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All Journal Jurnal Kreativitas PKM JFM (Jurnal Farmasi Malahayati) Jurnal Review Pendidikan dan Pengajaran (JRPP) Health Information : Jurnal Penelitian Jurnal Ners Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Jurnal Insan Farmasi Indonesia SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Pharmaceutical Sciences and Research (PSR) Journal of Community Empowerment and Innovation Pharmacy Action Journal Journal of Pharmacy and Halal Studies Borneo Journal of Pharmacy Jurnal Sains Farmasi dan Kesehatan Holistik Jurnal Kesehatan
Farmasita Budiastuti, Rizky
Universitas Global Jakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL

 1 
ROLE OF ANTIBIOTIC STEWARDSHIP PROGRAM IN IMPROVING RATIONAL THIRD-LINE ANTIBIOTIC USE IN TYPE-2 DM INPATIENTS AT FATMAWATI HOSPITAL Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8397

Abstract

Type-2 diabetes mellitus (T2DM) is the most common metabolic disorders, caused by a combination of two factors: damaged insulin secretion by pancreatic β-cell and the inability of insulin-sensitive tissues to respond appropriately to insulin. Epidemiological data reveal alarming values that predict a concerning future for T2DM. According to the International Diabetes Federation (IDF), in 2019, diabetes caused 4.2 million deaths, and 463 million adults aged between 20-79 years old were living with diabetes, a number that is projected to increase up to 700 million by 2045. Based on data from RISKESDAS in 2018, the prevalence of DM in Indonesia has increased from 6.9% in 2013 to 8.5% in 2018. The Antimicrobial Resistance Control Program (PPRA) team is essential in the development and implementation of evidence-based guidelines and policies. The purpose of this study was to determine the profile of patients receiving antibiotic therapy and the use of third-line antibiotics in T2DM patients at Fatmawati Hospital during the July-December 2021 period. This research used a retrospective descriptive design with a non-experimental approach. The sample size consisted of 52 medical records that met the inclusion criteria. The results showed that patients receiving the most antibiotic treatment were between the ages of 55-64 years (38.5%), women (52%), and those with diabetic foot complications (51.8%). The single and most used combination antibiotics were ampicillin-sulbactam (34.7%) and ampicillin-sulbactam+metronidazole (29.2%). 28.8% of the patients were recommended to receive third-line antibiotics and received considerations from the PPRA team, of which 73.33% obtained approval.
PENGARUH KONDISI KELEMBABAN LEMBAB DAN KERING TERHADAP JUMLAH DAN VIABILITAS SEL PUNCA MESENKIMAL PADA PASASE 6-9 Budiastuti, Rizky Farmasita
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8960

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh kondisi kelembaban inkubator terhadap jumlah dan viabilitas sel punca mesenkimal (Mesenchymal Stem Cell, MSC) pada pasase 6 hingga 9. Dua kondisi fisiologis diuji, yaitu kultur dalam inkubator dengan kelembaban tinggi (RH ±95%) dan kelembaban rendah (RH <80%) pada kondisi normoksia (37°C, 5% CO₂). Sel yang digunakan merupakan MSC manusia yang diperoleh dari jaringan lemak donor dewasa dan telah dikarakterisasi positif terhadap penanda CD73, CD90, dan CD105. Proses kultur dilakukan secara aseptis dengan media a-MEM yang diperkaya Human Platelet Lysate (HPL) serta antibiotik 1% penicillin-streptomycin. Parameter yang diukur meliputi jumlah total sel, viabilitas sel menggunakan pewarnaan Trypan Blue, dan Population Doubling Time (PDT). Hasil menunjukkan bahwa kelembaban tinggi memberikan hasil yang signifikan terhadap peningkatan jumlah sel dan viabilitas (p<0,05). Rata-rata jumlah sel akhir pada kondisi lembab mencapai 23,36×10⁶ dengan viabilitas 90,23%, sedangkan pada kondisi kering hanya 5,56×10⁶ dengan viabilitas 81,13%. Perbedaan kelembaban juga memengaruhi PDT, di mana kondisi lembab menghasilkan pertumbuhan lebih cepat (0,33 hari⁻¹) dibandingkan kondisi kering (0,54 hari⁻¹). Dengan demikian, kelembaban tinggi berperan penting dalam menjaga stabilitas fisiologis dan mempercepat proliferasi MSC in vitro.
Co-Authors Aep Saepullah, Aep Agung Pangestu Ahda Sabila Ahda Sabila Ahda Sabila Yusuf Anugerah Budiatama A Anugerah Budipratama Adina Anugrah Budipratama Adina Benny Efendie Benny Efendie Dedi Nugroho Dedi Nugroho Dedi Nugroho DEWI RAHMAWATI Eddy Yusuf, Eddy Eksanti Indriani Sabila Fatta, Chika Apselia Hasanah, Alfiyatun Herli, Amelia Hermawati, Shakira Putri Imanda, Radita Cahya Indriani, Melis Maksum Radji Maksum Radji Marintan Simanullang Mawazi, Saeid Mezail Nadia Farhanah Syafhan Nomiansa, Yuda Nopratilova Nopratilova Novita Fitria Ningsih Nugroh, Dedi Nugroho, Dedy Putra, Rizky Pramana Renya Vitalia Pasangka Retnosari Andrajati Rini Purnamasari Rini Purnamasari, Rini Rosyid Ridlo Al-Hakim Sabila, Ahda Santi Purna Sari Sari, Nindi Eka Siska Siska Sri Wahyuni Damanik Surbakti, Fitriani Tan, Suk Fei Tita Sidatunisa Veronica, Arbella Widianingsih Widianingsih Yanuar Zulardiansyah Arief yuwanda, alhara alhara Zhafira, Bilqis