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All Journal E-Jurnal Medika Udayana Jurnal Administrasi Kesehatan Indonesia AJIE (Asian Journal of Innovation and Entrepreneurship) Majalah Obat Tradisional Ngayah: Majalah Aplikasi IPTEKS Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Jurnal Ilmiah Medicamento Poltekita: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Emasains : Jurnal Edukasi Matematika dan Sains Jurnal Farmasi Indonesia Usadha JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Parapemikir Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia UNBI Mengabdi
Ni Made Dharma Shantini Suena
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Bilimbi (Averrhoa bilimbi L.) Leaf Extract Cream: Formulation and Efficacy in Accelerating Wound Healing in Male White Mice Suena, Ni Made Dharma Shantini; Nayaka, Ni Made Dwi Mara Widyani; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bilimbi (Averrhoa bilimbi L.) is known for its wound-healing potential due to its flavonoids, saponins, triterpenoids, and tannins. This study aims to develop a practical and stable dosage form of Bilimbi leaf extract, specifically a cream, and evaluate its efficacy as a wound-healing agent. Bilimbi leaf extract at 2% concentration was formulated into a cream with two variations of triethanolamine concentration as an emulsifier, F1 (2%) and F2 (4%). Data were collected through observation and measurement scales during the cream formulation stage. The effectiveness of the cream as a cut wound healer was assessed using a randomized control group pre-test and post-test design. Physical properties, including organoleptic properties, homogeneity, pH, and mechanical stability, were observed, and spreadability was measured. Both formulations met the criteria for creams with good physical quality and effectively reduced the wound length to 0 cm within the 7-day observation period. In contrast, in the control group, wounds still appeared to be 0.4-1 cm in size. In conclusion, the findings in this study indicate that the cream containing 2% Bilimbi leaf extract (Averrhoa bilimbi L.) has favorable physical characteristics and effectively heals incision wounds in male white mice. This formulation shows promise for further development regarding efficacy, safety, stability, and market acceptability.
Formulasi dan Identifikasi Senyawa Minyak Atsiri Citrus hystrix DC. dengan GC-MS untuk Aktivitas Repelan terhadap Nyamuk Aedes aegypti Juliadi, Debby; Cahyaningsih, Erna; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11352

Abstract

Plant-based mosquito control offers a promising alternative to reduce the health and environmental risks associated with chemical insecticides. Citrus hystrix DC. (kaffir lime), a member of the Citrus genus, produces essential oils rich in bioactive compounds such as limonene, citronellal, and terpinolene, which are known for antimicrobial and insecticidal properties. This study focused on extracting essential oil from kaffir lime fruit, identifying its chemical constituents using gas chromatography–mass spectrometry (GC-MS), and evaluating the repellent efficacy of its spray formulation against Aedes aegypti. Essential oil was obtained through steam distillation and analyzed by GC-MS to determine its chemical profile. Repellent activity was assessed experimentally using 100 adult mosquitoes divided into five treatment groups, with spray formulations prepared at concentrations of 5%, 10%, and 15%. Data was analyzed using one-way ANOVA followed by post-hoc tests. GC-MS analysis revealed 90 compounds, with five major constituents: D-limonene (14.57%), limonene (13.92%), citronellal (6.66%), terpinolene (6.47%), and α-terpineol (5.74%). Repellent testing demonstrated that the 15% concentration provided the highest protection against mosquito landings. These findings confirm the potential of kaffir lime essential oil as an effective natural mosquito repellent and provide a scientific basis for developing eco-friendly, plant-derived vector control products. This research contributes to reducing dependence on synthetic insecticides and supports sustainable strategies for vector management that prioritize human health and environmental safety.
Chemical and DPPH Free Radical Scavenging Stability of Avocado Seed Acetone Extract Against pH Changes Suradnyana, I Gede Made; Juliadi, Debby; Mendra, Ni Nyoman Yudianti; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12213

Abstract

Background: Avocado seeds contain phenol, flavonoid, and anthocyanidin compounds that have antioxidant activity. The stability of phenolic compounds depends on the pH of the solution. A decrease in total phenolic levels causes a decrease in antioxidant activity. The chemical stability and DPPH free radical scavenging activity of avocado seed extract against pH are not yet known.Objective: This study aimed to determine the effect of pH on the chemical stability and DPPH free radical scavenging activity of avocado seed extract.Methods: Chemical stability was observed from changes in total phenolic levels, and stability of DPPH free radical scavenging activity was observed from the difference in the percentage of DPPH reduction of the extract solution in phosphate-citrate buffer at pH 3.24, 5.52, and 7.44 before and after being heated at 60°C for 2 hours.Results: The average decrease in total phenolic levels of the extract in buffer pH 3.24, 5.52, and 7.44 before and after being heated was 5.76%, 3.89%, and 22.08%, respectively. The decrease in DPPH free radical scavenging activity of the extract in buffer pH 3.24, 5.52, and 7.44 before and after heating was 24.78%, 1.96%, and 56.09%, respectively. There is a significant difference in the total phenolic content and DPPH free radical scavenging activity of the acetone extract solution in phosphate–citrate buffer at pH 3.24 and 7.44 before and after heating, but there is no significant difference at pH 5.52.Conclusion: Therefore, in the development of formulations containing acetone extract of avocado seeds, buffering at a pH close to 5.22 is required.
Anti-Aging Efficacy of Mangrove Leaf Extract Cream Assessed by SPF and Collagen Density Enhancement: In Vitro and In Vivo Approaches Wardani, I Gusti Agung Ayu Kusuma; Adrianta, Ketut Agus; Udayani, Ni Nyoman Wahyu; Amaral, Meriana Barreto; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13138

Abstract

Background: Excessive ultraviolet (UV) exposure is a major contributor to skin photoaging through oxidative stress, inflammation, and collagen degradation. Mangrove leaf extract (Xylocarpus granatum J. Koenig) contains bioactive compounds with potential photoprotective properties. In this study, the extract was formulated into an oil-in-water (O/W) cream suitable for cosmetic applications.Objective: This study aimed to determine the in vitro sun protection factor (SPF), percentage of erythema transmission (%Te), and percentage of pigmentation transmission (%Tp) of the mangrove leaf extract cream, and to evaluate its effectiveness on UVB-exposed guinea pig skin using collagen density as an anti-aging biomarker.Methods: In vitro assessments of SPF, %Te, and %Tp were performed using UV–Vis spectrophotometry. In vivo evaluation was conducted using 20 guinea pigs to examine the effect of the cream on collagen density through histopathological analysis of UVB-exposed skin.Results: The mangrove leaf extract cream exhibited strong photoprotective activity, with SPF values ranging from 20.68 ± 0.51 to 33.70 ± 0.67, %Te values from 3.13 ± 0.08 to 1.75 ± 0.03, and %Tp values from 4.40 ± 0.12 to 3.31 ± 0.03. Furthermore, the cream significantly increased collagen density (71.77 ± 5.27–81.02 ± 0.96) compared with the positive control (52.16 ± 2.32) (p < 0.05).Conclusions: The mangrove leaf extract cream provides effective protection against UVB radiation, characterized by high-protection SPF, extra-protection %Te, and sunblock-level %Tp. The 5% formulation significantly enhanced collagen density, supporting its potential as a natural anti-aging active ingredient for photoaging prevention through improved UV protection and dermal structure.
Erratum to: In-use Stability of Hydrocortisone Injection Preparations at a Regional Referral Hospital in Central Java Genatrika, Erza; Sundhani, Elza; Adriana, Eka Fitri; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13794

Abstract

Erratum to: Jurnal Ilmiah Medicamento 2025; 11(2): 185-192 DOI original article: https://doi.org/10.36733/medicamento.v11i2.11538 After the publication of this article, errors were identified in the in-text citation, in Tables 2, 3, and 4, and in the reference list. The publisher wishes to apologize for any inconvenience this may have caused.
Formulasi Masker Peel Off Ekstrak Buah Naga Merah (Hylocereus lemairei Hook.) dan Pati Jagung dengan Variasi Konsentrasi Polyvinyl Alcohol (PVA) Ni Made Dharma Shantini Suena; I Gusti Agung Ayu Kusuma Wardani; Ni Putu Udayana Antari
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.3576

Abstract

Red dragon fruit is rich in nutrients and minerals as well as phytoalbumin and antioxidant compounds such as phenolic compounds and vitamin C. Corn contains vitamins A, B, and E as antioxidants, as well as Thiamin, which can reduce black spots on acne scars and dry out wounds. Peel-off masks are cosmetic preparations for facial care that can form a thin, transparent layer on the surface of the skin and can be peeled off after drying, so they are practical to use. Polyvinyl alcohol (PVA) is a film-forming polymer and can increase viscosity, which in turn plays a role in producing peel-off masks that have good physical quality. This study aims to formulate peel-off masks of red dragon fruit extract (Hylocereus lemairei Hook.) and corn starch with varying concentrations of PVA (F1:2.5%, F2:8.75%, F3:17.5%) in order to have a high-quality good physique. The evaluation of the physical quality of the red dragon fruit and corn starch peel-off masks was organoleptic, homogeneity, pH, spreadability, adhesion, and drying time. The organoleptic preparations (F1-F3) were brownish-orange in color, with a distinctive rose odor, with increased viscosity from F1 to F3, and remained stable for up to 4 weeks of storage. The homogeneity of preparation (F1-F3) was homogeneous and lasted for 4 weeks of storage. The pH value of the preparation on day 1, F1 and F2, had a pH of 4, and F3 had a pH of 4.5. From the 1st to the 4th week, the pH of preparations F1-F3 was 4.5, according to the physiological pH of the skin, 4-8. The spreadability of F1-F3 preparations was in the 5.5-6.5 cm range, according to 5-7 cm provisions. The adhesive power of the F1-F3 preparations was in the range of 5.29-40.1 seconds, which is recommended for more than 1 second. The drying time of F1-F3 preparations was in the range of 20.58-30.45 minutes, according to the provisions of 15-30 minutes. The three red dragon fruit and corn starch peel-off mask formulas (F1, F2, and F3) meet the requirements for good physical quality according to the criteria set and recommended. Increasing the PVA concentration did not affect the pH value and spreadability of the three formulas but increased the adhesiveness value and drying time.
Efektivitas Stick Herbal Usada Bali sebagai Antioksidan dan Anti-Inflamasi pada Mencit Putih Jantan yang Diinduksi Karagenan Adrianta, Ketut Agus; Bisama, I Putu Werda; Udayani, Ni Nyoman Wahyu; Suena, Ni Made Dharma Shantini; Wibawa, Agung Ari Chandra
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.71522

Abstract

: Inflamasi disebabkan oleh terlepasnya mediator pro inflamasi di dalam tubuh, seperti TNF-α, caspase-3, dan prostaglandin. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan antiinflamasi dari stick herbal Usada Bali yang mengandung rimpang kencur, bunga cengkeh, dan daun kelor pada mencit putih jantan yang diinduksi karagenan. Penelitian dilakukan dengan rancangan penelitian eksprimental laboratorium, dimana dalam pengujian antioksidan digunakan penelitian in-vtiro DPPH dengan instrument spektrofotometri UV-Vis, sedangkan pengujian antiinflamasi berupa penelitian in-vivo dengan rancangan randomize pre test and postest with control group design dan menggunakan hewan coba dengan rincian pembagian kelompok sebagai berikut: Kelompok 1 (P1) adalah kelompok perlakuan plasebo, kelompok 2 (P2) adalah kelompok perlakuan yang diberikan natrium diklofenak, kelompok 3 (P3) adalah kelompok perlakuan yang diberikan Stick Herbal Usada Bali. Pengujian antioksidan memberikan hasil bahwa sampel memiliki nilai IC50 82,285 µg/mL dengan kategori (kuat) dan nilai Antioxidant Activity Index 0,469 dengan katagori (sedang). Pengujian antiinflamasi berdasarkan analisis SPSS menunjukkan bahwa terdapat perbedaan bermakna antara kelompok kontrol negatif dengan kelompok perlakuan Stick Herbal Usada Bali dengan nilai p=0,000 (p<0,05), serta tidak terdapat perbedaan bermakna antara kelompok positif dengan kelompok perlakuan Stick Herbal Usada Bali p=0,222 (p>0,05). Efektivitas antioksidan dan antiinflamasi Stick Herbal Usada Bali dipengaruhi oleh senyawa yang terkandung di dalamnya yaitu flavonoid dan saponin yang diketahui memiliki khasiat sebagai antioksidan dan antiinflamasi. Sehingga, dapat disimpulkan bahwa Stick Herbal Usada Bali berpotensi sebagai alternatif terapi antiinflamasi dan memiliki efektivitas sebagai antioksidan.
Co-Authors Achmad Fudholi Achmad Fudholi Adriana, Eka Fitri Agung Ari Chandra Wibawa Agustini, Ni Putu Dewi Alfiana Naili Syirvia Amaral, Meriana Barreto Ariawa, Dewi Ariawa, Dewi Cahayani Astya Putri, Ni Kadek Dita Berata, Putu Febryana Suryaputri Bisama, I Putu Werda Debby Juliadi Devi, Putu Ika Divta Candra Dewa Ayu Made Adnya Swari Dewa Ayu Putu Satrya Dewi Dewi, Ni Nyoman Ayu Pramesti Erna Cahyaningsih Fitria Megawati Fridayana, Ni Luh Gede Erica Genatrika, Erza Giri, I Made Deny Sapta Herleeyana Meriyani I Gede Made Suradnyana I Gede Made Suradnyana Suradnyana I Gede Made Surdanyana I Gede Wayan Sujarna I Kadek Wirata I Putu Tangkas Suwantara Intansari, Ni Putu Ocha Indira Ketut Agus Adrianta Kusuma Wardani, I Gusti Agung Ayu Manik Suka Dewi Yani Ni Komang Maria Daniela Tupa Hokor Mayun Anak Agung Istri Mayuni, Putri Diah Gita Megawati, Fitria Mendra, Ni Nyoman Yudianti Meriyani, Herleeyana Ni Kadek Putri Krismawati Ni Ketut Karmini Sari Ni Luh Damayanti Ni Luh Wayan Mudia Ariani Ni Made Dwi Mara Widyani Nayaka Ni Nyoman Wahyu Udayani Ni Putu Dewi Agustini Ni Putu Udayana Antari Ni Wayan Ratih Purnama Sari Nurul Fatoni Nyoman Budiartha Siada Putu Eka Arimbawa Putu Era Sandhi Kusuma Yuda Rahadi, I Wayan Surya RR. Asih Juanita Satibi Satibi Satibi Satibi Sundhani, Elza Suradnyana, I Gede Made Suratmini, Putu Ayu Syirvia, Alfiana Naili Wardani, I Gusti Agung Ayu Kusuma Wintariani, Ni Putu Wirata, I Kadek Wirdana, Ni Putu Ria Agusthya Arya Yani Ambari Yeni Cendana