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INDONESIA
Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 478 Documents
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Effectiveness of Dexamethasone, Methylprednisolone and Hydrocortisone Administration on LDH, CRP, D-and PaO2/FiO2 Ratio Muhammad Zubaidi; Mohamad Isa; Ira Nurrasyidah
Berkala Kedokteran Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i1.15708

Abstract

Abstract: Steroids are the standard recommended therapy for COVID-19, especially in critically ill patients. Previous studies have shown that steroids are beneficial for inflammatory markers such as C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH) and D-dimer as well as the value of the PaO2/FiO2 ratio. This study aims to determine the differences in the effects of the steroid’s dexamethasone, methylprednisolone and hydrocortisone on inflammatory markers. This research is a retrospective cohort study. The samples were all COVID-19 patients with critical degrees from January to June 2021. The independent variables were dexamethasone, methylprednisolone and hydrocortisone. The dependent variables are CRP, LDH, D-dimer and the ratio of PaO2/FiO2. The statistical test used was the Kolmogorov-Smirnov test and continued with the Kruskal-Wallis test and the Mann-Whitney U test. A total of 148 subjects with a total sample of dexamethasone 60, methylprednisolone 55 and hydrocortisone 33. The statistical test results showed a significant difference in the effect of the steroid dexamethasone, methylprednisolone and hydrocortisone on the value of the PaO2/FiO2 ratio (p=0.04). Administration of hydrocortisone and dexamethasone was statistically superior to methylprednisolone for increasing the PaO2/FiO2 ratio.
The Risk of Adverse Drug-Drug Interactions for Stable Angina Pectoris Patients with Heart Failure Complication Prescribed Polypharmacy Fadillah, Ahmad Aldi; Bakhriansyah, Mohammad; Yustikasari, Intan; Nurikhwan, Pandji Winata; Adiputro, Dwi Laksono
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17404

Abstract

Stable angina pectoris (SAP) is an imbalance that occurs when myocardial oxygen need increases disproportionally, causing complaints of chest pain. Uncontrolled SAP can lead to a complication of heart failure (HF). Polypharmacy treatment frequently given to SAP patients with HF complications can be potentially detrimental for them. This study aims to determine the risk of adverse drug-drug interactions in SAP patients with HF complications prescribed polypharmacy. This was an analytic observational study with a cross-sectional approach using retrospective data from medical record data from 2020-2021 among hospitalized patients in cardiology ward Ulin General Hospital, Banjarmasin. Potential drug-drug interactions were determined using the Lexicomp tool from the UpToDate® site. Prevalence Odds Ratio (POR) and 95% Confidence Interval (95%CI) were determined using the Logistic Regression test at the 95% level of confidence. Twenty-four SAP patients with HF were recruited. According to its potential interactions, the most interactions were under category C (82.6%), followed by category B (11.3%) and category D (6.0%). Based on its level of severity, the most common was moderate (77.4%), followed by minor (13.0%) and major (9.5%). SAP patients with HF who were not prescribed polypharmacy had a lower risk of adverse drug-drug interactions by 64.7% compared to polypharmacy users, although it was not statistically difference (crude POR 0.353, 95% CI; 0.360-3.421; p-value = 0.369). This study shows that there is a tendency of lower risk of adverse drug-drug interactions in SAP patients with HF complication prescribed polypharmacy compared to those without polypharmacy, but the association is not statistically significant.
Risk Factors Analysis in Recurrent Stroke Events: Literature Review Sayeeda, Adinda; Agianto, Agianto; Agustina, Rismia; Rizany, Ichsan
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17428

Abstract

After the first stroke, according to epidemiological data, there is a 30% risk of recurrent stroke. That events are the population who had suffered stroke and the recurrence rate is 9 times compared to the normal population. Results of research from the Stroke Association stated that the possibility of recurrence stroke was 3.1% in 30 days, 11.1% within one year, 26.4% within five years, and 39.2% within 10 years. This literature review is intended to analyze the risk factors of recurrent stroke events. The literature review was carried out by searching for articles in 2011-2021 in Indonesian and English. There were four databases for providing electronic journal articles, namely Garuda, Google Scholar, Science Direct, and PubMed. The quality of the articles carried out using JBI's Critical Appraisal Tools. Narrative synthesized was used to analyze the data of the review.  There were 6 articles synthesized in this review. The review result showed that diabetes mellitus, hypertension, cardiovascular disorders, anemia, obesity, lack of physical activity, high serum of LDL/HDL, non-adherence to treatment, lack of confidence in treatment, lack of knowledge about the disease, and gender can encourage the occurrence of recurrent stroke. Many factors cause recurrent stroke events but diabetes mellitus, hypertension and  non-adherence to treatment are most widely discussed in the six articles.
Effectiveness of Ramania Leaves (Bouea macrophylla Griffith) from South Kalimantan as a Mosquito Larvae Biolarvicidal Aryzki, Saftia; Febrianti, Dwi Rizki
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17386

Abstract

Indonesia itself as a tropical country has many plants that can be used as biolarvicides, one of which is the ramania plant (Bouea macrophylla Griffith). Ramania fruit epidermis contains secondary metabolites such as flavonoids, saponins, phenolic tannins, alcohol, steroids and terpenoids where these compounds have a larvicidal effect. The purpose of this study was to determine the activity of the ethanol extract of the epidermis of the ramania fruit as a biolarvicidal Mosquito larvae from the LC50 value. This research is a laboratory experimental research. The treatment concentrations used in this study were 25 ppm, 50 ppm, and 100 ppm. Temephos 1% was used as a positive control. Concentrations were then tested on 20 larvae instar III. The results of SPSS analysis with a significance of <0.05 showed that there was an effect of treatment on the number of larvae deaths, where the results of Tuckey analysis showed that concentrations of 50 ppm and 100 ppm and Temephos 1% showed differences. which means the number of deaths of test larvae. The results showed that the ethanol extract of ramania rind of ramania fruit (Bouea macrophylla Griffith) was effective as a biolarvicidal mosquito larvae. The results of probit analysis showed that the LC50 of ethanol extract of ramania rind against larvae was 20,844 ppm which is a low toxic group in aquatic environments.
Coefficient Test of Antimicrobial Phenol Combination of Eichhornia crassipes and Pistia stratiotes Extract In Vitro as Alternative Disinfection Candidates Budiarti, Lia Yulia; Kaidah, Siti; Azhari, Nazla Puteri; Putri, Putri
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17409

Abstract

Eichhornia crassipes and Pistia stratiotes are weeds that often pollute water areas. These two contain various active compounds that act as antimicrobials, which have the potential as disinfection agents to prevent the transmission of pathogenic bacteria and fungi. An antimicrobial substance is said to be effective as a good disinfectant if it has a phenol coefficient value equal to or more than the 5% phenol comparison substance. The aim of this research was to test the effectiveness of a combination of Eichhornia crassipes and Pistia stratiotes extracts as a disinfection candidate through the phenol coefficient test. This in vitro experimental study was carried out using a dilution technique. The combination treatment of Eichhornia crassipes and Pistia stratiotes extracts and 5% phenol was tested against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and also Candida albicans yeast. Observations on the test media suspension tubes that were clear or did not show the growth of the test microbes for a period of 5, 10, and 15 minutes. The phenol coefficient value of the combination treatment of Eichhornia crassipes and Pistia stratiotes extracts was ≥1 with 5% phenol as comparison. Higher coefficient values were obtained for Staphylococcus aureus, equivalent values of 5% phenol were found for E.coli, P.aeruginosa, and C.albicans; whereas in S.typhi the value is <1. The combination treatment of E.crassipes and P.stratiotes extracts resulted in a phenol coefficient value equivalent to that of 5% phenol comparator, for several tested bacteria and yeasts. So it has effectiveness as a preparation for disinfection. The combination of Eichhornia crassipes and Pistia stratiotes extracts has antimicrobial effectiveness and can be developed as an alternative disinfection candidate.
The Effect of Wetland Geography on the Prevalence of Diabetes Mellitus in South Kalimantan Fajari, Nanang Miftah; Nur’amin, Hendra Wana
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17387

Abstract

Diabetes mellitus (DM) is a high-burden disease in Indonesia especially in South Kalimantan Province. South Kalimantan province lies in mostly wetlands areas. Identification of risk factors related to DM is necessary to prevent the disease. We conducted this study to assess the prevalence of DM in the South Kalimantan people, the impact of a wetlands area on DM prevalence, and other significant risk factors. A cross-sectional study approach was used to identify significant risk factors. We used adjusted multiple logistic regression to assess the association between risk factors and DM prevalence. There were 4612 subjects more than 18 years old in this study with 6.5% of them diagnosed as DM. Most of the subjects live in wetlands area (79.1%) and most of them >40 years old. Several important risk factors associated with DM were identified. Subjects in wetlands have a lower risk of DM compared to non-wetlands area (OR 0.73, CI 95%; 0.43-0.71, p<0.001). Age >40 years old increase the risk of DM (OR 2.24, CI 95 % 1.61-3.10, p<0.001), hypertension (OR 1.65, CI 95% 1.23-2.21, p<0,001), waist circumference >90 cm (OR 2.12, CI 95%. p<0.001), cholesterol level (>200 mg/dl) with DM prevalence (OR 1.38, CI 95% 1.02-1.87, p<0.04) and family history of DM (OR 10.28, CI 95% 7.67-13.76, p<0.001). This study found that wetlands areas may reduce the DM prevalence and other risk factors may increase the prevalence of DM. Further research is necessary to establish the relationship between wetlands area and DM.
Potential of Chemical Compounds from Coloring Plants (Stenochlaena palutris) as Competitors for ALK Protein Damage Due To Pesticide Exposure: In Silico Study Sarmila, Sarmila; Nafisah, Nafisah; Habibah, Hanna; Saputri, Indah; Setiawati, Indah; Komari, Noer
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17415

Abstract

Pesticide active ingredients have widespread toxicity effects on target and non-target organisms. Continuous exposure to pesticides causes cancer. Kelakai is thought to have potential cytotoxic activity against the growth of cancer cells. The aim of this research is to examine the potential activity of chemical compounds on Anaplastic Lymphoma Kinase (ALK) proteins exposed to organophosphate pesticides in silico. Protein and ligand preparation with the Chimera program, Docking using SwissDock, as well as virtual screening using the pkCSM web and ProTox. Ethion and neophytadiene have the most negative ∆G values of -8.62 kcal/mol and -8.39 kcal/mol, respectively. The binding site for ethion and neophytadiene compounds with the ALK protein is right at the active site of the ALK protein. Ethion is the most toxic organophosphate pesticide and has the potential to be cytogenic. Neophytadiene from kelakai compounds has the potential to act as a competitor in inhibiting the ALK protein. The similarity in the type and number of binding residues in ethion and neophytadiene in the ALK protein indicates competition between ethion and neophytadiene.
The Association between Coping Mechanisms and Depression in Patients with Chronic Kidney Disease Undergoing Hemodialysis at Dr. Moewardi Hospital Surakarta Zweiryadinda, Wim; Oktaviyantini, Tri; Kusuma, Wijaya
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17388

Abstract

Patients with chronic kidney disease (CKD) undergoing routine hemodialysis (HD) may experience psychiatric comorbidities like depression. The coping mechanism is thought to be associated with the emergence of depression in patients with CKD. This cross-sectional study examines the association between coping mechanisms and depression in CKD patients undergoing routine HD therapy at Dr. Moewardi Hospital, Surakarta. Brief COPE and Hospital Anxiety and Depression Scale (HADS) questionnaire were used as study instruments. The result showed that 29 (78.38%) research subjects used adaptive coping, while 8 (21.62%) used maladaptive coping. There are 13 (35%) participants with mild depression. Spearman’s rank correlation showed a strong negative correlation between adaptive coping mechanisms and the severity of depression in CKD patients undergoing hemodialysis (r=-0,655; p<0,01)
Home Sanitation and Clean Water Facilities in Stunting Cases at the Lampihong Health Center Area, Balangan Heriyani, Farida; Farida, Ainun; Ulfah, Maria
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17421

Abstract

Stunting is a condition of growth failure in children under five years old (toddlers) due to chronic malnutrition and recurrent infections, especially in the first 1,000 days of life. One of the indirect causes is the availability of clean water and poor sanitation. Lampihong Community Health Center Balangan Regency is one of the areas with the highest stunting cases in South Kalimantan. This study aims to analyze the relationship between home sanitation and clean water facilities with the incidence of stunting in the Lampihong Community Health Center, Balangan Regency. The research method is analytic observational with a case control approach. The research sample consisted of 30 mothers of stunted toddlers as the case group and 30 mothers of non-stunted toddlers as the control group. Data analysis used the chi square test at a 95% confidence level. The research results showed that the majority of stunted toddlers lived in houses with unhealthy water closet, wastewater disposal and waste management that did not meet the requirements. Most of the stunted and non-stunted toddlers use clean water that meets the requirements. The results show that there is a significant relationship between home sanitation that does not meet the requirements and the incidence of stunting in toddlers, but there is no significant relationship between clean water facilities and the incidence of stunting in toddlers in the Lampihong Health Center, Balangan Regency.
Description of Social Media Use and Self-Esteem of Adolescents in Makassar City Rahman, Framita; Jane, Brigita Sri; Ngandoh, Mutiara Cyesa Prasasti; Saputri, Wiwi; Tuhelelu, Puspa Akhlakul Karima
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17401

Abstract

Adolescence is a crucial period of time and very challenging period. There is an increase concern on how social media use and mental health of teenagers. In Makassar City, there is a high number of mental health in adolescence yet still rare research has been conducted to investigates about social media use and self-esteem on teenagers. The aim of this study is to give a description on how adolescence behaviour on social media use and their level of self-esteem. This research uses a quantitative study with descriptive study design. The participant was selected based on some inclusion criteria such as teenagers’ age 16-18 years old, able to speak Bahasa, stay in Makassar City and willingly to become participant. The participant was determined by using non-probability sampling using convenience sampling method. There are 118 participants on this research. Three types of instruments were used; demography questionnaire, intensity of social media use and Rosenberg Self-Esteem Scale. From 118 participants, 19 were male and 99 were female. There are 42 respondents spend more than 6 hours on social media, and 54 respondents spend 2-6 hours on social media per day. Most of the respondents use their social media for see feed (20%), give like (14%), stalking (9%), news sharing (9%) and give comment (6%). Most of the respondents have high social media use (70 respondents) and low self-esteem (66 respondents). Social media use is quite high among teenagers in Makassar City and the self-esteem is mostly low. Thus, it is important to investigate the relationship of social media use and self-esteem so that it can give a comprehensive understanding on adolescence’s mental health and wellbeing in Makassar City

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