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All Journal PROSIDING SEMINAR NASIONAL Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education PENGABDI: Jurnal Hasil Pengabdian Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Medical and Health Journal Molekul: Jurnal Ilmiah Kimia Linggamas: Jurnal Pengabdian Masyarakat Journal of Applied Science for Pharmaceuticals and Health
Widiartini, Catharina
Department Of Anatomy, Medical Faculty, Universitas Jenderal Soedirman, Purwokerto, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Gambaran Fibrosis Tubulus Ginjal Tikus Putih (Rattus norvegicus) Hiperurisemik Yang Diberikan Bawang Hitam Fajar Wahyu Pribadi; Catharina Widiartini; Gita Nawangtantrini; Hidayat Sulistyo
Journal of Applied Science for Pharmaceuticals and Health Vol 1 No 2 (2024): Journal of Applied Science for Pharmaceuticals and Health (Desember)
Publisher : Centre of Applied Science for Pharmaceutical Science Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jasph.2024.1.2.14876

Abstract

Hyperuricemia can cause damage to the kidneys through activation of the inflammatory cascade and an increase in free radicals. The level of damage that occurs in the kidneys can be seen through the picture of renal tubular fibrosis. Black garlic contains s-alyl cistein (SAC), tetrahydro-β-carbolines, alkaloids, and flavonoids that are thought to inhibit the work of the xanthine oxidase enzyme so that it can reduce uric acid and repair kidney damage that has occurred. The short-term goal of this study was to determine the picture of renal tubular fibrosis in hyperuricemic white rats given black garlic. The long-term goal to be achieved is the use of black garlic for prevention and or overcoming the negative effects of hyperuricemia on the kidneys. Rats were grouped into five groups: positive control, allopurinol group, 240mg, 480mg and 960mg black garlic groups. Induction of hyperuricemia was carried out by injection of potassium oxonate and the addition of cow brain for 14 days, followed by treatment. At the end of the study, termination and organ harvesting will be done to examine the picture of renal tubular fibrosis. This study is an experimental study. The results showed that the administration of various doses of black garlic can reduce fibrosis in hyperuricemia white rats (Rattus novergicus).
Co-Authors Agus Budi Setiawan, Agus Budi Ardansyah, Marsya Bunga Dis Dita Ayu Dewi Laras Sati Fajar Wahyu Pribadi Fajar Wahyu Pribadi, Fajar Wahyu Fitranto Arjadi Fitranto Arjadi Gita Nawangtantrini Hajid Rahmadianto Heidy Angelina Mulyadi Hidayah, Arfi Nurul Hidayat Sulistyo Kuncoro, Prasetyo Tri Mae Sri Hartati Wahyuningsih Miko Ferine Muhammad Zaenuri Syamsu Hidayat Nawangtantrini, Gita Nia Krisniawati Nor Sri Inayani Panuntun, Hilmi Puguh Prasetyo Tri Kuncoro Prasetyo Tri Kuncoro Pribadii, Fajar Wahyu Rizak Tiara Yusan Setiawati - Sindhu Wisesa Sutasman, Thomas Viva Ratih Bening Ati Yulia Fauziyah