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Revitalisasi Kulit dengan Body Scrub Kulit Buah Naga Merah: Dampak Variasi Asam Stearat dan Perbandingan dengan Produk Komersial Suena, Ni Made Dharma Shantini; Juanita, Rr. Asih; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9883

Abstract

The red dragon fruit peel (Hylocereus lemairei (Hook.) Britton & Rose) is rich in antioxidants like vitamins C, E, and A, along with alkaloids, terpenoids, flavonoids, saponins, and tannins, which protect against free radical damage. Despite its benefits, the peel is underused. This study compares the formulation and physical quality of a body scrub made from red dragon fruit peel extract to commercial products. Stearic acid was added to enhance consistency and stability, and commercial products served as benchmarks due to their compliance with physical, microbiological, and chemical standards. Formulations with stearic acid at 5% (F1), 10% (F2), and 15% (F3) were tested for physical quality—organoleptic properties, homogeneity, pH, adhesion, and spreadability—over 63 days as an intermediate time points, at controlled room temperature. Data were analyzed using SPSS Statistics 20 with a 95% confidence level (α = 0.05). Results showed that all formulations maintained a consistent pH of 6 and homogeneity. The adhesion properties were consistent across all formulas, showing no significant difference (p = 0.815; p > 0.05). In contrast, the spreadability exhibited a statistically significant difference between formulas (p = 0.001; p < 0.05). Stability tests revealed no significant differences in physical quality over time, indicating that the formulations remained stable. The body scrub formulated with red dragon fruit peel extract demonstrated stability and quality comparable to commercially available product. This ensures that the active ingredients in the body scrub remain potent, enabling them to effectively deliver their antioxidant properties to the skin.
Efektivitas Stick Herbal Usada Bali sebagai Antioksidan dan Anti-Inflamasi pada Mencit Putih Jantan yang Diinduksi Karagenan Ketut Agus Adrianta; I Putu Werda Bisama; Ni Nyoman Wahyu Udayani; Ni Made Dharma Shantini Suena; Agung Ari Chandra Wibawa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.71522

Abstract

: Inflamasi disebabkan oleh terlepasnya mediator pro inflamasi di dalam tubuh, seperti TNF-α, caspase-3, dan prostaglandin. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antiinflamasi dari stick herbal Usada Bali yang mengandung rimpang kencur, bunga cengkeh, dan daun kelor pada mencit putih jantan yang diinduksi karagenan. Penelitian dilakukan dengan rancangan penelitian eksprimental laboratorium, dimana dalam pengujian antioksidan digunakan penelitian in-vtiro DPPH dengan instrument spektrofotometri UV-Vis, sedangkan pengujian antiinflamasi berupa penelitian in-vivo dengan rancangan randomize pre test and postest with control group design dan menggunakan hewan coba dengan rincian pembagian kelompok sebagai berikut: Kelompok 1 (P1) adalah kelompok perlakuan plasebo, kelompok 2 (P2) adalah kelompok perlakuan yang diberikan natrium diklofenak, kelompok 3 (P3) adalah kelompok perlakuan yang diberikan Stick Herbal Usada Bali. Pengujian antioksidan memberikan hasil bahwa sampel memiliki nilai IC50 82,285 µg/mL dengan kategori (kuat) dan nilai Antioxidant Activity Index 0,469 dengan katagori (sedang). Pengujian antiinflamasi berdasarkan analisis SPSS menunjukkan bahwa terdapat perbedaan bermakna antara kelompok kontrol negatif dengan kelompok perlakuan Stick Herbal Usada Bali dengan nilai p=0,000 (p<0,05), serta tidak terdapat perbedaan bermakna antara kelompok positif dengan kelompok perlakuan Stick Herbal Usada Bali p=0,222 (p>0,05). Efektivitas antioksidan dan antiinflamasi Stick Herbal Usada Bali dipengaruhi oleh senyawa yang terkandung di dalamnya yaitu flavonoid dan saponin yang diketahui memiliki khasiat sebagai antioksidan dan antiinflamasi. Sehingga, dapat disimpulkan bahwa Stick Herbal Usada Bali berpotensi sebagai alternatif terapi antiinflamasi dan memiliki efektivitas sebagai antioksidan.
Formulasi Granul Sarang Walet Putih (Aerodramus fuciphagus) dengan Variasi Kombinasi Maltodextrin dan Povidon Suena, Ni Made Dharma Shantini; Adrianta, Ketut Agus; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1442.836 KB) | DOI: 10.35617/jfionline.v14i2.90

Abstract

Abstract: White swallow nest (SWP) contains Epidermal Growth Factor, which can increase immunity, and glutathione, which functions as an antioxidant. SWP has a high potential to become an antioxidant-rich immunomodulatory drink. Combining maltodextrin and povidone in a granule formula can protect the active substance from heat and maintain the flavor components. However, the wrong concentration can reduce the quality of the resulting granules. This study aims to obtain a combination of maltodextrin and povidone concentrations in SWP granule formulations that produce granules with the best quality and physical stability. The wet granulation method prepared the ten SWP formulas with combined concentrations of maltodextrin-povidone (code: F1 to F10). Evaluation of the physical quality of the granules (organoleptic, pH, soluble time, moisture content, compressibility index, and flow properties) was evaluated on the first, seventh, fourteenth, and twenty-first days. Linear regression is used to create an equation model of the effect of formulation on granule quality parameters. Formula F6 has the lowest compressibility index and the highest flow rate. There was no significant difference for all physical quality parameters of all formulas during storage (p>0.05). The effect of varying concentrations of maltodextrin is inversely proportional to the effect of varying concentrations of povidone on the physical quality of SWP granules. From the research results, it can be concluded that the combination of maltodextrin (5%) and povidone (1%) in F6 produces granules with the best physical quality. All formulas are stable during storage.
Aktivitas Antioksidan Ekstrak Etanol Kulit Biji dan Buah Bakau (Xylocarpus granatum J.Koenig) dengan Metode DPPH dan FRAP Wardani, I Gusti Agung Ayu Kusuma; Adrianta, Ketut Agus; Udayani, Ni Nyoman Wahyu; Fridayana, Ni Luh Gede Erica; Mendra, Ni Nyoman Yudianti; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9426

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Free radical compounds are molecules that possess reactive and unstable properties, which can damage biomolecules by disrupting the integrity of DNA, proteins and lipids. This condition can trigger oxidative stress, which can result in degenerative diseases. Humans require antioxidant intake from external sources when their own endogenous antioxidants are insufficient to counteract free radicals. Previous studies have demonstrated the high antioxidant activity of mangrove seeds. However, the antioxidant potential of mangrove seed coats and fruits remains underexplored, particularly when assessed using the DPPH and FRAP methods. This study aims to evaluate the antioxidant activity of seed coat and fruit extracts of Xylocarpus granatum J. Koenig using the DPPH and FRAP methods. This research is quantitative research with laboratory experimental approach. Antioxidant activity testing using DPPH and FRAP methods. Gallic acid was used as a comparison standard for antioxidant activity. The results obtained from the antioxidant activity testing of the ethanol extracts of seed shell, fruit and gallic acid were IC50 values of 10.83 mg/mL, 4.91 mg/mL and 0,793 mg/mL (DPPH) and RP50 of 4,455.63 mg/mL, 15,556.32 mg/mL and 34.04 mg/mL (FRAP). It is acknowledged that discrepancies in testing methodologies can influence the antioxidant activity of each extract, contingent on the nature of the free radical, the solvent, steric accessibility, and the pH of the medium.
Formulasi dan Evaluasi Mutu Fisik Lip balm dari Ekstrak Kulit Buah Hylocereus lemairei dengan Variasi Konsentrasi Cera Alba Suena, Ni Made Dharma Shantini; Intansari, Ni Putu Ocha Indira; Suradnyana, I Gede Made; Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5583

Abstract

Red dragon fruit skin (Hylocereus lemairei) contains flavonoid compounds (polyphenols), and vitamins C and E which play the main role as antioxidants, so they are good for moisturizing, nourishing, and maintaining skin health. Lip balm is a cosmetic preparation with main components such as waxes, fats, and oils from natural or synthesized extracts to prevent dryness by increasing lip moisture. The stability of preparation is very important in maintaining the physical quality of the preparation until it reaches the consumer. This study aims to determine the concentration of Cera alba as a stiffening agent needed to produce lip balm preparations of red dragon fruit skin extract (Hylocereus lemairei) with good physical quality. The response observed was the physical quality of the lip balm preparation which included organoleptic, homogeneity, pH, adhesion, and mechanical strength of the lip balm. Data analysis was carried out descriptively. This research begins with the extraction process of red dragon fruit skin using an ultrasonic wave-assisted maceration method using 96% ethanol and 1% HCl. In this study, a lip balm formulation was made from red dragon fruit peel extract with various concentrations of Cera alba 5% (F1), 10% (F2), and 15% (F3) as a stiffening agent. The resulting preparations were stored for 28 days, and their physical quality was observed. The results showed that lip balm preparations F3 produced good physical quality of lip balm preparations during storage. Dragon fruit peel extract can be properly formulated using Cera alba at a concentration of 15% to become a lip balm preparation that has high-quality physical characteristics and has the potential to be developed into a cosmetic preparation that is able to maintain skin moisture, especially the lips.
Potensi Tanaman Obat Terhadap Epitelisasi dalam Penyembuhan Luka Bakar Suratmini, Putu Ayu; Wardani, I Gusti Agung Ayu Kusuma; Suena, Ni Made Dharma Shantini
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

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Abstract

Burns are damage to the skin caused by fire, hot water, electricity, chemicals and radiation. In wound healing, epithelialization plays an important role in the regeneration of epithelial cells. Increased epithelialization causes wounds to close faster and improves the wound healing process. Treatment of burns must be done properly so that the healing process is not disturbed and infection is avoided. However, treating wounds using conventional drugs requires relatively more expensive costs, so alternatives are needed in treating burns by utilizing medicinal plants. This article review aims to determine the potential of medicinal plants for epithelialization in healing burns. The method used in this article is a literature review of scientific research journals that have been published from 2011 to July 10, 2021 in the Google Scholar, PubMed, Sciencedirect and Plos One databases. 11 Indonesian and English scientific research journals were obtained, then these journals were screened. From the results of the review of the articles, it was found that several medicinal plants have the potential for epithelialization in healing burns, including: Ampelopsis japonica, Ananas comosus, Anredera cordifolia, Bixa orellana, Carica papaya, Carissa spinarum, Curcuma longa, Phyllanthus niruri, Poincianella pluviosa, Rhaphidophora pinnata, and Solanum tuberosum.
Potensi Tanaman Herbal terhadap Peningkatan Jumlah Fibroblas dalam Penyembuhan Luka Bakar Devi, Putu Ika Divta Candra; Wardani, I Gusti Agung Ayu Kusuma; Suena, Ni Made Dharma Shantini
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

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Abstract

Luka bakar merupakan bentuk kerusakan jaringan yang diakibatkan oleh peristiwa perpindahan panas, yang sumber panasnya dapat bervariasi seperti kontak langsung atau tidak langsung dengan api, listrik, bahan kimia, gesekan atau radiasi. Luka bakar dapat terjadi pada semua kalangan mulai dari anak kecil dan orang tua yang merupakan populasi yang beresiko tinggi untuk mengalami luka bakar. Penyembuhan luka akan melewati beberapa fase yaitu fase haemostasis, fase inflamasi, fase proliferasi, dan fase maturasi Fibroblas sangat penting dalam proses penyembuhan luka. Jumlah fibroblas mengalami peningkatan selama fase proliferasi. Sejumlah studi menunjukkan bahwa tanaman tradisional potensial sebagai agen penyembuhan luka di samping pengobatan medis untuk luka bakar ringan sampai sedang. Review artikel ini bertujuan untuk memberikan informasi mengenai potensi tanaman herbal terhadap peningkatan jumlah fibroblas dalam penyembuhan luka bakar. Review ini menggunakan metode literatur review pada beberapa jurnal penelitian yang telah dipublikasi, digunakan 4 database termasuk Pubmed, Cochrane, Elsivier dan Google Scholar disaring dan dikumpulkan pada tahun 2011-2021 (hingga Juli). Didapatkan bahwa terdapat tanaman herbal beserta senyawa aktifnya yang berpotensi untuk penyembuhan luka bakar dengan meningkatkan jumlah fibroblas yakni Biji Kakao (flavonoid dan prosianidin), Daun Sirih (saponin, tannin, flavonoid), Daun Melati (saponin, tannin, flavonoid), Daun Remek Daging (flavonoid, tannin, saponi, dan fenol), Bij Edamame (isoflavon dan saponin), Daun Lidah Buaya (Acemannan), Daun Kaktus (alkaloid dan flavonoid), Batang Dan Daun Suruhan (flavonoid, alkaloid, tannin dan saponin), Bunga Saffron (Crocin, picrocracin dan safranal), Bunga Delima (tannin), Daun Kelapa Sawit (flavonoid).
Peran Metabolit Sekunder Tumbuhan dalam Pembentukan Kolagen pada Kulit Tikus yang Mengalami Luka Bakar Giri, I Made Deny Sapta; Kusuma Wardani, I Gusti Agung Ayu; Suena, Ni Made Dharma Shantini
Usadha Vol 1 No 1 (2021): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

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Abstract

Luka bakar (Combustio) merupakan sebuah kerusakan atau kehilangan jaringan yang terjadi karena adanya panas (api, cairan/lemak panas, uap panas), radiasi, sengatan listrik dan bahan kimia. Kolagen merupakan protein yang memiliki peranan penting dalam proses penyembuhan luka bakar. Kolagen berfungsi sebagai agen hemostatis, pembentuk matriks ekstraseluler, pembentukan scar, meningkatkan growth factor dan mendorong proses fibroplasia. Senyawa metabolit sekunder tumbuhan merupakan senyawa yang diketahui berfungsi untuk meningkatkan kepadatan kolagen pada kulit tikus yang mengalami luka bakar. Artikel review ini bertujuan untuk membahas peran metbaolit sekunder tumbuhan untuk meningkatkan kepadatan kolagen kulit tikus yang mengalami luka bakar. Metode yang digunakan dalam penelitian ini adalah literatur review yang dipublikasikan di database seperti Google Scholar, PUBMED, NCBI, Research Gate dan Science Direct. Hasil pencarian dan review artikel diperoleh beberapa senyawa yang diketahui berperan dalam meningkatkan kepadatan kolagen kulit tikus yang mengalami luka bakar yaitu senyawa flavonoid, saponin, alkaloid dan tannin.
Tablet Ekstrak Daun Spondias pinnata: Pengaruh Variasi Primojel® dan Maltodekstrin terhadap Karakteristik dan Stabilitas Fisik serta Aktivitas Antioksidan Suena, Ni Made Dharma Shantini; Mayuni, Putri Diah Gita; Dewi, Ni Nyoman Ayu Pramesti; Mendra, Ni Nyoman Yudianti; Rahadi, I Wayan Surya; Wardani, I Gusti Agung Ayu Kusuma
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.12233

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Cemcem leaves (Spondias pinnata) are rich in phenolic and flavonoid compounds with antioxidant potential. However, their traditional beverage form lacks stability, necessitating tablet formulation to improve stability and dosing convenience. This study evaluated the effect of varying concentrations of maltodextrin (binder) and Primojel® (disintegrant) on the physical quality and antioxidant activity of cemcem leaf extract tablets. Prior to formulation, extraction temperature optimization was performed using ultrasonic-assisted maceration at 30°C and 45°C, each for 3 minutes per cycle over three cycles. Three tablet formulations were prepared using optimized extract with different maltodextrin–Primojel® ratios: F1 (3%-8%), F2 (6.5%-5%), and F3 (10%-2%). Granule evaluation included moisture content, flow rate, angle of repose, and compressibility index. Tablets were assessed on days 1, 14, and 28 under room temperature storage for organoleptic properties, weight and size uniformity, hardness, friability, and disintegration time. Data were analyzed using Repeated Measures ANOVA and the Friedman test at a 95% confidence level. Extraction at 30°C yielded superior antioxidant activity, with lower IC₅₀ values and higher total flavonoid content and was therefore selected for formulation. All granules met physical quality standards; however, among tablet parameters, only disintegration time complied with pharmacopeial requirements. Formula F3, containing the highest maltodextrin concentration (10%) and lowest Primojel® concentration (2%), demonstrated the best physical stability from day 1 to day 28 (p > 0.05) and the strongest antioxidant activity, with the lowest IC₅₀ value (23.88 µg/mL; AAI 1.68). These findings confirm a causal relationship between excipient concentration and tablet performance, supporting F3 as a promising prototype for antioxidant supplement development.
Transfer knowledge teknologi formulasi granul untuk diversifikasi produk pengusaha sarang walet Suena, Ni Made Dharma Shantini; Juliadi, Debby; Suradnyana, I Gede Made; Antari, Ni Putu Udayana; Adrianta, Ketut Agus
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 6 No 2 (2023)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v6i2.19396

Abstract

Mitra program pengabdian kepada masyarakat ini adalah termasuk dalam kategori masyarakat yang bergerak ke arah ekonomi produktif yang melakukan usaha pengolahan sarang walet berupa jelly konsentrat sarang walet dalam skala industri rumah tangga dengan Merk “Maha Birdnest Bali” yang berlokasi di Denpasar, Bali. Mitra memiliki ternakan sarang walet di daerah Banggai-Sulawesi Tengah. Program pengabdian dengan metode Service Learning ini dirancang untuk memberikan manfaat kepada mitra dalam usahanya memasarkan produk olahan sarang walet dengan menginovasikannya menjadi bentuk granul sarang walet (GSW) yang memiliki ketahanan lebih lama, serta lebih nyaman dan praktis baik saat didistribusikan maupun saat dikonsumsi oleh konsumen. Pelaksanaan program pengabdian berupa transfer knowledge produksi GSW dan pendampingan produksi kepada mitra, serta penyediaan video tutorial produksi GSW bagi mitra. Program pengabdian ini memberikan manfaat nyata bagi peningkatan mutu produk Mitra, dari sisi inovasi bentuk dan rasa, peningkatan ketahanan, dan berpeluang besar meningkatkan omset dan produktivitas mitra. Program pengabdian berencana akan dilanjutkan berupa workshop atau pelatihan produksi GSW dan pengendalian-penjaminan mutu (quality control-quality assurance) bagi tenaga produksi untuk dapat terus menerus memproduksi produk yang berkualitas di tempat usaha mitra.