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Association between Body Mass Index and Clinical Features of Fibroadenoma Mammae in Hospitals at Jakarta and Tangerang in 2020-2024 Kasvana, Kasvana; Shalmont, Grace; Drew, Clement; Indarto, Fanny
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1498

Abstract

Background: Fibroadenoma mammae (FAM) is the most common benign breast tumor in women of reproductive age. Although generally non-malignant, its presentation as a palpable lump often causes concern among patients. Several risk factors have been associated with the development and clinical behavior of FAM, including hormonal, genetic, and environmental factors. Among these, body mass index (BMI) has been suggested as a potential modifier of tumor characteristics. However, studies exploring the association between BMI and the clinical presentation of FAM, particularly in the Indonesian population, remain limited. This study aims to evaluate the association between BMI and clinical characteristics of FAM, specifically tumor location, number, and size. Methods: This was an observational analytic study with a cross-sectional design involving 269 female patients diagnosed with FAM at two hospitals in Jakarta and Tangerang, conducted from 2020 to 2024. Inclusion criteria were women with a confirmed diagnosis of FAM based on ultrasound and/or histopathological findings. Clinical characteristics such as tumor location, number, and size were recorded. BMI was classified according to WHO standards. Statistical analysis was performed using the chi-square test, with a significance level set at p 0.05. Data analysis was conducted using SPSS version 24.0.Results: The majority of patients had a normal BMI and were within the productive age range. Most FAM cases presented as solitary tumors smaller than 3 cm located in one breast. A statistically significant association was found between BMI and tumor size (p = 0.0001), with overweight-obese individuals more likely to present with larger tumors. However, no significant association was observed between BMI and either the number or location of tumors (p 0.05).Conclusions: TThis study highlights a significant association between BMI and the size of FAM, suggesting that increased body weight may influence tumor growth. Future research should use prospective study designs that specifically collect and analyze data on potential confounders to determine whether BMI is an independent predictor of FAM size. These findings underline the importance of considering BMI in clinical evaluation and patient counseling.  
Correlation of Blood Glucose Levels, Uric Acid, and Lipid Profile with Hand Grip Strength: The Role of Age as A Control Variable Drew, Clement; Atzmardina, Zita; Santoso, Alexander Halim; Setiawan, Fiona Valencia
MAHESA : Malahayati Health Student Journal Vol 6, No 5 (2026): Volume 6 Nomor 5 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i5.22436

Abstract

ABSTRACT Handgrip strength (HGS) is an essential biomarker of muscle strength and physical health, with links to illnesses like cardiovascular disease, metabolic syndrome, and frailty. It is particularly important in aging populations, where physical strength promotes independence and quality of life. Blood glucose, uric acid, and lipid profiles all impact metabolic health, influencing physical performance. Elevated glucose levels, disturbed uric acid metabolism, and aberrant lipid profiles lead to impaired muscle function and increased cardiovascular risk. When combined with age-related alterations such as sarcopenia and metabolic dysregulation, these markers have an even greater impact on HGS. This study investigates the association between these metabolic markers and HGS, hypothesizing that aberrant profiles are associated with lower HGS, independent of age. This cross-sectional study in West Jakarta included 120 adults tested for handgrip strength, hemoglobin, blood sugar, uric acid, cholesterol, HDL, LDL, triglycerides, and the triglycerides-to-HDL ratio. Results showed positive correlations between HGS and hemoglobin, hematocrit, and blood sugar, highlighting their roles in oxygen transport and energy provision. The triglycerides-to-HDL ratio also correlated positively with HGS, indicating the influence of lipid metabolism on muscle performance. Age showed an inverse correlation with HGS, consistent with sarcopenia. This study examines the relationship between physiological factors and handgrip strength in the elderly, stressing the importance of optimizing hemoglobin, blood sugar, and cholesterol levels. Limitations include a cross-sectional design and gender bias, necessitating a long-term, comprehensive future study. Keywords: Aging, Handgrip Strength, Lipid Profile, Metabolic Health, Sarcopenia.