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All Journal Journal of Food and Pharmaceutical Science Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Biology, Medicine, & Natural Product Chemistry Journal of Islamic Pharmacy Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Pharmacopolium MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Pharmacoscript Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Berkala Ilmiah Kimia Farmasi Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Media Informasi Jurnal Farmasi SYIFA Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Nofriyaldi, Ali
Department Of Pharmacy, Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Uji aktivitas penyembuhan luka sayat menggunakan sediaan patch ektrak etanol daun jambu biji (psidium guajava l.) secara in vivo Mulyadi Dai Muhammad Hafidz; Lina Rahmawati Rizkulloh; Ali Nofriyaldi
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p100-107

Abstract

The ethanol extract of (Psidium guajava L.) leaves, containing key phytocmhemicals such as tannins, flavonoids, and saponins, has demonstrated potential in enhancing wound repair. This research aimed to formulate a transdermal patch and investigate its in vivo wound-healing activity. Extraction was carried out through maceration of the simplicia using 96% ethanol as the solvent. Patches were formulated with HPMC and PVP, containing 2.5%, 5%, and 10% extract (F1, F2, F3). Physical evaluation (homogeneity, pH, thickness, adhesion) was performed. Rabbits (n=5) with a 2 cm dorsal incision were treated daily with patches (F1-F3), A negative control was represented by a (patch without extract) while the positive control used (povidone-iodine). Wound length was measured for 7 days. All evaluations met the physical requirements except pH at (F2: 6,6±0,1; F3: 6,8±0,1). F3 (10% extract) showed the highest wound healing activity, reducing wound length to 2 mm on day 7, significantly better than the control (7 mm) and lower concentrations (F1: 4 mm; F2: 3 mm). Guava leaf extract patches were effective at healing incised wounds, with concentration-dependent efficacy.
Formulation and in vivo evaluation of fast disintegrating tablets containing avocado seed extract as an antidiabetic agent in male rats Ali Nofriyaldi; Sri Rohmawati; Alma Asyyaidah; Ratna; Silmi Sabila; Hana Lutpia
Pharmaciana Vol. 16 No. 2 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i2.31673

Abstract

Avocado seeds, often considered agricultural waste, contain bioactive compounds, such as flavonoids and alkaloids, with promising antidiabetic properties. This study aimed to develop fast disintegrating tablet (FDT) formulations utilizing avocado seed extract with varying concentrations of the superdisintegrant croscarmellose sodium (2%, 4%, 6%, and 8%). The tablets were evaluated for their physical characteristics, including hardness, friability, disintegration time, and uniformity of weight, to ensure compliance with pharmacopeial standards. All formulations demonstrated acceptable physical properties, indicating that the incorporation of avocado seed extract did not compromise tablet quality. In vivo testing was conducted in diabetic mice to assess the antidiabetic activity of each formulation. The results revealed that all FDTs were effective in reducing blood glucose levels, with the formulation containing 8% croscarmellose sodium showing the most significant hypoglycemic effect. This enhanced activity is attributed to the rapid disintegration and improved bioavailability of the active compounds, which allows a faster onset of action. The findings suggest that avocado seed extract can be successfully formulated into fast-disintegrating tablets, providing a novel and efficient delivery system for antidiabetic therapy. Moreover, the utilization of avocado seed waste highlights the potential of natural resources in pharmaceutical innovation, offering both therapeutic benefits and sustainable value.
Formulasi Sediaan Mouthwash Ekstrak Daun Sirsak (Annona muricata L.) dengan Penambahan Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Antibakteri Fahmi Faiz Firmansyah; Salsabila Adlina; Ali Nofriyaldi
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.32475

Abstract

Karies gigi adalah suatu kondisi kronis yang disebabkan oleh bakteri Streptococcus mutans yang dapat menyebabkan timbul plak gigi yang berlubang. Daun sirsak dan daun kelor mengandung senyawa metabolit sekunder yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan sediaan mouthwash kombinasi ekstrak daun sirsak dan daun kelor serta aktivitas antibakterinya terhadap Streptococcus mutans. Metode ekstraksi dengan maserasi menggunakan pelarut etanol 70%. Skrining fitokimia meliputi uji alkaloid, tanin, flavonoid, terpenoid, saponin, dan polifenol. Formulasi mouthwash ekstrak daun sirsak dikombinasikan dengan ekstrak daun kelor dengan tiga variasi konsenstrasi yaitu F1 (2,5%), F2 (5%), dan F3 (10%). Evaluasi sediaan mouthwash meliputi uji organoleptik, pH, bobot jenis, dan viskositas, sedangkan pengujian antibakteri menggunakan metode sumuran. Hasil penelitian menunjukkan senyawa yang terdapat pada daun sirsak yaitu tanin, alkaloid, steroid, favonoid, saponin, dan polifenol, sedangkan daun kelor mengandung alkaloid, polifenol, tanin, favonoid, dan saponin. Hasil evaluasi sediaan mouthwash menunjukan ketiga formula memenuhi persyaratan. Uji aktivitas antibakteri pada ketiga formula mempunyai nilai diameter zona hambat 9,75 ± 0,06 mm (F1), 12,46 ± 0,003 mm (F2), dan 14,27 ± 0,008 mm (F3). F1 termasuk dalam kategori sedang, sedangkan F2 dan F3 termasuk kategori kuat. Dapat disimpulkan bahwa penambahan ekstrak daun kelor pada sediaan mouthwash ekstrak daun sirsak dapat meningkatkan aktivitas antibakteri terhadap bakteri Streptococcus mutans. Semakin tinggi konsentrasi ekstrak daun kelor, maka semakin meningkat nilai zona hambat antibakterinya.
Co-Authors Ai Parida Mutiara Aida, Yopi Alma Asyyaidah AYU RAHMAWATI Ayu Rahmawati C Shintia Citra Shintia Dila Yanti Eddy Suhardiana Elin Endah, Sri Rezeki Nur Fadhilah, Siti Khoirul Fahmi Faiz Firmansyah Fakhirah, Deani Sucia Fatwa, Elsa Nur Gina Septiani Agustien Hana Lutpia Indri, Eneng Juniarin, Ananda Kamiel Roesman Bachtiar Lidia Novianty Afifah Lina Rahmawati Lina Rahmawati Rizkulloh Lina Rahmawati Rizkuloh Masril Malik Mulyadi Dai Muhammad Hafidz Nitya Nurul Fadilah Nurfadilah, Ratna Nurul Aini, Widya Putri, Desara Eka Rahmadevi Ratih Purwasih Ratna Resti Hastuti Richa Mardianingrum Ruswanto, Ruswanto Salsabila Adlina Sarwatiningsih, Yunia Selvy Isnaeni Septiani Agustien, Gina Septiani, Gina Silmi Sabila Sinta Nuraesa Sri Rohmawati Srie Rezeki Nur Endah Srie Rezeki Nur Endah Srie Rezeki Nur Endah Suhardiana, Eddy Suna Agustine Susanti Susanti Vikandari, Sonya Nurizki