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Dewi, Nadia Purnama
Baiturrahmah University
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Increase of Fibroblast Cells in Wound Healing of Diabetes Mellitus Male Rats (Rattus Norvegicus) Using Aloin Ade Teti Vani; Cindy Arlita; Lismawati Lismawati; Nadia Purnama Dewi; Dessy Abdullah; Meta Zuliyanti Oktora
Oshada Vol. 1 No. 4 (2024): Oshada Journal - August
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/3fvt9h57

Abstract

The healing process wound on the skin diabetic experience slowdown because dysfunction fibroblasts. Aloins boost expression fibroblasts that can accelerating the process of wound healing in patients with Diabetes Mellitus (DM). Objective study that is for now effect enhancement cell fibroblasts in wound healing wound I t mouse male DM with aloe giving. Method study use principle true experimental with approach post-test serial only control group design. Treatment form wound cut on mice. Group study using 4 groups with a negative control in the form mouse healthy, positive control form DM mouse. group action 1 in the form of DM rats were given 1.25 mg/ kg BW aloin and treatment 2 was in the form of DM rats given 2.5 mg/ kg BW aloin. Expression fibroblasts calculated on day 7 and day 14. Analysis bivariate using the Friedman test continued with the Wilcoxon Post- Hoc test. Research results that are there is enhancement fibroblasts significant in the group treatment given with aloein a dose of 1.25 mg/ kg and a dose of 2.5 mg/ kg. The conclusion is that Aloin accelerates wound healing wound incision in DM rats with mechanism enhancement expression fibroblasts with minimum dose of 1.25 mg/ KgBB. Research suggestions that is examination of re- epithelialization and density Dermal collagen in wound healing wound I t DM rats given aloein in the study next.
Chances of Presbycusis in Minangkabau Elderly Patients with Type 2 Diabetes Mellitus Without Complications in Padang City Irwan Triansyah; Salsabila Putri Amril; Fredia Heppy; Ade Teti Vani; Nadia Purnama Dewi; Dessy Abdullah
Oshada Vol. 1 No. 3 (2024): Oshada Journal - June
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/4ty69f72

Abstract

Background: Presbycusis is a loss of hearing ability that occurs slowly with age. One of the risk factors that plays a role in the occurrence of presbycusis is diabetes mellitus. Diabetes mellitus is an extrinsic factor that affects cochlear blood flow and reduces nutrient transport through deoxygenation, resulting in secondary degeneration of the organ of corti and the auditory nerve. Aim: To assess the increase in the chance of presbycusis in elderly people with type 2 diabetes mellitus without complications in the Minangkabau tribe in Padang City. Method: This research is unpaired categorical analytical research with a case control design using primary data. Samples were selected using consecutive sampling technique. Data analysis used univariate and bivariate analysis using the Chi-Square test. Results: Presbycusis was most commonly found in the young elderly group, 16 people (84.2%), the gender of the presbycusis elderly was mostly female, 12 people (63.2%), the longest time diagnosed with diabetes mellitus, the most presbycusis elderly was ≥5 years, 13 people (68.4%), the Minangkabau tribe with the most presbycusis elderly is Jambak 5 people (26.3%). The highest audiometric description of elderly people was mild, 16 people (45.7%). The majority of elderly people experienced mild presbycusis, 10 people (30.3%). There is a significant increase in the chance of presbycusis in elderly people with type 2 diabetes mellitus without complications with p=0.015 and an OR calculation of 3.431. Conclusion: There was an increased chance of presbycusis in elderly people with type 2 diabetes mellitus without complications.
Adolescent Reproductive Health Education: Midwives' Contribution to the Prevention of Unintended Pregnancy Cynthia Puspariny; Chusnul Zulaika; Devin Mahendika; Nadia Purnama Dewi; Suyadi Suyadi
Oshada Vol. 2 No. 1 (2025): Oshada Journal - February
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/mvfexf04

Abstract

Unplanned pregnancy among adolescents is a complex issue influenced by limited access to reproductive health education and adolescent-friendly contraceptive services. This phenomenon has multidimensional impacts, including increased risk of health complications, school dropout, and social stigma that hinders adolescent well-being. The role of midwives is crucial in bridging the gap in information and access to reproductive health services. Evidence-based reproductive health education has been shown to be effective in improving adolescents' understanding of their sexual and reproductive rights. However, the implementation of this program still faces challenges in the form of cultural resistance, lack of training for health workers, and social stigma that hinders open discussion. This study uses a qualitative approach with a literature review method to analyze the role of midwives in preventing adolescent pregnancy. The results of the study show that cross-sector collaboration and the use of digital technology can increase the effectiveness of reproductive health education. However, challenges such as misinformation and weak digital regulations must be addressed by strengthening digital literacy and content monitoring. With the right strategy, midwives can play a more optimal role in providing inclusive and evidence-based services, so that adolescents are able to make responsible decisions regarding their reproductive health.
Peran Fascia dalam Integrasi Struktural Tubuh: Suatu Tinjauan Literatur Anatomi Nadia Purnama Dewi; Ade Teti Vani; Rinita Amelia
Scientific Journal Vol. 4 No. 2 (2025): SCIENA Volume IV No 2, March 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i2.224

Abstract

Pendahuluan: Fascia adalah jaringan ikat yang membentuk sistem kontinu di seluruh tubuh manusia dan berperan penting dalam stabilitas, gerak, serta komunikasi antar sistem tubuh. Tetapi perannya dalam studi anatomi dan praktik klinis konvensional, sering terabaikan. Metode: Literatur review ini dilakukan terhadap artikel ilmiah yang diterbitkan antara tahun 2016 hingga 2025 dengan menggunakan basis data PubMed, Scopus, ScienceDirect, dan Wiley Online Library. Seleksi dilakukan mengikuti alur PRISMA. Artikel yang digunakan adalah artikel yang secara khusus membahas fascia dan integrasi struktural dalam anatomi manusia. Hanya terdapat 13 artikel memenuhi kriteria inklusi dan dianalisis secara tematik, dari 327 artikel.  Hasil: Fascia ditemukan memiliki struktur berlapis dan fungsional, dengan kemampuan mentransmisikan gaya antar jaringan, mendukung postur, dan mengatur propriosepsi serta persepsi nyeri. Studi menunjukkan fascia sebagai jaringan aktif yang memediasi integrasi biomekanik antara otot, tulang, dan organ. Beberapa pendekatan klinis seperti terapi myofascial dan integrasi struktural menunjukkan hasil positif dalam meningkatkan fungsi dan mengurangi nyeri. Kesimpulan: Studi terbaru menunjukkan fascia harus dilihat sebagai sistem jaringan aktif daripada hanya pembungkus otot. Ini menunjukkan bahwa standar pendidikan medis, fisioterapi, dan rehabilitasi perlu diubah. Studi lanjutan diperlukan untuk mengidentifikasi peran fascia dalam patologi sistemik dan mengevaluasi lebih lanjut efektivitas intervensi berbasis fascia
IMPLEMENTING RAPID NEEDS ASSESSMENT TO IMPROVE HUMANITARIAN AID DISTRIBUTION FOLLOWING THE 2025 FLASH FLOOD IN PADANG CITY, INDONESIA: A COMMUNITY SERVICE EXPERIENCE Ade Teti Vani; Irwan Triansyah; Nadia Purnama Dewi; Dessy Abdullah; Yuri Haiga; Debie Anggraini; Prima Adelin; Dita Hasni
Nusantara Hasana Journal Vol. 6 No. 1 (2026): Nusantara Hasana Journal, June 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v6i1.2254

Abstract

Humanitarian aid is one of the most critical components of disaster response. However, relief distribution during the emergency phase is frequently driven by donor availability rather than by the actual needs of affected communities. Consequently, while essential supplies such as food and drinking water are often adequately provided, personal necessities that directly influence dignity, hygiene, and daily living remain insufficient. Rapid Needs Assessment (RNA) is recommended as a systematic approach to identify priority needs and improve the effectiveness of humanitarian interventions. This community service program aimed to implement a Rapid Needs Assessment before humanitarian aid distribution for victims of the 2025 flash flood in Padang City, Indonesia. The program was conducted during the emergency response period following the flash flood on 26 November 2025. A collaborative team of university lecturers and members of the Indonesian Medical Association (IDI) Padang Branch conducted field observations and semi-structured interviews with affected households at evacuation sites. Information on assistance already received and unmet priority needs was collected and used to guide the procurement and distribution of relief items. Most affected households had already received temporary shelter, food, and clean water. However, essential personal items—including towels, baby supplies, underwear, blankets, prayer equipment, umbrellas, and raincoats—remained insufficient. Implementing Rapid Needs Assessment enabled the humanitarian team to provide targeted assistance, complement existing relief efforts, minimize duplication, and address overlooked needs. Rapid Needs Assessment improved the relevance and effectiveness of humanitarian aid distribution. Collaboration between higher education institutions and professional organizations offers a practical model for evidence-based community service in disaster response.
THE EFFECT OF ALOIN ADMINISTRATION ON FOAM CELL FORMATION IN THE KIDNEYS OF MALE MICE (MUS MUSCULUS) WITH DYSLIPIDEMIA-INDUCED OBESITY Nadya Mukhti; Ade Teti Vani; Khomeini Khomeini; Nadia Purnama Dewi; Dessy Abdullah; Rosmaini Rosmaini
Nusantara Hasana Journal Vol. 6 No. 1 (2026): Nusantara Hasana Journal, June 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v6i1.2255

Abstract

Dyslipidemia and obesity are major metabolic disorders characterized by abnormal lipid metabolism, chronic inflammation, and oxidative stress, all of which contribute to progressive renal injury. Excessive accumulation of oxidized low-density lipoprotein (ox-LDL) promotes macrophage infiltration and foam cell formation within renal tissue, accelerating glomerular damage and increasing the risk of chronic kidney disease. Aloin, the principal anthraquinone glycoside isolated from Aloe vera, possesses potent antioxidant and anti-inflammatory properties that may attenuate oxidative injury and inhibit foam cell formation. This study aimed to investigate the effect of oral aloin administration on renal foam cell formation in male Mus musculus with dyslipidemia-induced obesity. A true experimental study employing a posttest-only control group design was conducted using male mice with experimentally induced dyslipidemia and obesity. Animals were randomly allocated into control and treatment groups. The treatment group received oral aloin for 28 consecutive days following dyslipidemia induction. Kidney tissues were collected for histopathological examination using Hematoxylin–Eosin staining. Foam cell formation was evaluated microscopically, and differences between groups were analyzed using the Independent Samples t-test with a significance level of p < 0.05. Histopathological analysis demonstrated that aloin administration reduced renal foam cell formation compared with the untreated control group. The treatment group exhibited approximately 25% foam cell formation, whereas the control group demonstrated approximately 93.8%. These findings suggest that aloin suppresses lipid accumulation and inflammatory responses within renal tissue through its antioxidant activity. Nevertheless, the therapeutic effect remained lower than that reported for atorvastatin, indicating that aloin is more appropriately considered a complementary rather than a replacement therapy. Oral administration of aloin effectively reduced foam cell formation in the kidneys of dyslipidemia-induced obese male mice. The protective effect is likely mediated through antioxidant activity, inhibition of lipid peroxidation, and attenuation of inflammatory processes.
Deteksi Dini Faktor Risiko Kanker Serviks berbasis Data Klinis Pasien di RSUP. Dr. M.Djamil Padang Meta Zulyati Oktora; Debie Anggraini; Nadia Purnama Dewi
Abdika Sciena Vol 3 No 1 (2025): JURABDIKES Volume 3 No 1, Juni 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v3i1.269

Abstract

Latar Belakang : Kanker serviks merupakan salah satu kanker terbanyak pada perempuan di Indonesia dan sering terdiagnosis pada stadium lanjut. Deteksi dini dan edukasi faktor risiko sangat penting dalam menurunkan angka kejadian dan mortalitas. Tujuan : Penelitian ini bertujuan untuk mengidentifikasi faktor risiko kanker serviks pada wanita usia subur berbasis data klinis pasien serta mengintegrasikannya dalam kegiatan edukasi masyarakat. Metode: Kegiatan dilaksanakan di RSUP Dr. M. Djamil Padang pada September 2020–April 2021 dengan desain deskriptif analitik cross sectional. Populasi penelitian adalah 70 pasien kanker serviks yang dipilih dengan teknik simple random sampling. Data yang dikumpulkan meliputi usia menikah, jumlah paritas, serta lama penggunaan kontrasepsi hormonal. Kegiatan pengabdian meliputi penyuluhan, diskusi kelompok, distribusi leaflet, dan informasi mengenai skrining deteksi dini (Pap smear/IVA). Hasil: Sebanyak 42,9% pasien menikah pada usia <20 tahun, dan 80% pasien adalah multipara. Lama penggunaan kontrasepsi hormonal terbanyak <5 tahun (55,7%) dengan jenis terbanyak kontrasepsi suntik (62,9%). Sebagian besar pasien terdiagnosis pada stadium lanjut: stadium III (47,1%) dan stadium II (30%). Edukasi melalui penyuluhan dan distribusi media informasi berhasil meningkatkan pemahaman peserta mengenai faktor risiko dan pentingnya deteksi dini. Kesimpulan: Faktor risiko yang dominan pada pasien kanker serviks adalah usia menikah muda, multiparitas, serta penggunaan kontrasepsi hormonal jangka panjang. Edukasi kesehatan berbasis data klinis pasien efektif meningkatkan kesadaran wanita usia subur terhadap pencegahan dan deteksi dini kanker serviks.
Antibiotic-Resistant Lactic Acid Bacteria Pediococcus acidilactici Isolated from Buffalo’s Milk Fermentation (Dadiah) Bukittinggi, West Sumatera Nadia Purnama Dewi; Dessy Abdullah; Yudha Endra Pratama
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 10, No 2: Jurnal Pembelajaran Dan Biologi Nukleus July 2024
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v10i2.5699

Abstract

The use of antibiotics is still carried out in the health world so that it will cause a big problem, namely antibiotic resistance. The use of antibiotics has also been limited but cannot be stopped. The use of probiotics as therapy in the world of health is increasing every year, so it is necessary to study the combination of antibiotics and probiotics so as not to reduce the effectiveness of probiotics later. This study aims to determine the resistance ability of lactic acid bacteria (LAB) isolates from Buffalos Milk Fermentation (called as dadiah) Bukittinggi against antibiotics. This research uses a descriptive, experimental method where the observations made are related to the total mass of isolates per ml and the clear zone of LAB isolates from dadiah Bukittinggi against antibiotics. In this study, five types of LAB isolates from dadiah Bukittinggi were used, and it was found that the total mass of isolates ranged from 4-194 x108 CFU/ml. In addition to antibiotic resistance, it was known that dadiah LAB isolates resisted Kanamycin and Penicillin by 75%. While on the antibiotic chloramphenicol, ampicillin and tetracyclin, the four isolates are suspect to the antibiotic. The five LAB isolates of dadiah used in the study, DS1 isolate had the best total mass and was resistant to kanamycin and penicillin
PENGENALAN ISI PIRINGKU DENGAN METODE PENDEKATAN SENI GAMBAR DI SMP YARI PADANG Ade Teti Vani; Irwan Triansyah; Nadia Purnama Dewi; Dessy Abdullah; Aryaldi Zulkarnaini
Nusantara Hasana Journal Vol. 3 No. 8 (2024): Nusantara Hasana Journal, January 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i8.1048

Abstract

Motivation/Background: The contents of Isi Piringku determine the nutritional status of adolescents. The wrong type, and the amount of food will cause malnutrition problems in adolescents. Introduction to the method of drawing art is effective for teenagers because drawing art includes learning to play. This method makes it easier to accept the concept of Fill My Plate. The purpose of the service activity is to provide knowledge about the contents of my plate as the first step in implementing a nutrition-conscious attitude for YARI Padang Junior High School teenagers. Method: The method of service is in the form of counseling and workshops. Counseling is carried out at the beginning and end of service. Workshops in the form of drawing art are given as core activities. Results: The results of dedication were obtained by only 5% of students who just learned about the contents of Isi Piringku. During the workshop 100% of students can analyze the contents of Isi Piringku and at the end of the service, 100% of students can analyze the contents of Isi Piringku. Conclusions: The conclusion of this devotion is that the art of drawing effectively increases the knowledge of the contents of my plate. Furthermore, the devotion of Isi Piringku can be continued with a food workshop Isi Piringku.
KADAR KATEKIN DAN AKTIVITAS ANTIOKSIDAN GAMBIR (UNCARIA GAMBIR ROXB.) DI INDONESIA: TINJAUAN LITERATUR 10 TAHUN TERAKHIR (2015-2025) Ade Teti Vani; Irwan Triansyah; Nadia Purnama Dewi; Dessy Abdullah; Aryaldy Zulkarnaini
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1862

Abstract

Indonesia is the world’s largest producer of gambier (Uncaria gambir Roxb.), which is rich in catechin, a major bioactive compound with strong antioxidant activity. Variations in catechin content and antioxidant activity of Indonesian gambier are influenced by geographical origin, plant characteristics, and processing and extraction methods. This study aims to comprehensively review the catechin content and antioxidant activity of Indonesian gambier based on scientific publications from the last decade (2015–2025). A narrative literature review method was applied by collecting relevant articles from Google Scholar, ScienceDirect, PubMed, and Garuda databases. Selected studies were original research articles reporting quantitative data on catechin levels and/or antioxidant activity of gambier originating from Indonesia. The results indicate that Indonesian gambier, particularly from West Sumatra, exhibits high catechin content and strong antioxidant activity, although considerable variation exists among regions and extraction techniques. Advanced extraction and purification methods, including solvent optimization and ultrasonic-assisted extraction, were shown to enhance catechin concentration and antioxidant capacity. Indonesian gambier has significant potential as a natural antioxidant source, highlighting the need for quality standardization and further development of processing technologies to support value-added utilization and downstream product development.
Co-Authors Ade Teti Vani Ade Teti Vani Ade Teti Vani Ade Teti Vani Ade Teti Vani Adelin, Prima Adeteti Vani Adetetivani Adetetivani Anggraini, Debie Anisah Apriyani Anissa, Mutiara Anita Darmayanti Annisa Dhea Mutiara Aryaldi Zulkarnaini Aryaldy Zulkarnaini Budi Yulhasfi Febrianto Chusnul Zulaika Cindy Arlita Cynthia Puspariny Debie Anggraini Dessy Abdullah Dessy Abdullah Dessy Abdullah Devin Mahendika Dita Hasni Fandani Riskal Febianne Eldrian Fidiariani Sjaaf Fitria Chairal Ulfah Fredia Heppy Haiga, Yuri Irwan Triansyah Irwan Triansyah Khomeini Khomeini Khomeini Khomeini Khuntum Khairatul Ummah Lismawati Lismawati Meta Zuliyanti Oktora Meta Zulyati Oktora Mutiara Annisa Nadya Mukhti Ovi OKtavian Prima Della Fegita Rendri Bayu Hansah Rika Amran Rinita Amelia Roland Helmizar Rosmaini Rosmaini Salsabila Putri Amril Septiana Vina Tri Shyndi Berliana Putri Suyadi Suyadi Syarifah Fazhilah Djamalilleil Vella Audi Vivinia RA Putri Vudhya Ulhaq Kafrawi Yanti Fitri Yasa Yudha Endra Pratama