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All Journal Dentika Dental Journal Jurnal Kesehatan Gigi B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Buletin Ilmiah Nagari Membangun Bioscientia Medicina : Journal of Biomedicine and Translational Research Interdental Jurnal Kedokteran Gigi (IJKG) Medika Kartika : Jurnal Kedokteran dan Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Open Access Indonesian Journal of Medical Reviews Indonesian Community Empowerment Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal EduHealth Andalas Dental Journal Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Mentari Jurnal of Syiah Kuala Dentistry Society
Haria Fitri
Fakultas Kedokteran Gigi Universitas Andalas
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efek Terapi Adjuvan Gel Kolagen terhadap Kadar Matriks Metaloproteinase-8 Saliva pada Gingivitis Pasca Scaling Root Planing Fitri, Haria; Kasuma , Nila; Hardisman, Hardisman; Ali , Hirowati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1500

Abstract

Gingivitis is a reversible inflammatory condition of the gingival tissue without attachment loss, primarily caused by plaque accumulation, which can trigger an immune response. Matrix metalloproteinase-8 (MMP-8) is an enzyme that contributes to collagen degradation. Scaling and root planing (SRP) is the standard therapy; however, it may induce a transient inflammatory response and result in suboptimal tissue regeneration, thereby necessitating adjunctive therapy. This study aimed to evaluate the effect of adjunctive collagen gel therapy on salivary matrix metalloproteinase-8 levels in gingivitis. This experimental study employed a pre- and post-test control group design involving 50 subjects divided into five groups: healthy control, gingivitis treated with SRP, and gingivitis treated with SRP combined with 1%, 2%, and 4% collagen gel. Salivary MMP-8 levels were measured to assess the inflammatory response. Statistical analysis revealed that collagen gel at concentrations of 1% and 2% had a significant effect on MMP-8 levels. In conclusion, Collagen gel at 1% and 2% concentrations significantly modulated salivary MMP-8 levels, suggesting a potential role in the tissue remodeling phase following SRP.
Co-Authors Adriansyah Adriansyah Afifarsyah Rayatama Putra Ali , Hirowati Arini, Mustika Aulia, Rahmi Khairani Dedi Sumantri Dewi Muarofah Dika, Echa Febtri Eni Rahmi Fajriah Fajriah fajrin, fildzah Fildzah Nurul Fajrin, Fildzah Nurul Filzdah Nurul FAJRIN Firahmi Elga Fitri Rahmawati Fitri, Citra Fitriana, Aida Giant ERNESTO Gita Dwi Jiwanda Sovira Gita Dwi JS Hardisman Harfindo Nismal Hilda Lestari Ida Ayu Putu Sri Widnyani Kasuma , Nila Kurnia, Puji Murni Wati Mustika Arini Nabila Jihan Yandika Najla, Qaireenisa Netti Suharti Nila Kasuma Nila, Kasuma Nofika, Reni Puji Kurnia Putri, Novia Wirna Rahmatul Aini Rahmi Khairani Reno Wiska Wulandari Suci Rahma Sari Suci Rahma Sari Suci Rahmasari Susi Susi Tiara Adzakiyah Tiara Adzakiyah tomisha, sisi Widya Puspita Sari Wita Wita Wulandani Liza Putri Yandi, Satria Yona Ladyventini Yona Ladyventini