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All Journal E-Jurnal Medika Udayana e-CliniC Jurnal Kedokteran Brawijaya Damianus Journal of Medicine ODONTO Dental Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Alami Journal (Alauddin Islamic Medical) Journal Majalah Kesehatan Pharmamedika Odonto dental journal
Muis, Mirna
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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PERBANDINGAN DWI-ADC VALUE MRI 3.0 TESLA BERDASARKAN TIPE HISTOPATOLOGI PADA PENDERITA KANKER SERVIKS UTERI PRETERAPI Memah, Maya Fane; Muis, Mirna; Zainuddinn, Andi Alfian; Bachtiar, Nur Amelia
E-Jurnal Medika Udayana Vol 12 No 11 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i11.P04

Abstract

Kanker serviks menjadi kanker terbanyak keempat pada wanita di seluruh dunia. Saat ini, Magnetic Resonance Imaging (MRI) sudah banyak digunakan untuk pemeriksaan kanker serviks. Salah satu sekuens modalitas MRI yang berperan dalam penilaian tumor adalah gambaran Diffusion Weighted Image (DWI) dan Apparent Diffusion Coefficient (ADC), yang dapat memberikan data yang meyakinkan untuk diagnosis kanker serviks dan pemilihan strategi terapi yang optimal. Penelitian ini bertujuan untuk menilai perbedaan DWI-ADC value MRI 3.0 Tesla berdasarkan tipe histopatologi kanker serviks uteri preterapi. Penelitian ini dilaksanakan di Departemen Radiologi RSUP dr. Wahidin Sudirohusodo Makassar dari Januari tahun 2021 sampai Desember tahun 2022. Penelitian ini adalah penelitian retrospektif dengan menggunakan seluruh data yang tersimpan pada workstation MRI. Analisis data statistik berupa analisis unvariat dan analisis bivariat dengan pengujian t independent dan analisis ROC. Sampel penelitian yang masuk kriteria inklusi sebanyak 31 sampel. Berdasarkan hasil uji t independent, terdapat perbedaan yang bermakna secara statistik pada DWI-ADC value berdasarkan tipe histopatologi kanker serviks squamous cell carcinoma (SCC) dan adenocarcinoma (p < 0.001). Rerata DWI-ADC value pada tipe histopatologi kanker serviks adenocarcinoma lebih tinggi (1.104 ± 0.213 x 10-3 mm2/detik) dibandingkan dengan squamous cell carcinoma (0.669 ± 0.117 x 10-3 mm2/detik). Sebagai kesimpulan, terdapat perbedaan bermakna secara statistik pada DWI-ADC value berdasarkan tipe histopatologi kanker serviks. Nilai DWI-ADC pada tipe histopatologi adenocarcinoma lebih tinggi dibandingkan dengan SCC. Kata kunci : MRI; DWI ADC Value; kanker serviks uteri; SCC; Adenocarcinoma
Hubungan derajat herniasi diskus intervertebralis dengan tipe perubahan endplate modic pada pasien yang menjalani MRI lumbosakral Tanady, Kevin Julius; Ilyas, Muhammad; Muis, Mirna; Zainuddin, Andi Alfian; Basri, Muhammad Iqbal; Baan, Junus
Bahasa Indonesia Vol 21 No 2 (2022): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v21i2.3431

Abstract

Pendahuluan: Nyeri punggung bawah atau low back pain (LBP) adalah gangguan kesehatan yang sering dan memilki dampak sosial ekonomi yang berat. Kurang lebih 40% dari nyeri punggung bawah diakibatkan oleh herniasi diskus. Selain herniasi diskus, perubahan endplate tipe Modic juga telah diasosiasikan dengan kejadian nyeri punggung bawah. Meskipun memiliki insidensi yang relatif tinggi dan sering dihubungkan dengan LBP, hubungan antara perubahan endplate tipe Modic dengan penyebab lain LBP seperti herniasi diskus masih belum diketahui dengan jelas. Penelitian ini bertujuan untuk mengetahui hubungan antara derajat herniasi diskus dengan masing-masing tipe perubahan endplate Modic pada pasien yang menjalani pemeriksaan MRI lumbosakral. Metode: Penelitian ini dilakukan dengan desain observasi potong lintang menggunakan data sekunder pada 488 sampel. Derajat herniasi diskus intervertebrais dan tipe perubahan endplate Modic dinilai menggunakan pemeriksaan MRI lumbosakral. Hasil: Derajat herniasi diskus yang paling banyak ditemukan adalah protrusio sebanyak 199 sampel (40,8%) diikuti dengan bulging diskus sebanyak 154 sampel (31,6%). Tipe perubahan Modic yang paling banyak ditemukan pada level terjadinya herniasi diskus adalah perubahan Modic tipe II sebanyak 168 sampel (34,4%). Menggunakan analisa Chi-Square, didapatkan hubungan yang bermakna antara derajat herniasi diskus dengan tipe perubahan Modic dengan nilai p<0,001. Simpulan: Perubahan Modic tipe 1 lebih sering terjadi pada bulging diskus, sedangkan perubahan Modic tipe 2 dan 3 lebih banyak didapatkan pada derajat herniasi yang lebih berat seperti protrusio, ekstrusio dan sekuesterasi.
Efek Simvastatin terhadap Urin dan Jaringan Buli-Buli pada Tikus Model Sistitis Interstisial Akut yang Diinduksi Protamin Sulfat Hasanuddin, Abdi Dzul Ikram; Minhajat, Rahmawati; Muis, Mirna
Alami Journal (Alauddin Islamic Medical) Journal Vol 7 No 2 (2023): JULY
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/alami.v7i2.39062

Abstract

The pathophysiology of interstitial cystitis (IC) is complicated and related to statin drug use without any established underlying mechanisms. This study used a rat model of acute IC caused by protamine sulfate to examine the effects of simvastatin on bladder and urine macro-tissue after simvastatin treatment. There were 12 adult female Wistar rats. Simvastatin 10 mg/kgBB + protamine sulfate group (S10P), Simvastatin 50 mg/kgBB + protamine sulfate group (S50P), and Placebo + Protamin Sulfate group (KP) were the three groups (each n=4) into which the subjects were grouped. Simvastatin or placebo CMC 0,5% was administered orally to all animals for 30 days, followed by an intravesical protamine sulfate (10 mg/ml) instillation procedure. All animals were gathered three days after intravesical therapy to collect urine samples and bladder tissue. Simvastatin group participants' levels of hematuria were significantly higher than those of the control group (p = 0.03). Only relative bladder weight was substantially higher in the S50P group than in the control group (p=0.032). Simvastatin group members did not substantially vary from the control group regarding bladder macroscopic oedema and haemorrhage. To conclude, simvastatin may influence the condition of tissue hypervascularization and hypertrophy, contributing to the chronicity of acute interstitial cystitis.
Enhancing Diagnostic Precision: The Role of Specialized Head Coil MRI in Disc Displacement Diagnosis of Temporomandibular Joint Latief, Shofiyah; Murtala, Bachtiar; Thalib, Bahruddin; Muis, Mirna; Ilyas, Muhammad; Ruslin, Muhammad; Utama, Dharma; Bahar, Burhanuddin
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.208-221

Abstract

Background: This study discusses the use of coil heads in Magnetic Resonance Imaging (MRI) technology to diagnose Temporomandibular Joint Disc Dislocation (TMJ). TMJ disc dislocation is a common condition of the temporomandibular joint that can hurt a person's jaw and make it difficult for them to open their mouth fully. This study sought to assess the effectiveness of MRI with coil heads performed in locating and diagnosing TMJ disc dislocations. Method: Analytic observational with cross-sectional design. A diagnostic test to assess the validity of MRI. Predictor analysis was performed using a multivariate logistic regression test. Result: This study shows disparities in the findings of MRI and RDC tests for detecting temporomandibular joint disc dislocations. Clinical complaints have a strong correlation with disc displacement on MRI and RDC. In the MRI, disc dislocation was significantly correlated with all panoramic examination factors. Only the impaction variable in RDC significantly influences disc dislocation. Asymmetrical condyle position on panoramic inspection and complaints present for more than a year on physical examination indicate disc dislocation. These findings imply that MRI is more effective at identifying displaced temporomandibular joint discs, leading to a more precise diagnosis. Conclusion: The diagnosis of TMJ disc dislocations often involves MRI with coil heads. Medical practitioners can more easily spot disc abnormalities or changes in position thanks to this technology, which offers an accurate and thorough image of the temporomandibular joint's anatomy
Enhancing Diagnostic Precision: The Role of Specialized Head Coil MRI in Disc Displacement Diagnosis of Temporomandibular Joint Latief, Shofiyah; Murtala, Bachtiar; Thalib, Bahruddin; Muis, Mirna; Ilyas, Muhammad; Ruslin, Muhammad; Utama, Dharma; Bahar, Burhanuddin
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.208-221

Abstract

Background: This study discusses the use of coil heads in Magnetic Resonance Imaging (MRI) technology to diagnose Temporomandibular Joint Disc Dislocation (TMJ). TMJ disc dislocation is a common condition of the temporomandibular joint that can hurt a person's jaw and make it difficult for them to open their mouth fully. This study sought to assess the effectiveness of MRI with coil heads performed in locating and diagnosing TMJ disc dislocations. Method: Analytic observational with cross-sectional design. A diagnostic test to assess the validity of MRI. Predictor analysis was performed using a multivariate logistic regression test. Result: This study shows disparities in the findings of MRI and RDC tests for detecting temporomandibular joint disc dislocations. Clinical complaints have a strong correlation with disc displacement on MRI and RDC. In the MRI, disc dislocation was significantly correlated with all panoramic examination factors. Only the impaction variable in RDC significantly influences disc dislocation. Asymmetrical condyle position on panoramic inspection and complaints present for more than a year on physical examination indicate disc dislocation. These findings imply that MRI is more effective at identifying displaced temporomandibular joint discs, leading to a more precise diagnosis. Conclusion: The diagnosis of TMJ disc dislocations often involves MRI with coil heads. Medical practitioners can more easily spot disc abnormalities or changes in position thanks to this technology, which offers an accurate and thorough image of the temporomandibular joint's anatomy
Co-Authors A.A. Ketut Agung Cahyawan W Abdi Dzul Ikram Hasanuddin Alfian Z, Andi Alfian, Andi AMIN, ROSMINI Andi Alfian Zainuddin Asriyani, Sri Baan, Junus Bachtiar Murtala Bachtiar, Nur Amelia Badjeber, Alvia Novita Bahruddin Thalib Basri, Muhammad Iqbal Burhanuddin Bahar Cahyono Kaelan, Cahyono Daud, Nu’man As Fadjar Perkasa, Muhammad Faridin, Faridin Gaffar, Masyita Idris, Nurlaily Indra, Ryan Johan, Muhammad Phetrus Kurniawati, Wensri sevni Latief, Nikmatia Latief, Shofiyah Malik, Dwi Maheza Memah, Maya Fane Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Ilyas Muhammad Ruslin, Muhammad Muhibbah, A. Fitrah Nelwan, Dario A. Rahmawati Minhajat, Rahmawati Said, Suryani Siahaan, Surya Perdana Tanady, Kevin Julius Thahir, Musdalifah Utama, Dharma Zainuddin, Andi A. Zainuddinn, Andi Alfian Zainudin, Andi Alfian