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All Journal CHEMPUBLISH JOURNAL Majalah Farmaseutik CHEESA: Chemical Engineering Research Articles Jurnal Kreativitas PKM Pharmaceutical Journal of Indonesia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Inovasi Farmasi Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi dan Sains Indonesia (JFSI) Environmental and Toxicology Management (ETM) Gemakes: Jurnal Pengabdian Kepada Masyarakat FASKES : Jurnal Farmasi, Kesehatan, dan Sains JI-KES (Jurnal Ilmu Kesehatan)
Muadifah, Afidatul
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Antibacterial Activity of Ethyl Acetate and Cream Formulation of Coleus atropurpureus leaves Against Staphylococcus aureus Tarigan, Indra Lasmana; Muadifah, Afidatul; Susanto, Nindita Clourisa Clourisa Amaris; Huda, Choirul
Pharmaceutical Journal of Indonesia Vol. 7 No. 1 (2021)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2021.007.01.1

Abstract

Infectious diseases caused by Staphylococcus aureus (Sa) bacteria reaching 70% of cases in Asia and can attack and survive in epithelial cells including endothelial cells. Attempts to overcome the infection caused by Sa by giving antibiotics, which work as antibacterial. Myana (Coleus atropurpureus L. Benth) leaves contain several active compounds that might act as antibacterial agents. This study aimed to analyze the antibacterial activity of Coleus Extract in vitro and to evaluate the formulation of the extract cream against the bacteria causing infection, Sa. Coleus leaves ethyl acetate extract contains alkaloids and tannins, the absorbance of Sa at the 3rd hour was getting smaller, from 0.668 to 0.552, this showed that the longer the incubation time of the extract against bacterial inoculation, the more bacteria died. Our cream formulation with criteria: the pH value, homogeneity, spreadability, adhesion, and protection power. Our cream formulation results were then evaluated based on the standard, with criteria: the pH value, homogeneity, spreadability, adhesion, and protection power. It seems that our cream is per the cream standards. It is semi-solid, brownish-white in color, smells typical of Coleus, and pH 6. Moreover, the cream is homogeneous with 5 cm of spreadability, 7 seconds for adhesion, and colorless. Moreover, we found that Coleus extract cream has better antibacterial activity than positive control with a wound closure time of 7-14 days for extract while more than 14 days for positive control.
Co-Authors Arif Santoso Choirul Huda Danar Danar Datin An Nisa Sukmawati Etonihu, Anayo Christian Handaru, Windu Hariani Nurjanah, Mutia Ima, Ernisa Afidatul Imanez, Ketzia Adrian Indah Pratiwi, Putri Indra Lasmana Tarigan Jannah Triarini, Lailatul Jovanncha, Czellicya Karel Damayanti, Novita Kharisma, Mei Nabila Revina Kholifah, Siti Nurriyatul Khusna, Mursyidah Lathifatul Kristijono, Ary Kumalasari, Nurul Chamidah Lestari, Nasa Bela Dwi Lintang, Anggun Maida, Margarita Claudya MARTHA, RAHMA DIYAN Mashudi Mashudi Ngibad, Khoirul Nurjanah, Mutia Hariani Parbuntari, Hesty Pratiwi, Putri Indah Putri, Amalia Eka Rahma Diyan Martha Rahmawati, Desti Linda Dwi Rizki Amalia, Laily Safitri, Yunita Diyah Salsabila, Nabila Putri Sandi Mahesa Yudhantara Sari, Trianita Sowe, Momodou Salieu Sulastri Sulastri Susanto, Nindita Clourisa Clourisa Amaris Tilarso, Dara Tilarso, Dara Pranidya Ulayya, Nida Asma Ummah, Ratih Salimil Warni, Tri Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wiwik Handayani