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Differential Effects of Albumin Infusion between ICU and Non-ICU Hypoalbuminemia Patients Mariana, Nina; Wijaya, Surya Oto; Setyawati, Rumaisah; Maemun, Siti; Nafrialdi, Nafrialdi
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.3

Background: Hypoalbuminemia is frequent among hospitalized patients and is associated with poor outcomes. ICU patients are widely associated with more severe condition making albumin correction seems to be less effective. This study was aimed to compare the results of albumin correction in ICU and non-ICU patients at Sulianti Saroso Hospital, Jakarta.Â Methods: A cross sectional study was conducted on adult patients in ICU and non-ICU wards who received intravenous albumin infusion at Sulianti Saroso hospital, between January 2013 to March 2018. Paired t-test was used to analyze the changes of albumin level before and after albumin infusion.Â Results: 123 ICU patients (41 sepsis, 82 non-sepsis) and 206 non-ICU patients (34 sepsis, 172 non-sepsis) who received 20% or 25% albumin infusions were included. Significant increase in albumin levels were observed in sepsis patients both in ICU and non-ICU, while in non-sepsis patients, the significant increase only observed in non-sepsis patients. Overall, mean increase in albumin levels in ICU-and non-ICU patients were 0.13 (0.63) g/dL vs 0.35(0.54) g/dL, respectively (P= < 0,001).Â Conclusion: Non-ICU patients show better response to albumin infusion compared to ICU patients. This difference is presumably due to different degree of inflammation. It is suggested that the quantity needed for albumin infusion is calculated differently according to clinical condition of the patientsÂ Â Â

Differential Effects of Albumin Infusion between ICU and Non-ICU Hypoalbuminemia Patients Mariana, Nina; Wijaya, Surya Oto; Setyawati, Rumaisah; Maemun, Siti; Nafrialdi, Nafrialdi
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.3

Background: Hypoalbuminemia is frequent among hospitalized patients and is associated with poor outcomes. ICU patients are widely associated with more severe condition making albumin correction seems to be less effective. This study was aimed to compare the results of albumin correction in ICU and non-ICU patients at Sulianti Saroso Hospital, Jakarta.Â Methods: A cross sectional study was conducted on adult patients in ICU and non-ICU wards who received intravenous albumin infusion at Sulianti Saroso hospital, between January 2013 to March 2018. Paired t-test was used to analyze the changes of albumin level before and after albumin infusion.Â Results: 123 ICU patients (41 sepsis, 82 non-sepsis) and 206 non-ICU patients (34 sepsis, 172 non-sepsis) who received 20% or 25% albumin infusions were included. Significant increase in albumin levels were observed in sepsis patients both in ICU and non-ICU, while in non-sepsis patients, the significant increase only observed in non-sepsis patients. Overall, mean increase in albumin levels in ICU-and non-ICU patients were 0.13 (0.63) g/dL vs 0.35(0.54) g/dL, respectively (P= < 0,001).Â Conclusion: Non-ICU patients show better response to albumin infusion compared to ICU patients. This difference is presumably due to different degree of inflammation. It is suggested that the quantity needed for albumin infusion is calculated differently according to clinical condition of the patientsÂ Â Â

Effect of Fixed‐Dose Combinations Antituberculosis and Separate Formulations on Clinical Symptoms, Weight Gain, Adverse Effect and Plasma Concentration in Tuberculosis and HIV Coinfection Cases Sundari, Titi; Mariana, Nina; Permatasari, Debby Intan; Rusli, Adria; Sitompul, Pompini Agustina; Rosamarlina, Rosamarlina; Widiantari, Aninda Dinar; Maemun, Siti; Lisdawati, Vivi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.867

BACKGROUND: Fixed Dose Combination (FDC) was aimed to simplify TB therapy and facilitate physician and patient compliance. OBJECTIVE: We aimed to evaluate the effect of FDC antituberculosis and separate formulations (SF) on clinical symptoms, weight gain, adverse effect and plasma concentration in TB/HIV cases during the intensive phase. METHOD: Prospective cohort study was conducted in public hospital, Jakarta. We recruited TB-HIV patients in May 2018-May 2019. Patients (over than 18 years old) diagnosed with TB-HIV who consumed either FDC or SF and had not received antiretroviral. A total of 36 subjects were included in this study, 20 subjects in FDC group and 16 subjects in SF group. RESULT: There was not significant different between FDC and SF groups with an improvement of clinical symptoms (P = 0.70) and weight gain (P = 1.00). Gastrointestinal syndrome was 75% in FDC group; 62.5 % in SF group. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration after 2 weeks therapy in FDC group were 5.49 mg/L (±3.40 mg/L), 1.35 mg/L (±1.20 mg/L), 19.87 mg/L (±17.00 mg/L), respectively. Mean (±SD) of rifampicin, isoniazid, pyrazinamide plasma concentration in SF group were 6.42 mg/L (±4.80mg/L), 0.87 mg/L (±0.70 mg/L), 5.03 mg/L (±7.60 mg/L), respectively. CONCLUSION: There was not significant different between FDC and SF groups on improvement of clinical symptoms and weight gain in intensive phase of therapy, the highest of adverse effects was gastrointestinal syndrome, and all subjects had normal reference ranges of rifampicin concentrations, and isoniazid and pyrazinamide below the normal range.

Diphtheria Outbreak among Children in 2017–2018: a Single Centre Study in Indonesia Aliza, Nur; Maemun, Siti; Yoenoes, Dedet Hidayati; Syafendra, Mega Oktariena; Amin, Desrinawati Muhammad; Afrina, Yeni; Rahmawani, Atika; Aryanto, Dara Tyas Putri; Murtiani, Farida
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10951

Diphtheria is an acute infectious disease caused by the bacterium Corynebacterium diphtheriae. Accurate and prompt diagnosis is essential for effective case management, predicting disease prognosis, preventing complications, and ensuring cost-effective medical intervention. This study aimed to assess the variety of clinical symptoms exhibited by pediatric diphtheria cases during an outbreak. An observational cross-sectional study was conducted using data from the medical records of pediatric diphtheria cases at Sulianti Saroso Infectious Disease Hospital from November 1, 2017, to February 28, 2018. The study involved 202 cases, and statistical analysis was performed using the chi-square test. Out of the 202 cases, 58.4% were male. Age distribution was <1 year: 7.4%, 1–2 years: 3.5%, >2–5 years: 24.8%, >5–12 years: 45.5%, and >12 years: 18.8%. Anamnestic findings revealed the presence of fever in 88.1% of patients, pain upon swallowing in 73.3%, and cough in 55.4%. Clinically, every patient exhibited pseudomembrane formations. Other findings included bilateral tonsillar involvement in 53%, lymphadenopathy in 40.1%, bullneck in 17.8%, and snoring in 7.9%. Four significant variables were associated with the diphtheria diagnosis: fever, snoring, bullneck, and snoring (p<0.05) respectively. Clinical signs and symptoms are pivotal in establishing a diphtheria diagnosis in pediatric cases.

PENGARUH TERAPI SYUKUR DALAM MENINGKATKAN KUALITAS HIDUP PASIEN TERINFEKSI HIV Rahayu, Esti Kusuma; Azzam, Rohman; Yunitri, Ninik; Rayasari, Fitrian; Astuti, Widia; Ulina, Barita; Maemun, Siti
Jurnal Ilmiah Keperawatan IMELDA Vol. 10 No. 2 (2024): Jurnal Ilmiah Keperawatan IMELDA
Publisher : Program Studi S1/DIII-Keperawatan Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jikeperawatan.v10i2.1585

Background: Quality of life remains an important concern for people living with HIV/AIDS (PLHIV). The challenges experienced have a major impact on their well-being, including psychological aspects. This study aims to evaluate the effectiveness of gratitude therapy on the quality of life of PLHIV. Methods: This study is a pre-experiment with a total of 30 subjects at RSPI Prof. Dr Sulianti Saroso. The sample selection method is purposive sampling with inclusion criteria of adult ODHIV (age >18 years) and actively visiting RSPI Prof. Dr. Sulianti Saroso to take antiretroviral (ARV) drugs every month, while the exclusion criteria are pregnant women. Subjects will undergo gratitude therapy for six weeks. Gratitude therapy was measured with gratitude inventory instrument and quality of life with WHOQOL-HIV BREF instrument. Significant changes in average quality of life scores before and after gratitude therapy with Wilcoxon test. Results: The majority of participants were male (70%) with a median (IQR) age of 39.6 (26-52) years. After subjects received gratitude therapy, there was a significant improvement in quality of life, with a mean difference of 4.00 (95% CI: 3.00-5.65; SE 0.693; p-value <0.001) and an effect size measured by biserial rank correlation of 1.00. Conclusion: The findings of this study indicate that gratitude therapy has a significant and positive impact on improving the quality of life of PLWHA. Gratitude is a necessity in fostering a positive outlook on life. Gratitude therapy can be a standardised form of service in hospitals. Future research with qualitative studies to determine the magnitude of its effect on the psychology of PLHIV.

VIRAL LOAD AND OPPORTUNISTIC INFECTION AS THE INDICATOR OF QUALITY-OF-LIFE PEOPLE WITH HIV/AIDS Yuliaty, Rina; Rohman; Rayasari, Fitrian; Kurniasih, Dian Noviati; Aini, Nur; Shahroh, Yuni; Rusli, Adria; Maemun, Siti; Saadulloh, Dadang; Yunitri, Ninik
Nurse and Health: Jurnal Keperawatan Vol 13 No 2 (2024): Nurse and Health: Jurnal Keperawatan
Publisher : Institute for Research and Community Service of Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/nhjk.v13i2.690

Background: Human immunodeficiency virus (HIV) is a significant concern in the field of global health. However, studies on the relationship between viral load, opportunistic infections, and quality-of-life among them are limited. Objectives: This study aims to determine the relationship between viral load count, the presence of opportunistic infection, and the quality-of-life among people living with HIV. Methods: A cross-sectional study was used involving 35 respondents recruited through convenience sampling. The quality-of-life of individuals living with HIV was assessed using the World Health Organization Quality-of-Life instrument for HIV. Statistical analysis using descriptive statistics, including mean, standard deviation, and proportion, and bivariate analysis with p-value<0.05. Results: Of the 35 participants, the majority were male (57.1%), with a mean age of 41.63 (9.09), and had a low education level (51.4%). The mean quality-of-life score was 86.88 (12.27), with a mean duration of ARV treatment of 7.23 years (5.36), undetectable viral load (68.6%), living with opportunistic infections (80%), and with tuberculosis being the most common (52.63%). There was a significant correlation between viral load and overall quality-of-life (p-value 0.04). Conclusion: The results of viral load testing and the identification of opportunistic infections can serve as indicators to assess the quality-of-life among people living with HIV. The outcomes of this study have practical implications for enhancing healthcare services in clinical settings. This information can guide the implementation of targeted interventions to strengthen social relationships and these individuals' environmental quality-of-life.

The Relationship Between Climate Factors and Vector Density with the Incidence of Dengue Hemorrhagic Fever in East Jakarta Juwita, Disma; Maemun, Siti; Wibowo, Agus Ari; Suprono; Windiyaningsih, Cicilia
The Indonesian Journal of Infectious Diseases Vol. 11 No. 1 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i1.270

Background: Dengue fever is a vector-borne disease. The high incidence of DHF in an area is influenced by living things (vector density) and non-living things (air temperature, climate, humidity, and rainfall). The purpose of the study was to determine the relationship between air temperature, climate, vector density, rainfall, humidity, and the incidence of DHF in East Jakarta in 2022. Methods: This research was an observational ecological study. This research was conducted in Cakung and Pasar Rebo sub-districts, East Jakarta. Secondary data sources were from the VBPP laboratory, BBTKL PP Jakarta, and BMKG Indonesia. Results: The results showed that the container index (CI) correlated with the incidence of DHF (r = 0.118, p = 0.001), as well as the number of ownership-positive containers for larvae correlated with the incidence of DHF (r = 0.113, p = 0.001). Meanwhile, the variables of temperature, humidity, and the free number of larvae did not correlate with the incidence of DHF. Conclusion: It is expected that the community actively drains regularly and closes water storage containers at home.

Analysis of Risk Factors for Pulmonary Tuberculosis in Cirascas District, East Jakarta, 2022 Sopiani, Pina; Maemun, Siti; Azijah, Izzatul; Pratiwi, Tiara Zakiyah; Saputra, Rahmat
The Indonesian Journal of Infectious Diseases Vol. 11 No. 1 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i1.276

Background: Tuberculosis (TB) is a global public health problem, with Indonesia ranked second in the world in 2022. In East Jakarta, TB cases continue to increase, including in the Ciracas sub-district. This study aims to identify risk factors for pulmonary TB cases in the Ciracas sub-district in 2022. Methods: The method of this study was quantitative with a case-control design, involving 115 samples (23 cases and 92 controls) selected by purposive sampling technique. Results: The results showed that there was a relationship between contact history and TB patients (p=0.004; OR=6.27; 95% CI=1.86 – 21.11) and occupancy density (p=0.000; OR=29.52; 95%CI: 8.99 – 96.89) with Pulmonary TB infection. However, there was no significant relationship between gender, age, education, occupation, marital status, family income, and knowledge of patients with Pulmonary TB infection. Conclusion: In conclusion, contact with TB patients and housing density increases the risk of pulmonary TB infection. Therefore, it is recommended that isolation of TB patients to a place from the surrounding environment needs to be done to prevent transmission and airborne contamination

Spatial Mapping of Infectious Diseases Cases for Puskesmas Surveillance Officers in the Work Area of the Depok City Health Office Saputra, Rahmat; Devita, Yeni; Maemun, Siti; Fitri, Rahmi Pramulia; Zakiah, Zakiah
The Indonesian Journal of Infectious Diseases Vol. 11 No. 1 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i1.305

Background: Reflecting on the previous Covid-19 pandemic obtained from the results of the situation analysis, the author concludes that the Depok City Health Office must be able to conduct data analysis spatially, thus causing a lack of information about the spread of cases based on specific places such as villages and coordinate points (GPS), this data is useful for measuring how much disease spreads in an area and can support policy making and intervention quickly and appropriately. In addition, unlucky spa data is also useful for seeing the density of vectors in an area. Methods: The research method was Quasi Experimental using the One Group Pre-Test and Post-Test research design, with a sample size of 40 people. The data collection technique uses pre-test and post-test questions, spatial mapping practice exercises and data analysis and interpretation exercises. The training will be held from 19 to 20 November 2021 at the Depok City Health Office hall. The data analysis test used the Paired T-Test, because the data was not normally distributed, it was continued using Wilcoxon analysis. Results: The results of the study obtained a Z value of -5.581 with an Asymp value. Sig. (2-tailed) by 0.000. Because this value is < alpha (0.05), it can be concluded that there is a significant increase in knowledge by 5.6 times after receiving training. Conclusion: To improve the performance of officers in terms of spatial mapping of infectious diseases, it is expected to conduct evaluations every 3-6 months and transfer knowledge from old officers to new officers if there is a change of officers

Biomarkers for predicting COVID-19 mortality: A study at Sulianti Saroso Infectious Disease Hospital, Indonesia Maemun, Siti; Widiantari, Aninda D.; Murtiani, Farida; Herlina, Herlina; Tanjungsari, Dian W.; Wijiarti, Kunti; Pratiwi, Tiara Z.; Matondang, Faisal; Rusli, Adria; Rivaldiansyah, Rivaldiansyah; Tampubolon, Maria L.; Mariana, Nina; Setiawaty, Vivi; Purnama, Tri B.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1936

The high transmissibility and mortality rates of the COVID-19 pandemic pose significant challenges. Patients can deteriorate rapidly, making it crucial to identify laboratory biomarkers for high-risk individuals. The aim of this study was to evaluate the predictive value of various laboratory parameters, including C-reactive protein (CRP), D-dimer, ferritin, neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), and procalcitonin (PCT), in predicting COVID-19 mortality. A retrospective cohort study was conducted at Sulianti Saroso Infectious Disease Hospital, where COVID-19 patients were categorized into survivors and non-survivors. The Mann-Whitney test was used to assess group differences, while receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of each biomarker, with Youden's index (J) determining optimal cut-off values. Kaplan-Meier analysis was used to compare median survival times, and Cox regression assessed hazard rates and the relationship between biomarkers and mortality. A total of 1,598 patients were analyzed, the majority of whom were admitted with oxygen saturation levels >95% and classified as having mild to moderate disease severity. Among them, 216 patients died, resulting in a mortality rate of 13.52%. Significant variations in mortality rates were observed along the survival functions for NLR, ferritin, D-dimer, CRP, and PCT (p<0.001). The survival curves for these biomarkers demonstrated distinct trends across tertiles over time. Among hematological markers, NLR was significantly associated with mortality (p<0.001), with a 1.5–2.2% increased risk per unit increase. Biochemical markers (complete blood count) proved to be more effective than hematological parameters (NLR, ferritin, PT, D-dimer, CRP, PCT) when evaluating individual prognostic performance. Bivariate analysis of CRP, D-dimer, ferritin, NLR, PT, and PCT between survivors and non-survivors showed significant differences. Notably, NLR and PCT were highly relevant for predicting disease prognosis and mortality, with sensitivity and specificity values exceeding 80%.

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