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All Journal Jurnal Keteknikan Pertanian Tropis dan Biosistem Biopendix: Jurnal Biologi, Pendidikan dan Terapan Indonesian Biodiversity Journal Abdimas Indonesian Journal Indonesian Biodiversity Journal German für Gesellschaft (J-Gefüge)
Simal, Rufiati
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Analysis Of The Potential Of Natural Sterol Compounds From Tin (Ficus carica) Leaves as Anti-Hypercholesterolemia with In Silico Tests Taihuttu, Monalisa Pertiwi Jeriska; Manurung, Brian Saputra; Simal, Rufiati; Watung, Fernando A.
Indonesian Biodiversity Journal Vol. 6 No. 1 (2025): April 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v6i1.11961

Abstract

This study aims to determine the potential of natural sterol compounds from Tin (Ficus carica) leaves as anticholesterolemic using in silico test. This study employed an in silico approach using molecular docking methods to evaluate the potential of sterol compounds as anti-hypercholesterolemic agents, in comparison to other references compounds. Data processing and interpretation were conducted using molecular databases for both ligands and target proteins. The analysis utilized several computational tools, including PyRx 0.8, PyMOL, LigPlus, and Discovery Studio 2016 Client. The compounds used in this research  were sterol, fluvastatin and simvastatin (as control), with HMG CoA reductase as the target protein. The results showed that the highest binding affinity value was fluvastatin which is -8.3 kcal/mol. Sterol compounds are compounds with lower binding affinity which is -7.7 kcal/mol. From the visualization results, it is known that the binding distance between sterol compounds with target proteins (HMG CoA reductase) is between 2.69 to 5.49 Å, and the binding distance between simvastatin compounds with target proteins (HMG CoA reductase) is between 2.76 to 5.36 Å, and the binding distance between fluvastatin compounds with target proteins (HMG CoA reductase) is between 1.95 to 5.26 Armstrong. While based on the comparison of the binding side of strerol, simvastatin and fluvastatin, it is known that the three compounds have the same site because they bind to the same amino acid residues, namely ARG (B: 515), TYR (A: 533), TYR (B: 533), TYR (B: 517), PRO (A: 511). The results of this research indicate that the natural sterol compounds found in Tin (Ficus carica) leaves have potential as anti-hypercholesterolemic agents, based on reverse docking analysis. These sterol compounds bind to the same active site as the control drugs, simvastatin and fluvastatin, and exhibit comparable binding affinity values
Identification of Types of Ferns (Pteridophyta) in the STKIP Gotong Royong Masohi Environment Elly, Sovian Sesca; Simal, Rufiati
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 13 No 1 (2026): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol13issue1page1-6

Abstract

Ferns (Pteridohyta) are cormophyte plants that have spores and are able to live in varying environmental conditions. The diversity of fern species can be identified through identification activities. Identification is the initial process in classifying a type of plant. Ferns are widely found in the STKIP Gotong Royong Masohi campus environment, but their species are not yet known. Therefore, this study aims to identify the types of ferns in the STKIP Gotong Royong Masohi campus environment. The type of research used is descriptive exploratory with a qualitative approach. This research was conducted in the STKIP Gotong Royong Masohi campus environment in August 2024. This research consists of 4 stages, namely the preparation stage, the sampling stage and the fern type identification stage. Based on the research results, it is known that there are 7 families and 9 types of ferns found in the STKIP Gotong Royong Masohi campus environment, namely Phymatosorus sclopendria, Cristella dentata, Asplenium nidus, Nephrolepis biserrata, Selaginella Sp, Pyrrosia lanceolata, Davallia denticulata, Lygodium flexuosum, and Pteris ensiformis.
Sosialisasi Penyusunan Modul Ajar Bagi Guru Madrasah Ibtidaiyah Rifaiyah Limpung Khusnaini, Mukh; Suryaningrum, Sumarah; Simal, Rufiati; Mautang, Hizkia G.; Kahar, Siti Rahmawati
Abdimas Indonesian Journal Vol. 5 No. 2 (2025)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.v5i2.1049

Abstract

This community service activity was carried out as an effort to improve the professional competence of Madrasah Ibtidaiyah (MI) teachers in developing teaching modules that are in line with the independent curriculum and student needs. The background to this activity stems from the finding that most MI teachers still experience difficulties in understanding the structure and components of teaching modules, especially in designing integrated learning objectives, learning outcomes, and assessments. The focus of this activity is to provide socialization and technical assistance in developing teaching modules based on student characteristics and the local context of the madrasah. The activity implementation method uses a participatory approach through the stages of preparation, implementation of socialization, assistance in the practice of developing teaching modules, and evaluation of the results of the activity. Participants consisted of 23 teachers from MI Rifaiyah Limpung, Limpung District, Batang Regency. The results of the activity showed an increase in teachers' understanding and skills in developing teaching modules that are more systematic and relevant to learning needs. In addition, participants demonstrated high enthusiasm in adapting the format and principles of developing teaching modules in accordance with the curriculum guidelines. Based on the evaluation results, 85% of participants were able to produce teaching module designs that met the criteria for completeness and appropriateness of content. Thus, this socialization activity has proven effective in strengthening the capacity of MI Rifaiyah Limpung teachers in designing innovative and contextual teaching tools, as well as supporting the improvement of the quality of the learning process at the madrasah.
Co-Authors Apituley, Vicktor Henry Rony Baysi, Asmawati Rahma Elly, Sovian Sesca Fernando Andre Watung Ferymon Mahulette, Ferymon Kahar, Siti Rahmawati Karepesina, Fitriah Husna Karuwal, Ritha Khusnaini, Mukh Latumainasse, Anisa Latupeirissa, Louvenska N Latupeirissa, Louvenska Nona Manuhuttu, Debi Lisa Manurung, Brian Saputra Mautang, Hizkia G. Mautang, Hizkia Gymnastic Pattiasina, Eifan Boyke Raharusun, Ayu Ningsih Ratusehaka, Nopri Salmanu, Sriyanti Imelda Aksamina Sangur, Kristin Smith, Alwi Suryaningrum, Sumarah Taihuttu, Monalisa Pertiwi Jeriska Tomasoa, Yellia Tuapattinaya, Prelly M Tuapattinaya, Prelly Marsell Jolanda Warella, Juen Carla