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Penggunaan Antibiotik untuk Penanganan Ulkus dan Gangren Diabetikum Pasien Rawat Inap di Rumah Sakit Riyan Stiyanto; Iin Suhesti
Journal of Pharmascience Vol. 7 No. 2 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i2.8578

Penyakit Diabetes melitus yang tidak dikelola dengan baik dapat menyebabkan komplikasi dan membahayakan kehidupan pengidapnya. Salah satu komplikasi diabetik yang sering terjadi adalah neuropati (kerusakan syaraf) di kaki yang menyebabkan ulkus kaki, infeksi, dan bahkan keharusan untuk amputasi kaki. Penelitian ini bertujuan untuk mengidentifikasi persentase penggunaan antibiotika empiris yang rasional serta pengaruhnya terhadap outcome terapi pada pasien Diabetes melitus dengan ulkus dan gangren di RSUD Dr Moewardi Surakarta dan RSUD Bagas Waras Klaten. Penelitian ini merupakan penelitian observasional dengan pengambilan data pada penelitian dilakukan secara retrospektif dan prospektif selama periode Januari sampai Agustus 2018. Ketidakrasionalan penggunaan antibiotika empiris dievaluasi dengan metode Gyssens. Sebanyak 36 pasien yang memenuhi kriteria inklusi 75% pasien mendapatkan terapi antibiotika empiris yang rasional dan 25% pasien mendapatkan terapi antibiotika empiris yang tidak rasional. Uji Chi Square dengan taraf kepercayaan 5% (p < 0,05) digunakan untuk membandingkan rasionalitas pengunaan antibiotika terhadap outcome terapi. Hasil Fisherâ€™s Exact Test (Two Tailed) menunjukkan bahwa ada hubungan/pengaruh antara rasionalitas penggunaan antibiotika empiris dengan outcome terapi tetapi pemberian antibiotika empiris tidak berpengaruh pada angka leukosit bagi pasien, baik di RSUD Bagas Waras Klaten maupun RSUD dr. Moewardi Surakarta.Diabetes mellitus that is not managed properly can cause complications to endanger life. One of the diabetic complications that often occurs is foot neuropathy (nerve damage) inducing foot ulcers, infections, and even the necessity for a leg amputation. This study aims to determine the percentage of rational use of empirical antibiotics and their effects on outcomes therapy of diabetes mellitus patient with ulcers and gangrene in RSUD dr. Moewardi Hospital Surakarta and Bagas Waras Hospital Klaten. This study is an observational study with data collection in the study carried out retrospectively and prospectively from January to August 2018. The irrationality of using empirical antibiotics evaluated by the Gyssens method. Thirty six patients were enrolled and 75% of them treated with rational and empirical antibiotic therapy,. Chi-Square Test with a confidence level of 5% (p <0.05) used to compare the rationality of antibiotic use to the therapeutic outcome, the results of the Fisher Exact Test (Two-Tailed) indicated that there were relationship/influence between the rationality of using empirical antibiotics and outcomes therapy, but there was no influence between the rationality of using empirical antibiotics and leucocyte both in RSUD Bagas Waras Klaten and RSUD dr. Moewardi Surakarta.Keywords: Diabetes mellitus, therapeutic outcome, empirical antibiotic rationality

Formulation and Physical Stability Testing of Exfoliating Gel and Moisturizing Gel From Sugarcane Bagasse Extract Iin Suhesti; Ester Dwi Antari; Syafa Chasna Nasrina; Marzela Pancaya Putra
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.397

Sugarcane bagasse extract (Saccharum officinarum Linn.) has high antioxidant activity due to its phenolic compounds, which are beneficial for moisturizing dry skin, smoothing the skin, and combating free radicals. This study aimed to evaluate the physical stability of exfoliating and moisturizing gel formulations containing sugarcane bagasse extract at concentrations of 1%, 3%, and 5% using the cycling test method over six cycles (12 days) at temperatures of ±4°C and ±40°C. Parameters tested included organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesiveness. The results showed that the formulations without extract (control) and those with 1% extract concentration met the physical stability parameters and remained stable throughout the cycling test, with viscosity ranging from 13,665.7 to 20,180.6 cPs, pH between 4.76 and 5.43, spreadability from 3.25 to 5.64 cm, and adhesiveness from 0.42 to 1.52 seconds. In contrast, formulations with 3% and 5% extract concentrations exhibited physical instability, such as changes in pH, viscosity, and spreadability, failing to pass the stability test cycles.

Formulation and Physical Stability Testing of Exfoliating Gel and Moisturizing Gel From Sugarcane Bagasse Extract Iin Suhesti; Ester Dwi Antari; Syafa Chasna Nasrina; Marzela Pancaya Putra
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.397

Sugarcane bagasse extract (Saccharum officinarum Linn.) has high antioxidant activity due to its phenolic compounds, which are beneficial for moisturizing dry skin, smoothing the skin, and combating free radicals. This study aimed to evaluate the physical stability of exfoliating and moisturizing gel formulations containing sugarcane bagasse extract at concentrations of 1%, 3%, and 5% using the cycling test method over six cycles (12 days) at temperatures of ±4°C and ±40°C. Parameters tested included organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesiveness. The results showed that the formulations without extract (control) and those with 1% extract concentration met the physical stability parameters and remained stable throughout the cycling test, with viscosity ranging from 13,665.7 to 20,180.6 cPs, pH between 4.76 and 5.43, spreadability from 3.25 to 5.64 cm, and adhesiveness from 0.42 to 1.52 seconds. In contrast, formulations with 3% and 5% extract concentrations exhibited physical instability, such as changes in pH, viscosity, and spreadability, failing to pass the stability test cycles.

Formulation and Physical Stability Testing of Exfoliating Gel and Moisturizing Gel From Sugarcane Bagasse Extract Iin Suhesti; Ester Dwi Antari; Syafa Chasna Nasrina; Marzela Pancaya Putra
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.397

Sugarcane bagasse extract (Saccharum officinarum Linn.) has high antioxidant activity due to its phenolic compounds, which are beneficial for moisturizing dry skin, smoothing the skin, and combating free radicals. This study aimed to evaluate the physical stability of exfoliating and moisturizing gel formulations containing sugarcane bagasse extract at concentrations of 1%, 3%, and 5% using the cycling test method over six cycles (12 days) at temperatures of ±4°C and ±40°C. Parameters tested included organoleptic properties, homogeneity, pH, viscosity, spreadability, and adhesiveness. The results showed that the formulations without extract (control) and those with 1% extract concentration met the physical stability parameters and remained stable throughout the cycling test, with viscosity ranging from 13,665.7 to 20,180.6 cPs, pH between 4.76 and 5.43, spreadability from 3.25 to 5.64 cm, and adhesiveness from 0.42 to 1.52 seconds. In contrast, formulations with 3% and 5% extract concentrations exhibited physical instability, such as changes in pH, viscosity, and spreadability, failing to pass the stability test cycles.

The Effect of Varying Concentrations of Mugwort Leaf Extract (Artemisia vulgaris L.) on SPF and Cream Physical Stability Umi Nafisah; Adeta Selvia Devi; Iin Suhesti
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.793

Mugwort (Artemisia vulgaris L.) has antioxidant activity that can neutralize free radicals on the skin and also has sunscreen activity to protect the skin from UV exposure. This study highlights the benefits of the mugwort plant, which are currently unknown to the general public, requiring investigation into the formulation of its topical cream. This research aims to determine the stability of mugwort leaf extract cream and its SPF value. The extraction process uses the maceration method with 96% ethanol as the solvent. This study employed variations in mugwort leaf extract concentrations across formulas, starting from the control at 0% extract and increasing to 0.5%, 1%, 1.5%, and 2%. The organoleptic test results of the cream in the control formula showed a white color and green color in F1 to F4, with a characteristic smell and a semi-solid texture. The physical quality test for homogeneity indicates that all formulas are homogeneous. The pH test results of the formulation obtained values of 4,74-5,49, which meet the skin pH standard. The spreadability results obtained values of 6,15-6,38 cm. The cream's viscosity was in the range of 4,870-4,950 cPs. The hedonic test results showed that panelists preferred F1 with an extract concentration of 0.5%. The SPF test yielded scores ranging from 6,45 to 14,71. All formulations were able to preserve the physical quality stability of the preparations, according to the findings of the stability test conducted using the cycling test.

The Effect of Varying Concentrations of Mugwort Leaf Extract (Artemisia vulgaris L.) on SPF and Cream Physical Stability Umi Nafisah; Adeta Selvia Devi; Iin Suhesti
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.793

Mugwort (Artemisia vulgaris L.) has antioxidant activity that can neutralize free radicals on the skin and also has sunscreen activity to protect the skin from UV exposure. This study highlights the benefits of the mugwort plant, which are currently unknown to the general public, requiring investigation into the formulation of its topical cream. This research aims to determine the stability of mugwort leaf extract cream and its SPF value. The extraction process uses the maceration method with 96% ethanol as the solvent. This study employed variations in mugwort leaf extract concentrations across formulas, starting from the control at 0% extract and increasing to 0.5%, 1%, 1.5%, and 2%. The organoleptic test results of the cream in the control formula showed a white color and green color in F1 to F4, with a characteristic smell and a semi-solid texture. The physical quality test for homogeneity indicates that all formulas are homogeneous. The pH test results of the formulation obtained values of 4,74-5,49, which meet the skin pH standard. The spreadability results obtained values of 6,15-6,38 cm. The cream's viscosity was in the range of 4,870-4,950 cPs. The hedonic test results showed that panelists preferred F1 with an extract concentration of 0.5%. The SPF test yielded scores ranging from 6,45 to 14,71. All formulations were able to preserve the physical quality stability of the preparations, according to the findings of the stability test conducted using the cycling test.

The Effect of Varying Concentrations of Mugwort Leaf Extract (Artemisia vulgaris L.) on SPF and Cream Physical Stability Umi Nafisah; Adeta Selvia Devi; Iin Suhesti
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.793

Mugwort (Artemisia vulgaris L.) has antioxidant activity that can neutralize free radicals on the skin and also has sunscreen activity to protect the skin from UV exposure. This study highlights the benefits of the mugwort plant, which are currently unknown to the general public, requiring investigation into the formulation of its topical cream. This research aims to determine the stability of mugwort leaf extract cream and its SPF value. The extraction process uses the maceration method with 96% ethanol as the solvent. This study employed variations in mugwort leaf extract concentrations across formulas, starting from the control at 0% extract and increasing to 0.5%, 1%, 1.5%, and 2%. The organoleptic test results of the cream in the control formula showed a white color and green color in F1 to F4, with a characteristic smell and a semi-solid texture. The physical quality test for homogeneity indicates that all formulas are homogeneous. The pH test results of the formulation obtained values of 4,74-5,49, which meet the skin pH standard. The spreadability results obtained values of 6,15-6,38 cm. The cream's viscosity was in the range of 4,870-4,950 cPs. The hedonic test results showed that panelists preferred F1 with an extract concentration of 0.5%. The SPF test yielded scores ranging from 6,45 to 14,71. All formulations were able to preserve the physical quality stability of the preparations, according to the findings of the stability test conducted using the cycling test.

Formulasi dan Evaluasi Fisik Masker Gel Peel-Off Ekstrak Etanol Daun Jamblang (Syzygium cumini (L.) Skeels) dengan Variasi Konsentrasi PVA Ester Dwi Antari; Diyan Sakti Purwanto; IIn Suhesti; Nia Tri Mandasari
Generics: Journal of Research in Pharmacy Vol 6, No 2 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i2.30403

Tanaman jamblang merupakan tanaman yang bermanfaat sebagai antioksidan. Pemanfaatan antioksidan pada daun jamblang sebagai perawatan kulit untuk pencegahan penuaan dini. Salah satu produk kosmetik yang banyak dijumpai adalah masker gel peel off. Penelitian ini bertujuan untuk mengetahui formulasi dan evaluasi fisik masker gel peel off ekstrak daun jamblang dengan variasi konsentrasi PVA untuk menghasilkan masker yang memenuhi persyaratan. Penelitian ini menggunakan metode eksperimen. Masker gel peel off ekstrak daun jamblang dibuat dengan menggunakan konsentrasi PVA, F1 8%, F2 12% dan F3 16%. Masker gel peel off diuji fisik meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas, waktu kering dan diuji menggunakan SPSS. Hasil uji organoleptis ketiga formula memiliki tekstur semisolid, warna coklat kemerahan dan aroma khas jamblang. Semua formula masker gel peel off memenuhi syarat uji pH, daya lekat, daya sebar, viskositas, dan waktu kering. Uji evaluasi fisik gel yang meliputi uji pH, daya sebar, daya lekat, viskositas, dan waktu mengering telah menunjukkan memenuhi persyaratan pada formula 1, 2, dan 3. Berdasarkan hasil uji analisis data menggunakan One Way Anova dan Kruskal Wallis dapat disimpulkan bahwa variasi konsentrasi PVA berpengaruh terhadap uji daya sebar, daya lekat, viskositas, waktu kering dan tidak berpengaruh terhadap uji pH.

The Effectiveness Test Of Natural Hair Growth Tonic: Avemor (Aloe Vera And Moringa Oleifera) For Thickening Hair And Anti-Licknes Iin Suhesti; Annisa Diyan Meitasari; Nila Efa Sulistiana; Dinar Azizah
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 1 (2024): February 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i1.316

Avemor (Aloe vera and Moringa oleifera) is a natural hair growth tonic manufactured with a combination of aloe vera gel and dried moringa leaf extract as its active ingredients. Aloe vera includes a variety of vitamins and minerals, including vitamins A and C, amino acids, copper, inositol, and others. The extract from moringa leaves also includes tanins, vital amino acids, vitamin C, vitamin E, and other nutrients. One of the products with 2% minoxidil is employed as a positive control. Several hair diseases are treated off-label with the powerful arteriol vasoconstrictor minoxidil, which can also promote hair growth. In order to determine the effectiveness of Natural Hair Growth Tonic, tests were done on male New Zealand white rabbit hair. Avemor (Aloe vera and Moringa oleifera) is one of the products containing 2% minoxidil, with variations in the content of dried moringa leaf extracts of 2%, 4%, and 6% in comparison to the positive control. On the backs of five rabbits, six test regions were created, and each area received a different treatment every day using a sample volume of 0.5 ml. Results of the Natural Hair Growth Tonic's physical evaluation: Avemor (Aloe vera and Moringa oleifera) has a liquid shape, a distinct aroma, a pH of 6, and is homogeneous with the yellow-golden color of the formulae 1 and 2 as well as the golden brown in the formula 3. It also varies in the concentration of the dried moringa leaf extracts. Formula 4 (negative control) has the appearance of a liquid, is dazzling white in color, and emits a distinct odor. Additionally, formula 5 (positive control) has a liquid-like consistency, a vivid yellowish color, and a distinguishable scent. The average reserve viscosity for formula 1 was 2.96 ± 0.14 cPs, for formula 2 it was 2.99 ± 0.10 cPs, and for formula 3 it was 4.05 ± 0.07 cPs. Formula 4 (negative control) had a value 2.96 ± 0.10 cPs, and formula 5 (positive control) had a value of 1.82 ± 0.03 cPs. The average result of rabbit hair growth on the seventh day for treatment 1 is 0.22 ± 0.17 cm, treatment 2 is 0.30 ± 0.23 cm, treatment 3 is 0.42 ± 0.42 cm, treatment 4 is 0.58 ± 0.47 cm, treatment 5 is 0.68 ± 0.36 cm, and treatment 6 is 0.90 ± 0.42 cm. On the 14th day of treatment 1, the average result of rabbit hair growth was 0.43 ± 0.06 cm; on the same day, treatment 2, 0.27± 0.18 cm; on the same day, treatment 3, 0.42 ± 0.33 cm; on the same day, treatment 4, 0.77 ± 0.22 cm; on the same day, treatment 5, 0.28 ± 0.24 cm; and on the same day, treatment 6, 0.43 ± 0.38 cm. The average length of rabbit hair on the 21st day for treatment 1 was 0.43 ± 0.26 cm, for treatment 2 was 0.73 ± 0.19 cm, for treatment 3 was 0.32 ± 0.23 cm, for treatment 4 was 0.48 ± 0.31 cm, for treatment 5 was 0.13 ± 0.17 cm, and for treatment 6 was 0,43 ± 0.30 cm.

Formulasi dan Evaluasi Fisik Masker Gel Peel-Off Ekstrak Etanol Daun Jamblang (Syzygium cumini (L.) Skeels) dengan Variasi Konsentrasi PVA Ester Dwi Antari; Diyan Sakti Purwanto; IIn Suhesti; Nia Tri Mandasari
Generics: Journal of Research in Pharmacy Vol 6, No 2 (2026): Generics : Journal of Research in Pharmacy
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v6i2.30403

Tanaman jamblang merupakan tanaman yang bermanfaat sebagai antioksidan. Pemanfaatan antioksidan pada daun jamblang sebagai perawatan kulit untuk pencegahan penuaan dini. Salah satu produk kosmetik yang banyak dijumpai adalah masker gel peel off. Penelitian ini bertujuan untuk mengetahui formulasi dan evaluasi fisik masker gel peel off ekstrak daun jamblang dengan variasi konsentrasi PVA untuk menghasilkan masker yang memenuhi persyaratan. Penelitian ini menggunakan metode eksperimen. Masker gel peel off ekstrak daun jamblang dibuat dengan menggunakan konsentrasi PVA, F1 8%, F2 12% dan F3 16%. Masker gel peel off diuji fisik meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas, waktu kering dan diuji menggunakan SPSS. Hasil uji organoleptis ketiga formula memiliki tekstur semisolid, warna coklat kemerahan dan aroma khas jamblang. Semua formula masker gel peel off memenuhi syarat uji pH, daya lekat, daya sebar, viskositas, dan waktu kering. Uji evaluasi fisik gel yang meliputi uji pH, daya sebar, daya lekat, viskositas, dan waktu mengering telah menunjukkan memenuhi persyaratan pada formula 1, 2, dan 3. Berdasarkan hasil uji analisis data menggunakan One Way Anova dan Kruskal Wallis dapat disimpulkan bahwa variasi konsentrasi PVA berpengaruh terhadap uji daya sebar, daya lekat, viskositas, waktu kering dan tidak berpengaruh terhadap uji pH.

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