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All Journal HAYATI Journal of Biosciences Journal of Biomedicine and Translational Research JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Mandala Pharmacon Indonesia Jurnal Abdi Insani Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Rahmasari, Ratika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Public Health Social Sciences

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In vitro Antiviral Activity of Cat’s Claw (Uncaria tomentosa) bark Extract Against Human Influenza A Virus Makau, Juliann N; Talaam, Keith K; Odiwuor, Mike; Majanja, Janet M; Musenjeri, Sophia; Rahmasari, Ratika; Khamadi, Samoel A; Watanabe, Ken
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Influenza A viruses mutate very fast and this leads to the development of resistance to antivirals, hence the need to find new therapeutics. Due to their extensive traditional use, natural products are crucial resources for the discovery of drugs. Cat’s claw (Uncaria tomentosa), is a tropical vine known for various health benefits and in this study we evaluated its anti-influenza activity. Pulverized material of the stem bark was extracted using 80% ethanol, hot water, and 1% sodium bicarbonate. The extracts were dried and dissolved in dimethylsulfoxide before testing for cytotoxicity and antiviral activity using crystal violet assay. The extracts exhibited antiviral activity with a 50% inhibitory concentration range of 2.3 - 6.2 µg/mL. The 1% sodium bicarbonate extract had the least 50% cytotoxic concentration of 125 µg/mL and was used for further analyses. It was effective against several human influenza A virus strains including an oseltamivir-resistant clinical isolate of the 2009 H1N1 pandemic influenza. Time-of-addition experiments showed significant suppression of virus replication when the virus was pretreated with the extract before infecting to cells and also when the virus and extract were co-administered to the cells; suggesting that the extract was inactivating the virus. Oseltamivir was used as a positive control and only suppressed late stages of virus replication. These results were consistent with the hemagglutination inhibition assay data which showed direct virucidal activity on influenza virus particles. Our data demonstrates possible future use of Cat’s claw in influenza management. However, more investigation is needed to identify the bioactive components.
PELATIHAN DAN PENDAMPINGAN PEMBUATAN JAMU KESEHATAN PADA SUKU BADUY DI DESA KENEKES LEUWIDEMAR BANTEN Elya, Berna; Forestrania, Roshamur Cahyan; Rahmasari, Ratika; Andrajati, Retnosari; Nur, Syamsu; Agustiarni, Vitri
Jurnal Abdi Insani Vol 13 No 4 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i4.3725

Abstract

Suku Baduy, yang mendiami Desa Kenekes, Leuwidemar, Banten, memiliki kekayaan tradisi lokal yang salah satunya tercermin dalam pemanfaatan tanaman obat tradisional. Namun, pengetahuan dan teknik pengolahan produk jamu kesehatan tradisional ini masih terbatas. Kegiatan pengabdian masyarakat ini bertujuan untuk memberdayakan Suku Baduy dalam memanfaatkan potensi sumber daya alam lokal suku Baduy melalui pelatihan dan pendampingan yang berfokus pada teknik pembuatan jamu kesehatan yang higienis dan bervariasi. Jamu kesehatan yang dilakukan pelatihan yaitu jamu koneng ayu dan jamu kadeudeuh ti lembur. Metode kegiatan yang dilaksanakan meliputi tiga tahapan yaitu persiapan yang meliputi perizina, penyiapan materi, alat dan bahan, jamu koneng ayu meliputi kunyit, lada kering, asam jawa, gula aren dan air sedangkan kadeudeuh ti lembur menggunakan sereh, jahe emprit, kencur, cengkeh secang, gula aren dan air. Tahap pemberian materi meliputi pentingnya kebersihan, pemilihan bahan baku berkualitas, dan teknik pengolahan yang benar. Praktik langsung, di mana peserta didampingi secara intensif dalam proses pembuatan dan formulasi jamu. Evaluasi kegiatan untuk memastikan keberhasilan program dilihat dari proses diskusi dan nilai pretest dan postest. Hasil yang dicapai menunjukkan adanya peningkatan signifikan dilihat dari nilai pretest 70 dan nilai postest 80. Keberhasilan program ini meliputi sanitasi dan SOP sederhana dalam pembuatan jamu. Masyarakat Baduy mampu menghasilkan produk jamu kesehatan yang lebih terstandar dan dikemas tanpa meninggalkan nilai-nilai tradisi. Pelatihan ini juga berkontribusi pada upaya pelestarian kearifan lokal dalam meracik jamu.
Drug Repurposing for Monkeypox: An Alternative Strategy for Emergency Response Harbulcholizi, Luthfi; Malau, Jekmal; Alfiandri, Ihsan; Zulkifli, Iqbal; Rahmasari, Ratika
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.96215

Abstract

The global monkeypox (MPOX) outbreak, which has resulted in more than 100,000 confirmed cases across over 120 countries, underscores the urgent need for effective therapeutic strategies. MPOX, caused by a virus belonging to the Orthopoxvirus genus, poses significant clinical and public health challenges, particularly in regions with limited healthcare capacity. Although the World Health Organization declared MPOX a Public Health Emergency of International Concern in 2022, no specific antiviral treatment has yet been formally approved. While vaccination remains essential for long-term prevention, its impact is constrained by limited availability and unequal global distribution. Consequently, drug repurposing has emerged as a practical, rapid, and cost-efficient strategy to address immediate therapeutic demands during active outbreaks. This narrative review evaluates key repurposed antiviral agents including tecovirimat, brincidofovir, and cidofovir were originally developed for other Orthopoxvirus infections. A structured literature search using PubMed, ScienceDirect, and Google Scholar (2014–2024) identified studies providing clinically relevant evidence regarding their therapeutic roles in MPOX. Tecovirimat demonstrated consistent potential to improve viral clearance, shorten symptom duration, and reduce severe manifestations. Brincidofovir exhibited a more favorable safety profile, albeit with limited clinical data, whereas cidofovir showed antiviral activity but remains restricted by its nephrotoxicity. Collectively, current evidence suggests that drug repurposing offers a timely and resource-efficient option for managing MPOX and mitigating disease burden while vaccine accessibility continues to vary globally. When integrated with targeted public health interventions, repurposed drugs may serve as a crucial interim strategy to reduce transmission and enhance outbreak response capacity.
Co-Authors Adrian Hartanto, Adrian Agustiarni, Vitri Ahsanal Kasasiah Alfiandri, Ihsan Annajla, Fathina Annisa, Syifa Arifianti, Ayun Arifianti, Ayun Erwina Berna Elya Chairunissa, Ananda Hanny Donna Maretta Ariestanti Forestrania, Roshamur Cahya Forestrania, Roshamur Cahyan Hanandi, Sharon Harbulcholizi, Luthfi Herman Suryadi Hermosaningtyas, Anastasia Aliesa Indah Laily Hilmi Irianti, Marina Ika Jantan, Ibrahim Jekmal Malau Khamadi, Samoel A Kurnia Sari Setio Putri Kurnia Sari Setio Putri, Kurnia Sari Setio Larosa, Febri LS Majanja, Janet M Makau, Juliann N Makau, Juliann Nzembi Meilani, Nanda Diva Muhareva Raekiansyah Musenjeri, Sophia Odiwuor, Mike Okti Nadia Poetri Putri Mulia, Ocha Rani Sauriasari, Rani Retnosari Andrajati RR. Ella Evrita Hestiandari Sari, Rifta Septi, Annisa Frastica Septiarini, Tri Hastuti Siti Rohmah Sutriyo Syahdi, Rezi Riadhi Syamsu Nur, Syamsu Talaam, Keith K Urbaningrum, Lestari Mahardika Watanabe, Ken Wilbert Wylie Zahra, Aliya Azkia Zahro, Aurora Fatimatuz Zulkifli, Iqbal