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All Journal JURNAL FARMASIMED (JFM) Jurnal Prima Medika Sains International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengmas Kestra (JPK) Jurnal Indah Sains dan Klinis
Cahya, Cucu Arum Dwi
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Formulasi Sediaan Lulur Body Scrub Pelembab Kulit Ekstrak Daun Kedondong (Spondias dulcis) Cucu Arum Dwi Cahya; Andy Febriady; Sri Rezeki Anggriani
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.04

Abstract

Background: Body scrub is a skincare preparation that effectively removes dead skin cells caused by free radicals. Kedondong leaves are a plant with extraordinary wealth, especially its vitamins, namely A, B1, and C, and have a high antioxidant content, so they can be used as a natural moisturizer for the skin. Objective: This research aims to formulate a body scrub containing Kedondong leaf extract. Method: Kedondong leaf extract was formulated with a concentration of 10.0; 15.0; and 20.0%. Evaluation of the body scrub formulation includes organoleptic, homogeneity, pH, irritation and moisture using a skin analysis tool. Results: Research shows that the body scrub formulation with Kedondong leaf extract is homogeneous and has a shape, colour and pH value corresponding to skin pH standards. This formulation also does not irritate and provides adequate moisture for the skin. The formulation with a concentration of 20% (F4) shows the best effectiveness, being able to moisturize the skin up to 47.8%. Conclusion: Kedondong leaves can be formulated into an effective body scrub to improve the condition of dull skin to make it brighter, cleaner and smoother.
Test of the Anti-Inflammatory Effectiveness of Ethanol Extract Gel Preparation of Sabrang Onion Bulb (Eleutherine bulbosa) on Incisional Wounds in Wistar Rats Harahap, Hasni Yaturramadhan; Syarifuddin, Shofian; Cahya, Cucu Arum Dwi; Br Sinaga, Irma Suryani Kristina
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2317

Abstract

Background: The use of medicinal plants is increasingly widespread among the community, especially due to their properties in healing various diseases. One of the developing medicinal plants is bawang sabrang (Eleutherine bulbosa), which has been proven to accelerate the healing process of wounds. Objective: To evaluate the effectiveness of administering gel extract from bawang dayak tubers on the healing process of incised wounds in rats. The test subjects used were 25 male rats. Incisions measuring 2 cm were made on the backs of the rats using a surgical knife. Method: Laboratory experimental study with a Completely Randomized Design (CRD) consisting of five treatments: one positive control (bioplacenton gel), one negative control (gel base), and three graduated concentrations of gel extract, namely 5%, 10%, and 15%. Treatments were administered twice daily for 14 days. Results: Measurement of wound diameter showed that the gel extract of bawang sabrang at a concentration of 15% and the positive control provided a more effective healing effect compared to the gel extract at concentrations of 5%, 10%, and the negative control (gel base). Conclusion: Ethanol extract of bawang sabrang is effective as a gel for healing incised wounds in rats at a concentration of 15%. The physical properties of the gel show a characteristic aroma and a golden red color, homogenous without grains or lumps, a pH of 4.9, and a spreadability of 5 cm.Keywords: Bawang sabrang tuber, Anti-inflammatory, rats, Edema.
Analysis of Rhodamin B Levels in Lipbalms Sold Online Using Uv-Vis Spectrophotometry Cahya, Cucu Arum Dwi; Saragih, Agustinus; Br Sinaga, Hana Lorenta
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2352

Abstract

A frequent cosmetic preparation for moisturizing and shielding dry lips is lip balm. The textile industry uses a synthetic dye called rhodamine B. Because rhodamine B is a synthetic dye having carcinogenic qualities that can encourage the formation of cancer cells if used repeatedly, the Indonesian Food and Drug Administration (BPOM) forbids its usage as a cosmetic colorant. The purpose of the study is to ascertain, both qualitatively and quantitatively, if five distinct lip balm brands sold online contain the dangerous synthetic pigment Rhodamine B. The study was conducted quantitatively using UV Vis spectophotometry and qualitatively using the Thin Layer Chromatography (TLC) test and color response test with the reagents used, 10% NaOH. One of the five samples (sample B) tested positive for Rhodamine B according to the color response and TLC tests. With an Rf value of 0.91, which is near the typical Rhodamine B Rf value of 0.96, this was demonstrated by a color shift to red-orange upon the addition of 10% NaOH. Visual inspection of Sample B revealed a pink area as well. Rhodamine B was not detected in samples A, C, D, or E.Sample B had an average Rhodamine B content of 3,2281 mg/g.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Formulation and Evaluation of Nanogel from Tubifex  Worms (Tubifex  sp.) as a Future Therapeutic Agent for Burn Wounds Syarifuddin, Aminah; Cucu Arum Dwi Cahya
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/p1z1pm37

Abstract

Background: Burns are one of the most common types of injuries found in the community. Burn treatment tends to be relatively expensive, which often leads to suboptimal care and prolonged healing time. Therefore, innovation in pharmaceutical formulations that are more effective, affordable, and based on natural ingredients is needed. One of the widely used dosage forms is semisolid gel, as it is practical, non-sticky, and comfortable to use. Currently, nanogel development has attracted significant attention because it can enhance the absorption of active compounds, provide more controlled drug release, and reduce toxicity. Indonesia, with its rich biodiversity, has great potential for the exploration of natural materials, including the aquatic worm Tubifex sp. Objective: This study aimed to formulate and evaluate Tubifex sp.-based nanogel as a therapeutic agent for burn wounds. Methods: The study employed an experimental method, including physical stability tests of the nanogel and in vivo tests on male white rats with controlled burn injuries. Results: The results showed that all treatment groups experienced progressive wound diameter reduction over 14 days. The negative control showed only 36.6% healing, while the positive control reached 90%. The Tubifex sp. nanogel demonstrated promising results, with formula F1 (3.75%) and F2 (7.5%) achieving 80–86.6% healing, while formula F3 (15%) reached 93.3%, even surpassing the positive control. The effectiveness of the nanogel is believed to be related to the protein, collagen, and antioxidant content in Tubifex sp., which play important roles in tissue regeneration.Conclusion: Tubifex sp. nanogel has the potential to become an innovative, natural-based therapy for burn treatment in the future.
Anti-Inflammatory Effectiveness Test Of Ethanol Extract Of Ara Sungsang Leaf ((Asystasia gangetica) On Male White Mice (Mus musculus )Induced By 1% Carrageenan Cahya, Cucu Arum Dwi; Putri Alvanisia Saragih
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/brjms302

Abstract

Background: Leaf Ara Sungsang, also known as Asystasia gangetica, is a plant that has been used for a long time to treat different health issues, including inflammation. This plant has compounds called flavonoids and tannins, which are thought to help reduce inflammation by stopping certain chemicals that cause it. Objective: This study looked at how well the ethanol extract from Asystasia gangetica leaves works as an anti-inflammatory treatment in male white mice that had been given 1% carrageenan to induce inflammation. Methods: The study used 25 mice, which were split into five groups. One group received sodium diclofenac at 6.5 mg per kg of body weight as a positive control. Another group got 0.5% Na-CMC as a negative control. The other three groups received different doses of the ethanol extract: 100 mg/kg, 200 mg/kg, and 250 mg/kg. All the mice were given 1% carrageenan to create inflammation. Result: The highest level of inflammation was seen at 6 hours. The strongest anti-inflammatory effect was found in the group that received sodium diclofenac. The groups that received the ethanol extract also showed some anti-inflammatory effects, with the highest dose (250 mg/kg) being the most effective. The Na-CMC group did not show any significant anti-inflammatory effect. The data was analyzed using One Way ANOVA, and there were significant differences in the percentage of inflammation reduction between the different treatment groups (p < 0.05). Conclusion:  Based on the percentage of inhibition, it can be concluded that the ethanol extract of ara sungsang leaves at a dose of 250 mg/kgBB has the best anti-inflammatory effect after sodium diclofenac.
Antioxidant Potential Of Ethanol Extract Of Kendondong Leaves (Spondias Dulcis), Characterization And Examination Of Quercetin By TLC Method Cahya, Cucu Arum Dwi; Harahap, Urip; Nasution, M. Pandapotan
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.854

Abstract

Indonesia has a variety of plants that can be used to cure various diseases. Natural therapies offer little negative effect, especially in degenerative diseases, due to decreased function of body cells damaged by oxidation. Antioxidants have a vital role in counteracting free radicals to prevent degenerative diseases. One of the most abundant sources of antioxidant compounds is flavonoids. Kedondong leaf (Spondias dulcis) is one of the plants which is also suspected to contain flavonoids. Spondias species contain triterpenoids, namely oleanolic acid and flavonoids such as quercetin, kaempferol, kaempferida and rhamnetin. Examination of simplicia characteristics, phytochemical screening, examination of quercetin with Thin Layer Chromatography, and determination of antioxidant activity and IC50 value of Kedondong leaves using the DPPH method were carried out in this study. The results of the characteristic examination showed that simplicia met the requirements with a water content of 8.63%, a water-soluble extract content of 19.42%, an ethanol-soluble extract content of 5.17%, a total ash content of 12.43%, an acid-insoluble ash content of 7 .81%. Phytochemical screening showed that the bright kedondong leaves contained flavonoids, alkaloids, glycosides, saponins, tannins, and steroids/triterpenes. Examination of quercetin thin layer chromatography with chloroform: methanol (70: 30) as eluent produced six stains with Rf values (0.5; 1; 1.2; 3; 4.3; 6.6), and compared with quercetin raw material on the sixth stain with an Rf value of 6.6 has the same stain as the ethanol extract of kendondong leaves. The results of antioxidant testing at a 400 – 800 nm wavelength using UV-Vis spectrophotometry obtained a maximum wavelength of 515 nm. IC50 value obtained an IC50 value of 68.6260 ppm, so it can be concluded that the ethanol extract of kendondong leaves has antioxidant activity in the strong category.
Antibacterial Activity Test Of Methanolic Extract Of Rambutan Leaves (Nephelium Lappaceum L.) Against Propionibacterium Acnes Growth Cahya, Cucu Arum Dwi; Desi Elmasari Manik
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/92bkef26

Abstract

Background: Diseases caused by bacterial infections remain one of the leading health problems in Indonesia. Infections are among the most common illnesses suffered by the population, including skin infections such as acne (acne vulgaris). Therefore, alternative solutions are needed to address this issue by utilizing antimicrobial compounds derived from plants. One commonly used medicinal plant comes from the Sapindaceae family. A species from this family, the rambutan leaf (Nephelium lappaceum L.), has been reported to inhibit the growth of Propionibacterium acnes. Objective: To determine whether methanol extract of rambutan leaves (Nephelium lappaceum L.) contains tannins, flavonoids, saponins, and terpenoids; to assess its ability to inhibit the growth of Propionibacterium acnes; and to identify the most effective concentration among 15%, 35%, and 50% for antibacterial activity. Methods: The antibacterial activity was tested using the disc diffusion method to evaluate the potential of rambutan leaf extract as an antibacterial agent. Results: The study showed that the methanol extract of rambutan leaves inhibited the growth of Propionibacterium acnes, with inhibition zone diameters of 7.4 mm (15%), 9.53 mm (35%), and 11.53 mm (50%). The positive control showed an inhibition zone of 15.3 mm, while the negative control showed no antibacterial activity. Conclusion: The results indicate that the methanol extract of rambutan leaves exhibits antibacterial activity that increases with concentration, with the highest effectiveness observed at 50%. This activity is presumed to be due to the presence of secondary metabolite compounds that inhibit the growth of Propionibacterium acnes.
Co-Authors Andy Febriady Arifin Putra Zai Asti Pratiwi Asti Pratiwi Br Sihombing, Amelya Chyntia Br Sinaga, Hana Lorenta Br Sinaga, Irma Suryani Kristina Br Turnip, Nur Ulina M. Br. Turnip, Nur Ulina M. Debi Dinha Octora Debi Meilani Desi Elmasari Manik Feronika Sidabutar Harahap, Hasni Yaturramadhan Hasibuan, Ahmad Syukur Lubis, Devi Febby Yola Mega Silalahi Melinda Sari Nasution, M. Pandapotan Nur Ulina M. Br. Turnip Pebriani Nainggolan Priasa, Ayunda Purba, Novandi Putri Alvanisia Saragih Rahmah Tusyifa Regina Elyanda Tampubolon Reh Malem br Karo Romaulianna Theresia Marbun Samran, Samran Saragih, Agustinus Silalahi, Mega Sinurat, Jhon Patar SRI RAHAYU Sri Rezeki Anggriani Suci Wulandari Suci Wulandari Sunariati, Sunariati Syarifuddin, Aminah Nur Syarifuddin, Shofian Syukur, Ahmad Syukur Urip Harahap Yosi Darmirani