Agung Endro Nugroho; Suwijiyo Pramono
Majalah Obat Tradisional Vol 19, No 2 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Sambiloto herb (Andrographis paniculata (Burm. f.) Nees.) and pegagan herb (Centella asiatica (L.) Urban) are excellent medicinal plants which are being developed as traditional for antidiabetic. The research aims to see the effect of combination from purified extract of sambiloto herb and pegagan herb of translocation of GLUT-4 protein in model type 2 diabetes mellitus rats-insulin resistance compared with the use of each purified extract. Test preparations were divided into 8 groups include three from combination purified extract of sambiloto herb and pegagan herb: I (912,1: 300), II (651,5: 500), III (390,9: 700) in mg/kg BW, IV (purified extract of sambiloto herb 1303 mg/kg BW), V (purified extract of pegagan herb 1000 mg/kg BW), VI (positive control metformin 45 mg/kg BW), VII (negative control CMC-Na 0.5%) and VIII (normal control). Parameters measured semi quantitative data translocation of GLUT-4 protein in cells muscles of the thigh (soleus muscle) rats using Immunohistochemistry methods. Test animals are of type 2 diabetes mellitus insulin-resistance was induced by fructose (1,8 g/kg BW) and fat-rich food (95% pellet, 5% egg yolks and 5 mL/ 200 g BW lard) for 70 days. Determination of insulin resistance used 3 parameters such as blood glucose levels, lipid levels (triglycerides, LDL, cholesterol, and HDL), and hypoglikemic tests with glibenklamid compared to normal controls animals. Insulin resistance test results using statistical analysis Independent Samples t-Test showed significant differences (p< 0.05) between normal rats with fat-fructose rats at day-50 and -70. This indicate fat-fructose rats indicated type 2 DM insulin resistance. Group of combination I (combination purified extract of sambiloto herb and pegagan herb (912,1: 300 mg/kg BB) showed effect of translocation of GLUT-4 protein was better than each purified extract with significantly p<0.05 with oneway ANOVA.

PENGARUH ENKAPSULASI EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP TEKANAN DARAH ARTERI PADA TIKUS Siti Aminah; Suwaldi Suwaldi; Achmad Fudholi; Wahyono Wahyono
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Rutin and quercetin are flavonoid compounds containing in the extract of mulberry (Morus alba L.) leaves have an influence on the cardiovascular system. This study aims to assessment of the blood pressure effect and cardiac puls after giving ethanolic extract of mulberry leaves. The extract was made using 95% ethanol by remaseration method. The content of rutin and quercetin in the extract were determined by using HPLC(High Performance Liquid Chromatography). The formula of the encapsulation containing extract 0.25% w/v, chitosan 0.5mg/mL and TPP (sodium tripolyphosphate) 1mg/mL. Characterization of extract encapsulated was done on the particle size, encapsulation efficiency and FTIR. Extract encapsulated was given to rats orally, subsequently arterial blood pressure and heart rate were measured using Coda Non-Invasive Blood Pressure System. The results showed that mulberry extract contains rutin (0.879±0.138) mg/g and quercetin (4.427±0.065) mg/g. Ratio of chitosan-TPP with 0.5:1 forms particle size were 25.11-45.2 nm, encapsulation efficiency (76.14±2.29)%. Mulberry leaves extract and encapsulated extract could decrease arterial blood pressure.

FORMULASI MOUTHWASH NANOEMULSI KOMBINASI MINYAK SEREH (Cymbopogon citratus) DAN MINYAK JERUK PURUT (Citrus hystrix) SEBAGAI ANTIKANDIDIASIS ORAL TERUJI IN VITRO TERHADAP Candida albanicans ATCC 10231 Meta Juniatik; Khoirunnissa Hida; Fransisca Priskaningtyas Wulandari; Nurul Pangestuti; Ni'matul Munawaroh; Ronny Martien; Sylvia Utami Tunjung Pratiwi
Majalah Obat Tradisional Vol 22, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kandidiasis adalah penyakit infeksi jamur yang masih menjadi masalah kesehatan di Indonesia, kandidiasis terutama oral sebagian besar dikarenakan pertumbuhan abnormal Candida albicans pada rongga mulut. Minyak jeruk purut dan serai telah terbukti memiliki aktivitas antijamur terhadap Candida albicans. Komposisi limonen, α-terpineol, sitronelil assetat, terpineol, β-pinene, pada minyak jeruk purut dan citronelal pada minyak sereh membuat kombinasi keduanya minyak memiliki potensi sebagai terapi alternatif untuk kandidiasis oral. Kedua minyak ini dapat diformulasikan dalam bentuk nanoemulsion obat kumur. Nanoemulsion dipilih karena memiliki beberapa keuntungan seperti yang jelas, stabil, dan meningkatkan aktivitas antijamur minyak sereh dan minyak jeruk purut. Penelitian ini dimulai dengan determinasi tanaman, uji karakterisasi minyak atsiri (kelarutan, indeks bias, dan berat jenis), dan analisis kandungan minyak atsiri dengan GC-MS. Nanoemulision diformulasikan dengan metode titrasi air. Optimalisasi campuran minyak dan VCO dilakukan untuk mendapatkan nanoemulsion yang jernih dan stabil. Formula terbaik dikarakterisasi (ukuran partikel, viskositas, potensi zeta, dan stabilitasnya), dilakukan analisis senyawa kimia minyak atsiril dalam formula optimum dan menguji efek penghambatan formula oleh metode mikrodilusi. Analisis data daya hambat dilakukan dengan One Way ANOVA. Berdasarkan hasil penelitian, 0,4% minyak campuran, 3,6% VCO, 17,3% tween 80, 8,7% PEG 400 dan 70% air merupakan formula terbaik yang dapat membentuk sistem nanoemulsion dengan rata-rata ukuran partikel 21,4 nm, viskositas rendah, potensi zeta yang rendah dan stabil selama penyimpanan freez-thaw. Nanoemulsi secara signifikan memiliki efek penghambatan lebih efektif daripada kontrol positif.

PENGARUH LAMA PENYIMPANAN TERHADAP STABILITAS FISIK DAN KIMIA LOTION PENUMBUH RAMBUT EKSTRAK BIJI KEMIRI (Aleurites moluccana L. Willd.) Anas Putro Senu Prasojo; Sri Mulyani; Mufrod Mufrod
Majalah Obat Tradisional Vol 17, No 1 (2012)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Etanolic extract 70% of candlenut which has 5% concentration have been reported to have hair restoring activity. This study aims to investigate the effect of length storage on physical stability and flavonoid content of hair restoring lotion candlenut extract so that produce an acceptable form. Lotion were made in variation of xanthan gum concentration 0.5%; 1%; 1.5%. Flavonoid content were measured by densitometry. Observation result of physical stability such as latched power, viscosity test, and flavonoid content were statistically analyzed. Result of formula orientation showed that lotion which has 1% concentration of xanthan gum was the best which has latched power less than 1 second, viscosity increased weekly, and segregation was not occur. Type of emulsion result was o/w. Densitometry result showed that there were decrease of relative flavonoid ontent before and after storage, but it was not significant (α = 0.58).

The usage of Jati Leaves Extract (Tectona grandis L.f) As color of lipstick Rety Setyawaty; Meldina R. Pratama
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Lipstick is one of the most used cosmetics by women. According to Tranggano and Latifah (2007), lipstick is a cosmetic applied to the lips, to protect the lips in cold and dry air so that the lips are not easy to dry and crack. Lipstick is used by women for a long time so that lipstick should be safe and do not cause irritation. Chemicals substances in the manufacture of lipstick can accidentally be consumed and long-term use so that its accumulation in the body would be harmful to health. Synthetic lipstick color is one part of the dangerous lipstick making material. Synthetic substances can be replaced with natural dyes. The use of natural dye limits on cosmetics is 5-15% (Mercado, 1991). One example of natural dyes that can be used is the dye from the Jati leaves (Tectona grandis L.f). This study aim is to prove that Jati leaves (Tectona grandis L.f) can be used as a natural dye in the material of lipstick. The method used in this research is the method of extraction maceration with jati leaf samples of 300 grams and ethanol of 96%. Component of lipstick formula which are cera alba, lanolin, vaseline, cetyl alcohol, paraffin solid, oleum ricini, oleum rosae, propylene glycol, butyl hydroxytoluene, methyl paraben, and the addition Jati leaf extract under the concentration of 0%, 18% , and 22%. The material of lipstick is easy to apply, stable, brown color, homogeneous, melting point of 600C, range pH between 3 at 4 and lipstick have a breaking point of 500 grams. Jati leaf extract (Tectona grandis L.f) can be used as a dye or color of lipstick.

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