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ANOM BOWOLAKSONO
Departemen Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Indonesia, Kampus Depok, Depok 16424
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Susceptibility of the Punctulatus group (Diptera: Culicidae) to insecticide carbamate in Papua, Indonesia LEPA SYAHRANI; ASTARI DWIRANTI; PUJI BUDI SETIA ASIH; ISMAIL EKOPRAYITNO ROZI; DENDI HADI PERMANA; ANOM BOWOLAKSONO; DIN SYAFRUDDIN
Biodiversitas Journal of Biological Diversity Vol. 26 No. 3 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260338

Abstract

Abstract. Syahrani L, Dwiranti A, Asih PBS, Rozi IE, Permana DH, Bowolaksono A, Syafruddin D. 2025. Susceptibility of the Punctulatus group (Diptera: Culicidae) to insecticide carbamate in Papua, Indonesia. Biodiversitas 26: 1376-1383. Insecticide Treated Nets (ITNs) and Indoor Residual Spraying (IRS) are the primary vector control tools recommended for reducing malaria transmission in endemic areas. However, the emergence and spread of pyrethroid resistance among the Anopheles punctulatus group poses a significant challenge for malaria vector control in Papua, Indonesia. While carbamate-based IRS is a potential strategy to mitigate resistance, its effectiveness within malaria control programs requires continuous monitoring. This study assessed the susceptibility of the Punctulatus group to bendiocarb (0.1%) and analyzed the underlying resistance mechanisms. Bioassays were conducted in three sub-districts of Keerom District, Papua. Additionally, biochemical assays were performed to measure the activity of detoxifying enzymes, including esterases, Glutathione S-Transferases (GSTs), and acetylcholinesterase. Ace-1 fragments were amplified using Polymerase Chain Reaction (PCR), followed by sequencing to detect nucleotide substitution at codon 119. Results indicated full susceptibility (100%) of the Punctulatus group to bendiocarb at all study sites. Compared to unexposed controls, bendiocarb-exposed populations exhibited significantly higher GST (p: 1.403e-06), elevated esterase activity (p: 0.247), and reduced acetylcholinesterase inhibition (p: 0.002). PCR sequencing of 29 samples confirmed that all carried the wild-type Ace-1 allele (GGG, GGC, and GGT). These findings provide crucial evidence for malaria control programs in selecting appropriate vector control products and managing insecticide resistance. Despite full susceptibility to bendiocarb, elevated detoxification enzyme activity suggests potential early-stage metabolic resistance. Further molecular studies are recommended to investigate metabolic resistance mechanisms, along with rigorous monitoring using bioassays, biochemical assays, and molecular tools to track insecticide susceptibility trends over time.
Hormonal and Laboratory Profile of Polycystic Ovarian Syndrome (Pcos) Women Visiting Fertility Center in Indonesia Ayu Mulia Sundari; Tri Aprilliana Wulandari; Nurul Muhammad Prakoso; Astari Dwiranti; Abinawanto; Arief Boediono; Hiroaki Funahashi; Anom Bowolaksono
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7546

Abstract

Our study aims to scrutinize the hormonal and laboratory profile of women with PCOS visiting a fertility center in Indonesia. A computerized database of 120 PCOS women and 120 controls was retrospectively reviewed and analyzed. According to analysis, the concentration of AMH and basal LH were significantly more elevated in the PCOS group than in the control group (6.77 vs. 2.05, P<0.001; and 6.8 vs. 5.3, P<0.001, respectively). The level of basal FSH was significantly lower in the PCOS group (5.83 vs. 7.86; P<0.001). After an IVF cycle, PCOS women had significantly higher retrieved oocytes and mature oocytes compared to controls (18 vs. 8, P<0.001; 12 vs. 6, P<0.001). The number of fertilizations, cleavages, and top-quality cleavages were also higher in the PCOS group than in the control group (10 vs. 4, P<0.001; 10 vs. 4, P<0.001; 4 vs. 2, P<0.001). At the blastocyst stage, patients with PCOS had a higher number of blastocysts and top-quality blastocysts than control (9 vs. 4, P<0.001); 4 vs. 1, P<0.01). However, the clinical pregnancy was significantly higher in the control group than in the PCOS group (52.6% vs. 16.7%; P = 0.045).
From silk waste to cancer therapy: a review of the therapeutic potential and in vitro cytotoxicity of sericin Lisya Mutiara Dewi; Moch Saifur Rijal; Lia Amelia Tresna Wulan Asri; Astari Dwiranti; Anom Bowolaksono
Current Research on Biosciences and Biotechnology Vol. 8 No. 1 (2026)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2026.8.1/0G4ZT95U

Abstract

Cancer is a disease characterized by uncontrolled cell growth, often leading to death. The high incidence of cancer has led to continued exploration of potential therapeutics, particularly those derived from natural products. One of the potential natural products is sericin, which has been shown to have anticancer effects against several types of cancer through various in vitro studies. Previous studies generally indicate that sericin's anticancer effects are reflected in its ability to reduce cancer cell viability and induce apoptosis by regulating the expression levels of its related proteins. Studies have suggested that the expression levels of apoptosis-related proteins are known to influence the metastatic potential of cancer cells. Although the specific antimetastatic effects of sericin, an industrial waste by-product, remain largely unexplored, this review comprehensively evaluates its role as an anticancer agent and its underlying cellular mechanisms. Sericin modulates the apoptotic pathway by shifting the Bax/Bcl-2 ratio, specifically through upregulating the pro-apoptotic Bax and suppressing the anti-apoptotic Bcl-2, leading to the sequential activation of pro-caspase-9 and downstream effector caspases. Beyond its established pro-apoptotic activity, we highlight the ability of sericin to restore the apoptotic threshold, which may effectively limit the survival of circulating tumour cells and their capacity to metastasize. Consequently, while sericin offers a promising frontier for future therapeutic investigation, realizing this remarkable potential requires addressing critical experimental gaps, specifically the current lack of dedicated in vitro migration/ invasion assays and in vivo metastasis models to evaluate sericin impact on disrupting the metastatic cascade.
Co-Authors Abinawanto Advent Tri Joy Simamora Ady Suryawan Afifa Hasna Ahmad Aulia Jusuf ALFI SOPHIAN Amin Soebandrio Amira, Qanita Hana ANANG HARI KRISTANTO Anita Mayasari Arief Boediono Asmarinah Astari Dwiranti Aucky Hinting Ayu Mulia Sundari Ayu Mulia Sundari BENEDIKTUS YOHAN David Kusmawan DENDI HADI PERMANA DIN SYAFRUDDIN Dionisius Denis DIONISIUS DENIS ELIZABETH NOVI KUSUMANINGRUM Fadhilah Fadilah Firmansyah, Ardi Funahashi, Hiroaki Gustina, Ira HANI HAMIDAH Heatubun, Charlie D. Hiroaki Funahashi Huriyah Adani Saoemi Ismail ISMAIL EKOPRAYITNO ROZI Jatna Supriatna Justus Sievers LEPA SYAHRANI Lia Amelia Tresna Wulan Asri Liling, Irman Lisya Mutiara Dewi LUTHFIRALDA SJAHFIRDI MARIANA D. BAYU INTAN Moch Saifur Rijal Moudy Soraya Mufti Petala Patria Nova Anita Nurul Muhammad Prakoso Oktaviani Naulita Turnip Perdana, Silvia M. Petrus Supardi PIPIH SUNINGSIH EFENDI Prakoso, Nurul Muhammad PUJI BUDI SETIA ASIH Putri Irwanti Sari R. Tedjo Sasmono R. TEDJO SASMONO RAHMA F. HAYATI Rahma Suryaningsih Rajagukguk, Selly Setiati Randall C Kyes RETNO LESTARI RETNO LESTARI RETNO LESTARI Retno Lestari RIZKA ALAWIYAH RUDHY GUSTIANO Rudi Afnan RURY EPRILURAHMAN Sabar Pambudi Setiorini, Setiorini Silvia werdhy lestari Siti Z Musthofa SUCI LESTARI Sundari, Ayu Mulia TRI ZULISTIANA Tri Aprilliana Wulandari Utomo, Doddy Irawan Setyo WISNU WARDHANA