Machin, Abdulloh
3Departement Of Neuorology, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia

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Journal : Asian Journal of Health Research

Headache Characteristic in Covid-19 Infected Patient: A Systematic Review Vina Lidya Setjaputra; Steven Christian Susianto; Abdulloh Machin
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.113

Abstract

Introduction: The neurotropism of COVID-19 virus has been addressed in several studies, and headache is one of the most frequent neurologic manifestations of COVID-19, with various results of characteristics and phenotype. In this systematic review, we aimed to characterize the most common phenotype of headache in COVID-19 infected patients. Methods: A systematic literature was conducted through Pubmed, SciElo and Cochrane databases with keywords (headache[Title]) AND (covid-19[Title]), ((neurological) AND (headache) AND (characteristic)) AND (covid-19), ((phenotype) AND (headache)) AND (covid-19). We extracted the study design, demographics of subjects, and characteristics of headache (onset, site, lateralization, quality, intensity, and additional symptoms related to headache). Results: We included 1381 subjects with COVID-19 infection who experienced headache symptoms from eligible 9 studies. The majority of our patients had headaches that occurred with COVID-19 symptoms onset (94.2%), ranging from 1 to 10 days after the first COVID-19 symptoms. The most common headache site was frontal (42.3%), followed by diffuse/ holocranial (40.1%), periorbital/retroorbital (24.2%), and temporal (23.8%), with no lateralization/occurring bilaterally (85.9%), and pain characteristic predominantly pressing and tightening (55.9%), throbbing (25.3%), and stabbing (9.8%). Headache intensity measured by VAS score ranged mild to moderate in most cases with duration mostly 1-24 h. 57% of headache patients were also accompanied by fever symptoms. Additional headache symptoms were also recorded, predominantly anosmia/ageusia, followed by photophobia/phonophobia, and nausea/vomiting. Conclusion: Bilateral, long-lasting, with pressing-tightening characteristic headaches accompanied by fever, were more frequent in COVID-19 infected patients, in conjunction with anosmia/ageusia. These features may help physician to determine the headache related to COVID-19.
Co-Authors , Retnaningsih Afif Nurul Hidayati, Afif Nurul Alia, Safia Ardiansyah, Djohan Aris Widayati Arlia Ayu Damayanti Ayu Imamatun Nisa Baarid Luqman Hamidi Basuki, Mudjiani Christrijogo Soemartono Waloejo Damayanti, Arlia Ayu Dedy Kurniawan Dewi Sekarsari Didik Hasmono Dienanta, Savira DYAH FAUZIAH, DYAH Edfina Rahmarini Fahmi Achmad Faisal Fahmi, Achmad Farmindo Hartono Farmindo Hartono Fatihuddin, M Fata Fauzan, Rizki Ahmad Fauzi, Asra Al Fedik Abdul Rantam Firdha, Azizah Amimathul Hamidi, Baarid Luqman Hanifah, Anny Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Husni, Nadya Imami, Nabilah Hasna Jeffri Nagasastra Jenar Harumi Jovian Philip Swatan Kim, Beom Joon Meo, Maria Lettisia Mohammad Fathul Qorib Muhammad Hamdan Muhammad Hamdan Muhammad Ja'far Shodiq Muhammad Ja'far Shodiq Nabilah Hasna Imami Nadiva, Shafa Karin Nagasastra, Jeffri Nisa, Ayu Imamatun Nugraha, Priya Paulus Sugianto Paulus Sugianto, Paulus Pearl Dhodik Wirasman Prastiya I. Gunawan Priya Nugraha Qorib, Mohammad Fathul Rahmarini, Edfina Retnaningsih Safia Alia Sensusiati, Anggraini Dwi Setjaputra, Vina Lidya Shodiq, Jakfar Shodiq, Muhammad Ja'far Siti Khaerunnisa Siti Khaerunnisa SOETJIPTO . Steven Christian Susianto Sudibyo, Devi Ariani Sugondo, Alexander Tikara Suharjanti, Isti Suprapto, Djoko Agus Susianto, Steven Christian Swatan, Jovian Philip Talaway, Athalia Anastasia Turchan, Agus Vina Lidya Setjaputra Viskasari P. Kalanjati Wibi Riawan