Abstrak Latar Belakang: Berdasarkan SKI tahun 2023, didapatkan bahwa cakupan tablet Fe yang diterima remaja putri sebesar 76,2%, dari 76,2% tersebut sebanyak 80,9% mendapatkan tablet Fe di sekolah (anak sekolah). Di Kabupaten Muna Terdapat 1 Kecamatan yang paling jauh dari Pusat Ibukota Kabupaten yaitu Kecamatan Tongkuno Selatan memiliki tingkat konsumsi tablet tambah darah yang lebih tinggi dari rata-rata provinsi dan kabupaten sebesar 27,82%. Tujuan: Menganalisis pengaruh pengetahuan, sikap, dan motivasi remaja putri terhadap konsumsi tablet tambah darah di Kecamatan Tongkuno Selatan Kabupaten Muna Metode: Menggunakan metode kuantitatif dengan Uji Regresi Linear Berganda dan analisis data menggunakan spss untuk mengetahui pengaruh. Hasil: Hasil penelitian menemukan pengaruh antara pengetahuan terhadap kepatuhan konsumsi tablet tambah darah (p=0,009), pengaruh antara sikap terhadap kepatuhan konsumsi tablet tambah darah (p=0,009), dan tidak ada pengaruh antara motivasi terhadap kepatuhan konsumsi tablet tambah darah (p=0,142). Kesimpulan: Pengetahuan dan sikap mempengaruhi kepatuhan konsumsi tablet tambah darah, sedangkan motivasi tidak mempengaruhi kepatuhan konsumsi tablet tambah darah pada remaja putri di Kecamatan Tongkuno Selatan Kabupaten Muna. Abstract Background: Based on the 2023 SKI, it was found that the coverage of Fe tablets received by adolescent girls was 76.2%, of which 76.2%, 80.9% received Fe tablets at school (school children). In Muna Regency, there is 1 sub-district that is the furthest from the Regency Capital Center, namely Tongkuno Selatan Sub-district, which has a higher level of consumption of iron tablets than the provincial and district average of 27.82%. Objective: To Analyze the influence of knowledge, attitudes, and motivation of adolescent girls on the consumption of iron tablets in Tongkuno Selatan District, Muna Regency. Method: Using quantitative methods with Multiple Linear Regression Test and data analysis using SPSS to determine the influence. Results: The study found an influence between knowledge on compliance with consumption of iron tablets (p=0.009), an influence between attitudes on compliance with consumption of iron tablets (p=0.009), and no influence between motivation on compliance with consumption of iron tablets (p=0.142). Conclusion: Knowledge and attitude influence compliance in consuming iron supplement tablets, while motivation does not influence compliance in consuming iron supplement tablets in female adolescents in Tongkuno Selatan District, Muna Regency.