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All Journal Biology, Medicine, & Natural Product Chemistry Media Farmasi Journal of Pharmaceutical and Medicinal Sciences ad-Dawaa : Journal of Pharmaceutical Sciences Wal'afiat Hospital Journal Jurnal Pengabdian Kefarmasian JURNAL KESEHATAN YAMASI MAKASSAR WAL'AFIAT HOSPITAL JOURNAL Media Farmasi Indonesian Journal of Jamu
Muslimin, Lukman
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Evaluasi Penggunaan Antibiotik Pada Pasien Rawat Jalan Infeksi Saluran Kemih Di RS Pendidikan Universitas Hasanuddin Paluseri, Andi; Rosyid, Sujud Zainur; Asriani, Asriani; Muslimin, Lukman; Guntur, Muhammad
Wal'afiat Hospital Journal Vol 3 No 2 (2022): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v3i2.90

Abstract

Infeksi saluran kemih (ISK) bawah seperti uretritis, sistisis, epididimis, prostatitis merupakan inflamasi kandung kemih yang paling sering disebabkan oleh infeksi asenden dari uretra. Tujuan penelitian ini yaitu untuk mengetahui pengobatan apa saja yang diberikan pada pasien ISK dan mengetahui kerasionalan penggunaan antibiotik pada pasien ISK. Penelitian ini dilakukan di Rumah Sakit Pendidikan Universitas Hasanuddin (RSP UNHAS) pada tahun 2021 - 2022. Sampel yang digunakan dalam penelitian ini adalah rekam medik pasien ISK rawat jalan. Penilaian kondisi pasien dilakukan dengan membandingkan data pada literatur Drug Information Handbook edisi 24, Guideline Urological Infections 2015 dan modul penggunaan obat rasional Kemenkes RI 2011. Hasil penelitian menunjukkan bahwa pada pasien ISK bawah paling banyak menderita pada pasien perempuan (57,3%) dibandingkan dengan laki-laki (41,3%). Berdasarkan usia ISK bawah tertinggi terjadi pada kelompok umur 23-78 dibandingkan dengan usia kurang dari 22 tahun. Penggunaan antibiotik rasional sebanyak 70 kasus (92,01%) dan melebihi waktu yang direkomendasikan sebanyak 4 kasus (5,3%). Akan tetapi sebagian besar kasus tidak rasional disebabkan oleh kondisi penyakit pasien yang tidak membaik.
Development and Evaluation of a Stable Topical Cream Formulated with Annona squamosa Seed Extract as a Natural Pediculosis Agent Nur Khairi; Lukman Muslimin; Fhahri Mubarak; Maulita Indrisari; Fajriansyah Fajriansyah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1355-1363

Abstract

Head lice infestation (Pediculosis capitis) remains a global public health concern, exacerbated by growing resistance to conventional pediculicides such as permethrin and malathion. This study aimed to evaluate the pediculicidal activity and formulation stability of a topical cream containing Annona squamosa (sugar apple or srikaya) seed extract as a natural alternative for treating pediculosis. The ethanolic extract of A. squamosa seeds was obtained through maceration, producing a 10.005% yield. Pediculicidal assays were conducted using various extract concentrations (5%, 7.5%, and 10%), followed by formulation of oil-in-water creams with extract concentrations of 7.5%, 10%, and 12.5%. Physical stability tests included assessments of viscosity, pH, spreadability, adhesion, and homogeneity. Results showed a dose–response relationship, with lice mortality increasing from 60% at 5% extract to 87% at 10%. Extract. The formulated creams demonstrated high efficacy—86% to 96% mortality—comparable to 1% permethrin. All formulations maintained acceptable physicochemical properties (pH 4.8–5.5, viscosity within 27,000–47,000 cps) and remained stable after accelerated storage. These findings indicate that A. squamosa seed extract is a potent pediculicidal agent that can be effectively incorporated into a stable topical formulation. The study supports the potential of A. squamosa as a safe, sustainable, and plant-based alternative for managing pediculosis while addressing the challenge of chemical resistance.
Cytotoxic Interaction Between Cisplatin and Eclipta alba Extract in HeLa Cervical Cancer Cells Putri Awaliah Aldina; Surawalia Said; Muhammad Ilham Hamzah; Nur Afiq Zaky Ananda; Fityatun Usman; Zulkifli Zulkifli; Widya Hardiyanti; Nurfadilah Nurfadilah; Andi Ulfah Magefirah; Lukman Lukman
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.449

Abstract

Cervical cancer remains a major cause of cancer-related mortality among women worldwide. Cisplatin is a first-line chemotherapeutic agent, but its use is limited by resistance and dose-dependent toxicity. This study evaluated the cytotoxic interaction between cisplatin and Eclipta alba extract in HeLa cervical cancer cells. Ethanolic maceration yielded 17.38 g of extract, corresponding to 10.22%. Thin-layer chromatographic screening indicated flavonoids, coumarins, and triterpenoid saponins, while LC–MS/MS tentatively identified eclalbasaponin I, wedelolactone, pinoquercetin, luteolin, and quercitrin. Cytotoxicity was assessed using the MTT assay. The IC₅₀ values were 1.15 ± 0.16 µg/mL for cisplatin and 598.29 ± 42.89 µg/mL for the extract. Under fixed sub-IC₅₀ cisplatin conditions, 0.42 µg/mL, the extract IC₅₀ decreased to 64.97 ± 5.41 µg/mL. Combination index values below 1 suggested synergistic interaction under fixed-dose conditions, indicating a potential dose-sparing strategy requiring further validation.
KNOWLEDGE OF DRUG MANAGEMENT OFFICERS AND DRUG AVAILABILITY AT PRIMARY HEALTH CENTERS IN MAKASSAR CITY Andi Paluseri; yuniati; Lukman Lukman
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/e10wv796

Abstract

Adequate drug availability at primary health centers (Puskesmas) is a key indicator of effective drug management and may be influenced by the knowledge of drug management officers. This study aimed to examine the relationship between officers’ knowledge and drug availability at selected Puskesmas in Makassar City. A descriptive analytical observational study with a cross-sectional design was conducted on May 16–17, 2025, at Paccerakkang, Mamajang, Pattingalloang, and Mangasa Puskesmas, which were selected using cluster random sampling. All eligible drug management officers were included through total sampling, resulting in seven respondents. Knowledge was assessed using a 20-item questionnaire with excellent reliability (Cronbach’s alpha = 0.9675), while drug availability was evaluated using 2024 Drug Usage and Request Reports (LPLPO) for 40 indicator drugs. Data were analyzed using the Shapiro–Wilk normality test and Pearson’s correlation test. The mean knowledge score was 90%, categorized as good; six respondents had good knowledge and one had sufficient knowledge. Drug availability varied across facilities: one Puskesmas was categorized as good (69.87%), while three were categorized as sufficient, with an average availability of 46.29%. Pearson’s correlation showed no significant relationship between officers’ knowledge and drug availability (r = -0.853; p = 0.147). These findings suggest that drug availability is likely influenced more by procurement policies, distribution systems, and health budget allocation than by officers’ knowledge alone.
Co-Authors Aksa, Rahmat Ali Djamhuri Andi Paluseri Andi Paluseri Andi Ulfah Magefirah Arisah, Arisah Asriani Asriani, Asriani Astuti Amin aswad, hijral Awaluddin, Akbar Burhanuddin Taebe Dewingsky, Lyevy Djamaluddin, Suci F Fajriansyah Fajriansyah Fhahri Mubarak Fityatun Usman Irwana, Rina Karla Fransiska Khairi, Nur Lestari, Desy Ayu Lyevy Dewingsky Maria Ulfa Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari Maulita Indrisari Maulita Indrisari, Maulita Megawati - Michrun Nisa Muhammad Guntur, Muhammad Muhammad Ilham Hamzah Mus, Suwahyuni Nur Afiq Zaky Ananda Nur Khairi Nur Rahma Rumata Nurfadilah Nurfadilah Nurkhairi Nurkhairi Nurkhairi, Nurkhairi Nursamsiar Nursamsiar Nurul Mufliha, Andi Naura Nurwijayanti paluseri, Andi Putri Awaliah Aldina Reny Syahruni Risfah Yulianty Riska Rahayu Rosyid, Sujud Z Rosyid, Sujud Zainur Sami, Fitriyanti Sitti Rahimah Surawalia Said Suwahyuni Suwahyuni Syamsu Nur, Syamsu Wahyu Hendrarti Widya Hardiyanti yuniati Yuri Pratiwi Utami Zulkifli Halid