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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Riset Kesehatan Nasional Jurnal Ilmiah Medicamento Jurnal Penelitian Agama Hindu Jurnal Kesehatan Primer Poltekita: Jurnal Pengabdian Masyarakat JRKN Jurnal Farmasi Indonesia Usadha Borneo Journal of Pharmacy Jurnal Kesehatan Primer
Dwi Arymbhi Sanjaya
Universitas Mahasaraswati Denpasar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Kajian Literatur: Study Design Dalam Farmakoepidemiologi Untuk Mengetahui Resistensi Bakteri Terhadap Antibiotik Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Rr Asih Juanita; Nyoman Budiartha Siada
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 1 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i1.61651

Abstract

Penelitian terkait resistensi bakteri terhadap antibiotik dapat dilakukan dengan berbagai study design. Study design merupakan salah satu titik kritis dalam penelitian resistensi bakteri terhadap antibiotik. Penelitian ini bertujuan untuk memberikan gambaran kelebihan dan kekurangan dari study design yang digunakan dalam penelitian farmakoepidemiologi tentang resistensi bakteri terhadap antibiotik. Pencarian literatur dilakukan secara elektronik untuk artikel yang dipublikasikan tahun 2011 hingga 30 Juni 2021 pada basis data EBSCO, Plos One, Proquest, PubMed, ScienceDirect, dan Google Scholar. Kriteria inklusi meliputi original article dengan desain cohort (prospective dan retrospective), case control, cross-sectional dan ecological study; memiliki Digital Object Identifier (DOI); dipublikasi 10 tahun terakhir; serta mengunakan Bahasa Inggris. Artikel dalam bentuk review, tidak merupakan full text, dan artikel dengan jumlah sampel penelitian yang tidak jelas tidak disertakan dalam kajian ini. Artikel yang terkumpul dari 6 database sejumlah 209 artikel (EBSCO 45 artikel, Plos One 42 artikel, ProQuest 32 artikel, PubMed 68 artikel, ScienceDirect 19 artikel dan Google Scholar 3 artikel). Duplikasi artikel dieksklusi (29 artikel). Artikel tidak memenuhi kriteria inklusi (86 artikel), 64 artikel tidak relavan dengan tujuan penelitian, sehingga diperoleh 30 artikel dalam studi ini. Rancangan penelitian pada penelitian ini yaitu case-control (2 artikel), cohort-prospective (14 artikel), cohort-retrospective (5 artikel), cross-sectional (8 artikel) dan ecological study (1 artikel). Masing-masing rancangan memiliki kelebihan dan kekurangannya masing-masing. Pemilihan desain studi dalam penelitian resistensi bakteri terhadap antibiotik dilakukan sesuai dengan tujuan penelitian, jenis paparan yang diamati, jenis outcome serta tipe penelitian (comparative, correlative study) serta ketersediaan sumber daya dalam melakukan penelitian resistensi bakteri terhadap antibiotik.
Evaluasi Rasionalitas Pengobatan Pasien Dengue Hemorrhagic Fever dengan Komplikasi dan Komorbiditas di Rumah Sakit “X” Provinsi Bali Rr Asih Juanita; Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Nyoman Budiartha Siada; Nyoman Ayu Prascitasari
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.92941

Abstract

Penggunaan obat pada pasien Dengue Hemorrhagic Fever (DHF) dengan komplikasi dan komorbiditas perlu mendapat perhatian khusus untuk menghindari kejadian Drug Related Problems (DRPs) yang dapat memengaruhi luaran klinis. Penelitian ini bertujuan untuk mengevaluasi rasionalitas pengobatan pada pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross-sectional. Data rekam medis pasien dikumpulkan secara retrospektif tahun 2020-2021. Penilaian rasionalitas pengobatan dilakukan dengan analisis DRPs menggunakan instrumen Pharmaceutical Care Network Europe Association (PCNE) versi 9.1. Luaran klinis dianalisis berdasarkan nilai trombosit, hematokrit, leukosit, dan hemoglobin. Analisis hubungan rasionalitas pengobatan terhadap luaran klinis dilakukan menggunakan uji Chi-square. Dari total 115 pasien yang memenuhi kriteria penelitian, terjadi DRPs pada 33% pasien dan 67% tidak terjadi DRPs. DRPs yang terjadi yaitu P3.2 Unclear problem/complaint (51%); P1.2 Effect of drug treatment not optimal (28%); P1.3 Untreated symptoms or indication (13%); serta P3.1 Unnecessary drug-treatment (8%). Rasionalitas pengobatan tidak berhubungan dengan luaran klinis pasien DHF dengan komplikasi dan komorbiditas di Rumah Sakit “X” Provinsi Bali (p>0,05).
The Association between Resistance of Sepsis-Inducing Bacteria to First-Line Antibiotics and Sepsis Outcome: A Retrospective Cross-Sectional Study Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Rr. Asih Juanita; Nyoman Budiartha Siada; I Wayan Maysa Yudiartha; Kadek Suryawan
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13597

Abstract

Background: Sepsis is a significant infectious disease linked to high mortality rates. Several bacterial pathogens that cause sepsis have shown resistance to first-line antibiotics. This resistance in sepsis-causing bacteria to initial antibiotic agents threatens treatment success, elevating mortality risk, healthcare costs, and prolonged hospital stays.Objective: This study aimed to investigate the relationship between the resistance of sepsis-causing bacteria to first-line antibiotics and sepsis treatment outcomes.Methods: This cross-sectional study was a single-center retrospective study. Data were collected from sepsis patients admitted to the intensive care unit of a general hospital in Bali between 2022 and 2023. The patients included in this study were those with a positive bacterial infection, as provided in the culture result. Therapy outcomes were evaluated based on discharge status: improved or unimproved (deceased). The resistance of sepsis-causing bacteria to first-line antibiotics, including fluoroquinolones, third- and fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin, was assessed through blood cultures. The relationship between antibiotic resistance and therapy outcomes was analyzed using the Gamma correlation coefficient. This study included 57 of 108 sepsis patients, primarily male (57.89%) and older than 60 years (57.89%).Results: A strong, significant positive correlation was observed between the resistance of sepsis-causing bacteria to third-generation cephalosporins and therapy outcomes (p=0.001; r=0.637). In contrast, resistance to fluoroquinolones (p=0.108; r=0.387), fourth-generation cephalosporins (p=0.377; r=-0.199), piperacillin-tazobactam (p=0.816; r=-0.060), and vancomycin (p=0.911; r=0.030) did not significantly impact therapy outcomes. The outcome of sepsis therapy is associated with resistance of sepsis-causing bacteria to third-generation cephalosporins but not to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, or vancomycin. This study uses a relatively small sample size, which precludes subgroup analyses.Conclusion: Non-significant findings for some antibiotics may reflect insufficient power; further study is needed to assess the correlation between resistance of sepsis-causing bacteria to fluoroquinolones, fourth-generation cephalosporins, piperacillin-tazobactam, and vancomycin.
Association Between Antibiotic Consumption and Pseudomonas aeruginosa Non-Susceptibility: A Five-Year Ecological Study at Bali Regional General Hospital Dwi Arymbhi Sanjaya; Herleeyana Meriyani; Rr. Asih Juanita; Nyoman Budiartha Siada; I Putu Yudistira Mahaputra
Jurnal Ilmiah Medicamento Vol 12 No 2 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i2.14763

Abstract

Background: Pseudomonas aeruginosa is a major cause of healthcare-associated infections (HAIs), which are difficult to eradicate because of the bacterium’s intrinsic and acquired resistance mechanisms. However, evidence regarding the association between hospital antibiotic consumption and antimicrobial resistance remains inconsistent.Objective: This study determines the association between systemic antibiotic consumption and P. aeruginosa non-susceptibility using five years of hospital surveillance data.Methods: A retrospective ecological study was conducted using surveillance data from Bali Regional General Hospital between January 2019 and December 2023. The relationship between antibiotic consumption [defined as daily doses (DDD) per 100 patient-days] and resistance was analyzed by a generalized linear model in which the number of non-susceptible isolates was used as the dependent variable. Moreover, antibiotic consumption, the bed occupancy rate (BOR), the calendar year, and the antibiotic agent (with meropenem taken as the reference category) were used as independent variables.Results: The study included 77 P. aeruginosa isolates and 35 antibiotic-year observations. No statistically significant association was found between antibiotic consumption and non-susceptibility (OR 1.049, 95% CI 0.980–1.122; p = 0.168) or between BOR and non-susceptibility (OR 1.024, 95% CI 0.992–1.057; p = 0.152). Calendar year was inversely associated with the modeled non-susceptibility outcome (OR 0.716, 95% CI 0.592–0.866; p < 0.001). Ceftazidime and cefepime had higher odds of non-susceptibility than meropenem.Conclusion: Antibiotic consumption does not fully explain P. aeruginosa non-susceptibility. Factors such as antibiotic-specific resistance mechanisms and infection prevention and control practices might also have a role in the differences in non-susceptibility.
Co-Authors AA Istri Mas Padmiswari Agus Baratha Suyasa Asthadi Mahendra Bhandesa, Asthadi Mahendra Desak Ketut Ernawati Emanuel Ileatan Lewar Erna Cahyaningsih Herleeyana Meriyani I Gede Agus Shuarsedana Putra I Putu Yudistira Mahaputra I Wayan Maysa Yudiartha Ida Ayu Manik Damayanti Kadek Suryawan Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Komang Triani Lestari LEWAR, EMANUEL ILEATAN Luh Risma Putri Rahayu Lusy Noviani Made Agus Deny Mahendra Putra Made Elvenia Ambara Damayanti Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Maria Malida Vernandes Sasadara Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Kadek Refi Mariska Ni Kadek Sukertiasih Ni Luh Kade Arman Anita Dewi Ni Luh Putu Inca Buntari Agustini Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Putu Nadya Kirana Wulandari Ni Wayan Sukma Antari Nurul Chusna Nyoman Ayu Prascitasari Nyoman Budiartha Siada Pretty Falena Atmanda Kambira Puspawati, Made Putra, I Gede Agus Shuarsedana Putu Era Sandhi Kusuma Yuda Putu Sukma Purnamasari Rr Asih Juanita Rr Asih Juanita Rr Asih Juanita Rr. Asih Juanita RR. Asih Juanita Sukmayanti, Ni Kadek Suyasa, Agus Baratha Swari, Ni Luh Putu Triska Ananda Rahayu Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang