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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN ACNE PATCH EKSTRAK ETANOL DAUN CENGKIH (Syzygium aromaticum) TERHADAP BAKTERI Propionibacterium acnes Nurfadilah, Ratna; Rizkuloh, Lina Rahmawati; Nofriyaldi, Ali
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p145-155

There are many major problems with the skin, especially the face, that occur in some men and women. Acne is a skin disorder characterized by inflammation of the skin. Acne caused by Propionibacterium acnes bacteria is generally treated by Clindamycin capsules 300 g. However, the drug clyndamicin used by the oral route has side effects. So, there are alternative anti-acne drugs that have fewer side effects. Clove leaves from the clove tree can be used as medicine. The tannin compounds in clove leaves have antibacterial activity. In this research method, an acne patch preparation is made from clove leaf extract (includes collecting the ingredients to be tested, namely clove leaves, processing simplicia, making extracts, making acne patch formulations, and testing the antibacterial activity of Propionibacterium acnes using the well method. The results of the highest inhibition large, namely at F3 (10%) at 21,213mm very strong, F2 (7.5%) at 19,658mm strong and F1 (5%) at 18,788mm strong.

ANTIBACTERIAL ACTIVITY OF JAVANESE CARDAMOMUM FRUIT ESSENTIAL OIL (Wurfbainia compacta) ON Propionibacterium acnes Nofriyaldi, Ali; Rahmawati, Ayu; Endah, Sri Rezeki Nur
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1140

Cardamom fruit contains the essential oils cineol, terpineol and borneol which have the potential to act as antibacterials against the growth of Propionibacterium acnes. This study aimed to determine the percentage yield of essential oil and the value of the inhibition zone for the antibacterial activity of cardamom fruit oil. The research method begins with the preparation of dried simplicia from cardamom fruit, which is then distilled using water steam. The essential oil obtained was subjected to antibacterial activity using the well diffusion method. The results of the research showed that the yield of cardamom fruit essential oil was 1,66%. Cardamom fruit simple powder contains secondary metabolite compounds alkaloids, flavonoids, saponins, steroids, triterpenoids and polyphenols. The antibacterial activity test against Propionibacterium acnes at concentrations of 3%, 6%, and 12% produced inhibition zones of 3.2 mm, 4.7 mm, and 10.1 mm, respectively. Therefore, it can be concluded that at concentrations of 3% and 6%, it is included in the medium category, while at a concentration of 12%, it is included in the strong category. Keywords: Antibacterial, Oil of Cardamomum Fruit, Propionibacterium acnes, Wurfbainia compacta

Karakterisasi Sediaan Gel Face Scrub Yang Mengandung Variasi Ampas Kelapa (Cocos nucifera L.) Sebagai Exfoliating Nofriyaldi, Ali; Endah, Srie Rezeki Nur; Aida, Yopi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.4926

Ampas Kelapa (Cocos nucifera L.) merupakan sumber protein rendah lemak bebas gluten yang membantu menjaga kulit tetap terhidrasi. Tujuan penelitian ini yaitu untuk memformulasikan ampas kelapa kedalam bentuk sediaan gel face scrub dan mengetahui stabilitas sediaan gel face scrub ampas kelapa. Metode yang digunakkan dalam penelitian ini yaitu metode eksperimental dengan membuat sediaan gel face scrub dengan variasi konsentrasi dari ampas kelapa (Cocos nucifera L.) sebagai exfoliating. Hasil pengujian sediaan gel face scrub ampas kelapa variasi konsentrasi 3%, 6% dan 9% pada pengujian organoleptis sediaan berbentuk gel, bau ampas kelapa dan berwarna putih, dan putih kecoklatan, sediaan homogen, nilai pH memenuhi syarat yang ditentukan 4,5-6,5, daya sebar berkisar antara 5-7 cm, daya lekat berkisar lebih dari 1 detik, dan untuk viskositas masuk kedalam rentang standar yaitu antara 2000-4000 Cp.

Formulasi Mucoadhesive Edible Film Ekstrak Etanol Buah Kapulaga (Amomum compactum Sol. Ex Maton) Sebagai Antihalitosis Susanti, Susanti; Endah, Srie Rezeki Nur; Nofriyaldi, Ali; Indri, Eneng; Adlina, Salsabila
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.625

Ekstrak etanol buah kapulaga diketahui mempunyai aktivitas antibakteri yang baik terhadap Streptococcus mutans penyebab halitosis, sehingga cocok diformulasikan ke dalam sediaan oral, salah satunya sediaan Mucoadhesive edible film. Tujuan dari penelitian ini untuk membuat formulasi sediaan Mucoadhesive edible film ekstrak etanol buah kapulaga dan untuk mengetahui aktivitasnya terhadap bakteri Streptococcus mutans. Sediaan Mucoadhesive edible film dibuat menjadi 4 formula yaitu F0 (basis), F1 (ekstrak etanol buah kapulaga 2%), F2 (ekstrak etanol buah kapulaga 4%), dan F3 (ekstrak etanol buah kapulaga 6%). Evaluasi sediaan Mucoadhesive edible film meliputi uji organoleptis, uji ketebalan, uji keseragaman bobot, uji pH dan uji waktu hancur. Uji aktivitas antibakteri sediaan mucoadhesive edible film menggunakan sediaan klorheksidin 0,2% sebagai pembanding, dengan metode difusi cakram. Hasil penelitian menunjukan bahwa ekstrak etanol buah kapulaga dengan konsentrasi 2%, 4% dan 6% dapat diformulasikan menjadi sediaan mucoadhesive edible film yang memenuhi syarat evaluasi fisik sediaan. Hasil uji aktivitas antibakteri sediaan Mucoadhesive edible film memberikan diameter rata-rata daya hambat sebesar F1 (9,03 mm), F2 (7,10 mm), dan F3 (6,30 mm) terhadap bakteri Streptococcus mutans. Berdasarkan analisis varian satu arah (ANOVA) menunjukan hasil p-value 0,00< 0,05) yang menunjukan adanya perbedaan yang signifikan.

Pengaruh Bioenhancer Lidah Buaya terhadap Stabilitas Sediaan Emulgel Ekstrak Moringa oleifera L Adlina, Salsabila; Vikandari, Sonya Nurizki; Nofriyaldi, Ali; Putri, Desara Eka
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.960

Di daerah tropis, paparan sinar ultraviolet (UV) yang intens menjadi salah satu faktor utama pemicu penuaan dini kulit melalui aktivasi pembentukan radikal bebas. Untuk mengatasi hal ini, penelitian ini bertujuan mengevaluasi pengaruh bioenhancer lidah buaya (Aloe vera L) terhadap stabilitas fisik dan kimia sediaan emulgel berbasis ekstrak daun kelor (Moringa oleifera Lam.). Ekstrak daun kelor diekstraksi menggunakan metode maserasi dengan etanol 70?%, kemudian diformulasikan ke dalam emulgel dengan variasi konsentrasi ekstrak 0?%, 1?%, 2?%, dan 3?% serta penambahan lidah buaya pada konsentrasi 3,5?%. Sediaan diuji kestabilan fisik-kimianya meliputi konsistensi, nilai pH, dan viskositasmenggunakan metode cycling test pada suhu 4?°C dan 40?°C. Hasil menunjukkan bahwa semua formulasi stabil, dengan pH tetap pada 5,8?±?0,2 tanpa fluktuasi signifikan dan viskositas yang relatif stabil pada rentang 21.000 – 23.000 cPs. Tidak terjadi perubahan warna, endapan, atau pemisahan fase, menandakan kestabilan fisik yang baik. Semua formulasi memiliki tekstur homogen dan mudah diaplikasikan, namun formulasi dengan konsentrasi 3?% ekstrak daun kelor dan 3,5?% lidah buaya menunjukkan kinerja terbaik dalam hal stabilitas dan kesesuaian penggunaan topikal. Dengan demikian, penambahan lidah buaya sebagai bioenhancer secara signifikan meningkatkan kinerja emulgel ekstrak daun kelor, menjadikannya kandidat potensial sebagai sediaan kosmetik atau dermatologis alami untuk perlindungan kulit dari dampak UV di lingkungan tropis.

The Effect of Maltodextrin Concentration Variations on the Microencapsulation of Probiotics from Manonjaya Salak Fruit Juice (Salacca zalacca (Gaert.) Voss) Nofriyaldi, Ali; Fakhirah, Deani Sucia; Nurzaman, Mochamad Herdi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24203

Probiotic beverages have weaknesses in terms of shelf life related to stability. One way to maintain the stability of probiotic beverages is to encapsulate them into microcapsules using maltodextrin. The objective of this study is to determine the characteristics and effects of varying maltodextrin concentrations F1 (20%), F2 (40%), F3 (60%) on the physical properties of microcapsules from Manonjaya salak fruit (Salacca zalacca) probiotic beverages. This study was conducted experimentally in the production of microcapsules using the freeze-drying method. Data were analyzed descriptively, including organoleptic evaluation, measurement of total lactic acid, pH, lactic acid bacteria (LAB) count, moisture content, and morphological characterization using a Scanning Electron Microscope (SEM). The results of the characteristics of Manonjaya snake fruit juice microencapsulation can be concluded that variations in maltodextrin concentration affect the characteristics of microcapsules where all formulas meet the requirements, except for the results of the water content test between 10–10.33% which does not meet the requirements (≤ 3%). Thus, further research is needed in optimizing the microencapsulation formula of snake fruit juice, such as using a combination of coatings, longer freeze drying optimization time, and evaporation of snake fruit juice.

The Effect of Maltodextrin Concentration Variations on the Microencapsulation of Probiotics from Manonjaya Salak Fruit Juice (Salacca zalacca (Gaert.) Voss) Nofriyaldi, Ali; Fakhirah, Deani Sucia; Nurzaman, Mochamad Herdi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24203

Probiotic beverages have weaknesses in terms of shelf life related to stability. One way to maintain the stability of probiotic beverages is to encapsulate them into microcapsules using maltodextrin. The objective of this study is to determine the characteristics and effects of varying maltodextrin concentrations F1 (20%), F2 (40%), F3 (60%) on the physical properties of microcapsules from Manonjaya salak fruit (Salacca zalacca) probiotic beverages. This study was conducted experimentally in the production of microcapsules using the freeze-drying method. Data were analyzed descriptively, including organoleptic evaluation, measurement of total lactic acid, pH, lactic acid bacteria (LAB) count, moisture content, and morphological characterization using a Scanning Electron Microscope (SEM). The results of the characteristics of Manonjaya snake fruit juice microencapsulation can be concluded that variations in maltodextrin concentration affect the characteristics of microcapsules where all formulas meet the requirements, except for the results of the water content test between 10–10.33% which does not meet the requirements (≤ 3%). Thus, further research is needed in optimizing the microencapsulation formula of snake fruit juice, such as using a combination of coatings, longer freeze drying optimization time, and evaporation of snake fruit juice.

Molecular Dynamic Study of Java Cardamom (Wurfbania compacta) Leaf Compounds Targeting Xanthine Oxidase for Antihyperuricemia Ali Nofriyaldi; Nitya Nurul Fadilah; Selvy Isnaeni
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1247-1256

Hyperuricemia is a disorder marked by elevated concentrations of uric acid in the bloodstream, which can trigger gout and other metabolic complications. Conventional therapies such as allopurinol are effective but often cause side effects. This study aims to explore the potential of bioactive compounds from cardamom leaves (Wurfbania compacta) as antihyperuricemic agents through an in silico approach. The methods used include mining phytochemical data from the literature, predicting pharmacokinetic properties and toxicity (ADMET), molecular docking as well as molecular dynamic. The screening results show that the compound with the most stable interaction from cardamom (Wurfbania compacta) with receptors that play a role in inhibiting xanthine oxidase enzyme in silico is the compound kaempferol with a Binding energy value of -8.1 kcal/mol and Ki 1.15 uM (micromolar). ADMET analysis indicates that the main candidate has a good pharmacokinetic profile and low toxicity potential. Based on the results of the RMSD and RMSF molecular dynamic analysis, the kaempferol compound shows a stable level of interaction and has 3 amino acid similarities with the comparison drug allopurinol, namely THR1010, VAL1011 and ALA1078, so it has the potential to be used as a candidate antihyperuricemia drug. These findings suggest that cardamom leaves have prospects as a source of natural antihyperuricemia compounds. Further in vitro and in vivo studies are needed to verify the biological activity and safety of its use.

UJI AKTIVITAS ANTIBAKTERI MASKER GEL PEEL-OFF EKSTRAK DAUN KEPEL (Stelechocarpus burahol) TERHADAP Propionibacterium acnes Ali Nofriyaldi; Lidia Novianty Afifah; Lina Rahmawati
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.2793

Acne is a common skin disorder caused by Propionibacterium acnes. Kepel leaves (Stelechocarpus burahol) contain secondary metabolites, including flavonoids, alkaloids, saponins, and tannins, which possess antibacterial potential. This study aimed to formulate a peel-off gel mask containing ethanolic extract of Kepel leaves and evaluate its antibacterial activity against Propionibacterium acnes. The research included extraction using 96% ethanol, phytochemical screening, formulation of peel-off gel masks, physical evaluation, and antibacterial testing using the agar diffusion method. Three formulations containing different extract concentrations were prepared: F1 (1%), F2 (3%), and F3 (5%). All formulations showed acceptable physical characteristics for topical preparations, including homogeneity, pH, viscosity, drying time, and stability. Antibacterial testing demonstrated concentration-dependent inhibitory activity, with inhibition zones of 14.64 mm, 19.11 mm, and 21.10 mm for F1, F2, and F3, respectively. Statistical analysis revealed significant differences among groups (p < 0.001). Although the antibacterial activity of all formulations was lower than 1% clindamycin, the 5% extract formulation exhibited the strongest inhibitory effect against Propionibacterium acnes. These findings indicate the potential of Kepel leaf extract as a natural antibacterial agent in topical anti-acne formulations.

UJI AKTIVITAS ANTIJAMUR SABUN PEMBERSIH KEWANITAAN EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight) Walp.) TERHADAP Candida albicans ANTIFUNGAL ACTIVITY OF FEMININE HYGIENE BAY LEAF EXTRACT (Syzygium Polyanthum (Wight) Walp.) AGAINST Candida albicans Dila Yanti; Gina Septiani Agustien; Ali Nofriyaldi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.12694

Daun salam (Syzygium polyanthum (Wight) Walp.) merupakan tanaman yang memiliki aktivitas antijamur terhadap C. albicans. Penelitian ini bertujuan untuk mengevaluasi sifat fisik formulasi sediaan sabun cair pembersih kewanitaan ekstrak daun salam dan aktivitasnya dalam menghambat pertumbuhan C. albicans. Sediaan dibuat 3 formula dengan konsentrasi ekstrak daun salam 6%, 9% dan 12%. Ekstrak daun salam dibuat dengan cara maserasi menggunakan pelarut etanol 96% dan diperoleh ekstrak kental sebanyak 22,74%. Uji aktivitas antijamur dilakukan dengan metode difusi sumuran menggunakan media Potato Dextrose Agar. Evaluasi fisik sediaan meliputi organoleptis, homogenitas, pH, tinggi busa, dan viskositas. Hasil pengujian menunjukkan sediaan sabun pembersih kewanitaan ekstrak daun salam telah memenuhi standar uji evaluasi fisik dan memiliki aktivitas antijamur. Diameter zona hambat sabun pada konsentrasi ekstrak 6% dan 9% secara berurutan adalah 6,84 mm dan 8,60 mm, yang termasuk klasifikasi respon daya hambat sedang. Sementara itu, konsentrasi 12% memiliki diameter zona hambat sebesar 11,92 mm dengan klasifikasi respon daya hambat kuat.

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