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All Journal Medical Journal of Indonesia Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Faal Olahraga Indonesia Jurnal Kedokteran Meditek Indonesian Journal of Biomedicine and Clinical Sciences
Santoso, Dewi Irawati Soeria
Departemen Fisiologi Medik, Fakultas Kedokteran, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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Preventive Effect of Exercise on Kidney Fibrotic Pathway in Hypertension Afifah, Farabillah; Dewi Irawati Soeria Santoso
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/532

Abstract

Uncontrolled hypertension can progress to kidney damage characterized by structural and functional changes, ultimately contributing to kidney fibrosis. Although, hypertension can be treated. However, the prevalence of hypertension in Indonesia is increasing. Therefore, proper treatment is necessary. Elevated levels of Transforming Growth Factor-β1 and Connective Tissue Growth Factor are critical factors that are key drivers of fibrogenic pathway. Appropriate exercise can control blood pressure, renal function, and prevent kidney fibrosis due to hypertension by activating the nitric oxide signaling pathway and reducing the regulation of the TGF-β, p-Smad2/3 and CTGF. This study aims to determine the optimal type of exercise to prevent kidney fibrosis caused by hypertension. Articles used are limited to the publication year between 2018 and 2024. We analyzed the role of exercise on kidney fibrotic pathway in hypertension using PRISMA methods from PubMed, ScienceDirect, Scopus, and Google Scholar. We found 7 articles and proved several significant effects of exercise on hypertension subjects. This study summarized that moderate-intensity exercise is more influential in controlling blood pressure and renal function, as well as inhibits kidney fibrosis due to hypertension.
Co-Authors ., William Afifah, Farabillah Ahmad Aulia Ahmad Aulia Jusuf Alfrina Hany Antoni, Marcel Badriul Hegar Bambang Supriyatno Boenyamin, Hafizh Ahmad Djer, Mulyadi Muhammad Evita Karianni Bermanshah Fakhrul Gamal Putra Goenarjo, Roman Ardian Imelda Rosalyn Sianipar Irena Ujianti Isdoni Bustaman Iskandar, Adhi Teguh Perma Jalma, Monica Dwi Jeanne J. Pawitan Joedo Prihartono Kautsar, Ahmad Mailani, Rena Murti, Krishna Aditya Nadjib Advani Naibaho, Fitri Boru Najib Advani Neng Tine Kartinah Almuktabar Nurhadi Ibrahim Nurjati Chairani Siregar Nurul Paramita Patwa Amani, Patwa Prasetyo S. Redjeki Rahmadhany, Anisa Riki Siswandi Rinawati Rohsiswatmo Risma Kerina Kaban, Risma Kerina Rustiana Tasya Ariningpraja Saleha Sungkar Sophie Yolanda Sophie Yolanda Sri Redjeki Suhendro Sutjipto, Fiolita Indranita TATI NURHAYATI Tetty Yuniarti Tetty Yuniati Trinovita Andraini William . Wresti Indriatmi Yvan Vandenplas