Article Per Year (5 Year)
p-Index From 2021 - 2026
4.354
P-Index
This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Biology, Medicine, & Natural Product Chemistry Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Pharmacopolium MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Pharmacoscript Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Berkala Ilmiah Kimia Farmasi Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Media Informasi Jurnal Farmasi SYIFA Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Nofriyaldi, Ali
Department Of Pharmacy, Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

Published : 33 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 33 Documents
Search

 1   2   3   4 
Formulasi Sediaan Mouthwash Ekstrak Daun Sirsak (Annona muricata L.) dengan Penambahan Variasi Konsentrasi Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Antibakteri Nofriyaldi, Ali
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.32475

Abstract

Karies gigi adalah suatu kondisi kronis yang disebabkan oleh bakteri Streptococcus mutans yang dapat menyebabkan timbul plak gigi yang berlubang. Daun sirsak dan daun kelor mengandung senyawa metabolit sekunder yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan sediaan mouthwash kombinasi ekstrak daun sirsak dan daun kelor serta aktivitas antibakterinya terhadap Streptococcus mutans. Metode ekstraksi dengan maserasi menggunakan pelarut etanol 70%. Skrining fitokimia meliputi uji alkaloid, tanin, flavonoid, terpenoid, saponin, dan polifenol. Formulasi mouthwash ekstrak daun sirsak dikombinasikan dengan ekstrak daun kelor dengan tiga variasi konsenstrasi yaitu F1 (2,5%), F2 (5%), dan F3 (10%). Evaluasi sediaan mouthwash meliputi uji organoleptik, pH, bobot jenis, dan viskositas, sedangkan pengujian antibakteri menggunakan metode sumuran. Hasil penelitian menunjukkan senyawa yang terdapat pada daun sirsak yaitu tanin, alkaloid, steroid, favonoid, saponin, dan polifenol, sedangkan daun kelor mengandung alkaloid, polifenol, tanin, favonoid, dan saponin. Hasil evaluasi sediaan mouthwash menunjukan ketiga formula memenuhi persyaratan. Uji aktivitas antibakteri pada ketiga formula mempunyai nilai diameter zona hambat 9,75 ± 0,06 mm (F1), 12,46 ± 0,003 mm (F2), dan 14,27 ± 0,008 mm (F3). F1 termasuk dalam kategori sedang, sedangkan F2 dan F3 termasuk kategori kuat. Dapat disimpulkan bahwa penambahan ekstrak daun kelor pada sediaan mouthwash ekstrak daun sirsak dapat meningkatkan aktivitas antibakteri terhadap bakteri Streptococcus mutans. Semakin tinggi konsentrasi ekstrak daun kelor, maka semakin meningkat nilai zona hambat antibakterinya.
Molecular Dynamic Study of Java Cardamom (Wurfbania compacta) Leaf Compounds Targeting Xanthine Oxidase for Antihyperuricemia Ali Nofriyaldi; Nitya Nurul Fadilah; Selvy Isnaeni
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1247-1256

Abstract

Hyperuricemia is a disorder marked by elevated concentrations of uric acid in the bloodstream, which can trigger gout and other metabolic complications. Conventional therapies such as allopurinol are effective but often cause side effects. This study aims to explore the potential of bioactive compounds from cardamom leaves (Wurfbania compacta) as antihyperuricemic agents through an in silico approach. The methods used include mining phytochemical data from the literature, predicting pharmacokinetic properties and toxicity (ADMET), molecular docking as well as molecular dynamic. The screening results show that the compound with the most stable interaction from cardamom (Wurfbania compacta) with receptors that play a role in inhibiting xanthine oxidase enzyme in silico is the compound kaempferol with a Binding energy value of -8.1 kcal/mol and Ki 1.15 uM (micromolar). ADMET analysis indicates that the main candidate has a good pharmacokinetic profile and low toxicity potential. Based on the results of the RMSD and RMSF molecular dynamic analysis, the kaempferol compound shows a stable level of interaction and has 3 amino acid similarities with the comparison drug allopurinol, namely THR1010, VAL1011 and ALA1078, so it has the potential to be used as a candidate antihyperuricemia drug. These findings suggest that cardamom leaves have prospects as a source of natural antihyperuricemia compounds. Further in vitro and in vivo studies are needed to verify the biological activity and safety of its use.
UJI AKTIVITAS ANTIBAKTERI MASKER GEL PEEL-OFF EKSTRAK DAUN KEPEL (Stelechocarpus burahol) TERHADAP Propionibacterium acnes Ali Nofriyaldi; Lidia Novianty Afifah; Lina Rahmawati
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/6bz1a488

Abstract

Acne is a common skin disorder caused by Propionibacterium acnes. Kepel leaves (Stelechocarpus burahol) contain secondary metabolites, including flavonoids, alkaloids, saponins, and tannins, which possess antibacterial potential. This study aimed to formulate a peel-off gel mask containing ethanolic extract of Kepel leaves and evaluate its antibacterial activity against Propionibacterium acnes. The research included extraction using 96% ethanol, phytochemical screening, formulation of peel-off gel masks, physical evaluation, and antibacterial testing using the agar diffusion method. Three formulations containing different extract concentrations were prepared: F1 (1%), F2 (3%), and F3 (5%). All formulations showed acceptable physical characteristics for topical preparations, including homogeneity, pH, viscosity, drying time, and stability. Antibacterial testing demonstrated concentration-dependent inhibitory activity, with inhibition zones of 14.64 mm, 19.11 mm, and 21.10 mm for F1, F2, and F3, respectively. Statistical analysis revealed significant differences among groups (p < 0.001). Although the antibacterial activity of all formulations was lower than 1% clindamycin, the 5% extract formulation exhibited the strongest inhibitory effect against Propionibacterium acnes. These findings indicate the potential of Kepel leaf extract as a natural antibacterial agent in topical anti-acne formulations.
Co-Authors Agustien, Gina Septiani Ai Parida Mutiara Aida, Yopi AYU RAHMAWATI Ayu Rahmawati Ayu Rahmawati C Shintia Citra Shintia Eddy Suhardiana Elin Endah, Sri Rezeki Nur Fadhilah, Siti Khoirul Fakhirah, Deani Sucia Fatwa, Elsa Nur Hafidz, Mulyadi Dai Muhammad Indri, Eneng Juniarin, Ananda Kamiel Roesman Bachtiar Lidia Novianty Afifah Lina Rahmawati Lina Rahmawati Rizkuloh Masril Malik Nitya Nurul Fadilah Nurfadilah, Ratna Nurul Aini, Widya Putri, Desara Eka Rahmadevi Ratih Purwasih Resti Hastuti Richa Mardianingrum Rizkulloh, Lina Rahmawati Ruswanto, Ruswanto Salsabila Adlina Sarwatiningsih, Yunia Selvy Isnaeni Septiani Agustien, Gina Septiani, Gina Sinta Nuraesa Srie Rezeki Nur Endah Srie Rezeki Nur Endah Srie Rezeki Nur Endah Suhardiana, Eddy Suna Agustine Susanti Susanti Vikandari, Sonya Nurizki Vincent O. Imieje Widya Nurul Aini Yanti, Dila