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INDONESIA
Science and Technology Indonesia
Published by Universitas Sriwijaya
ISSN : 25804405     EISSN : 25804391     DOI : -
Core Subject : Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics
An international Peer-review journal in the field of science and technology published by The Indonesian Science and Technology Society. Science and Technology Indonesia is a member of Crossref with DOI prefix number: 10.26554/sti. Science and Technology Indonesia publishes quarterly (January, April, July, October). Science and Technology Indonesia is an international scholarly journal on the field of science and technology aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that covers a typical subject of natural science and technology such as: > Chemistry > Biology > Physics > Marine Science > Pharmacy > Chemical Engineering > Environmental Science and Engineering > Computational Engineering > Biotechnology Journal Commencement: October 2016
Arjuna Subject : -
Articles 551 Documents
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Properties and Generalizations of Altered Jacobsthal Numbers Squared and their GCD Sequences Koken, Fikri; Ergun, Halime; Uzun, Yusuf
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.273-282

Abstract

This paper investigates two types of altered Jacobsthal numbers, namely G(2)J(n) (a) and H(2)J(n) (a), which are obtained by adding or subtracting a specific value, denoted with {a}, from the square of the nth Jacobsthal numbers. These numbers exhibit a close relationship with the consecutive products of the Jacobsthal numbers. The study establishes consecutive sum-subtraction relations for the altered Jacobsthal numbers, and derives their Binet-like formulas. Furthermore, the greatest common divisor (Gcd) sequences of r-successive terms, represented by {G(2)J(n),r (a)} and {H(2)J(n),r (a)}, r ∈ {1, 2, 3, 4} are investigated. It is observed that these sequences display either a periodic or Jacobsthal structure.
Physical Properties of Biodegradable Chitosan-Cassava Starch Based Bioplastic Film Mechanics Kusumawati, Rinta; Syamdidi; Abdullah, Akbar Hanif Dawam; Nissa, Rossy Choerun; Firdiana, Bonita; Handayani, Rini; Munifah, Ifah; Dewi, Fera Roswita; Basmal, Jamal; Wibowo, Singgih
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.191-200

Abstract

Petroleum-derived plastics are widely used but pollute the environment significantly. The development of biodegradable plastics is urgently needed to be replaced. The mechanism for making bioplastic films from cassava starch-chitosan/glycerol uses a double-screw extruder process. The film took into account the multi-hydroxyl capacity of starch by combining glycerol (in a ratio of 3:1 w/w) and chitosan (at concentrations of 0.5, 1.0, and 1.5% (w/w). The impact of chitosan involvement on the characteristics of the bioplastic material was studied, including physical, thermal, mechanical, and biodegradability properties. The findings showed that using chitosan as a filler in cassava starch bioplastics resulted in bioplastic films with high compressive capacity and water resistance. The resulting biopolymer’s contact angle was increased by including C-O functional groups in the molecule, as evidenced at a wavelength of 1028 cm-1 of the FTIR spectra. The contact angle was increased from theta = 65.3059 ± 2.7936◦ to theta = 68.6047 ± 3.2391◦. An increase in tensile strength was also observed, indicating increased stiffness compared to chitosan-free bioplastics. The best bioplastic blend was the formulation of cassava starch and glycerol containing 0.5% chitosan. Bioplastic has physical properties of density 0.8625 ± 0.0277 g/mL; contact angle 68.6046 ± 3.2391◦; water uptake 11.0660 ± 0.3709%; tensile strength 2.0181 ± 0.0594 MPa; elongation 54.2243 ± 3.2623%; thermal 137.5◦C; moisture content 4.9464 ± 0.1172%; and the fastest biodegradation rate. The bioplastic synthesized in this study is readily biodegradable in the natural environment, making it highly sustainable and more environmentally friendly, and it can be a viable substitute to reduce the use of petroleum-based bioplastic.
Enhancing the Solubility and Dissolution Rate of Tenoxicam through Co-Amorphous Formation with Meglumine by a Solvent Dropped Grinding Method Fitriani, Lili; Arif, Zhafira; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.131-138

Abstract

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID), one of the oxicam group. It is categorized as Biopharmaceutical Classification System class II, as its low solubility and high permeability. The aims of this research were to enhance the solubility and dissolution rate of tenoxicam by its modification into a co-amorphous phase with meglumine at a molar 1:1 ratio. The co amorphous form of tenoxicam-meglumine was prepared by a solvent drop grinding method, and characterized by thermal analysis using differential scanning calorimetry (DSC), solid phase by powder X-ray diffraction (PXRD), identification of functional group by Fourier-transform infrared (FT-IR) spectroscopy, and morphology by polarized light microscopy (PLM) and scanning electron microscopy (SEM). The solubility test was conducted in water, whereas the dissolution test was performed in 0.1 N HCl solution and water. The DSC thermogram demonstrated a decrease in the endothermic peak of the co-amorphous tenoxicam-meglumine. The PXRD diffractogram revealed a reduction in the peak intensity of the X-ray diffraction, which formed a halo pattern. The FT-IR spectroscopy analysis indicated the formation of the co-amorphous system. The co-amorphous of tenoxicam-meglumine solubility’s increased by 42.71-fold as compared to intact tenoxicam. The co-amorphous tenoxicam meglumine exhibited a dissolution rate of 92.71% and 100% in 0.1 N HCl and distilled water, respectively, after 60 minutes, and resulting in separate increases in dissolution efficiency by 3.05 and 9.12-times in 0.1 N HCl and distilled water. In summary, the formation of the co-amorphous phase of tenoxicam and meglumine successfully enhanced the solubility and dissolution of tenoxicam.
Fluorine Substitution in Diamine Covalent Organic Frameworks: Computational Analysis of CO2/N2 Adsorption and Permeability Darmawan, Noviyan; Apriliyanto, Yusuf Bramastya; Jati, Andreas Ary Chrisna; Kusumawardani, Cahyorini
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.18-26

Abstract

In this study, we investigated the effect of fluorine substitution on a previously reported diamine based covalent organic framework (COF), designated as IPB-2H. A new fluorinated analogue namely IPB-2F2 was modeled and its adsorption and permeability characteristics for CO2/N2 gas mixtures were evaluated through computational analysis. Ab initio structural optimization results showed that the reduced pore size of IPB-2F2 compared to IPB-2H was attributed to the larger atomic size and higher electronegativity of fluorine compared to hydrogen atom. Molecular dynamics (MD) simulations demonstrated that IPB-2F2 exhibited lower permeation rates for CO2 and N2 than its non fluorinated counterpart; indicating that fluorine atoms effectively reduced gas permeation. Adsorption isotherms revealed enhanced adsorption capacities for IPB-2F2, with increased CO2 affinity resulting from strong van der Waals interactions. Selectivity analyses showed that IPB-2F2 preferentially absorbed CO2 over N2, with selectivity values consistently greater than 1. The enhanced gas uptake capacity and hydrophobicity of IPB-2F2 highlighted its potential for industrial applications as a post-combustion CO2 capture material.
Development of a Gelatin-Based Genomic Reference Material for Halal Authentication Using Real-Time PCR Rahma, Anisa Aula; Meilani, Nanda Diva; Sulistiawati; Ainaputri, Aliza Salsabila; Damara, Dandy Satria; Malau, Jekmal
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.27-42

Abstract

Indonesia, home to over 270 million people, has the largest Muslim population globally, with approximately 87.18% adhering to Islam, driving significant demand for halal products, particularly in the food and pharmaceutical sectors. Gelatin, commonly used in medicinal capsules, often originates from porcine sources, necessitating precise halal authentication methods. This study presents the development of a novel genomic DNA-based Reference Material (RM) for gelatin, specifically for porcine DNA detection, employing Real-Time Polymerase Chain Reaction (qPCR) techniques. The methodology encompassed in-silico primer design, sample extraction optimization, DNA quality and quantity analysis, linearity assessment, limit of detection (LoD) and quantification (LoQ) determination, and RM characterization. Results indicated that the designed primers could reliably and efficiently detect porcine DNA, with optimal annealing at 58°C and primer concentration at 500 nM, achieving a PCR efficiency of 96.74%. The LoD and LoQ for pork meat samples were determined to be 0.02 pg/uL and 0.004 pg/uL, respectively, while the LoD for porcine gelatin was 0.27 ng/uL. The RMs exhibited robust homogeneity (Sig. 0.052), significant intergroup differences (Sig. 0.000), and low variation (CV 0.96%). Short-term storage at -80°C and -20°C preserved Ct value stability and consistency. Conclusively, this study successfully developed a novel gelatin-based genomic DNA RM for halal authentication, offering a scientifically validated tool that strengthens the halal assurance system, addressing Indonesian consumers’ demand for porcine-free products. These findings hold substantial implications for regulatory authorities, especially in Indonesia, and could inform the development of standardized qPCR RMs for porcine DNA detection in halal compliance testing.
A Comprehensive Review on the Biological Activities, Usage Areas, Chemical and Phenolic Compositions of Lycium barbarum Used in Traditional Medicine Practices Sevindik, Mustafa; Uygun, Asuman Evrim; Uysal, Imran; Sabik, Ali Erdem
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.173-182

Abstract

Plants are organic substances extensively utilized in conventional medicinal procedures. We conducted a comprehensive review of the literature to assemble information on the biological activities, areas of use, total phenolic and flavonoid concentrations, as well as the chemical and phenolic compositions of Lycium barbarum L. The literature investigation revealed that Lycium barbarum has been extensively studied for its antioxidant, antibacterial, and anticancer properties. Furthermore, it was observed that various components of the plant, including the fruit, leaves, flower, root, and bark, were utilized for distinct purposes. Furthermore, it was observed that the chemical and phenolic compositions documented in it exhibited variations depending on the specific parts that were utilized. Chlorogenic acid, p-coumaric acid and ferulic acid are common compounds found in the leaves, flowers and fruit parts of the plant. It is thought that it will be an important material in future studies because it is a source of phenolic compounds reported in the plant. Therefore, L. barbarum is believed to have significant potential as a natural resource in the development of pharmacological strategies.
Micro-Magnetic Activity of the Fabricated MnFe2O4 via Co-Precipitation from Natural Iron Sand Rianna, Martha; Hussain, Muhammad Khalid; Sembiring, Timbangen; Guk-Guk, Herwati Permata Indah Raja; Sitorus, Kurnia Jesiska; Setiadi, Eko Arief; Tetuko, Anggito P.; Sebayang, Perdamean
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.221-227

Abstract

This study explores the micromagnetic behaviour of MnFe2O4 derived from natural iron sand through the coprecipitation method, without the need for calcination. Using manganese chlo-ride and iron sand as precursors, one can create MnFe2O4. Through the utilisation of X-ray Diffraction (XRD), Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), and Vibrating Sample Magnetometer (VSM), one can effectively analyse and understand the crystal structure, morphology, and magnetic properties. The crystal size was reduced by a fac-tor of 0.40 nm, as revealed by XRD crystal structure analysis. Additionally, the XRD results indicated the absence of impurities, confirming the presence of a single phase. In addition, the SEM analysis revealed that samples 1, 2, and 3 underwent agglomeration. The particles have a cubic shape. The analysis using EDX indicates that there are no other elements present in the Mn, Fe, and O. Additionally, the VSM analysis confirms that the sample exhibits magnetic hardness. Sample 1 exhibits exceptional magnetic properties, with Ms values of 217.53 emu/g, Mr 34.27 emu/g, and Hc 127.42 emu/g. Photoluminescence (PL) spectroscopy was used to observe the optical properties of MnFe2O4. Sample 1 exhibits a distinct emission spectrum at 440 nm, representing the purple band. Sample 2 displays a sharp emission spectrum at 448 nm, indicating the blue band. Lastly, Sample 3 demonstrates a clear emission spectrum at 427 nm, signifying the purple band.
Desalination of Seawater using Pahae Natural Zeolite-Activated Carbon derived from Kepok Banana Peel (Musa paradisiaca Linn.) Susilawati; Nitsae, Merpiseldin; Sinuhaji, Perdinan; Irma, Mutia; Lubis, Hariyati; Rinaldi, Fajar; Rafly Ihsan As Siddiq, Muhammad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.56-71

Abstract

The escalating demand for freshwater due to increased global population and intensified industrial activities necessitates innovative approaches to water desalination. This study explores the efficacy of a novel composite adsorbent material consisting of Pahae natural zeolite and activated carbon derived from Kepok banana peels for seawater desalination. This research synthesizes and evaluates the composite under varying conditions to ascertain its potential as an effective adsorbent material. Characterization methods included scanning electron microscopy (SEM), energy dispersive X-ray (EDX), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), and salinity removal measurement. The results demonstrated that the 85:15% zeolite to activated carbon ratio exhibited the highest porosity of 61.04% and a significant water absorption capacity of 86.65%. This composition also achieved the most substantial salinity reduction, lowering the initial salinity from 27.70‰ to 18.53‰ with a removal efficiency of 33.10%. SEM analyses revealed a more porous surface morphology at 85:15% which corroborated with the higher salinity removal efficiency. BET results indicated that the optimal pore size and distribution occurred in the 85:15% composition which directly correlated with enhanced adsorption capacities. This study reports the potential of using sustainable materials such as zeolite and agricultural waste-derived activated carbon for cost effective and environmentally friendly desalination processes. The findings suggest that such composites can be tailored to improve performance and provide a viable solution to the global freshwater scarcity challenge.
Development and Validation of the RP-HPLC Method for Dexamethasone Sodium Phosphate Determination in Nasal Chitosan Microsphere Preparations Desnita, Rise; Noviana, Eka; Zai, Khadijah; Sulaiman, Teuku Nanda Saifullah
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.165-172

Abstract

The purpose of this work was to provide a robust, sensitive, accurate, and straightforward analytical method for measuring dexamethasone sodium phosphate (DSP) in chitosan microspheres preparedn using the spray drying method. DSP was quantitatively analyzed using RP-HPLC with an ultraviolet detector at 254 nm, a mobile phase that contained a mixture of acetonitrile and 0.1% sodium dihydrogen phosphate monohydrate (50:50) operating isocratically at a flow rate of 1.0 mL/min, and a stationary phase that was a C18 PrincetonSPHER-100 C18-QB 100A HPLC Column (250 × 4.6 mm, 5 um). The ICH recommendations were followed in the validation of the analytical method. DSP had a retention duration of 2.899 minutes and a tailing factor of 0.827. The RP-HPLC method was linear (R = 0.9992) in the 15-60 ug/mL concentration range. The limits of quantitation (LOQ) and detection (LOD) were 4.425 ug/mL and 1.327 ug/mL, respectively. The relative standard deviations for the intra-day and inter-day precisions were 0.057-0.876% and 0.780-0.949%, respectively. The recovery percentages at 50, 100, and 200% concentration levels were within the 99.269-100.980% range. The validated method has been successfully applied to determine DSP entrapment efficiency in chitosan microspheres. A linear, sensitive, accurate, precise, and robust technique of determining DSP in chitosan microsphere preparations is offered by the established RP-HPLC method.
Stability of Biologically Synthesized Silver Nanoparticles (AgNPs) Using Acalypha indica L. Plant Extract as Bioreductor and Their Potential as Anticancer Agents Against T47D Cells Madaniyah, Luailik; Fiddaroini, Saidun; Hayati, Elok Kamilah; Rahman, Moh. Farid; Sabarudin, Akhmad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.101-110

Abstract

This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments.

Page 42 of 56 | Total Record : 551

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