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All Journal Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA As-syifaa Jurnal Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) J-ADIMAS (Jurnal Pengabdian kepada Masyarakat) Journal of halal product and research (JHPR) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Kesehatan Rustida Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical Care Anwar Medika Jurnal Ilmiah Medicamento Berkala Ilmiah Kimia Farmasi Berkala Penelitian Hayati Journal of Innovation Research and Knowledge Jurnal Bakti Untuk Negeri Journal of Halal Science and Research Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Camellia Medical Sains : Jurnal Ilmiah Kefarmasian KOPEMAS
Nurrosyidah, Iif Hanifa
3Doctoral Student Of Doctoral Program, Faculty Of Pharmacy, Universitas Of Airlangga, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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THE POTENTIAL OF BLACK CUMIN SEED OIL (Nigella sativa L.) AS A HALAL ANTIBACTERIAL AGENT AGAINST EXTENDED SPECTRUM ?-LACTAMASE (ESBL)-PRODUCING ESCHERICHIA COLI Tomi; Nurrosyidah, Iif Hanifa; Muzzayinah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1706

Abstract

Infectious diseases remain a major issue in tropical countries such as Indonesia. Infectious diseases can be caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi. Development of antibacterial agents from natural sources is essential to combat the growing issue of antibiotic resistance. One potential plant is black cumin seed (Nigella sativa L.) contains thymoquinone, a compound known for its antibacterial properties. In addition to thymoquinone, the essential oil of black cumin contains thymol, carvacrol, and p-cymene, along with metabolites such as alkaloids, saponins, and tannins. This study aimed to investigate the antibacterial activity of black cumin seed oil (Nigella sativa L.) against Extended Spectrum ?-lactamase-producing Escherichia coli (E. coli ESBL). The antibacterial test in this study used the disc diffusion method at various concentrations, including 100%, 75%, 50%, and 25%. The extract was obtained by distillation, using pure water as the solvent. The test groups included a negative control, positive control using chloramphenicol, and negative control using pure water. The results of the antibacterial activity test showed that the positive control produced an average inhibition zone of 25 mm, classified as susceptible, whereas the negative control showed no inhibition zone (0 mm). At 100% concentration, the inhibition zone averaged 18,67 mm, at 75% it averaged 16 mm, at 50% it averaged 11,67 mm, and at 25%, the inhibition zone averaged 6,67 mm. The three lower concentrations were categorized as resistant.  
Formulasi Deterjen Eco-Friendly Ekstrak Etanol Biji Buah Lerak (Sapindus rarak DC) Kombinasi Surfaktan Decyl Glucoside dan Lauryl Glucoside Nurrosyidah, Iif Hanifa; Putri, Erica Novia; Klau, Ivan Charles Seran; Wulandari, Ina; Ramadhan, Arif
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 1 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i1.17955

Abstract

Pendahuluan: Deterjen merupakan limbah rumah tangga yang paling banyak mencemari lingkungan karena kandungan surfaktan turunan sulfonate yang tidak bisa dibiodegradasi. Sehingga diperlukan inovasi detergen ramah lingkungan. Penelitian   ini   bertujuan   untuk   mengembangkan   formula   deterjen   ramah lingkungan yang mengandung ekstrak etanol biji buah lerak (Sapindus rarak DC) kombinasi surfaktan decyl glucoside dan lauryl glucoside. Metode: penelitian meliputi pembuatan deterjen cair menggunakan tiga formula  yaitu FI, FII, dan FIII dengan variasi konsentrasi ektrak etanol biji buah lerak yang digunakan. Hasil: pH detergen adalah 9,92 (F1), 8,9 (F2) dan 7,85 (F3); viskositas sebesar 16,33 mPas (F1), 8,33 mPas (F2) dan 15 mPas (F3); stabilitas busa yaitu diperoleh kisaran 84,09 % - 89,99 %; bobot jenis sebesar 1,027 g/ml (F1),1,025 (F2) dan 1,032 g/ml (F3). Kesimpulan: Hasil penelitian menunjukkan bahwa ketiga formula detergen cair ekstrak biji buah lerak  memenuhi mutu fisik sesuai syarat SNI 06-4075-1996.
Prospects of red passion fruit seeds (Passiflora edulis Sims.) as a source of halal probiotics Nurrosyidah, Iif Hanifa; Mertaniasih, Ni Made; Isnaeni, Isnaeni
Journal of Halal Science and Research Vol. 4 No. 1 (2023): February
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v4i1.7004

Abstract

Indonesia is the most biodiversity country in the world, with a majority Muslim population, so halal issues are a priority. Natural resources are abundant, especially the tropical fruit that Allah SWT bestowed with a wide variety. Red Passion fruit (Passiflora edulis Sims.) is one of the tropical fruits widely consumed because of its delicious taste, rich in vitamins, minerals, and other active ingredients. The research reported that probiotics of Bacillus spp. Isolated from the red passion fruit seeds was proven to inhibit pathogenic microbes. Extended Strain Beta-Lactamase and Methicillin Resistant Staphylococcus aureus. The isolates also showed the ability to increase gamma interferon levels in the peripheral blood mononuclear cells in adult TB patients. Halal critical points for products containing probiotics can derive from raw material sources, especially those from animals. The Red passion fruit is classified as a safe, halal category. The process of isolating probiotics from red passion fruit seeds using fermentation technology in De man Rogose Sharp media, using simple materials, tools, and steps that are guaranteed to be halal. The compatibility of two probiotic isolates is the potential to be developed into a probiotic consortium for health supplement preparations and therapeutic complements.
Patok Paku: Pengembangan Toga dan Pijat Akupresur untuk Upaya Preventif dan Promotif Kesehatan Keluarga Hamsidi, Rini; Nurrosyidah, Iif Hanifa; Latifah, Maasyitoh Sari; Adianti, Myrna; Sumardiko, Dwi Setiani; Puruhito, Edith Frederika; Puspita, Dwi Indah; Zidan, Reza Akni Arifia; N.N, Damayanti; Azzahra, Devita Fitri
Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 3 (2025)
Publisher : FKIP Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36709/amalilmiah.v6i3.473

Abstract

Masyarakat pedesaan Kabupaten Lamongan khususnya di Desa Randubener masih menghadapi tantangan dalam menjaga kesehatan keluarga secara mandiri dikarenakan oleh pemanfaatan potensi lokal seperti Taman Obat Keluarga (TOGA) dan terapi akupresur yang belum optimal. Oleh karena itu, perlu dilakukan penyuluhan, pelatihan dan pembinaan mengenai TOGA dan akupresur agar dapat meningkatkan potensi yang telah dimiliki dalam mengatasi keluhan kesehatan ringan secara preventif dan promotif, serta mudah diterapkan dalam kehidupan sehari-hari. Program PATOK PAKU hadir untuk mengoptimalkan pemanfaatan TOGA dan akupresur melalui pelatihan dan pendampingan intensif kepada kader PKK, kader TOGA, dan warga Randubener dengan pendekatan partisipatif dan berkelanjutan. Hasil kegiatan menunjukkan peningkatan pengetahuan dan keterampilan masyarakat dalam membudidayakan TOGA dan menerapkan teknik dasar akupresur, peningkaatan pengetahuan masyarakat dalam mengaplikasikan TOGA dan metode menanam tanaman obat di rumah. Dengan demikian, program ini menjadi langkah strategis dalam mendorong kemandirian dan keberlanjutan kesehatan keluarga berbasis kearifan lokal.  
PENGARUH SEDUHAN SERBUK SIMPLISIA BUAH TRENGGULI (Cassia Fistula L) TERHADAP GANGGUAN KONSTIPASI PADA REMAJA WANITA Myrna Adianti; Rania Ratri Fauziyah; Nurmawati Fatimah; Iif Hanifa Nurrosyidah; Arifa Mustika; Rini Hamsidi; Dwi Setiani Sumardiko; Edith Frederika Puruhito
Journal of Innovation Research and Knowledge Vol. 5 No. 7 (2025): Desember 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Konstipasi merupakan gangguan yang sering terjadi pada remaja wanita, terutama akibat asupan serat dan cairan yang tidak mencukupi. Penggunaan obat laksatif secara terus-menerus dapat menimbulkan efek samping, sehingga diperlukan alternatif terapi yang lebih aman. Buah trengguli (Cassia fistula L.) diketahui mengandung senyawa antrakuinon yang berpotensi sebagai laksatif alami. Tujuan: Penelitian ini bertujuan untuk mengetahui perbandingan dosis seduhan buah trengguli (Cassia fistula L.) terhadap penanganan konstipasi pada remaja wanita. Metode: Penelitian ini menggunakan pre test post test control goup design dengan tiga kelompok. Dua kelompok perlakuan yang masing-masing menerima dosis berbeda seduhan serbuk simplisia buah trengguli, dan satu kelompok kontrol. Hasil: Hasil penelitian menunjukkan bahwa kedua dosis seduhan serbuk simplisia buah trengguli mampu menurunkan skor CSS secara signifikan pada remaja wanita dengan konstipasi fungsional, dibandingkan dengan kelompok kontrol. Analisis statistik menunjukkan perbedaan bermakna antar kelompok perlakuan dan kontrol (p < 0,05). Kesimpulan: Terdapat perbedaan persentase penurunan skor CSS antara dua dosis seduhan serbuk buah trengguli, meskipun tidak signifikan. Pemberian dosis 1,6 g menurunkan skor CSS sebesar 64%, sedangkan pemberian dosis 0,8 g sebesar 62%.
Uji Stabilitas Fisik Sediaan Sabun Padat Ekstrak Rimpang Temugiring (Curcuma heyneana Valeton & Zijp) Iif Hanifa Nurrosyidah; Milu Asri; Alfian FM
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 16 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v16i2.4505

Abstract

Kulit memiliki peranan yang sangat vital bagi manusia. Kulit berfungsi sebagai barier utama melawan infeksi, paparan zat kimia dan sinar matahari, dan kontaminan fisik lainnya sehingga kotoran akan mudah menempel pada kulit. Oleh karena itu, sangat penting menjaga dan memelihara kebersihan kulit untuk kesehatan. Sabun padat mampu membersihkan kotoran pada kulit. Kelemahan sabun padat yang selama ini beredar di pasaran adalah relatif menyebabkan kulit kering. Ekstrak temugiring (Curcuma heyneana Valeton & Zijp) memiliki aktivitas sebagai antiradikal bebas dan mampu membantu menghaluskan kulit. Oleh karena itu dibutuhkan sebuah formulasi sabun padat yang mampu membersihkan, menghaluskan kulit, dan tidak menyebabkan kulit kering. Tujuan penelitian ini adalah melakukan studi formulasi sabun padat opaque dengan perbedaan konsentrasi ekstrak rimpang temugiring. Berdasarkan hasil penelitian diperoleh pH sabun padat ekstrak rimpang temu giring formula I,II, dan III sebesar 10. Nilai pH sediaan sabun memenuhi persyaratan sesuai literatur yaitu 9-11. Kadar air pada formula I, II, dan III sebesar berturut-turut 14; 14,55; dan 15%. Kadar air sediaan memenuhi persyaratan SNI yaitu tidak lebih dari 15%. Uji stabilitas busa sediaan sabun padat berkisar antara 73–95%. Uji organoleptis sabun padat untuk aroma, warna, dan tekstur serta efek melembabkan untuk formula I, II, dan III memiliki nilai tingkat kesukaan yang sama.
Uji Aktivitas Antioksidan Masker Gel Peel-off Ekstrak Etanol Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dengan Metode DPPH (1,1-Diphenyl-2-picryhydrazyl) Yani Ambari; Syafiatul Fitri; Iif Hanifa Nurrosyidah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 18 No. 01 Juli 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i1.8700

Abstract

Masker gel peel off merupakan kosmetik yang digunakan untuk perawatan kulit wajah berbentuk gel. Masker gel peel off kelopak bunga rosela (Hibiscus sabdarifa L.) mengandung senyawa antosianin yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan masker gel peel off dari ekstrak etanol kelopak bunga rosela dengan metode DPPH. Ekstrak etanol kelopak bunga rosela yang digunakan sebagai bahan aktif pada pembuatan masker gel peel off dengan konsentrasi ekstrak etanol kelopak bunga rosella sebesar 0,5% (F1), 0,7% (F2), dan 1% (F3). Uji aktivitas antioksidan dilakukan dengan menggunakan metode DPPH. Hasil uji aktivitas antioksidan menunjukkan bahwa formula masker gel peel off ekstrak etanol kelopak bunga rosela dapat memberikan aktivitas antioksidan. Aktivitas antioksidan yang paling tinggi adalah masker gel peel off dengan konsentrasi ekstrak etanol kelopak bunga rosela sebesar 1% (F3) dengan nilai IC50 sebesar 22 ppm dan nilai AAI sebesar 4,54. Sedangkan aktivitas antioksidan rendah adalah masker gel peel off dengan konsentrasi ekstrak 0,5% (F1) dengan nilai IC50 sebesar 50,53 ppm dan nilai AAI sebesar 1,97%. Semakin tinggi konsentrasi ekstrak etanol kelopak bunga rosela pada sediaan masker gel peel off maka aktivitas antioksidannya akan semakin kuat.
STUDI ETNOBOTANI TUMBUHAN OBAT BERBASIS PENGETAHUAN LOKAL DI DESA SELOLIMAN KECAMATAN TRAWAS KABUPATEN MOJOKERTO JAWA TIMUR Iif Hanifa Nurrosyidah; Milu Asri Riya; Alfian Fachruddin Ma’ruf
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 3 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i3.101

Abstract

Indonesia is the country with the second largest biodiversity after Brazil, where 20,000 species of medicinal plants in which 1,000 species have been documented and 300 species have been used as traditional medicine. Seloliman is a village located on the slopes of Mount Penanggungan, Trawas District, Mojokerto Regency, East Java. The people of Seloliman village still depend on nature, most people still use natural materials for treatment and daily needs. Therefore in this research ethnobotany study and identification of medicinal plants based on local knowledge will be conducted in Seloliman Village, Trawas District, Mojokerto Regency, East Java. The study was conducted by exploring the potential of the community as a place of ethnobotany research with open observation and interview methods. The technique for selecting informants is based on information from local residents or village heads who are most aware of medicinal plants. Collecting data on medicinal plants used for traditional medicine through structured interviews. Data recorded are local names, Latin names, family names, ways of obtaining, parts of plants used, diseases treated, and how they are used. Furthermore, each type of plant used is documented. Based on the results of research conducted is the type of plant used for treatment varies greatly, the plant parts used are mostly the leaves (57%), flowers (10%), and the rest are the stem, bark, rhizome, roots, flowers, fruit and seeds. Sources of plants used are mostly cultivated plants (46%), wild (30%), wild and cultivated (17%) and bought on the market (7%). While the way to use it is mostly boiled. Most of the Seloliman village community, Trawas Subdistrict, Mojokerto Regency, East Java have been influenced by outside cultures, so that their local knowledge about plants used in medicine needs to be further explored in order to be preserved. There are only two speakers (traditional healers) in the village of Seloliman who still hold the tradition related to treatment using natural materials.
PENGARUH LAMA WAKTU FERMENTASI KOMBUCHA ROSELA (Hibiscus sabdariffa L.) TERHADAP AKTIVITAS ANTIBAKTERI Escherichia coli Adinda Ismu Cholidah; Dwi Danu; Iif Hanifa Nurrosyidah
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 3 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i3.102

Abstract

Roselle flower (Hibiscus sabdarifa L.) is one of the medicinal plants which is often used as traditional medicine. Roselle flower (Hibiscus sabdarifa L.) contains phenolic compounds such as tannins, saponins and flavonoids that are as antibacterial. Roselle flower (Hibiscus sabdarifa L.) can be made as a kombucha tea. Kombucha ia useful as an antibacterial, anticancer, improves liver function, anticholesterol, detoxification, improves the digestive system and maintains stamina. The purpose of this research were to find out the effect of kombucha roselle (Hibiscus sabdarifa L.) fermentation time against antibacterial activity of Escherichia coli. Kombucha roselle made by fermenting roselle stew, starter 10% and sugar 10% for 1 day, 3 days, 5 days, 7 days, 9 days, 11 days, 13 days and 15 days. Then, testing the effectiveness of antibacterial by method Cup-plate technique. The results showed that fermentation of kombucha rosella was able to inhibit the growth of Escherichia coli bacteria with different results according to the length of fermentation time. The results of data analysis using spearman test showed the fermentation time were take effect on e.coli antibacterial activity and continued with Mann Whitney test showed the fermentation of kombucha roselle has a significant inhibitory effect on bacterial growth. The most optimum inhibitory zone in inhibiting Escherichia coli is 15 days fermentation of kombucha roselle for 21,5 mm wich is categorized as very strong antibacterial activity.
FORMULASI DETERJEN RAMAH LINGKUNGAN DENGAN SERBUK SIMPLISIA DAUN WARU (Hibiscus tilliaceus L.) DAN BUAH LERAK (Sapindus rarak DC.) SEBAGAI SURFAKTAN Iif Hanifa Nurrosyidah; Erica Novia Putri; Berlian Adi Satria
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.346

Abstract

The purpose of this study was to develop an environmentally friendly detergent formula containing simplicial powder of hibiscus leaf (Hisbiscus tiliaceus L.) and lerak fruit (Sapindus rerak DC.) and combined with biodegradable surfactants (Decyl Glucoside and Lauryl Glucoside) so that they are easy to biodegrade. The research method includes making liquid detergent using three formulas, namely F I, F II, and F III with variations in the concentration of hibiscus leaf and lerak fruit simplicial powder used. Physical characteristic test of liquid detergent according to the quality requirements of SNI SNI 06-4075-1996 includes organoleptic, pH, foam stability test, and contamination analysis by determining the total plate number (ALT). Based on the results of this study, the three detergent formulas have physical characteristics according to the quality requirements of SNI
Co-Authors Abd Syakur Achmad Toto Poernomo Adinda Ismu Cholidah Alfian Fachruddin Ma’ruf Alfian FM Amriyati Fitriana Kusumastuti Anjani, Helen Silvia Anwari, Farida Aprelita Nurelli Dwiana Arifa Mustika Arista Wahyu Ningsih Arista Wahyu Ningsih Arista Wahyu Ningsih Arlin Oscardini Saputri Asri, Milu Azzahra, Devita Fitri Berlian Adi Satria Butet Sinaga Cholidah, Adinda Ismu Danang Afi Kurniawan Danu, Dwi Dedi Murdiyanto Devi Melinda Hardianti Dian Rahmawaty Dimas Candra Rahmadani Dwi Danu Edith Frederika Puruhito, Edith Frederika Erdina Kusumastuti Erica Novia Putri Fatimah, Nurmawati Hapsari, Fitra Nanda Dwi Hermawati, Retna Hisbiyah, A'yunil Holifah Idha Kusumawati Isnaeni Isnaeni Isnaeni Isnaeni izudin, ikhsan Klau, Ivan Charles Seran Kusumo, Sukarno Tejo Latifah, Maasyitoh Sari Ma’ruf, Alfian Fachruddin Mariana Wahjudi, Mariana Milu Asri Milu Asri Milu Asri Riya Milu Asri Riya Muhammad Ainul Yahya Muzzayinah Myrna Adianti N.N, Damayanti Nanda Rezita Ni Made Mertaniasih Puspita Raras Anindita Puspita, Dwi Indah Putri, Erica Novia Ramadhan, Arif Rania Ratri Fauziyah Regar, Ria Rini Hamsidi Risma Andriani Riya, Milu Asri Saputri, Arlin Oscardini Sela Mustika Sari Sinaga, Butet Sumardiko, Dwi Setiani Syafiatul Fitri Tomi Wulandari, Ina Yahya, Muhammad Ainul Yani Ambari Yani Ambari Zidan, Reza Akni Arifia