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Physical Characterization of Chitosan-based Syzygium polyanthum Leaves Extract Nanoparticles Hidayati, Evi Nurul; Rahayyu, Annisa Maulidia; Azzahra, Fauzia
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23296

Indonesia is one of the most abundant in natural resources countries in the world. The bay leaves are well- known among the locals and have various pharmacological properties, including anti dyslipidemia. Currently, the use of nanoparticle technologies in dyslipidemia treatment is quite popular. These treatments have numerous advantages such as enhancing the potency of dyslipidemia agents. The purpose of this study is to develop chitosan-based nanoparticles made from Syzygium polyanthum leaves extract using crosslink method. Chitosan is used as the polymer and STPP as the crosslinker with the ratio of chitosan:STPP is 5:1. Two formula is generated, F1 is chitosan-based nanoparticle extract and F2 is chitosan-base nanoparticle blank. Syzygium polyanthum extract contains alkaloid, flavonoid, saponin, quinone, and tannin, as determined by secondary metabolites screening. The total flavonoid content of Syzygium polyanthum leaves extract determined as quercetin is 0.04%. Physical properties of generated nanoparticles such as size, polydispersity index (PI) and zeta potential are investigated. Particle sizes of nanoparticles F1 and F2 are 180.1 ± 0.5 nm and 464.3 ± 25.98 nm with the PI values of F1 and F2 are 0.220 ± 0.02 and 0.563 ± 0.112 respectively. Zeta potential value for F1 is 21.8 ± 1.74 mV and F2 is 17.8 ± 0.21 mV. The entrapment efficiency is evaluated to determine the extract content of the nanoparticle, and the result is 47.13%. From this research, the chitosan-based nanoparticles containing Syzygium polyanthum formula have good physical properties. Further investigation is needed to evaluate its potential as anti-dyslipidemia.

PELATIHAN INOVASI OLAHAN COKLAT MENJADI SELAI DAN MASKER COKLAT UNTUK MASYARAKAT DESA TARAHAN Nabila, Novrilia Atika; Tantri Liris Nareswari; Auli, Winni Nur; Rahayyu, Annisa Maulidia; Rooswita, Putri Amelia; Hidayaturahmah, Rizky
JURNAL ABDIMAS DOSMA (JAD) Vol. 3 No. 2 (2024): JUNI
Publisher : IKATAN ALUMNI DOSEN MAGANG KEMENRISTEKDIKTI TAHUN ANGKATAN 2017

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70522/jad.v3i2.22

South Lampung Regency is the second largest cocoa bean producer in Lampung Province. This natural resource is very abundant, one of which is in Tarahan Village, South Lampung, but until now it has not been optimally processed and is only sold in the form of dry brown beans which have low selling value. This is because the villagers does not know how to process cocoa beans into cocoa products. Therefore, this service program aims to assist the target community in processing cocoa beans into ready-to-sell products (jam and mask) to improve people welfare. This activity consisted of providing material and training in making jam and chocolate masks for 1 day. After the training, the villagers were able to understand and practice making the chocolate jam and mask. This program is expected to increase chocholate selling value as local regional commodities.

Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.

Molecular docking and pharmacokinetic prediction of isoniazid and curcumin compounds against N-acetyltransferase 2 (NAT2) protein Simanullang, Gayatri; Rahayyu, Annisa Maulidia; Nabila, Novrilia Atika; Hammami, Akmal; Wardani, Intan Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1699

NAT2 serves as the key enzyme responsible for metabolizing the INH compound, with its expression and functional activity significantly contributing to the risk of hepatotoxicity. Due to the possible inhibitory role of curcumin on NAT2, it is important to assess its effect on the metabolic processing of INH and to examine the enzyme-related interactions that may occur between drugs. Molecular docking studies demonstrated that curcumin can localize in the hydrophobic pocket and form a strong bond with NAT2. The aim of this study was to predict the potential interaction of the isoniazid and curcumin compounds against NAT2 protein. In this study, NAT2 protein (PDB ID: 2PFR) was used as a receptor. The results obtained showed the binding energies of native ligand, isoniazid, and curcumin were -5.78, -4.47, -8.35 kcal/mol, respectively. The findings of this research suggest that curcumin is capable of suppressing NAT2 activity, thereby affecting the pharmacokinetics of INH. These results may offer insights into minimizing INH-related liver toxicity and enhancing its effectiveness through co-administration with curcumin.

Photoprotective efficacy and physicochemical stability of sunscreen gel containing Averrhoa bilimbi L. leaf extract Wittami, Rega Gustiya; Rahayyu, Annisa Maulidia; Ramadhani, Untia Kartika Sari
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.110

Chronic UV-B exposure causes significant skin damage, necessitating effective photoprotective strategies. This study developed and evaluated sunscreen gel formulations containing ethanolic extracts of Averrhoa bilimbi leaves at varying concentrations. Extraction was performed using ultrasonic-assisted extraction (UAE), while sun protection factor (SPF) determination employed the Mansur spectrophotometric method. Four gel formulations were prepared: F0 (0%, control), F1 (0.2%), F2 (1%), and F3 (5% extract). Physicochemical characterization revealed that all formulations exhibited acceptable organoleptic properties, homogeneity, pH (4.5 to 7.0), viscosity (2,000 to 50,000 cps), spreadability (5 to 7 cm), and adhesiveness (>1 second). Accelerated stability testing demonstrated stable pH, viscosity, spreadability, and SPF values, although adhesiveness showed statistical variation while remaining within acceptable limits. SPF analysis revealed concentration-dependent photoprotective efficacy: F1 achieved maximum protection, while F2 and F3 demonstrated ultra protection, with F3 exhibiting the highest SPF value of 36.9. These findings confirm that increased A. bilimbi extract concentration correlates with enhanced photoprotective activity, establishing the potential of this natural ingredient for sunscreen applications.

Pemberdayaan Masyarakat Gadingrejo Timur Melalui Edukasi dan Inovasi Herbal Diabetes Fauziyya, Riri; Nabila, Novrilia Atika; Windari, Nurul Irna; Rooswita, Putri Amelia; Rahayyu, Annisa Maulidia; Moerbi, Thania Raya Tri; Harum, Zu’ami Sekar; Nabila, Keisya; Nursyahfira, Azra Azreena; Jasmine, Kaylla Rasikha; Putri, Kais Kaila Ladeva
JPEMAS: Jurnal Pengabdian Kepada Masyarakat Vol. 4 No. 2 (2026): JPEMAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/adc.v4i2.1534

Diabetes Melitus (DM) merupakan penyakit kronis dengan prevalensi yang terus meningkat dan berpotensi menimbulkan komplikasi serius apabila tidak dikelola dengan baik. Berdasarkan data Badan Pusat Statistik Kabupaten Pringsewu tahun 2024, Pekon Gadingrejo Timur menempati peringkat kedua kasus DM setelah Kecamatan Pringsewu dengan 982 penduduk terdiagnosis. Kondisi ini disebabkan oleh pola hidup tidak sehat, rendahnya kesadaran untuk pemeriksaan gula darah secara rutin, serta kurangnya pemahaman masyarakat mengenai pengendalian DM. Oleh karena itu, diperlukan upaya intervensi berbasis edukasi dan pemberdayaan masyarakat. Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan pengetahuan, kesadaran, dan keterampilan masyarakat dalam mencegah DM melalui edukasi kesehatan dan demonstrasi pembuatan produk herbal “Teh Cinta” berbahan kayu manis, jahe, pandan, dan pegagan. Program dilaksanakan di Balai Pekon Gadingrejo Timur, Kabupaten Pringsewu, pada 5 Agustus 2025 dengan peserta sebanyak 31 orang. Metode yang digunakan meliputi pemeriksaan kesehatan (cek gula darah dan tekanan darah), penyuluhan mengenai pengertian DM, faktor risiko, komplikasi, serta pencegahannya, dilanjutkan dengan pelatihan pembuatan produk herbal. Efektivitas kegiatan diukur menggunakan pre-test dan post-test yang dianalisis melalui uji paired t-test. Hasil menunjukkan peningkatan signifikan pada pemahaman peserta (p-value 0,003), disertai antusiasme tinggi dalam praktik pembuatan produk herbal. Kegiatan ini diharapkan mampu menjadi langkah awal dalam menciptakan masyarakat tangguh tanpa diabetes melalui pendekatan edukasi dan pemanfaatan bahan alam yang sederhana dan berkelanjutan.

Formulation of paracetamol tablets using sodium starch glycolate (SSG) derived from pineapple stem starch (Ananas comosus (L.) Merr) as a super disintegrant using wet granulation Rahayyu, Annisa Maulidia; Novi Andreyani Safitri; Riri Fauziyya; Musa Musa; Novi Kuswardani; Okta Nama Putra
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30317

The pineapple stem, a byproduct of the pineapple plant, contains a high starch content suitable for conversion into the super disintegrant sodium starch glycolate (SSG). The starch content of pineapple stems can be modified into the super-disintegrant sodium starch glycolate (SSG). This study aims to explore the potential of modified pineapple stem starch as SSG, evaluate its physicochemical characteristics, and determine the optimal tablet. Pineapple stem starch was modified into SSG through crosslinking and carboxymethylation. Tablets were then prepared using the wet granulation method, followed by physical evaluations of tablets (weight and size uniformity, disintegration time, hardness, and friability). Four formulations with varying super disintegrant concentrations were tested: F0 (4% imported SSG, control), F1 (2% pineapple stem SSG), F2 (4% pineapple stem SSG), and F3 (6% pineapple stem SSG). The tablet evaluations for all formulations met standard requirements for each test. The study's results concluded that pineapple stem starch can be modified into SSG, exhibiting a faster swelling ability compared to natural starch. The typical functional groups of SSG appear at peaks of 1410 cm-1, 1411 cm-1, and 1415 cm-1. The best formula, F3, which is based on the physical properties of the tablets, has met the requirements with the fastest disintegration time.

Uji Aktivitas Hepatoprotektor Tablet Curcuma® terhadap Kadar SGPT dan SGOT pada Tikus yang Diinduksi Isoniazid Simanullang, Gayatri; Nabila, Novrilia Atika; Rahayyu, Annisa Maulidia; Wardani, Intan Kusuma; Hammami, Akmal
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.848

Isoniazid (INH) merupakan obat anti tuberkulosis yang penggunaannya dapat menimbulkan efek samping berupa hepatotoksisitas. Kondisi ini dapat dipantau melalui peningkatan kadar enzim hati, yaitu serum glutamic pyruvic transaminase (SGPT) dan serum glutamic oxaloacetic transaminase (SGOT). Oleh karena itu, diperlukan suatu agen pelindung untuk meminimalisir efek samping hepatotoksik yang ditimbulkan. Temulawak (Curcuma xanthorrhiza Roxb.) dikenal memiliki aktivitas hepatoprotektor yang berpotensi melindungi hati dari kerusakan. Berdasarkan hal tersebut, penelitian ini bertujuan untuk mengetahui pengaruh pemberian sediaan tablet Curcuma® terhadap kadar SGPT dan SGOT pada tikus putih jantan yang diinduksi INH, serta menganalisis korelasi antara dosis Curcuma® dengan penurunan kadar kedua enzim hati tersebut. Metode pada penelitian ini yaitu menggunakan hewan uji berupa tikus putih jantan yang dibagi menjadi tiga kelompok dengan pemberian dosis INH yang sama: kelompok 1 diberikan INH 5,4 mg/kgBB, kelompok 2 curcuma® 0,36 mg/kgBB + INH, dan kelompok 3 curcuma® 0,72 mg/kgBB + INH. Perlakuan diberikan selama 14 hari secara oral untuk diukur kadar SGPT dan SGOT, rasio berat hati, serta pengamatan makroskopis hati. Hasil penelitian menunjukkan bahwa pemberian curcuma® memberikan efek yang berbeda pada kelompok 2 dan 3. Pada kelompok 3, kadar SGPT dan SGOT mengalami penurunan. Sedangkan, pada kelompok 2 hanya kadar SGPT yang menurun, untuk kadar SGOT mengalami peningkatan. Meskipun demikian, perbedaan penurunan kadar SGPT dan SGOT antara kedua kelompok tidak terdapat perbedaan yang signifikan secara statistik (p > 0,05). Rasio hati pada kelompok 1 (3,16%), kelompok 2 (2,83%), dan kelompok 3 (2,71%). Rasio hati pada kelompok 3 menunjukkan persentase yang lebih rendah dibandingkan kelompok perlakuan lainnya. Secara makroskopis, hati pada kelompok 3 memiliki warna segar, licin, dan kenyal, mendekati kondisi hati normal. Pemberian sediaan tablet curcuma® mampu melindungi hati dari kerusakan karena memiliki potensi sebagai hepatoprotektor terhadap tikus putih jantan yang diinduksi isoniazid.

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