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All Journal Gadjah Mada Journal of Psychology The Indonesian Biomedical Journal Universa Medicina Jurnal Medik Veteriner Journal Of Widya Medika Junior INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Widya Medika Folia Medica Indonesiana
Novita, Bernadette Dian
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary

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The Effect of Cinnamomum burmannii Water Extraction Against Staphylococcus aureus, Enterobacter spp., Pseudomonas aeruginosa, and Candida albicans: In Vitro Study Novita, Bernadette Dian; Sutandhio, Silvia
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

High-intensity exercise (3000-meter runner) contributes to muscle fatigue. Fatigue can be determined by measuring blood lactate levels. Blood lactate levels are a product of anaerobic metabolism. Lactate accumulation due to anaerobic physical activity can inhibit the glycolytic enzyme that affects decreased ATP production, damage of the calcium and sodium pumps in the muscles and causes fatigue. This study aimed to analyze the effect of vitamin E on the level of fatigue through the response of blood lactate levels in the runner 3000 meters. This research was a quasi-experimental research with a pretest-posttest design. Research subjects were 9 volunteer athletes (3000 meters runners) Aceh province, male, and aged 15-20 years. The treatments were vitamin E at a dose of 1x400 IU per day and administered for 14 days. Blood lactate levels were examined using the method of calorimetry. The statistical analysis was using the homogeneity test of variance (Levene's test), the normality test (Kolmogorov-Smirnov test) and paired t-test with a significant level of 5% (p-value<0.05). The results showed that blood lactate levels decreased approximately 13.93% after vitamin E supplementation. There was no significant difference (p=0.27) between blood lactate levels before and after vitamin E supplementation in athletes. In conclusion, vitamin E supplementation did not significantly lower blood lactate levels therefore vitamin E did not significantly reduce muscle fatigue in men's athletics.
The Effect of The Cucumber Consumption To The Level of Sodium Potassium in Mus Muscullus's Urine Production Elicia, Vincensa; Tjipto, Bambang Wasito; Novita, Bernadette Dian
Folia Medica Indonesiana Vol. 57, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Cucumber (Cucumis sativus L.). was known for lowering blood pressure agents. Some researches show that Cucumber had a similar mechanism with a loop diuretic (Furosemide), exceeding sodium and potassium excretion. However, a part of Cucumber that gives a better effect on managing water and sodium balance remains unknown. This study was to explain the differences potential diuretic among parts of Cucumber (Cucumis sativus L.). This study was using a post-test only control group designed in animals. There were 44 male Mus musculus tested in this study. All of the animal testings was divided into 9 different treatment groups and 2 control groups. All Mus musculus got 1 mL methanol extract of Cucumber (Cucumis sativus L.) according to their group. The animal testing was put on metabolic cage to measure urine volume for 24 hours. The flesh and rind part of Cucumber (Cucumis sativus L.) showed a similar result with furosemide as diuretics agents. However, whole part of the fruit of Cucumber (Cucumis sativus L.) (flesh, rind, and seed) showed as natriuretic dan kaliuretic, Cucumber (Cucumis sativus L.) has a similar potential diuretic with Furosemide. Even in low concentrations of Cucumber extract, it led to having a potential diuretic, with natriuretic and kaliuretic effects in the whole part of the fruit. This could be suggested to people with chronic kidney diseases to prevent hyperkalemia.
Efficacy of Live Attenuated Dengue Vaccines: CYD-TDV, TDV (TAK-003), and TV003/TV005 Hertanto, Yoseph Jeffry; Novita, Bernadette Dian
Folia Medica Indonesiana Vol. 57, No. 4
Publisher : Folia Medica Indonesiana

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Highlight: • Differences in the efficacy of CYD-TDV versus the other TAK-003 and TV003/TV005 were discussed. • One licensed dengue vaccine is CYD-TDV (Dengvaxia). Abstract: Dengue fever is the most common tropical disease, but there still remains no specific therapy that can overcome it. Special attention needs to be paid to this disease, because there were large increases in incidence in the last decade. As an effective preventive strategy, finding a new vaccine for dengue fever with higher potentiation and efficacy is highly necessary to stop dengue transmission especially in the endemic area. Vaccine triggers an immune response, so that it can create a robust immune response when infected. Nowadays, there is only one licensed dengue vaccine that is CYD-TDV (Dengvaxia). However, this vaccine still has many weaknesses, namely its dependency on the serostatus of the recipient. There are also other dengue vaccines that are in ongoing clinical testing and have promising results, TDV (TAK-003) and TV003/TV005. These three vaccines are live attenuated vaccines with various results. This review discussed differences in the efficacy of CYD-TDV against the other TAK-003 and TV003/TV005; considering the known and unknown various factors.
PROTOCOL OPTIMIZATION OF RT-qPCR FOR NF-ΚB DETECTION IN CARDIAC TISSUE FROM HFHS-FED MICE Jaya, Ferdinand Wiliam; Novita, Bernadette Dian; Suwandito, Laurensius; Wijaya, Hendy; Tjahjono, Yudy; Hendrata, Adi Pramono; Dewi, Sianty; Wijaya, Sumi; Ervina, Martha; Kuncorojakti, Suryo
JURNAL WIDYA MEDIKA Vol. 12 No. 1 (2026): March
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i1.8196

Abstract

Accurate detection of gene expression in challenging tissues requires methodological optimization to ensure reproducibility. Cardiac tissue, with its low cell density and variable RNA yield, presents particular difficulties for RT‑qPCR analysis. This study aimed to refine NF‑κB detection in HFHS‑fed C57BL/6 mice by comparing a standard 2‑ΔΔCt approach with an optimized protocol incorporating individualized calibrators adjusted for RNA concentration. Six male mice were divided into standard-diet (STD) and high‑fat, high‑sucrose (HFHS) groups, and cardiac RNA was extracted after 8 weeks of feeding. While relative NF‑κB expression trends were higher in the HFHS group, differences were not statistically significant; however, the optimized method consistently reduced variability and improved measurement reliability compared to the generalized approach. These findings highlight the value of individualized calibration as a protocol refinement for RT‑qPCR, offering a more rational framework for gene expression analysis in heterogeneous or technically demanding tissue samples.
Co-Authors Amadeo, Jovan Angelina, Zenia Bambang Wasito Tjipto Budipramana, Vicky Sumarki Dewi, D. A. Liona Dewi, I.G.A.P.D Ekaristy, Mergivia Elicia, Vincensa Erwin, Ferdinand Hendrata, Adi Pramono Hertanto, Maria Patricia Dian Hertanto, Yoseph Jeffry Inge Wattimena Jaya, Ferdinand Wiliam Jong, FX Himawan Haryanto Julian, Alvin Khudrati, Wilson Christianto Kuncorojakti, Suryo Lucia Hendriati Malonda, Franklin Vincentius Martha Ervina Meredith, Jennifer Oenarta, Dave Gerald Parengkuan, Irene Paul L Tahalele Purnama, Stephany Venesia Putra, Brilliant Dwi Ricardo, Evan S.Pd. M Kes I Ketut Sudiana . Samsudin, Kevin Sianty Dewi Silvia Sutandhio Sincihu, Yudhiakuari Soediono, Endang Isbandiati Sumi WIjaya, Sumi Suwandito, Laurensius Suwasanti, Niluh Teguh Widodo Theodora, Imelda Tjahjono, Yudy Wedharga, I Gede Putu Adhi Wijaya, Hendy Willianto, Vincentius Michael Yesiana Dwi W. Werdani, Yesiana Dwi W. Young, Andre