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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 259 Documents
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Delivering a Birth Safely – Case Reports of Perineal Infection Prevention among Pregnant Women Living Around Ex-landfills Lisa Herliyana; Anita Purnamayanti; Fransiscus Octavianus Hari Prasetyadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.131-137

Abstract

Background: Pregnant women living around ex-landfills have a higher risk of infection due to slum milieu, poor nutritional status, and fetal head pressure on the perineum during labor which can cause it to tear. Objective: This research aimed to emphasize the importance of limiting prophylaxis antibiotics for the 1st and 2nd degrees of perineal tears due to their negligible risk of infection. Case presentations: This is a report of two primigravid women aged 19 years old (cases 1 and 2) and multiparous women aged 29 and 30 yo (cases 3 and 4) who managed to give birth safely in Puskesmas (Indonesian primary healthcare facilities), despite having low blood pressure and non-adherence to antenatal care. All of them suffered from 2nd degree of perineal tears and received analgesics, iron, vitamin B complex, and vitamin A tablets. The subjects attended puerperium care on days, 14, and 42 postpartum at Puskesmas. Discussion: In March 2020, Puskesmas' healthcare team performed a new 1st and 2nd-degree perineal tears prevention without antibiotics following normal vaginal birth. Standard care consists of personal hygiene, perineal wound care, and education on the importance of nutritious food and adherence to maternal supplementation. All subjects presented with complete perineal wound healing without infection at day-42 postpartum. Conclusion: It can be concluded that 2nd-degree perineal tears infection following normal vaginal birth could be prevented without antibiotics. It is strongly suggested to control the maternal nutritional states, potentially interfering with the maternal ability to heal the perineal wound.
Analysis of Factors Affecting the Stress Level and Self-Medication Practice in Primary Dysmenorrhea in Adolescents during COVID-19 Pandemic Nurul Kusumawardani; Endang Darmawan; Jasmine Amira Hatisuci; Iftita Nuratika Ramadhanti; Rahma Sakti Oktavia; Very Ainun Fauziah; Trisna Styawaty; Ratih Nugraeni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.155-167

Abstract

Background: During the novel coronavirus (COVID-19) pandemic, reports of adolescent pain and worsening of the menstrual cycle increased with increasing stress levels. Objective: Analysis of determinant factors that influence the ability to self-medication for menstrual pain, including socio-demography and medical history, to determine the effect of stress levels on the menstrual cycle of adolescent women during the COVID-19 pandemic. Methods: The method is descriptive observational, through a cross-sectional study on adolescent females in Indonesia was conducted in October-November 2020. Data collection through a simple survey method using a self-medication online questionnaire survey and the Kessler psychological distress scale (KPDS) by consecutive sampling technique. About 258 women agreed to participate in the study. The results are presented in the form of frequency and percentage (%), and the determinants are analyzed using χ2-test and binary logistic regression models. Result: About 78.3% of respondents had stress during the pandemic COVID-19 with primary dysmenorrhea (70.2%), and 58.9% of respondents had low self-medication for managing primary dysmenorrhea. The predictors of self-medication understanding were the mother's education level and history of menstrual pain (p-value = 0.045; 0.005). In addition, respondents' stress levels during the COVID-19 pandemic affected their menstrual cycles (OR=5.110; 95% CI: 1.767–14.782, p-value=0.003). Conclusion: The role of pharmacists in the community and mothers as pioneers of family health is vital in increasing the understanding and implementation of the practice of self-medication for primary dysmenorrhea. This role needs to manage the stress of adolescent women. It can affect the reduction in the menstrual cycle, especially during the COVID-19 pandemic.
A Community's Knowledge and Attitude in Recognizing Symptoms and Diarrhea Management in Children Arina Dery Puspitasari; Novitri Wulandari; Bindaria Mutmaina Prabawati; Liza Yudistira Yusan
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.101-106

Abstract

Background: Diarrhea is the world's second-biggest cause of death among children. Children suffer from severe dehydration due to the lack of understanding of treating diarrhea properly. Objective: This study aimed to assess the level of community knowledge and attitudes toward the treatment of diarrhea in children. Methods: This was an observational, cross-sectional study conducted in a community in Gresik, Indonesia, in 2019. A Likert scale questionnaire, consisting of 10 items on knowledge and five on community attitudes on diarrhea management in children, was used to collect data. Results: One hundred and seven participants responded to the survey, and 89.72% were women. 'Respondents' mean age was 41.84 ± 11.27 years with various levels of education. It was found that the community had good knowledge of diarrhea management in children, as shown by the finding that 84.11% of the participants provided the correct answers. About 87.85% of the participants were aware of the signs and symptoms of diarrhea in children. However, there is still a shortage of understanding about managing diarrhea properly, particularly when identifying the necessary medicine. About 89.72% of the participants demonstrated a "positive" attitude in diarrhea management, while approximately 78.51% agreed that children with diarrhea should be given oral rehydration. Conclusion: The knowledge about recognizing signs and symptoms of diarrhea in children was good, while the knowledge about diarrhea management needed to be improved. Overall, the respondents had a positive attitude about diarrhea management in children.
Effect of Sodium Alginate Concentration on Characteristics, Stability and Drug Release of Inhalation Quercetin Microspheres Tekla Kalalo; Andang Miatmoko; Hanafi Tanojo; Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.107-114

Abstract

Background: Quercetin is a flavonoid compound that has anti-inflammation activity. However, poor stability presents significant problems for the formulation into dosage forms. Microspheres are one of the potential lung delivery systems because of their ability to encapsulate various types of drugs, protect drugs from environmental effects and can release drugs in a sustained release. Objective: In the present study, the microsphere inhalation system of the anti-inflammation drug, quercetin was developed and evaluated to achieving the targeted delivery of these drugs to the lung. Method: The drug-loaded ca-alginate microspheres were prepared by aerosolization ionic gelation technique followed by freeze-drying. Result: The result of this study showed that particle size was less than 2 µm, the yield ranged from 41.33-76.14%, drug loading was less than 6%, entrapment efficiency ranged from 74.153% - 93.805% and flow properties showed that all formula had an excellent flow. Spherical microspheres were demonstrated by formulations containing 1 and 1.5% sodium alginate. A drug release study showed that the highest drug release of 30.649% was from the formulation with 2.5% sodium alginate, and the lowest drug release of 26.625% was from the formulation with 2% sodium alginate. , A stability study at temperatures of 25áµ’C and 40áµ’C for 28 days showed a decrease in drug loading and entrapment efficiency but an increase in particle size. The formulation containing 1.5% sodium alginate showed the optimal formula. Conclusion: These findings indicated that quercetin ca-alginate microspheres are the potential for inhalation to be delivered to the lung.
Direct Medical Cost Analysis of Dengue Patients: A Retrospective Study Imaniar Noor Faridah; Tuty Lia Syahfitri; Reza Aditya Nugroho; Woro Supadmi; Haafizah Dania; Dyah Aryani Perwitasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.177-184

Abstract

Background: Dengue infection is an arboviral disease that could lead to severe illness. The incidence of severe dengue will impact patients' financial aspects. As an important clinical feature, platelet level on admission day might contribute to the direct medical cost. Objective: This study aimed to examine the direct medical cost among patients with dengue fever (DF) or dengue hemorrhagic fever (DHF) in Yogyakarta, Indonesia. Methods: This study was a retrospective study conducted in two private hospitals in Yogyakarta, Indonesia. Participants included in this study were hospitalized patients diagnosed with DF or DHF. Data were extracted from medical records and finance departments in each hospital. Results: Among 174 dengue patients included in this study, the mean age of DHF patients (18.44 + 14.87) was lower than in DF patients (23.47 + 18.99). Patients with DHF (4.88 days) also showed prolonged hospitalization compared with DF (4.18 days) patients. In terms of medical cost, DHF patients need a higher dengue treatment cost, which is about 329.74 USD compared to 220.68 USD for DF patients in hospital 2. Mainly related to room charges, which increased by 9.48% in hospital 1 and 66.28% in hospital 2 compared with DF patients. Furthermore, DHF patients with thrombocytopenia on the first day of admission present higher medical costs in terms of laboratory fees (36.08%), medicine (18.17%), and total medical costs (9.84%). Conclusion: Severe form of dengue will contribute to economic burden. Therefore, prevention and adequate treatment are essential to reduce the prognosis of severe dengue and higher medical cost.
Isoprinosine along with Favipiravir or Oseltamivir in Patients with Moderate Covid-19 at RSD Dr. Soebandi Jember Chrysnanda Maryska; Didik Hasmono; Sofiati Diah Baisuni; Ayunda Nur Hidayatiningsih; Arina Dery Puspitasari; Retna Dwi Puspitarini; Budi Suprapti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.209-219

Abstract

Background: Isoprinosine is an immunomodulator that is now being used to treat Covid-19 patients. Objectives: To evaluate Isoprinosine with Favipiravir or Oseltamivir in moderate Covid-19. Methods: In a retrospective observational analysis, in-hospital moderate Covid-19 patients treated between June 2020 and June 2021 were included. Results: Inclusion criteria for 364 patients were met, with 135 receiving Favipiravir-Isoprinosine (Group 1) and 229 receiving Oseltamivir-Isoprinosine (Group 2). In group 1, the majority of patients (58.50%) were female (35.60%), had no comorbidities (71.60%), were discharged with a positive PCR (74.80%), did not require a breathing apparatus (99.26%), had leukocyte levels between 4,5-11,0 (82.22%), lymphocyte levels between 25-33 (34.07%), and were discharged with no ground-glass opacity (34.07%) (54.10%), LOS was 9-13 days (50.37%), while the mortality rate was 0.70%. In group 2, the majority of patients were male (54.10%), with the highest age range being 42-56 years (35.80%), without comorbidities (69.0%), discharged with a positive PCR (72.50 %), and without the need for a breathing apparatus (99.13%), with leukocyte levels ranging from 4.5 – 11.0 (81.22 %), with lymphocyte levels ranging from 25.0 – 33.0 (26.20 %), and were discharged with no ground-glass opacity (49.34 %), LOS was 9 - 13 days (34.06 %), and the mortality rate was 0.87%.Conclusion: In this trial, it was determined that combining isoprinosine with antivirals favipiravir or Oseltamivir could produce significant clinical improvement.
Assessment of Antibiotic Use in ICU Patients with Pneumonia Using ATC/DDD as a Quantitative Analysis Method Mareta Rindang Andarsari; Zedny Norachuriya; Sarah Mahmudatun Nabila; Toetik Aryani; Alfian Nur Rosyid
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.138-145

Abstract

Background: Pneumonia is an infection of the lung tissue which is mainly caused by bacteria. High utilization and inappropriate use of antibiotics increase resistant bacteria, morbidity, mortality, and treatment cost. Quantitative evaluation becomes one of the indicators to assess the use of antibiotics which is one indicator of the quality of the antimicrobial resistance control program. Objective: This study aimed to evaluate the use of antibiotics an effort to increase the rationality of the use of antibiotics. Methods: This study was a retrospective observational study with a sampling method of time-limited sampling in Universitas Airlangga hospital from January until December 2019. Quantitatively using Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD). Result: The samples obtained were 68 severe pneumonia patients who met the inclusion criteria. From the result of the study, there were 13 types of antibiotics used for pneumonia therapy, and the three most used were Levofloxacin, Ceftriaxone, and Meropenem, with a total of all antibiotics 73.64 DDD/100 patients-days. Most useful is parenteral Levofloxacin at 21.92 DDD/100 patient-days, Ceftriaxone at 20.45 DDD/100 patient-days and Meropenem at 14.29 DDD/100 patient-days. Conclusion: The DDD value indicates high antibiotic usage, but high antibiotic use does not imply unreasonable drug use, so we must undertake a qualitative review of antibiotic use.
Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin Tutik Sri Wahyuni; Adita Ayu Permatasari; Chie Aoki-Utsubo; Aty Widyawaruyanti; Achmad Fuad
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.125-130

Abstract

Background: Hepatitis c virus infection is a global health problem which chronically infected 71 million people in the world. This infection has a risk of becoming liver cirrhosis and hepatocellular carcinoma. Since the current HCV therapy has been developed by direct-acting antivirals (DAA), however, most patients get limited access due to the high cost. Therefore, further development anti-HCV agent still greatly needed. Ruta angustifolia is a natural resource which was reported to possess anti-HCV activity. Ribavirin is an antiviral agent used to treat several virus infections, either DNA or RNA. Ribavirin was known to inhibit HCV infection by regulated immune system in host cells and interfering the replication of HCV by inhibit HCV RdRp. Objective: The current study evaluated the combination treatment of R. angustifolia extracts and ribavirin by in vitro culture cells of Huh 7it. Method: The study was conducted under an invitro cell culture of Huh 7it and infected with JFH1a. Result:  The result demonstrated an enhancement effect of the extract by increasing the anti-HCV activity 3.5-fold higher compared to ribavirin alone. The 50% inhibitory concentration of ribavirin by single treatment was 10.43 ± 0.18 µg/mL, while in combination with Ruta angustifolia extract was 2.80 ± 0.03 µg/mL. Further analysis of the combination by CompuSyn software mediated a synergistic effect among the combination with a combination index value of 0.691. Conclusion: These results suggested that combination of Ribavirin and Ruta angustifolia should be considered in developing anti-hepatitis C virus agents.
Formulation and Characterization of Carbamazepine Chitosan Nanoparticle Citra Ariani Edityaningrum; Ariza Nur Zulaechah; Widyasari Putranti; Dewa Ayu Arimurni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.146-154

Abstract

Background: Carbamazepine is an antiepileptic drug used to treat trigeminal neuralgia and pain associated with neurological disorders. The drug belongs to class II of the Biopharmaceutical Classification System (BCS), which has low solubility. Hence, dissolution is a rate-limiting step. Objective: This study aimed to determine the best formula for carbamazepine nanoparticles based on physical characteristics and determine the effect of chitosan and Na-TPP concentration variation on nanoparticle characterization. Methods: The carbamazepine chitosan nanoparticles were prepared using ionic gelation method with a concentration of 0.1% w/v carbamazepine and the ratio of chitosan and Na-TPP concentrations of 0.2%:0.1% (F1), 0.2%:0.2% (F2), and 0.3%:0.1% w/v (F3). The parameters evaluated included particle size, polydispersity index, zeta potential, particle morphology, and entrapment efficiency. Statistical analysis was conducted on the evaluation data using One Way ANOVA. Results: The results showed that the effect of increasing the concentration of chitosan reduced particle size (p<0.05), increased zeta potential (p<0.05), and had no effect on the value of entrapment efficiency (p>0.05). Furthermore, F3 had a particle size of 169.8±13.71 nm with a polydispersity index of 0.378±0.02, the zeta potential of +28.80±2.44 mV, entrapment efficiency of 84.3±7.50%, and spheric particle morphology which was measured using Transmission Electron Microscope (TEM). Conclusion: Therefore, F3 with the ratio of chitosan and Na-TPP concentrations of 0.3%:0.1% was the formula that provided the best characteristics of chitosan carbamazepine nanoparticles.
The Effect of Decyl Glucoside on Stability and Irritability of Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations Rufaidah Azzahrah; Noorma Rosita; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.220-228

Abstract

Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLC-GTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HET-CAM test.

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