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Antidiarrhea Activity of Ethanol Extract of Rambutan Leaves (Nephelium lappaceum L.) in Capsule Form on Male Mice Nurul Fadilah, Nitya; Ali Nofriyaldi; Ayu Rahmawati; Srie Rezeki Nur Endah; Widya Nurul Aini; Vincent O. Imieje
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.291-297

Background: Diarrhea is characterized by changes in stool form to soft or liquid, with an intensity of bowel movements more than three times a day. One of the plants used as an alternative treatment for diarrhea is rambutan, particularly its leaves. Previous studies have shown that rambutan leaf extract can treat diarrhea. Objective: The purpose of this study was to determine the antidiarrhea activity of ethanol extracts of rambutan leaves containing tannins and flavonoids that inhibit intestinal motility. Methods: This study was conducted experimentally using the intestinal transit method, which measures the length of the intestine passed through a marker. The smaller the ratio between the length of the intestine and the marker, the greater the decrease in intestinal motility in the mice. Group 1: loperamide HCl at a dose of 4 mg/kg BW; Group 2: placebo; Group 3: FI, FII, and FIII capsules at doses of 50 mg, 100 mg, and 150 mg. Results: The test results showed that Formulations 1, 2, and 3 had activities of 23.3%, 26.8%, and 32.3%, respectively. The capsule with the best results was formulation 3, at a dose of 150 mg. Compared with the positive control, the effectiveness of this capsule was 22% higher than that of loperamide. Conclusion: The results of this study showed that rambutan leaves extracted in capsule form effectively treats diarrhea. The one-way ANOVA test showed a significant difference between the FI, FII, and FIII groups (p <0.05).

A Activity Test Of Antidiarrheal Granule Ethanol Extract Of Rambutan Leaf (Nephelium lappaceum L.) In Mice (Mus musculus) Fadilah, Nitya Nurul; Nurul Aini, Widya; Nur Endah, Srie Rezeki; Nofriyaldi, Ali; Rahmawati, Ayu
Health Information : Jurnal Penelitian Vol 17 No 1 (2025): Januari-April
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v17i1.1610

Ringkasan: Latar belakang: Diare adalah perubahan konsistensi tinja menjadi lunak dan peningkatan frekuensi buang air besar yang dapat menyebabkan dehidrasi hingga kematian. Daun rambutan mengandung tanin dan flavonoid sebagai adstringen yang menghambat motilitas usus untuk terapi antidiare. Tujuan: Menganalisis efektivitas antidiare granul ekstrak etanol daun rambutan dengan metode transit intestinal pada mencit. Metode: Penelitian eksperimental menggunakan 25 mencit Swiss Webster jantan, dibagi 5 kelompok: kontrol positif (loperamide HCl 4 mg/kg), kontrol negatif (granul tanpa ekstrak), dan tiga kelompok uji dengan granul ekstrak daun rambutan dosis 50 mg, 100 mg, 150 mg. Analisis One Way ANOVA dengan signifikansi p<0,05. Hasil: Efektivitas antidiare berturut-turut 23,3%, 26,8%, dan 32,3%, dengan efektivitas tertinggi pada dosis 150 mg. Uji ANOVA menunjukkan perbedaan signifikan antar kelompok (p<0,05). Simpulan: Granul ekstrak etanol daun rambutan memiliki aktivitas antidiare berbanding terbalik dengan rasio transit intestinal. Saran: Penelitian lanjutan diperlukan untuk uji pra-klinis seperti kadar etanol, farmakokinetik, dan toksisitas.

FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN ACNE PATCH EKSTRAK ETANOL DAUN CENGKIH (Syzygium aromaticum) TERHADAP BAKTERI Propionibacterium acnes Nurfadilah, Ratna; Rizkuloh, Lina Rahmawati; Nofriyaldi, Ali
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p145-155

There are many major problems with the skin, especially the face, that occur in some men and women. Acne is a skin disorder characterized by inflammation of the skin. Acne caused by Propionibacterium acnes bacteria is generally treated by Clindamycin capsules 300 g. However, the drug clyndamicin used by the oral route has side effects. So, there are alternative anti-acne drugs that have fewer side effects. Clove leaves from the clove tree can be used as medicine. The tannin compounds in clove leaves have antibacterial activity. In this research method, an acne patch preparation is made from clove leaf extract (includes collecting the ingredients to be tested, namely clove leaves, processing simplicia, making extracts, making acne patch formulations, and testing the antibacterial activity of Propionibacterium acnes using the well method. The results of the highest inhibition large, namely at F3 (10%) at 21,213mm very strong, F2 (7.5%) at 19,658mm strong and F1 (5%) at 18,788mm strong.

ANTIBACTERIAL ACTIVITY OF JAVANESE CARDAMOMUM FRUIT ESSENTIAL OIL (Wurfbainia compacta) ON Propionibacterium acnes Nofriyaldi, Ali; Rahmawati, Ayu; Endah, Sri Rezeki Nur
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1140

Cardamom fruit contains the essential oils cineol, terpineol and borneol which have the potential to act as antibacterials against the growth of Propionibacterium acnes. This study aimed to determine the percentage yield of essential oil and the value of the inhibition zone for the antibacterial activity of cardamom fruit oil. The research method begins with the preparation of dried simplicia from cardamom fruit, which is then distilled using water steam. The essential oil obtained was subjected to antibacterial activity using the well diffusion method. The results of the research showed that the yield of cardamom fruit essential oil was 1,66%. Cardamom fruit simple powder contains secondary metabolite compounds alkaloids, flavonoids, saponins, steroids, triterpenoids and polyphenols. The antibacterial activity test against Propionibacterium acnes at concentrations of 3%, 6%, and 12% produced inhibition zones of 3.2 mm, 4.7 mm, and 10.1 mm, respectively. Therefore, it can be concluded that at concentrations of 3% and 6%, it is included in the medium category, while at a concentration of 12%, it is included in the strong category. Keywords: Antibacterial, Oil of Cardamomum Fruit, Propionibacterium acnes, Wurfbainia compacta

Karakterisasi Sediaan Gel Face Scrub Yang Mengandung Variasi Ampas Kelapa (Cocos nucifera L.) Sebagai Exfoliating Nofriyaldi, Ali; Endah, Srie Rezeki Nur; Aida, Yopi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.4926

Ampas Kelapa (Cocos nucifera L.) merupakan sumber protein rendah lemak bebas gluten yang membantu menjaga kulit tetap terhidrasi. Tujuan penelitian ini yaitu untuk memformulasikan ampas kelapa kedalam bentuk sediaan gel face scrub dan mengetahui stabilitas sediaan gel face scrub ampas kelapa. Metode yang digunakkan dalam penelitian ini yaitu metode eksperimental dengan membuat sediaan gel face scrub dengan variasi konsentrasi dari ampas kelapa (Cocos nucifera L.) sebagai exfoliating. Hasil pengujian sediaan gel face scrub ampas kelapa variasi konsentrasi 3%, 6% dan 9% pada pengujian organoleptis sediaan berbentuk gel, bau ampas kelapa dan berwarna putih, dan putih kecoklatan, sediaan homogen, nilai pH memenuhi syarat yang ditentukan 4,5-6,5, daya sebar berkisar antara 5-7 cm, daya lekat berkisar lebih dari 1 detik, dan untuk viskositas masuk kedalam rentang standar yaitu antara 2000-4000 Cp.

Formulasi Mucoadhesive Edible Film Ekstrak Etanol Buah Kapulaga (Amomum compactum Sol. Ex Maton) Sebagai Antihalitosis Susanti, Susanti; Endah, Srie Rezeki Nur; Nofriyaldi, Ali; Indri, Eneng; Adlina, Salsabila
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.625

Ekstrak etanol buah kapulaga diketahui mempunyai aktivitas antibakteri yang baik terhadap Streptococcus mutans penyebab halitosis, sehingga cocok diformulasikan ke dalam sediaan oral, salah satunya sediaan Mucoadhesive edible film. Tujuan dari penelitian ini untuk membuat formulasi sediaan Mucoadhesive edible film ekstrak etanol buah kapulaga dan untuk mengetahui aktivitasnya terhadap bakteri Streptococcus mutans. Sediaan Mucoadhesive edible film dibuat menjadi 4 formula yaitu F0 (basis), F1 (ekstrak etanol buah kapulaga 2%), F2 (ekstrak etanol buah kapulaga 4%), dan F3 (ekstrak etanol buah kapulaga 6%). Evaluasi sediaan Mucoadhesive edible film meliputi uji organoleptis, uji ketebalan, uji keseragaman bobot, uji pH dan uji waktu hancur. Uji aktivitas antibakteri sediaan mucoadhesive edible film menggunakan sediaan klorheksidin 0,2% sebagai pembanding, dengan metode difusi cakram. Hasil penelitian menunjukan bahwa ekstrak etanol buah kapulaga dengan konsentrasi 2%, 4% dan 6% dapat diformulasikan menjadi sediaan mucoadhesive edible film yang memenuhi syarat evaluasi fisik sediaan. Hasil uji aktivitas antibakteri sediaan Mucoadhesive edible film memberikan diameter rata-rata daya hambat sebesar F1 (9,03 mm), F2 (7,10 mm), dan F3 (6,30 mm) terhadap bakteri Streptococcus mutans. Berdasarkan analisis varian satu arah (ANOVA) menunjukan hasil p-value 0,00< 0,05) yang menunjukan adanya perbedaan yang signifikan.

Pengaruh Bioenhancer Lidah Buaya terhadap Stabilitas Sediaan Emulgel Ekstrak Moringa oleifera L Adlina, Salsabila; Vikandari, Sonya Nurizki; Nofriyaldi, Ali; Putri, Desara Eka
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.960

Di daerah tropis, paparan sinar ultraviolet (UV) yang intens menjadi salah satu faktor utama pemicu penuaan dini kulit melalui aktivasi pembentukan radikal bebas. Untuk mengatasi hal ini, penelitian ini bertujuan mengevaluasi pengaruh bioenhancer lidah buaya (Aloe vera L) terhadap stabilitas fisik dan kimia sediaan emulgel berbasis ekstrak daun kelor (Moringa oleifera Lam.). Ekstrak daun kelor diekstraksi menggunakan metode maserasi dengan etanol 70?%, kemudian diformulasikan ke dalam emulgel dengan variasi konsentrasi ekstrak 0?%, 1?%, 2?%, dan 3?% serta penambahan lidah buaya pada konsentrasi 3,5?%. Sediaan diuji kestabilan fisik-kimianya meliputi konsistensi, nilai pH, dan viskositasmenggunakan metode cycling test pada suhu 4?°C dan 40?°C. Hasil menunjukkan bahwa semua formulasi stabil, dengan pH tetap pada 5,8?±?0,2 tanpa fluktuasi signifikan dan viskositas yang relatif stabil pada rentang 21.000 – 23.000 cPs. Tidak terjadi perubahan warna, endapan, atau pemisahan fase, menandakan kestabilan fisik yang baik. Semua formulasi memiliki tekstur homogen dan mudah diaplikasikan, namun formulasi dengan konsentrasi 3?% ekstrak daun kelor dan 3,5?% lidah buaya menunjukkan kinerja terbaik dalam hal stabilitas dan kesesuaian penggunaan topikal. Dengan demikian, penambahan lidah buaya sebagai bioenhancer secara signifikan meningkatkan kinerja emulgel ekstrak daun kelor, menjadikannya kandidat potensial sebagai sediaan kosmetik atau dermatologis alami untuk perlindungan kulit dari dampak UV di lingkungan tropis.

The Effect of Maltodextrin Concentration Variations on the Microencapsulation of Probiotics from Manonjaya Salak Fruit Juice (Salacca zalacca (Gaert.) Voss) Nofriyaldi, Ali; Fakhirah, Deani Sucia; Nurzaman, Mochamad Herdi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24203

Probiotic beverages have weaknesses in terms of shelf life related to stability. One way to maintain the stability of probiotic beverages is to encapsulate them into microcapsules using maltodextrin. The objective of this study is to determine the characteristics and effects of varying maltodextrin concentrations F1 (20%), F2 (40%), F3 (60%) on the physical properties of microcapsules from Manonjaya salak fruit (Salacca zalacca) probiotic beverages. This study was conducted experimentally in the production of microcapsules using the freeze-drying method. Data were analyzed descriptively, including organoleptic evaluation, measurement of total lactic acid, pH, lactic acid bacteria (LAB) count, moisture content, and morphological characterization using a Scanning Electron Microscope (SEM). The results of the characteristics of Manonjaya snake fruit juice microencapsulation can be concluded that variations in maltodextrin concentration affect the characteristics of microcapsules where all formulas meet the requirements, except for the results of the water content test between 10–10.33% which does not meet the requirements (≤ 3%). Thus, further research is needed in optimizing the microencapsulation formula of snake fruit juice, such as using a combination of coatings, longer freeze drying optimization time, and evaporation of snake fruit juice.

Molecular Dynamic Study of Java Cardamom (Wurfbania compacta) Leaf Compounds Targeting Xanthine Oxidase for Antihyperuricemia Nofriyaldi, Ali; Fadilah, Nitya Nurul; Isnaeni, Selvy
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1247-1256

Hyperuricemia is a disorder marked by elevated concentrations of uric acid in the bloodstream, which can trigger gout and other metabolic complications. Conventional therapies such as allopurinol are effective but often cause side effects. This study aims to explore the potential of bioactive compounds from cardamom leaves (Wurfbania compacta) as antihyperuricemic agents through an in silico approach. The methods used include mining phytochemical data from the literature, predicting pharmacokinetic properties and toxicity (ADMET), molecular docking as well as molecular dynamic. The screening results show that the compound with the most stable interaction from cardamom (Wurfbania compacta) with receptors that play a role in inhibiting xanthine oxidase enzyme in silico is the compound kaempferol with a Binding energy value of -8.1 kcal/mol and Ki 1.15 uM (micromolar). ADMET analysis indicates that the main candidate has a good pharmacokinetic profile and low toxicity potential. Based on the results of the RMSD and RMSF molecular dynamic analysis, the kaempferol compound shows a stable level of interaction and has 3 amino acid similarities with the comparison drug allopurinol, namely THR1010, VAL1011 and ALA1078, so it has the potential to be used as a candidate antihyperuricemia drug. These findings suggest that cardamom leaves have prospects as a source of natural antihyperuricemia compounds. Further in vitro and in vivo studies are needed to verify the biological activity and safety of its use.

The Effect of Maltodextrin Concentration Variations on the Microencapsulation of Probiotics from Manonjaya Salak Fruit Juice (Salacca zalacca (Gaert.) Voss) Nofriyaldi, Ali; Fakhirah, Deani Sucia; Nurzaman, Mochamad Herdi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24203

Probiotic beverages have weaknesses in terms of shelf life related to stability. One way to maintain the stability of probiotic beverages is to encapsulate them into microcapsules using maltodextrin. The objective of this study is to determine the characteristics and effects of varying maltodextrin concentrations F1 (20%), F2 (40%), F3 (60%) on the physical properties of microcapsules from Manonjaya salak fruit (Salacca zalacca) probiotic beverages. This study was conducted experimentally in the production of microcapsules using the freeze-drying method. Data were analyzed descriptively, including organoleptic evaluation, measurement of total lactic acid, pH, lactic acid bacteria (LAB) count, moisture content, and morphological characterization using a Scanning Electron Microscope (SEM). The results of the characteristics of Manonjaya snake fruit juice microencapsulation can be concluded that variations in maltodextrin concentration affect the characteristics of microcapsules where all formulas meet the requirements, except for the results of the water content test between 10–10.33% which does not meet the requirements (≤ 3%). Thus, further research is needed in optimizing the microencapsulation formula of snake fruit juice, such as using a combination of coatings, longer freeze drying optimization time, and evaporation of snake fruit juice.

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