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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 259 Documents
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The Effect of Quercetin on Coenzyme HMG-CoAR, ABCA1 Transporter, Dyslipidemia Profile and Hepatic Function in Rats Dyslipidemia Model Ignasius Agyo Palmado; Sulistyanaengci Winarto; Honey Dzikri Marhaeny; Yusuf Alif Pratama; Chrismawan Ardianto; Khotib, Junaidi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.274-290

Abstract

Background: Dyslipidemia is a lipid metabolic disorder that increases the risk of cardiovascular disease, typically marked by abnormalities in triglycerides (TG), low-density lipoprotein (LDL), and total cholesterol (TC), along with decreased high-density lipoprotein (HDL) levels. This study explored the potential of quercetin, a natural substance, as a preventive agent against dyslipidemia induced by high-fat diet (HFD) in a rat model. Simvastatin, a standard cholesterol-lowering drug, was used for the comparison. Objective: The main objective of this research was to evaluate the potential of quercetin in lipid metabolism for dyslipidemia caused by HFD and compare its effects with the first-line drug therapy simvastatin, which has a similar mechanism. Methods: Rats fed a HFD were treated with quercetin and simvastatin, and their lipid profiles, liver enzyme activities, and molecular markers related to cholesterol metabolism were analyzed. Results: Quercetin markedly decreased cholesterol levels by inhibiting the enzyme 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMG CoAR). Cellular observation revealed that it also prevented liver damage and showed a protective effect on liver enzyme activity. Quercetin enhanced the expression of the Adenosine Triphosphate Binding Cassette subfamily A member 1 (ABCA1) protein, showing a protective effect against dyslipidemia akin to simvastatin, yet with a reduced likelihood of liver toxicity. Conclusion: Quercetin may serve as an effective and safer alternative to simvastatin for treating dyslipidemia, offering cholesterol-lowering benefits without hepatotoxic risks associated with long-term statin therapy.
A Case Report of Lurasidone-Induced Tardive Dyskinesia: Therapeutic Role of Valbenazine Ambika Nand Jha; Varsha Ratan Gaikwad
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.269-273

Abstract

Background: Tardive dyskinesia (TD) is a complex, potentially irreversible movement disorder primarily associated with the long-term use of antipsychotic medications, particularly typical neuroleptic drugs. TD can develop during treatment and persist long after the discontinuation of the culprit medication. The etiology of this condition involves dysregulation of dopaminergic signalling, especially within the striatum, leading to activation of D2 dopamine receptors. This imbalance affects the homeostasis of neurotransmitters, including GABA and Glu. Chronic dopamine receptor antagonism incites neuroadaptive alterations that may linger post-therapy, resulting in abnormal involuntary movements affecting the orofacial regions, limbs, and trunk, which profoundly diminish patient quality of life. Case: A 29-year-old female with a known history of schizophrenia presented with sudden-onset neurological symptoms, notably persistent orofacial dyskinesias such as lip smacking and grimacing, which had developed over a 24-hour period. A thorough review of her medications indicated that lurasidone, classified as an atypical antipsychotic, was likely responsible for the onset of these dyskinetic movement features. Consequently, the physician opted to discontinue lurasidone and initiate valbenazine at 40 mg once daily with the intent of managing the dyskinetic symptoms while considering the overall psychiatric and medical treatment plan for the patient. Conclusion: The emergence of orofacial dyskinesias in this patient suggests a possible adverse reaction to lurasidone, necessitating re-evaluation of her psychopharmacological regimen. Valbenazine, a selective vesicular monoamine transporter 2 inhibitor, may provide a tailored approach to mitigate dyskinetic movements, while maintaining therapeutic efficacy in psychiatric care.
Phytochemical Screening and Anti-hyperglycemic Effect Test of Ethanol Extract of Waru Leaf (Hibiscus tiliaceus) on Glucose-loaded Mice Sofia, Vivi; Firdaus, Tya Novita; Saputri, Muharni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.345-355

Abstract

Background: The treatment of diabetes mellitus relies on synthetic drugs with various side effects. Therefore, it is necessary to explore alternative treatments with herbal therapies, such as Hibiscus tiliaceus leaves. Objectives: The aim of this study was to determine the anti-hyperglycemic effect of an ethanol extract from Hibiscus tiliaceus leaves in glucose-loaded mice. Methods: The initial stage of dried leaf characterization was to ensure the identity, quality, purity, and safety to be used, and then extracted using the maceration method with 70% ethanol solvent. The next step was phytochemical screening to identify secondary metabolite content. The anti-hyperglycemic effect was evaluated using the oral glucose tolerance test (OGTT) on 25 male mice divided into five treatment groups. The negative control group was given Na CMC 0.5% w/v Na CMC, and the positive control group was administered glibenclamide. The ethanol extract of Hibiscus tiliaceus leaves was administered at doses of 200, 400, and 800 mg/kg. Approximately 200 µL of blood was collected and analyzed for glucose levels. The data were statistically analyzed using one-way analysis of variance (ANOVA) with SPSS ver. 25 program. Results: Hibiscus tiliaceus leaves contain alkaloids, flavonoids, saponins, and tannins. The highest decrease in blood glucose levels was observed in the ethanol extract group at a dose of 400 mg/kg BW, with a decrease of 78.52%, followed by a dose of 200 mg/kg BW of 76.63%, a dose group of 800 mg/kg BW of 73.48%, and a positive control group (glibenclamide) of 34.68%, which was significantly different from the negative control group (Na CMC 0.5%) (p < 0.05). Conclusion: The ethanol extract of H. tiliaceus has anti-hyperglycemic effects.
Formulation and Evaluation of Transdermal Dissolving Microneedle Loaded with Ethanol Extract of Cocor Bebek Leaves (Kalanchoe pinnata) Balapadang, Rachel Noveriachristie; Sarie, Aldila Divana; Rosyidah, Safira; Zulqifli, Iqbal; Akifah, Muthia Nur; Zahra, Aliya Azkia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.378-385

Abstract

Background: Acne is a chronic skin inflammation caused by blockage of the sebaceous glands in the skin and hypercolonization of the acne-causing bacteria Propionibacterium acnes. Cocor bebek leaves (Kalanchoe pinnata) are known to contain various secondary metabolites, including flavonoids, with antibacterial activity. Objective: In an effort to prevent side effects from using oral and topical antibiotics to treat acne, an alternative acne treatment that is safer and more effective with a strong drug delivery system is needed: microneedle patch technology containing natural ingredients. Methods: A microneedle patch formulation of Cocor bebek leaf extract was developed using a combination of HPMC and PVP polymers. The evaluation of microneedle patches included irritation tests with rat test animals and antibacterial activity tests against Propionibacterium acnes. The results showed the formation of yellow microneedle patches with uniform needles. The evaluation results showed that the microneedle patch has an irritation index value classified as non-irritant and has antibacterial activity against Propionibacterium acnes, with the highest inhibitory diameter at an extract concentration of 30% with a moderate inhibition category. Conclusion: The microneedle patch cocor bebek leaf extract shows potential as an effective drug delivery system for the treatment of acne that is safe for use on the skin.
Potassium Profile in Heart Failure Patients Before and After Hospitalization at Prof. Dr. I.G.N.G. Ngoerah Hospital Kadek Indra Aryani; Ni Putu Ika Swastiartha; Ni Komang Ayu Krisma Suriatha Putri; Ni Kadek Mas Ari Pratiwi; Made Suta Wahyudi; Rini Noviyani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.37-49

Abstract

Background: Hypokalemia in patients with heart failure is increasing, with an increasing incidence of 6.8% in Asia and 19.7% in Indonesia; globally, 63 million people suffer from heart failure. Hypokalemia is defined as a serum potassium level below 3.5 mEq/L [mmol/L], which can lead to decreased heart function, muscle weakness, arrhythmias and cardiac arrest. The use of diuretic drugs such as furosemide in heart failure patients may be a risk factor for hypokalemia. Objective: This study aims to determine the difference in potassium levels before and after furosemide administration as well as the possibility of hypokalemia due to furosemide administration in inpatients diagnosed with heart failure at Prof. Dr. I.G.N.G. Ngoerah Hospital. Methods: This is a cross-sectional observational study with retrospective medical record collection. The minimum sample size was calculated using Lemeshow's Formula of One Proportion Estimation Method with Absolute Precision Proportion, data normality test with Kolmogorov-Smirnov (p>0.05) and parametric test with paired t-test (p<0.05). This study included 101 patients that met the inclusion criteria with 11 patients having more than one inpatient visit, so a total 114 'patients' medical records were obtained. Results: Potassium levels before and after hospitalization showed a significant difference (p<0.05). A total of 84 'patients' data showed a decrease in potassium levels, with 49 of them showing a reduction in >15% and 35 showing a decrease of ≤15%. Conclusion: Prevalence of hypokalemia in patients with a diagnosis of heart failure and furosemide therapy at Prof. Dr. I.G.N.G. Ngoerah Hospital during January 2022-December 2023 after hospitalization was 29%.
Optimization Using D-Optimal Design of Nanostructured Lipid Carrier (NLC) with Variation of Surfactants and Co-surfactant Athiyyah, Wafa'ul; Soeratri, Widji; Rosita, Noorma; Siti Hartini Hamdan
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.1-14

Abstract

Background: Nanostructured lipid carriers (NLC) are topical delivery systems designed to address the challenges associated with active ingredients, such as poor solubility and limited skin penetration. NLCs incorporate surfactants, such as sorbitan monooleate and lauryl glucoside, to stabilize the system, while the addition of soy lecithin as a co-surfactant further enhances NLC stability. A D-optimal design was employed to optimize the NLC components, ensuring that the formulation achieved the desired characteristics. Objective: To determine the optimal NLC formulation. Method: Optimization was conducted using the D-optimal design method. The NLCs were prepared using the high-shear homogenization method with an Ultra-Turrax device. Characterization included measuring the particle size, polydispersity index (PDI), pH, and creaming index. Results: All formulations resulted in homogeneous emulsions with a white color, slight aroma of castor oil, smooth texture, and thick consistency. The particle sizes ranged from 200 to 500 nm, although the polydispersity index was not significantly influenced by surfactants or co-surfactants. All the formulations maintained an appropriate pH range for skin compatibility and product stability. The %creaming index demonstrated that the co-surfactant effectively reduced creaming in the NLCs. Conclusion: The optimal formulation consisted of 0.284% sorbitan monooleate, 3.429% lauryl glucoside, and 0.287% soy lecithin.
Design and Optimization of Nanostructured Lipid Carriers for Quercetin in Skin Lightening Applications Ressa Marisa; Widji Soeratri; Tristiana Erawati Munandar
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.15-25

Abstract

Background: Quercetin, a potential skin-lightening agent, reduces intracellular and fungal tyrosinase activities. However, its poor water solubility and limited skin permeability hinder its applications. Nanostructured lipid carriers (NLCs), which are composed of biocompatible and biodegradable lipids, enhance drug stability and skin penetration. The lipid type, surfactant concentration, and formulation parameters influence NLC stability. Objective: This study aimed to optimize NLC formulations for quercetin delivery by evaluating their organoleptic properties, particle size, polydispersity index (PDI), and pH.  Methods: NLCs were prepared using 10% total lipids (4% solid and 6% liquid lipids) and surfactant mixtures at varying concentrations via High Shear Homogenization. Initial formulations using myristic acid and castor oil were unstable and underwent phase separation within five days. Results: Substituting the solid lipid with a 1:3 combination of beeswax and cocoa butter produced a stable formulation during storage at room temperature. The lipid and surfactant compositions significantly influenced the particle size and PDI. While the pH remained stable, statistical analysis revealed significant changes in particle size and PDI across the formulations. Conclusion: Optimized NLC formulations for quercetin delivery demonstrated improved stability and potential for effective skin lightening. Further research is warranted to evaluate the in vivo efficacy and scalability of this approach.
Curcuma caesia. Roxb as a Potential Inhibitor of STAT3 and EGFR: a Molecular Docking Approach in Diabetic Nephropathy Farid, Muhammad; Almaduri, Shalahuddin; Riyadi, Sujono
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.26-36

Abstract

Background: Diabetes mellitus (DM) is a chronic disorder marked by persistent hyperglycemia, leading to various complications, including diabetic nephropathy (DN). The STAT3-EGFR signaling axis plays a crucial role in the development and progression of diabetic nephropathy, with EGFR activation leading to STAT3 phosphorylation. Curcuma caesia Roxb, rich in curcuminoids, shows promise in managing DN due to its anti-inflammatory and antioxidant properties. This study aims to predict the inhibitory potential of Curcuma caesia compounds on STAT3 and EGFR in DN using molecular docking techniques. Methods: This study utilized molecular docking to evaluate the inhibitory potential of Curcuma caesia compounds on STAT3 and EGFR. Protein structures were obtained from the RCSB database and prepared using Biovia Discovery Studio. Redocking validated the method via RMSD analysis, while docking simulations assessed binding energy (ΔG). ADMET predictions analyzed physicochemical properties and toxicity, ensuring the compounds' suitability as drug candidates. Results: Redocking process validated the method, with RMSD values indicating accuracy. Curcumin (-9.71) and ar-Curcumene (-5.02) showed the lowest binding energy for both proteins, suggesting strong interactions. Visualization revealed significant amino acid interactions, particularly involving hydrogen bonds. Additionally, pharmacokinetic and toxicity analyses indicated that most compounds are suitable drug candidates, exhibiting good absorption, distribution, and safety profiles, thus supporting Curcuma caesia's therapeutic promise in diabetic nephropathy management. Conclusion: Curcuma caesia demonstrates significant potential as a therapeutic agent for diabetic nephropathy, with favorable molecular interactions, strong binding affinity to STAT3 and EGFR, and promising pharmacokinetic and safety profiles.
Antiinflammatory Activity of Bangle Rhizome (Zingiber purpureum Roxb) Ethanol Extract on Rat Carrageenan Induced and Erythema Method Mia Ariasti; Muhammad Eka Putra Ramandha; Sri Winarni Sofya
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.50-58

Abstract

Background: Inflammation is a physiological response triggered by cellular damage, typically characterized by symptoms such as edema. Objective: This study was conducted to evaluate the anti-inflammatory activity of the ethanol extract of Bangle rhizome (Zingiber purpureum Roxb.) using the carrageenan-induced paw edema method and the UVB-induced erythema method. The most effective dose demonstrating significant anti-inflammatory activity was also determined. Methods: The bangle rhizome (Zingiber purpureum Roxb) was subjected to maceration using 96% ethanol. A total of 25 rats were randomly divided into five groups: negative control (0.5% CMC-Na), positive control (diclofenac sodium at 0.9 mg/200 g body weight), and treatment groups receiving ethanol extract of bangle rhizome at doses of 5, 10, and 20 mg/200 g body weight. In the carrageenan-induced method, the edema volume in the rat paw was measured following the administration of 0.8% lambda-carrageenan. In the erythema method, the degree of inflammation was assessed using UVB-induced erythema scoring. Results and Conclusion: Anti-inflammatory activity was observed at doses of 5, 10, and 20 mg/200 g body weight in the carrageenan model and at doses of 10 and 20 mg/200 g in the erythema model. The most potent anti-inflammatory effect was recorded at the dose of 20 mg/200 g body weight, which was comparable to the positive control in both models. The presence of flavonoids and steroids in the extract may contribute to the observed anti-inflammatory activity.
Assessment of Geriatrics Patients with Cardiovascular Disease Prescriptions for Appropriateness of Medications by Using Beers Criteria in Muhammadiyah Lamongan Hospital Puspita Sari, Dyah; Irma Susanti; Anisa Zulfa Fatihah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.59-66

Abstract

Background: Number of geriatric residents has increased annually. Owing to pathological and physiological conditions, the geriatric population tends to consume more medications, thereby increasing their risk of adverse side effects and drug interactions. Objective: This study was to evaluate the appropriateness of therapy for outpatient geriatric patients with cardiovascular disease at Muhammadiyah Lamongan Hospital from August to October 2023. Methods: American Geriatrics Society (AGS) Beers Criteria are one of the tools used to identify drugs whose potential harm outweighs the expected benefits and should be avoided in the elderly population. This study employed a descriptive method, with retrospective data collection from secondary sources, including medical records and electronic prescriptions. Results: Findings revealed that out of 252 prescriptions for geriatric patients with cardiovascular disease, four types of medications were potentially inappropriate according to the Beers Criteria: nifedipine with 23 prescriptions (9.13%), amiodarone with one prescription (0.40%), digoxin with 13 prescriptions (5.16%), and diltiazem with four prescriptions (1.59%). Conversely, three types of medications were deemed appropriate: aspirin (96 prescriptions, 38.10%), digoxin (30 prescriptions, 11.90%), and diltiazem (11 prescriptions, 4.37%). In conclusion, of the 252 prescriptions reviewed for geriatric patients with cardiovascular disease, three types of drugs are appropriate, while four types increase the risk of potentially inappropriate treatment (PIM) based on the Beers Criteria. Conclusion: These findings underscore the need for careful consideration to mitigate the risk of drug reactions. If the medication cannot be used in geriatric patients, an alternative therapy should be used or a dose adjustment may be necessary.

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