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All Journal Jurnal Kesehatan Masyarakat Journal of Health Education SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Epidemiology and Public Health Media Keperawatan Indonesia Unnes Journal of Public Health Jurnal Keperawatan Malang (JKM) Poltekita: Jurnal Pengabdian Masyarakat Quality : Jurnal Kesehatan Jurnal Ilmiah Kesehatan Masyarakat Indonesian Journal of Nursing and Health Sciences (IJNHS) Indonesian Journal of Public Health and Nutrition SALUTA: Jurnal Pengabdian Kepada Masyarakat Engagement: Jurnal Pengabdian Kepada Masyarakat Unnes Journal of Public Health Panakeia Journal of Epidemiology Proceeding Mulawarman International Conference on Tropical Public Health Jurnal Kesehatan Masyarakat
Saefurrohim, Muhamad Zakki
Universitas Mulawarman
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Journal : Jurnal Kesehatan Masyarakat

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Unsuccessful Drug-Resistant TB Treatment Outcomes among Patients with Short-Term Regimen in Central Java, Indonesia Ardiani, Intan Henda; Rejeki, Dwi Sarwani Sri; Wijayanti , Siwi Pramatama Mars; Saefurrohim, Muhamad Zakki
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.9483

Abstract

Tuberculosis which shows resistance to various types of drugs poses a significant burden in efforts to prevent and control tuberculosis globally. Since 2020, guidelines from the WHO have recommended a shorter treatment with an all-oral regimen for Drug Resistant Tuberculosis (DR-TB), with the inclusion of bedaquiline instead of an injectable agent. However, the treatment success rate for DR-TB in Indonesia is still low. This study aimed to determine factors contributing to unsuccessful DR-TB treatment using STR in Central Java. This was a nested case-control study of 412 DR-TB patients enrolled with a Short-Term Regimen, registered in 2021 to 2023 who had treatment results in a subset of the Tuberculosis Information System cohort data. Independent variables analyzed included age, gender, patient employment status, history of previous TB treatment, DM status, HIV status, resistance pattern, initial sputum examination results, drug side effects, treatment initiation interval, body mass index, and BPJS ownership status. Statistical analysis was done using SPSS version 22 software, with logistic regression analysis to identify the determinants. The determinant of unsuccessful treatment outcome in Central Java Province which is 51.04% was the positive results of initial sputum examination of treatment (aOR=10.501; 95%CI=5.056-21.807), drug side effects (aOR=1.853; 95%CI=1,000-3.436), obesity (aOR=3.115; 95%CI=1.188-8.166) and BPJS non-possession status (aOR=2.213; 95%CI=0.932-5.255). More strategies are needed to improve the success of treatment with STR.
Co-Authors Abdul Hakam Aidil Fitrah, Muhammad Akhmad Azmiardi Al-Ayubi, Moch Thoriq Assegaf Alvy Fajri Amanda Hesti Pratiwi Andreas Wilson Setiawan Anggun Dessita Wandastuti Ardiani, Intan Henda Arfandi, Muh Amri Ariyanti, Rea Arulita Ika Fibriana Atika Aulia Atika Aulia Aufiena Nur Ayu Merzistya Aufiena Nur Ayu Merzistya Azmiardi, Akhmad Akhmad Baiq Diken Safitri Basrowi, Ray Wagiu Casmuti, Casmuti Dani Miarso Dina Nur Anggraini Ningrum Dwi Sarwani Sri Rejeki Farida, Eko Fatihah, Ana Nur Fitria Ningsih Intan Zainafree Intan Zainafree, Intan Irfansyah Baharuddin Pakki Irsam, Muhamad Irwan Irwan Isbandi Isbandi Jusran, Alek Kholifah, Siti Putri Nur Lukman Fauzi Mahalul Azam Masruroh1,2, Ah Yusuf3 , Nikmatur Rohmah4, Irfansyah Baharudin Pakki5 , Anita Dewi Prahastuti Prasojo6 , Qurnia Andayani1 , *Agung Dwi Laksono7 Minhajul Mubarok Mona Subagja Muh. Amri Arfandi Muhamad Anbiya Nur Islam Mustafa Daru Affandi Mustika Suci Susilastuti Nadia Syukria Nindy Nurhalizah Nur Dian Rakhmawati Nur Dian Rakhmawati Nur Wahidah Nur Wahidah Prasetya, Henky Yoga Rahayu, Eka Putri Ratih Wirapuspita Wisnuwardani Rina Tri Agustini Risva Rr. Sri Ratna Rahayu S Siswanto Silfia Addina Siswanto SITI MARIA ULFA Soesmeyka Savitri Sri Ratna Rahayu Suci Susilastuti , Mustika Tatik Atmini Ulfa, Siti Lutfiyah Utami, Dian Margi Utomo , Dewi Natalista Dwi Warsono Warsono Widya Hary Cahyati Wijayanti , Siwi Pramatama Mars Yuliana, Roma Zaimatuddunia, Irma Zainafree , Intan Zuyyinatun Muflikhah