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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 564 Documents
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Effects of Polyherbal Tablet for Hypertensive Patients Woro Rukmi Pratiwi; Eti Nurwening Sholikhah; Dwi Aris Agung Nugrahaningsih; Mia Munawaroh Yuniyanti; Mustofa Mustofa; Setyo Purwono
Majalah Obat Tradisional Vol 25, No 3 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.62363

Abstract

Hypertension is a degenerative disease whose prevalence is high and continues to increase over time. Polyherbal tablet have long been used by Indonesian people for hypertension drugs containing garlic (Alium sativum), jelawe (Belericae fructus), temu ireng rhizomes (Curcumae aeruginosae) and kapulaga (Amomi fructus) extracts. This study aims to determine the effect of polyherbal tablet on hypertensive patients. The subjects of 29 hypertensive patients participated in a open-randomized-without comparison-study for 6 weeks. Subjects were divided into 3 groups, each subject received polyherbal tablet with a dose of 2x600 mg (group 1), 2x1200 mg (group 2) and 2x2400 mg (group 3). Blood pressure was monitored on D-0, D-3, D-5, D-7, W-2, W-3, W-4, W-5 and W-6. There was a significant decrease in systolic and diastolic blood pressure at the sixth week in all three treatment groups. The highest decrease in systolic blood pressure was in group 1 while diastolic blood pressure was in group 2 (-22.94 ± 5.871 and 13.13 ± 4.324 respectively). The lowest reduction in systolic and diastolic blood pressure occurred in the third group (-15.07 ± 3,519 and 8.98 ± 3,394 respectively). This study suggests that polyherbal tablet contains garlic (Alii sativi), jelawe (Belericae Fructus), temu ireng rhizome (Curcumae aeruginosae) and cardamom (Amomi Fructus) can reduce blood pressure in patients with hypertension. 
Carbonated Hydroxyapatite Containing Propolis as an Antibacterial Agent Candidate against Aggregatibacter actinomycetemcomitans Ayunda Nur Sukmawati; Sri Pramestri; Al. Sri Koes Soesilowati; Suryono Suryono
Majalah Obat Tradisional Vol 25, No 3 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.62712

Abstract

One of the periodontal pathogenic bacteria that can cause periodontitis and alveolar bone destruction is Aggregatibacter actinomycetemcomitans. An alveolar bone defect can be treated using a bone graft. Carbonated hydroxyapatite (CHA) is an alloplastic graft material. Alloplastic materials do not have vascularization, which will increase the risk of bacterial adhesion. Therefore, adding an antibacterial agent is needed to prevent bacterial adhesion, which will improve periodontal healing. Propolis is a natural ingredient that has broad-spectrum antibacterial activity and does not cause bacterial resistance. This study aimed to assess the antibacterial activity of carbonated hydroxyapatite after being incorporated with propolis against Aggregatibacter actinomycetemcomitans. Carbonated hydroxyapatite was embedded into four different concentrations of propolis solution (2.5%, 5%, 7.5%, and 10%). An antimicrobial assay against Aggregatibacter actinomycetemcomitans was done using the disc diffusion test method. The inhibition zone was measured to determine the antibacterial ability of the specimens. The inhibition zone was found on the carbonated hydroxyapatite incorporated with propolis at all concentrations. Carbonated hydroxyapatite incorporated with 10% propolis showed the largest inhibition zone. Data analysis using the Kruskal–Wallis test showed a significant difference between the groups tested (p <.05). In conclusion, carbonated hydroxyapatite incorporated with propolis has antibacterial activity against Aggregatibacter actinomycetemcomitans
Formulation and Evaluation of Water Fraction Hair tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves (Camellia sinensis L.) Elsa Fitria Apriani; Adik Ahmadi; Vini Noviani
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53665

Abstract

Hair growth tonics containing herbal and synthetic ingredients have been developed to overcome hair loss and baldness. Advanced technological developments made many Indonesians prefer to use herbal products compared to synthetic products due to their fewer side effects. Green tea leaves (Camellia sinensis L.) is a plant believed to increase hair growth rates due to its flavonoid compounds. The purpose of this study is to formulate hair tonic from water fraction ethanolic extract green tea leaves, to look at the activity of hair growth-promoting, and also to look at physical stability, irritation tests, and microbial contamination.  The positive control used is 2% Minoxidil. The hair growth activity test was carried out by applying a hair tonic to rabbits. Hair growth measurement data were statistically tested by the ANOVA test. The formulated green tea leaves tonic met the physical properties test. The tonic produces similar growth activities with the positive control (significance difference (p> 0.05)). In addition, the tonic does not have a skin irritation effect on rabbit skin and is free from bacteria.
Antioxidants and Antityrosinase Activity of Ethanolic Basil Leaves Extract (Ocimum americanum L.) and Eygenol Dio Damara Handoyo; Ermi Girsang; Ali Napiah Nasution; I Nyoman Ehrich Lister
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.56081

Abstract

Harm effect from UV light, both UV-A and UV-B is contributing as a disease trigger and has an impact on human health. To investigate the bioactive compound, antioxidant, and the potential of basil leaves as antiaging sources particularly as the tyrosinase inhibitor. This study used phytochemical screening for the bioactive compound, DPPH scavenging activity for antioxidant assay, and tyrosinase inhibition activity for the antiaging property. The phytochemical screening shows that the basil leaves extract has flavonoid, saponin, phenol, steroid, and alkaloid. The basil leaves extract has lower antioxidant activity (20.55 ± 0.04 μg/mL) compared with eugenol (2.44 ± 0.26 μg/mL) through DPPH scavenging activity. The basil leaves extract (35.59 ± 0.83 μg/mL) has lower antiaging activity particularly as antityrosinase activity compared with eugenol (10.87 ± 0.41 μg/mL). Our findings suggest that basil leaves can be used as an antioxidant and antiaging source, particularly as a tyrosinase inhibitor.
Antibacterial Activity of Self-Nanoemulsifying Drug Delivery System (SNEDDSS) Loaded with Mangosteen (Garcinia mangostana L.,) Peels against Baccilus subtitis, Bacillus cereus, and Staphylococcus aureus isolated from Diabetic Foot Ulcer Patients Liza Pratiwi
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.58116

Abstract

Diabetic Foot Ulcer is a complication of diabetes mellitus characterized by open sores on the surface of the skin or mucous membranes as well as extensive dead tissue followed by bacterial invasion. Patients with Diabetic Foot Ulcer are resistant to some antibiotics so that alternative therapies such as potential traditional medicines involving mangosteen peels are being developed. Mangosteen peels contain compounds of phenolic, tannin, flavonoid, and xanton. To improve the stability of α-mangostin and improve bioavailability, it requires the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS). This study aimed to analyze the antibacterial effect of optimal SNEDDS of ethyl acetate fraction from mangosteen peels against Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus and to analyze the comparison of inhibition zone diameter between the optimal SNEDDS formula of the ethyl acetate fraction from mangosteen peels and ethyl acetate fraction without SNEDDS against the bacteria. This study began with making 70% ethanol extract from mangosteen peels which was then fractionated to obtain the ethyl acetate fraction. Furthermore, the ethyl acetate fraction was made into optimal SNEDDS formula resulted of Design Expert software with Tween 80, PEG 400, and VCO. The optimal SNEDDS formula of the ethyl acetate fraction from the mangosteen peels was tested for its antibacterial effectiveness against Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus. The results revealed that SNEDDS loaded of ethyl acetate fraction from mangosteen peels had antibacterial activity against both types of Gram-positive bacteria, Bacillus subtilis, and Staphylococcus aureus, which cause diabetes ulcers, and that it did not have antibacterial activity against Bacillus cereus. Moreover, the tested SNEDDS loaded ethyl acetate fraction and ethyl acetate fraction without SNEDDS had strong inhibitory activity against Bacillus subtilis. Meanwhile, they provided such a smaller inhibition zone as tested against Staphylococcus aureus that they had moderate antibacterial activity.
Hydroxyl Radical Scavenging Activity of Stachytarpheta jamaecensis Root Extract using In Vitro Deoxyribose Degradation Assay Juliyatin Putri Utami; Yusrinie Wasiaturrahmah; Deby Kania Tri Putri
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.61746

Abstract

Use and demand of traditional medicinal plants currently growing in the direction that research in traditional medicines have also increased. One of the plants that is efficacious as a medicine is S. jamaecensis. This plant is usually used by people as a traditional medicine to treat various diseases. This study aims to determine the antioxidant activity of porterweed root. Antioxidant activity assays performed using hydroxyl radical scavenger that begins with the extraction by maceration. Dry roots of S. jamaecensis  (250 g) was soaked with ethanol 96% for 3x24 hours at room temperature. The liquid extract obtained is evaporated by rotary evaporator and waterbath till viscous extracts is obtained. Then to extract performed phytochemical screening by quantitative and qualitative method. The antioxidant test was carried out using the hydroxyl radical scavenger method. The extract concentrations were varied, namely 125, 250, 500 and 1000 ppm. The data obtained was performed one-way ANOVA test. The results of the phytochemical screening showed the extract contains flavonoids, alcaloids, saponins, phenols and tannins. The results obtained were significant values from the antioxidant test with the antiradical scavenger method, the largest average value of root extract was 60.606% at a concentration of 1000 ppm. The results of spectrophotometric measurements showed that the extract has IC50 was 683.5294 µg/ml, while vitamin C has  IC50 lower value (251.700 µg/ml). Q
Ethanolic Extract of Pluchea indica Less leaf Increases Serum Growth Hormone in Lactating Rats Rul Afiyah Syarif; Nungki Anggorowati; Mia Munawaroh; Mae Sri Hartati Wahyuningsih
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.62060

Abstract

The objectives of the study were to evaluate the effect of ethanolic extract of P. indica Less leaf (EPI) on serum growth hormone (GH), milk yield, body weight gain of dams, and dam’s organ weight in lactating rats. A total of 25 lactating rats with six pups were randomized and distributed to one of five treatments (control (RO water), standard (domperidone 2,5 mg/kg BW/day), EPI 250 (250 mg/kg BW of EPI), EPI 500 (500 mg/kg BW of EPI), and EPI 750 (750 mg/kg BW of EPI)). The treatment was administered daily starting from the 2nd until the 15th day of lactation. On the 16th day serum growth hormone level, body and organ weight of rats were measured. Serum GH levels in the EPI 750 group (1963.25 ± 360.91 pg/µL) increased significantly compared to the domperidone (409.46 ± 28.80 pg/µL) and the control group (723.40 ± 95.78 pg/µL, p0.05). There was significant body weight gain in the EPI 750 group compared with the domperidone group. There was no significant difference in organ weight gain in each group. The study revealed that ethanolic extract of P. indica Less leaf can increase serum growth hormone in lactating rats.
In Vitro ACE Inhibitory Activity and Bioactive Compounds of Aqueous Extract of Citrus amblycarpa I Gusti Ayu Wita Kusumawati; I Made Wisnu Adhi Putra; Ida Bagus Agung Yogeswara
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.65028

Abstract

Citrus amblycarpa contain flavonoid-rich compounds and play important role in suppressing the conversion of angiotensin-converting enzyme 1 (ACE 1) to angiotensin-enzyme 2 (ACE 2). This study aimed to determine the bioactive compounds in the lime peel extract and their ability as in vitro ACE inhibitor activity. The lime peel extract was obtained by boiling the dried peel and dried leaves for 7 min at 70oC. The bioactive compound of the peel and the leaves were compared. The total phenolic, quercetin, rutin, and GABA were further quantified using spectrophotometer UV vis. The aqueous extract of C. ambylcarpa peel showed a high concentration of phenolic, quercetin, rutin, and GABA than that of the leaves extract. Furthermore, the peel extract at low concentration (0.0001 g/mL) has high efficiency in inhibiting ACE activity up to 133%. It can be concluded that the peel of C. amblycarpa is a good candidate for the management of hypertension.
The Effects of Green Betel Leaf (Piper betle) Extract Eye Drops on the Number of Staphylococcus aureus Colonies in Conjunctivitis Wistar Rats Model (Rattus novergicus) Mahira Aisyah Putri Nur; Sudaryanto Sudaryanto; Endang Sri Lestari; Erwin Kresnoadi
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.65242

Abstract

Irrational use of antibiotics can cause resistance to some diseases such as bacterial conjunctivitis caused by Staphylococcus aureus. Previous research said that green betel leaf (Piper betle) contains antimicrobial compounds such as eugenol, cavalry, tannins, saponins, and flavonoids which also have antiseptic power as well as antibiotics. This study aims to prove the decrease in the number of Staphylococcus aureus colonies after giving green betel leaf eye drops (Piper betle) to conjunctivitis Wistar rats (Rattus norvegicus). This research was true experimental with a pretest-posttest control group design. 25 male white Wistar rats as objects were selected by simple random sampling and grouped into 5 groups randomly. The rats were given Staphylococcus aureus, control group K+ was given 0.5% levofloxacin eye drops, and K- was given aquadest as a comparison. Treatment groups P1, P2, and P3 were given different concentrations of betel leaf eye drops. Swab pretest was done 3 days after the rats were inoculated with Staphylococcus aureus and swab post-test was done 5 days after the rats were given green betel leaf eye drops, the calculation of Staphylococcus aureus bacteria colonies used the Total Plate Count (TPC) method. There was a significant decrease (p<0.05) in the number of bacterial colonies for K-, K+, P1, P2, and P3 groups. In addition, there was a significant difference (p<0.05) between K+ with P1 and K+ with P3. There was a decrease in the number of Staphylococcus aureus for all groups of conjunctivitis Wistar rats (Rattus norvegicus)
Application of Ozonated Olive Oil as Adjunctive Therapy after Periodontal Pocket Curettage towards Collagen Density of Alveolar Bone in Periodontitis Healing Process (In Vivo Study with Sprague dawley) Dahlia Herawati; Etty Cahya Pertiwi
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.65984

Abstract

Periodontitis is an inflammatory disease of the supporting tissue of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with periodontal pocket formation. Application of ozonated olive oil in dentistry is based on the actions such as antimicrobial and therapeutic agent, needed as adjunctive therapy after periodontal pocket curretage. Collagen is the main constituent of alveolar bone extracellular matrix and needed as a scaffold in the formation of mineralized matrix. The aim of this study was to determine the density of collagen in alveolar bone on periodontitis healing process after adjunctive topical application of ozonated olive oil in periodontal pocket curretage. In this study, 32 Sprague dawley rats were randomly divided into two groups: curetted-topical application of ozonated olive oil as treatment groups and curetted-topical application of 1% CMC-Na as placebo group. Periodontitis induced by placing silk-ligature around submandibular incisors for 7 days. Subsequently, the rats were sacrificed on days 3, 5, 7, and 14 after curetted and topical application, and each group was represented by four rats. The staining was done using Mallory staining method. All the results were statistically analyzed using Kruskal-Wallis and Mann-Whitney tests. The results showed that there were significant differences (p<0,05) in the density of collagen between two groups. The study concluded that adjunctive topical application of ozonated olive oil after periodontal pocket curretage significantly increase the density of collagen in alveolar bone on periodontitis healing process in Spraque dawley.

Page 42 of 57 | Total Record : 564

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