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All Journal Rekayasa: Jurnal Penerapan Teknologi dan Pembelajaran Indonesian Journal of Cancer Chemoprevention Jurnal Psikologi Indonesian Journal of Biotechnology Indonesian Journal of Chemical Science Knowledge Engineering and Data Science Jurnal Eurekamatika Pattimura Proceeding : Conference of Science and Technology International Journal of Cell and Biomedical Science
Amalina, Nur Dina
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Semarang State University, Semarang
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Energy Engineering Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences

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Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in Ameliorating Renal Fibrosis: A Comprehensive Narrative Review Amansyah, Fajar; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.55

Abstract

Chronic kidney disease (CKD) represents a global health challenge with limited therapeutic options, often progressing to end-stage renal disease requiring dialysis or transplantation. Renal fibrosis, characterized by excessive extracellular matrix deposition and loss of functional nephrons, constitutes the final common pathway for most progressive kidney diseases. Conventional therapies primarily target symptoms rather than underlying pathological mechanisms. Mesenchymal stem cells (MSCs) have emerged as promising candidates for regenerative therapy due to their multipotent differentiation capabilities, immunomodulatory properties, and paracrine effects. Growing evidence suggests that the therapeutic benefits of MSCs are predominantly mediated through their secretome—a complex mixture of soluble factors, extracellular vesicles, and exosomes. This narrative review comprehensively examines the current understanding of MSC-based therapies for renal fibrosis, with particular emphasis on their secretome. We explore the mechanisms of action, preclinical evidence, ongoing clinical trials, and challenges in translating MSC secretome-based therapies to clinical applications. Recent advances in secretome characterization, bioengineering approaches to enhance therapeutic efficacy, and targeted delivery strategies are also discussed. Despite promising results, several hurdles remain, including standardization of preparation protocols, identification of key therapeutic components, and optimization of delivery methods. This review highlights the transformative potential of MSC secretome in renal fibrosis treatment while acknowledging the need for further research to realize its full clinical potential.
Cytotoxic Activity of Hyptis Pectinate Extracts on MCF-7 Human Breast Cancer Cells Amalina, Nur Dina; Suzery, Meiny; Cahyono, Bambang
Indonesian Journal of Cancer Chemoprevention Vol 11, No 1 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss1pp1-6

Abstract

Hyptis pectinata (L.) poit, popularly known in the world as “comb bushmint” is a medicinal plant commonly used for the treatment of throat and skin inflammations, bacterial infection, pain and cancer. The objective of this research is to determine the cytotoxic and antiproliferative effect under Hyptis pectinata ethanolic extract (HPE) treatment on breast cancer cells. The effect HPE of on cytotoxicity was examined by MTT assay on MCF-7 breast cancer cells. This assay also used to determine cell proliferation over 3 days of treatment with 1.5 – 100 µg/mL HPE. HPE showed that exhibited cytotoxic effects with IC50 value of 30 µg/mL for 24 hours and changes the physiological morphology on MCF-7 cells. Interestingly, the treatment of HPE for 48 and 72 hours highly decreases cell viability on MCF-7 with dose and time-dependent manner compared to untreated cells. These results indicate that HPE has antiproliferative activities and maybe the potential to be developed as a natural chemotherapeutic agent.Keywords: Hyptis pectinata (L.) poit extract, cytotoxicity, antiproliferative, MCF-7 cells
A Hierarchical Density-Based Spatial Clustering of Applications with Noise (HDBSCAN) Approach for Identifying Potential Villages in Buleleng Regency Amalina, Dina Nur; Fauzan, Achmad
Knowledge Engineering and Data Science
Publisher : citeus

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Abstract

Buleleng Regency, located in Bali Province, possesses diverse village potential, including agricultural production and tourist attractions. However, this potential has not been fully optimized. Therefore, it is important to enhance village potential by clustering villages based on their specific characteristics to identify and prioritize those requiring special attention. This approach aims to promote equitable village development and reduce poverty levels. This study clusters villages in Buleleng Regency based on their potential using the Hierarchical Density-Based Spatial Clustering of Applications with Noise (HDBSCAN) method. The data utilized in this study comprises village potential data obtained from the Buleleng Regency Statistics Office (BPS) for all districts and the Statistical Service Information System. The variables used in this study are based on aspects of population, communication, tourism, trade, health, religion, social affairs, and public welfare. Tuning parameters were performed to determine the optimal parameters, resulting in optimal parameters, such as minimum cluster size = five and minimum samples = 2, which produced two main clusters. The first cluster comprises six villages, while the second includes 118 villages. Additionally, a noise cluster representing outliers, consisting of 24 villages, was identified. The findings indicate that the first cluster exhibits higher village potential than the second cluster. Based on these results, it is recommended that the government prioritize the second cluster when designing and implementing targeted programs and policies to reduce poverty by developing village potential.
Co-Authors Achmad Fauzan, Achmad Agung Putra Agung Putra Amalia, Najla Amansyah, Fajar Bambang Cahyono Bayu Tirta Dirja Chodidjah Chodidjah Damar Nurwahyu Bima Dedy Hermansyah Dewi Antari, Arini Edy Meiyanto Encum Sumiaty, Encum Endang Susilaningsih Hadi Sarosa Hakim, Denny Ivanal Harjito - Husain, Sofian Azalia Hutabarat, Nenny Lynda Caroline Ibrahim, Sugeng Ika Putri Nurhayati Jumena, Finanda Kurniasari, Laviona Tiara Kusumo, M. Hidayat Budi Marpaung, Adelia Septianingrum Masta, Al Azhary Meiny Suzery Minidian Fasitasari Muhammad Abdan Shadiqi Muna, Nugraheni Itsnal Murbangun Nuswowati Nanik Wijayati Pangesti Drawina Purwaningsih, Hesti Rujitoningtyas, Karimatussholikah Safitri, Nadiya Nur Salbiyah, Siti Sitompul, Faya Nuralda Sri Andriyani Sri Kadarwati Sri Priyantini Subchan, Prastyowati Sulistyo, Sona Taufiqurrachman Nasihun Titiek Sumarawati Tjipta, Arya Wigati, Hilmi U. Yan Wisnu Prajoko