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All Journal Althea Medical Journal Global Medical and Health Communication Universa Medicina JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Health and Medical Journal Jurnal Ilmiah Kesehatan Jurnal Prima Medika Sains
Gunadi, Julia Windi
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Global Medical and Health Communication

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The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet Jasaputra, Diana Krisanti; Yumilia, Hoo; Gunadi, Julia Windi; Lesmana, Ronny; Permadi, Andieni Faqhira
Global Medical & Health Communication (GMHC) Vol 11, No 3 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i3.10993

Abstract

High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel. One of the mechanisms of blood fat-lowering drugs is to increase the expression of the PPARα gene. The purpose of this study was to assess the effect of turmeric and mangosteen peel on the expression of the PPARα gene in the rat liver induced by a high-fat diet. This research was conducted at Maranatha Biomedical Research Laboratory in February–October 2021, using male Wistar rats that were divided into 5 groups (n=5): negative control groups (no treatment), positive control groups (high-fat diet), turmeric, mangosteen, and fenofibrate groups, that was given high-fat diet continued by ethanol extract of turmeric, ethanol extract of mangosteen peel, and fenofibrate. At the end of the study, the animals were terminated, and the liver was extracted for RNA extraction and semi-quantitative PCR. The results showed that there was an increase in PPARα gene expression in the turmeric group and fenofibrate group, which were significantly different from the positive control group that received a high-fat diet (p<0.05) and between the fenofibrate group compared to negative controls that received standard chow diet (p<0.05). In conclusion, turmeric and fenofibrate are suggested to increase the expression of the PPARα gene in the liver induced by a high-fat diet.
Vitamin D Levels and Their Correlation with Predisposing Factors and Estimated Fetal Weight in Third Trimester of Pregnancy: an Observational Study Indahwati, Dwiwahju Dian; Jasaputra, Diana Krisanti; Budiono, Arief; Gunadi, Julia Windi; Lesmana, Ronny; Kusmawan, Steven Zerin Putra
Global Medical & Health Communication (GMHC) Vol 12, No 1 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i1.11953

Abstract

Vitamin D has a broad impact on the human body, including affecting the bones and the immune system. Vitamin D deficiency in pregnant women is a risk factor in several circumstances, such as preeclampsia, gestational diabetes, premature birth, and low birth weight babies. This study aimed to determine the vitamin D levels and their relationship to predisposing factors and estimated fetal weight in the third trimester of pregnancy. Eighteen pregnant women in their third trimester of pregnancy who received antenatal care in the Obstetric Clinic of Immanuel Hospital Bandung from January to December 2022 were used as subjects of this study. The inclusion criteria are third-trimester pregnant women, healthy, while the exclusion criteria are currently taking drugs that have side effects in pregnancy or having pregnancy disorders. Blood was taken to measure vitamin D levels, fetal weight was estimated with obstetric ultrasound, and the subjects filled in questionnaires about predisposing factors. The results showed ten pregnant women (56%) had vitamin D deficiency below 20 ng/mL in their third-trimester pregnancy. We found non-significant relationships (p>0.05) between predisposing factors (daily consumption of vitamin D, sun exposure, maternal age), estimated fetal weight, and vitamin D levels. This study concludes that 56% of pregnant women in their third trimester of pregnancy have vitamin D deficiency with no significant relationship with its predisposing factors and estimated fetal weight.
Co-Authors Albert Manggading Hutapea Ardo Sanjaya Arief Budiono Astrid, Stephanie Camillo, Keyshia Valentine Daud, Fari Ananda Decky Gunawan, Decky Diana Krisanti Jasaputra Dominika, Katharina Ellen Fanny Rahardja Fen Tih Gani, Irna Permanasari Ginting, Justin Hadi, Harry Tribowo Hanna Goenawan Hutagalung, Albert Rodney Indah Kusuma Dewi, Indah Kusuma Indahwati, Dwiwahju Dian Indriany, Dini Ishak, Lani Jason, Daniel Jatnika, Danti Dja Kasnadi, Crystallica Luna Kastella, Faysal Kusmawan, Steven Zerin Putra Miguna, Landry Natasia, Caroline Putri Nathania, Kezia Octavallen, Andri Octavia, Chitra Oeij Anindita Adhika Pamungkas, Raden Aprian Surya Putra Pangestuti, Balqist Sriprobo Permadi, Andieni Faqhira Ray, Hamidie Ronald Daniel Rizamena, Melya Ikbar Ronny Lesmana Rosali, Alexandrina Everdine Rudijanto, Yohanes Rumanti, Rizna Tyrani Rusli, Joseph Siringo Ringo, Nalaraty Wahyu Sugiaman, Angela Mulyana Surawijaya, Ade Kurnia Tanuwijaya, Farrell Teresa Lucretia, Teresa Titing Nurhayati Valerie, Rachel Vita Murniati Tarawan Wahyudianigsih, Roro Waty, Wenny Wijayanto, Karen Regina Yumilia, Hoo Zecha, Rosa Nurul