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All Journal Jambura Journal of Health Sciences and Research Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Kesehatan Tambusai Jurnal Buana Farma Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Health & Medical Sciences Jurnal Indah Sains dan Klinis
Simanjuntak, Nerly Juli Pranita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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UJI AKTIVITAS ANTIBAKTERI DARI FRAKSI ETIL ASETAT EKSTRAK METANOL DAUN KERAI PAYUNG (Filicium decipiens) TERHADAP BAKTERI Propionibacterium acne. Br Sihite, Rani Marselina; Br Karo, Reh Malem; Simanjuntak, Nerly Juli Pranita
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.26252

Abstract

Kerai payung (Filicium-decipiens) merupakan tanaman yang termasuk kedalam keluarga sapindaceae, dengan penghasil saponin yang cukup beracun. P acne yaitu bakteri gram-positif  yang bisa hidup dengan cara anaerob fakultatif (tidak ada oksigen). Kebaruan dari penelitian ini adalah melakukan uji aktivitas antibakteri dari fraksi etil asetat ekstrak metanol daun kerai payung (filicium-decipiens) terhadap bakteri propionibacterium acne. Tujuan pengujian ini adalah agar dapat memahami aktivitas dari antibakteri ekstrak daun kerai payung dalam proses penghambatan perkembangan p acne. Ekstrak didapat dengan cara proses maserasi memakai metanol. kemudian diteruskan keproses partisi sampai didapatkan fraksi etil asetat. Konsentrasi fraksi etil asetat daun kerai payung dibuat dengan variasi konsentrasi sebagai berikut: 5 %, 10 %, 25 %, 50 %, 75 %, 100 %. Uji tersebut dibuat memakai metode difusi cakram. Berdasarkan hasil pengujian didapat zona hambat terbesar pada konsentrasi ekstrak 75% yaitu konsentrasi paling efektif untuk menghambat pertumbuhan Propionibacterium acne karena mempunyai rata-rata zona hambat tertinggi sebesar 23,88 mm. Konsentrasi 5 %, 10 %, 25 %, 50 %, 100 % merupakan  7.25 mm, 8.88 mm, 9.00 mm, 9.63 mm, 13.00 mm. Kontrol positif(+) adalah Cifrofloxacin 41.38 mm. Kesimpulan bahwa fraksi etil asetat ekstrak metanol kerai payung (Filicium-decipiens) mempunyai aktivitas sebagai antibakteri P acne.
Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Abstract

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.
Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Simanjuntak, Nerly Juli Pranita; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4303

Abstract

Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN KUMIS KUCING (ORTHOSIPHON STAMINEUS) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS Batubara, suci hasibah; Simanjuntak, Nerly Juli Pranita; Yunus, Muhammad
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.54328

Abstract

Penelitian ini bertujuan untuk memformulasikan sediaan gel hand sanitizer berbasis ekstrak etanol daun kumis kucing serta mengevaluasi aktivitas antibakterinya terhadap Staphylococcus aureus. Penelitian ini merupakan studi eksperimental laboratorium secara in vitro. Sampel penelitian berupa ekstrak etanol daun kumis kucing yang berasal dari Kabupaten Mandailing Natal dan diformulasikan ke dalam sediaan gel dengan konsentrasi 7,5% dan 12,5%. Variabel independen adalah konsentrasi ekstrak dalam formulasi gel, sedangkan variabel dependen meliputi karakteristik fisik sediaan dan aktivitas antibakteri. Evaluasi dilakukan melalui uji organoleptik, homogenitas, pH, daya sebar, serta uji aktivitas antibakteri menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa ekstrak etanol daun kumis kucing mengandung senyawa fenolik, alkaloid, flavonoid, steroid, tanin, dan saponin. Formulasi gel dengan konsentrasi 7,5% menghasilkan zona hambat sebesar 7,41–10,27 mm terhadap Staphylococcus aureus, sedangkan konsentrasi 12,5% tidak menunjukkan zona hambat. Seluruh formulasi memenuhi persyaratan mutu fisik sediaan gel, kecuali pada parameter daya sebar. Kesimpulan penelitian ini menunjukkan bahwa gel hand sanitizer dengan ekstrak etanol daun kumis kucing konsentrasi 7,5% memiliki aktivitas antibakteri lemah terhadap Staphylococcus aureus dan berpotensi dikembangkan sebagai pembersih tangan berbahan alami.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) MENGGUNAKAN METODE DPPH Raja, Hera Derliana Lumban; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1610

Abstract

Antioxidants play an important role in warding off free radicals that can cause oxidative stress and various degenerative diseases. One potential source of natural antioxidants is red ginger leaves ( Zingiber officinale var. rubrum ). This study aims to determine the antioxidant activity of ethanol extract of red ginger leaves using the DPPH method. Extraction was carried out using ethanol solvent, then the antioxidant activity was tested at various concentrations of 20, 30, 40, and 50 ppm. The parameters observed included absorbance value, inhibition percentage, and IC ₅₀ value . The results showed that the inhibition percentage increased with increasing extract concentration. The IC₅₀ value obtained was 45.50 ppm , indicating that the ethanol extract of red ginger leaves has very strong antioxidant activity. Based on these results, it can be concluded that red ginger leaves have the potential as a source of natural antioxidants that can be developed in the fields of health and functional foods.
EFEKTIVITAS GEL DAUN KIPAHIT (Tithonia diversifolia) TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS Khadijah, Siti; Br Ginting, Astriani Natalia; Simanjuntak, Nerly Juli Pranita
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1614

Abstract

Diabetes mellitus is a chronic disease commonly associated with complications such as diabetic wounds, which are characterized by impaired tissue perfusion, prolonged inflammation, and increased susceptibility to infection, resulting in delayed wound healing. Although various topical therapies have been developed, the use of herbal-based formulations for diabetic wound management remains an area of ongoing research. Leaves of Tithonia diversifolia are known to contain secondary metabolites such as flavonoids, tannins, alkaloids, and saponins, which may support the wound healing process. This study aimed to evaluate the effectiveness of Tithonia diversifolia leaf extract gel on wound healing in streptozotocin (STZ)-induced diabetic rats. This experimental study used 30 male white rats divided into six groups: normal control, negative control (gel base), positive control (octeniline gel), and treatment groups receiving Tithonia diversifolia extract gel at concentrations of 5%, 10%, and 15%. The extract was obtained by maceration using 70% ethanol and formulated into a topical gel. Wound length was observed on days 0, 3, 7, and 14, and the data were analyzed using One-Way ANOVA followed by Tukey HSD test. The results showed that Tithonia diversifolia extract gel significantly affected wound healing from day 3 to day 14 (p < 0.05). The 10% and 15% formulations demonstrated better wound healing than the negative control, while the 15% formulation showed the most optimal result, with a mean wound length of 0.40 mm on day 14. Therefore, Tithonia diversifolia extract gel has potential to be developed as a topical preparation supporting wound healing under diabetic conditions.
FORMULASI SEDIAAN HAND BODY GEL DENGAN SARI BUAH RAMBUTAN (Nephelium lappaceum L.) Azizah, Nailan; Simanjuntak, Nerly Juli Pranita; Bangar, Roy Indrianto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1673

Abstract

Rambutan fruit (Nephelium lappaceum L.) contains vitamins A, B, and C, which act as antioxidants and are beneficial for skin health. The utilization of rambutan fruit juice in a hand body gel formulation aims to produce a natural moisturizing product that is safe for use. This study was conducted experimentally by formulating rambutan fruit juice into hand body gel at concentrations of 3%, 5%, and 7%, along with a blank formulation. Each formulation was evaluated for its physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, and viscosity. In addition, skin irritation testing and skin moisture testing using a skin analyzer were performed over three weeks of use. The results showed that all formulations had good physical quality, pH values suitable for the skin, and did not cause irritation. Skin moisture testing indicated an increase in skin moisture in all formulations, with the 7% concentration showing the highest improvement. In conclusion, rambutan fruit juice can be formulated into a hand body gel that is safe and effective as a skin moisturizer, with the 7% concentration being the best formulation.
UJI AKTIVITAS EKSTRAK ETANOL DAUN SIRIH CINA (PEPEROMIA PELLUCIDA L.) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA DAN PROPIONIBACTERIUM ACNES Sinaga, Helsi Herdiani; Ginting, Astriani Natalia br; Simanjuntak, Nerly Juli Pranita
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1678

Abstract

The Chinese betel leaf plant (Peperomia pellucida L.), a herbal plant belonging to the Piperaceae family, has antibiotic properties against the growth of acne-causing bacteria. The Chinese betel leaf plant is also known to have antibacterial activity. This study aimed to determine the antibacterial activity of the ethanol extract of Chinese betel leaf against Pseudomonas aeruginosa and Propionibacterium acnes. The method used was disc diffusion with varying concentrations of 10%, 20%, and 30%. Inhibition zone data were analyzed using a One-Way ANOVA test. The results showed that the ethanol extract of Chinese betel leaf was able to inhibit the growth of both bacteria and there was a significant difference between extract concentrations (p < 0.05). The ethanol extract of Chinese betel leaf has the potential as a natural antibacterial.
Co-Authors Asyrun Alkhairi Lubis Azizah, Nailan Bangar, Roy Indrianto Batubara, suci hasibah Br Ginting, Astriani Natalia Br Sihite, Rani Marselina Erida Novriani Finna Piska Ginting, Astriani Natalia Br Hasibuan, Fitriah Parmadami Lubis, Graida Tsuraiya Lubis, Razoki Meutia , Rena Meutia, Rena Muhammad Yunus Nainggolan , Intan Natalia , Astriani Ndruru, Masiria Ndruru, Titi Marlina Neswita, Elfia Novriani , Erida Novriani, Erida nurasni, nurasni Puput, Puput Virgia Ningrum Raja, Hera Derliana Lumban Razoki Razoki, Razoki Reh Malem br Karo Rosidah Saragih, Maria Lady Sinaga, Helsi Herdiani Sinulingga, Enjellika Yemina Br. Sipayung, Sry Anita Siregar, Nurhakiki Siti Khadijah Vera Estefania Kaban Yuandani