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All Journal Jurnal Farmasi Udayana JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Pharmaceutical Science and Technology Pharmascience Media Kesehatan Politeknik Kesehatan Makassar PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Dunia Farmasi Majalah Farmasetika Indonesian Journal of Pharmaceutical and Clinical Research Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Borneo Journal of Pharmacy

Ihsanul Hafiz

Departemen Farmakologi, Fakultas Farmasi Dan Ilmu Kesehatan, Institut Kesehatan Helvetia, Medan, Sumatera Utara

Author-ID : 1332878

Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Evaluasi dan Potensi Daya Hambat Gel Antiseptik Tangan Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) terhadap Bakteri Patogen Pseudomonas aeruginosa dan Staphylococcus epidermidis Ruth Mayana Rumanti; Sri Handayani; Tetty Noverita Khairani; Ihsanul Hafiz
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13490

Penggunaan gel antiseptik tangan merupakan upaya untuk menghindari kontaminasi kulit dari bakteri patogen. Daun kemangi diketahui memiliki kandunganflavonoid, alkaloid, tanin, dan linalool yang efektif sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kestabilan dan daya hambat antibakteri gel antiseptik ekstrak etanol daun kemangi (Ocimum sanctum L.) terhadap bakteri patogen di udara yaitu Pseudomonas aeruginosa dan Staphylococcus epidermidis. Simplisia daun kemangi sebelumnya dikarakterisasi lalu diekstraksi secara perkolasi menggunakan etanol 96%. Ekstrak diformulasi menjadi sediaan gel antiseptik dan diuji kestabilannya dengan metode cycling test selama 6 siklus. Daya hambat antibakteri dengan metode difusi sumuran pada konsentrasi 1,5%; 3%; dan 4,5%. Data penelitian dianalisis secara statistik Uji One Way Anova. Hasil evaluasi kestabilan pada 6 siklus tidak ada perubahan yang signifikan pada pengujian organoleptis, viskositas, pH, daya sebar sementara pertumbuhan bakteri Pseudomonas aeruginosa dan Staphylococcus epidermidis dihambat pada konsentrasi 4,5% dengan diameter daerah hambat masing-masing sebesar 25,5 mm dan 26,6 mm termasuk kategori kuat. Kata Kunci: Daun Kemangi (Ocimum sanctum L.), Gel Antiseptik Tangan, Potensi Daya Hambat, Pseudomonas aeruginosa, Staphylococcus epidermidis The use of hand antiseptic gel is an effort to avoid skin contamination from pathogenic bacteria. Kemangi leaves are known contain flavonoids, alkaloids, tannins, and linalool which are effective as antibacterial. This study aims to determine the stability and antibacterial inhibition of the antiseptic gel of the ethanolic extract of Kemangi leaves (Ocimum sanctum L.) against pathogenic bacteria in the air, namely Pseudomonas aeruginosa and Staphylococcus epidermidis. The simplicia of kemangi leaves was previously characterized and then extracted by percolation using 96% ethanol. The extract was formulated into an antiseptic gel preparation and tested for stability by the cycling test method for 6 cycles. Inhibition of antibacterial by agar well diffusion method at concentrations of 1.5%, 3%, and 4.5%. The research data were statistically analyzed by the One Way Anova Test. The results of the stability evaluation at 6 cycles showed no significant changes in organoleptic testing, viscosity, pH, dispersion, while the growth of Pseudomonas aeruginosa and Staphylococcus epidermidis was inhibited at a concentration of 4.5% with a diameter of 25.5 mm and 26.6 mm respectively is included in the strong category.

Validasi Metode Penentuan Tablet Allopurinol Menggunakan Spektrofotometri Ultraviolet dalam Larutan Asam Suprianto Suprianto; Ihsanul Hafiz; Hendri Faisal; Hasrat Masa Harefa
Jurnal Kimia Sains dan Aplikasi Vol 22, No 2 (2019): Volume 22 Issue 2 Year 2019
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Allopurinol sebagai obat tablet banyak beredar di pasaran, sehingga kadar allopurinol haruslah memenuhi persyaratan agar kualitas obat dijamin. Pada penelitian ini, validasi metode penentuan obat tablet allopurinol dalam tiga konsentrasi HCl, yaitu 0,05 N; 0,10 N; dan 0,15 N menggunakan spektrofotometri ultraviolet telah dilakukan. Parameter validasi meliputi uji linieritas, akurasi, presisi berulang, dan presisi menengah dan spesifik. Penentuan konten yang dilakukan dalam larutan HCl 0,10 N menghasilkan akurasi terbaik. Hasil penelitian menunjukkan bahwa panjang gelombang maksimum adalah pada 251 nm di mana linearitas, akurasi, presisi ulang, presisi pada pelarut HCl 0,10 N masing-masing adalah 0,9995; 100.1% - 100.6%; 0,076%; 0,057% - 0,127%. Tes spesifisitas menunjukkan hasil yang baik. Kandungan rata-rata allopurinol dalam tablet adalah 100,7% -102,3%. Sehingga kandungan rata-rata allopurinol dalam tablet memenuhi standart yang mengacu Indonesian Pharmacopoeia V Edition.

Ointment Formulation of Tapak Dara (Catharanthus roseus (L.) G. Don) Flower Ethanol Extract and its Activity in Burn-Healing Leny Leny; Tetty Noverita Khairani Situmorang; Rensus Siagian; Ihsanul Hafiz; Benni Iskandar
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.3155

Treatment done on burn wounds is intended to provide local therapy to heal as quickly as possible. The content of secondary metabolites in the tapak dara (Catharanthus roseus (L.) G. Don) flower can help the healing process of burns, namely alkaloids, saponins, tannins, and flavonoids. Alkaloids act as antibacterial; saponins can trigger collagen formation; tannins as astringents that cause shrinkage of skin pores and stop minor bleeding in wounds; and flavonoids have anti-inflammatory effects. This study aimed to formulate an ointment of C. roseus flower ethanol extract and determine its physical characteristics such as organoleptic test, homogeneity, pH value, dispersion, and stability test of the preparation and examine the activity as a burn healer in white male rats. The research data were analyzed statistically using the ANOVA method, followed by the LSD test (least significant difference) to see how the ointment-containing extract reduced the diameter and percentage of the burn wounds. The results show that all ethanol extracts of C. roseus flower ointments met the requirements for its physical characteristic tests. It offers a good activity as a burn healer in white male rats. The most effective concentration is an ointment containing 15% of ethanol extract from C. roseus flower (F3 group), which shows a significant difference (p <0.05) from the blank and the other group formula in burn wound healing.

Antibacterial Activity of Gel of Ethanol Extract of Papaya Leaves (Carica papaya L.) againts Propionobacterium acnes Pertiwi, Dewi; Ihsanul Hafiz; Rahmalia Salma
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract Papaya plants (Carica papaya L) besides being a food ingredient are also believed to have medicinal properties and are used traditionally, one of which is in dealing with acne problems. The purpose of this study was to formulate papaya leaf extract in the form of a gel preparation and test its antibacterial activity against the Propionibacterium acnes bacteria. The preparation of the ethanol extract of papaya leaves was made in three concentrations namely 5, 10 and 15%, then tested for antibacterial activity and compared with negative controls (blank gel) and positive control (erythromycin). The results showed that the papaya extract ethanol extract of 10 and 15% leaves had significantly different activities to the negative controls, but the 5% gel formula did not show any different activity towards negative controls. The conclusion of this study is that active papaya leaf ethanol extract gel inhibits bacterial growth at concentrations of 10 and 15%. Keywords: Carica papaya L., gel formula, antibaterial activity, Propionibacterium acnes

The Antioxidant Activity of Pagoda Flower (Clerodendrum paniculatum L.) Ethanol Extract using Visible Spectrophotometric Method Hafiz, Ihsanul; Ginting, Mandike; Yuermaileni, Yuermaileni
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract. Pagoda flower is one of the plant species included in the genus Clerodendrum which has a number of different species of 580 species, and is spread evenly in Asia, Africa, America, and Australia. A number of species of this genus have been used in traditional medicine in Asia and Africa. India, China, Korea, Thailand and Japan. The antioxidant activity of this plant is known to be very strong, so in this article the antioxidant activity of the flower part of the Clerodendrum paniculatum L. species will be described. The ability of antioxidant activity was measured by the DPPH method (1,1-diphenyl-2-picrylhydrazyl) which was measured using a Visible spectrophotometer using Vit C as a comparison. The results showed that the ethanol extract of pagoda flowers has antioxidant activity with an IC50 value of 64.889 ppm (strong). The Vit C comparison has an IC50 value of 8.539 ppm (very strong). Keyword: Antioxidant, Clerodendrum Paniculatum L., Visible Spectrophotometric. Abstrak. Bunga Pagoda merupakan salah satu spesies tanaman yang termasuk dalam genus Clerodendrum yang memiliki jumlah spesies yang berbeda sejumlah 580 spesies, dan tersebar merata di Asia, Afrika, Amerika, dan Australia. Sejumlah spesies dari genus ini telah digunakan dalam pengobatan tradisional di kawasan Asia dan Afrika. India, China, Korea, Thailand, dan Jepang. Aktivitas antioksidan dari tanaman ini diketahui sangat kuat, sehingga dalam artikel ini akan dipaparkan aktivitas antioksidan yang dimiliki oleh ekstrak etanol bagian bunga dari spesies Clerodendrum paniculatum L. Pengujian aktivitas antioksidanya dilakukan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) yang diukur menggunakan spektrofotometer Visibel dengan menggunakan Vit C sebagai pembanding. Hasil penelitian menjukkan bahwa ekstrak etanol bunga pagoda memiliki aktivitas antioksidan dengan nilai IC50 sebesar 64,898 ppm (kuat). Pembanding Vit C memiliki nilai IC50 sebesar 8,539 ppm (sangat kuat). Kata Kunci: Antioksidan, Clerodendrum paniculatum L., DPPH, Spektrofotometri Vis.

Co-Authors BENNI ISKANDAR Dewi Pertiwi Dewi Pertiwi Evi Ekayanti Ginting FRANSISKA, ELLA Ginting, Mandike Hasrat Masa Harefa Hendri Faisal Indra Ginting Jacub Tarigan Kartika, Yulis Khairani Fitri Leli Masliana Leny Leny Leny Leny, Leny Leny, Leny Mandike Ginting Nababan, Herbet Nurul Husna Nuzulul Safitri Oktavienty Oktavienty Panal Sitorus Rahmalia Salma Ratna Kumala Rensus Siagian Ruth Mayana Rumanti Sihombing, Delima Siti Fatimah Hanum Sri Handayani Suprianto Suprianto Tetty Noverita Khairani Tetty Noverita Khairani Tetty Noverita Khairani Situmorang Tiary N Sitohang Warnus Laia Winata, Hanafis Sastra Yuermaileni, Yuermaileni

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