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All Journal HAYATI Journal of Biosciences Journal of Biomedicine and Translational Research Indonesian Journal of Pharmaceutical Science and Technology PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Rahmasari, Ratika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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In vitro Antiviral Activity of Cat’s Claw (Uncaria tomentosa) bark Extract Against Human Influenza A Virus Makau, Juliann N; Talaam, Keith K; Odiwuor, Mike; Majanja, Janet M; Musenjeri, Sophia; Rahmasari, Ratika; Khamadi, Samoel A; Watanabe, Ken
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Influenza A viruses mutate very fast and this leads to the development of resistance to antivirals, hence the need to find new therapeutics. Due to their extensive traditional use, natural products are crucial resources for the discovery of drugs. Cat’s claw (Uncaria tomentosa), is a tropical vine known for various health benefits and in this study we evaluated its anti-influenza activity. Pulverized material of the stem bark was extracted using 80% ethanol, hot water, and 1% sodium bicarbonate. The extracts were dried and dissolved in dimethylsulfoxide before testing for cytotoxicity and antiviral activity using crystal violet assay. The extracts exhibited antiviral activity with a 50% inhibitory concentration range of 2.3 - 6.2 µg/mL. The 1% sodium bicarbonate extract had the least 50% cytotoxic concentration of 125 µg/mL and was used for further analyses. It was effective against several human influenza A virus strains including an oseltamivir-resistant clinical isolate of the 2009 H1N1 pandemic influenza. Time-of-addition experiments showed significant suppression of virus replication when the virus was pretreated with the extract before infecting to cells and also when the virus and extract were co-administered to the cells; suggesting that the extract was inactivating the virus. Oseltamivir was used as a positive control and only suppressed late stages of virus replication. These results were consistent with the hemagglutination inhibition assay data which showed direct virucidal activity on influenza virus particles. Our data demonstrates possible future use of Cat’s claw in influenza management. However, more investigation is needed to identify the bioactive components.
Pharmacogenomics β-Blockers in Cardiovascular Disease: Implications for Blood Pressure and Clinical Outcomes Zulqifli, Iqbal; Malau, Jekmal; Aditya, Fitra Ari; Nursyafillah, Rizki Noval; Harbulcholizi, Luthfi; Rahmasari, Ratika; Raekiansyah, Muhareva; Hermosaningtyas, Anastasia Aliesa
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.60681

Abstract

Hypertension is a chronic condition that increases the risk of cardiovascular disease and death. β-blockers, including atenolol, metoprolol, bisoprolol, and carvedilol, lower blood pressure by blocking adrenergic receptors. However, variations in response and side effects are often influenced by genetic differences that affect drug metabolism and action. This narrative review analyzes studies published between 2014 and 2024 in PubMed, ScienceDirect, and Google Scholar using keywords related to genetic variation, β-blockers, hypertension, pharmacogenetics, and polymorphisms. Original studies in English, clinical trials on genetic polymorphisms and β-blocker response were included; reviews and incomplete studies were excluded. Clinical outcomes included changes in systolic and diastolic blood pressure, heart rate, hypotension, aortic root z-score, LVOT gradient, NT-proBNP, and premature ventricular contractions, which were associated with polymorphisms in the ADRB1, ADRB2, ACY3, FGD5, SLC4A1, and SLC25A31 genes. Metabolic outcomes, impaired fasting glucose, new-onset diabetes, and melatonin metabolite changes were associated with variants in PRKCB, DPYS, PAH, and PLEKHH2. Most data came from European and North American populations, with limited representation from Asia, limiting generalizability. These findings support the use of pharmacogenomics to personalize β-blocker therapy and improve hypertension management, despite challenges related to high costs, limited infrastructure, the lack of clinical guidelines, and population heterogeneity.
Co-Authors Aditya, Fitra Ari Adrian Hartanto, Adrian Ahsanal Kasasiah Annajla, Fathina Annisa, Syifa Arifianti, Ayun Arifianti, Ayun Erwina Berna Elya Chairunissa, Ananda Hanny Donna Maretta Ariestanti Forestrania, Roshamur Cahya Forestrania, Roshamur Cahyan Hanandi, Sharon Harbulcholizi, Luthfi Herman Suryadi Hermosaningtyas, Anastasia Aliesa Indah Laily Hilmi Jantan, Ibrahim Jekmal Malau Khamadi, Samoel A Kurnia Sari Setio Putri Kurnia Sari Setio Putri, Kurnia Sari Setio Larosa, Febri LS Majanja, Janet M Makau, Juliann N Makau, Juliann Nzembi Marina Ika Irianti Meilani, Nanda Diva Muhareva Raekiansyah Musenjeri, Sophia Nursyafillah, Rizki Noval Odiwuor, Mike Okti Nadia Poetri Putri Mulia, Ocha Rani Sauriasari, Rani RR. Ella Evrita Hestiandari Sari, Rifta Septi, Annisa Frastica Septiarini, Tri Hastuti Siti Rohmah Sutriyo Syahdi, Rezi Riadhi Syamsu Nur, Syamsu Talaam, Keith K Urbaningrum, Lestari Mahardika Watanabe, Ken Wilbert Wylie Zahra, Aliya Azkia Zahro, Aurora Fatimatuz Zulqifli, Iqbal