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All Journal Jambura Journal of Health Sciences and Research Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Kesehatan Tambusai Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Health & Medical Sciences Jurnal Indah Sains dan Klinis
Simanjuntak, Nerly Juli Pranita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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UJI AKTIVITAS ANTIBAKTERI DARI FRAKSI ETIL ASETAT EKSTRAK METANOL DAUN KERAI PAYUNG (Filicium decipiens) TERHADAP BAKTERI Propionibacterium acne. Br Sihite, Rani Marselina; Br Karo, Reh Malem; Simanjuntak, Nerly Juli Pranita
Jambura Journal of Health Sciences and Research Vol 6, No 3 (2024): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v6i3.26252

Abstract

Kerai payung (Filicium-decipiens) merupakan tanaman yang termasuk kedalam keluarga sapindaceae, dengan penghasil saponin yang cukup beracun. P acne yaitu bakteri gram-positif  yang bisa hidup dengan cara anaerob fakultatif (tidak ada oksigen). Kebaruan dari penelitian ini adalah melakukan uji aktivitas antibakteri dari fraksi etil asetat ekstrak metanol daun kerai payung (filicium-decipiens) terhadap bakteri propionibacterium acne. Tujuan pengujian ini adalah agar dapat memahami aktivitas dari antibakteri ekstrak daun kerai payung dalam proses penghambatan perkembangan p acne. Ekstrak didapat dengan cara proses maserasi memakai metanol. kemudian diteruskan keproses partisi sampai didapatkan fraksi etil asetat. Konsentrasi fraksi etil asetat daun kerai payung dibuat dengan variasi konsentrasi sebagai berikut: 5 %, 10 %, 25 %, 50 %, 75 %, 100 %. Uji tersebut dibuat memakai metode difusi cakram. Berdasarkan hasil pengujian didapat zona hambat terbesar pada konsentrasi ekstrak 75% yaitu konsentrasi paling efektif untuk menghambat pertumbuhan Propionibacterium acne karena mempunyai rata-rata zona hambat tertinggi sebesar 23,88 mm. Konsentrasi 5 %, 10 %, 25 %, 50 %, 100 % merupakan  7.25 mm, 8.88 mm, 9.00 mm, 9.63 mm, 13.00 mm. Kontrol positif(+) adalah Cifrofloxacin 41.38 mm. Kesimpulan bahwa fraksi etil asetat ekstrak metanol kerai payung (Filicium-decipiens) mempunyai aktivitas sebagai antibakteri P acne.
Uji efektivitas antidiare ekstrak etanol biji asam Jawa (Tamarindus indica L.) terhadap mencit jantan dengan metode transit intestinal Simanjuntak, Nerly Juli Pranita; Neswita, Elfia; Lubis, Asyrun Alkhairi; Yunus, Muhammad
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.458

Abstract

Tamarindus indica is a member of the Fabaceae plant family, often used as a food source and traditional medicine. For generations, tamarind has often been used in medicine. One part of this plant that is often used is the seeds, which treat various conditions such as asthma, bronchitis, leprosy, tuberculosis, wounds, stomach problems, diarrhea, dysentery, vertigo, and diabetes. The active components of tamarind seeds include tannin compounds, fatty acids, flavonoids, saponins, alkaloids, and glycosides. This study used the intestinal transit method to examine the antidiarrheal effect of ethanol extract from tamarind seeds on male mice. This research method uses the intestinal transit method, namely comparing the length of the intestine through which the marker passes. The results of the observation of the antidiarrheal effect of the ethanol extract of tamarind seeds at a dose of 50 mg/kg bw gave the weakest antidiarrheal effect. The 450 mg/kg bw dose gave the most substantial antidiarrheal effect. Increasing the tamarind seed ethanol extract dose increased the antidiarrheal effect. The results of statistical analysis showed that administration of 2% tamarind seed ethanol extract suspension at a dose of 150 mg/kg bw and 450 mg/kg bw to male mice showed a practical antidiarrheal effect because it was not significantly different from loperamide 0.52 mg/kg bw which showed an impact. Antidiarrheal in Duncan's mean difference test (P > 0.05). The conclusion is that the ethanol extract of tamarind seeds has an antidiarrheal effect when given to male mice induced with oleum ricini using the small intestine passage method.
Pengaruh konseling obat terhadap pengetahuan dan tingkat kepatuhan pasien hipertensi Tahun 2023 Nainggolan , Intan; Nurasni, Nurasni; Simanjuntak, Nerly Juli Pranita; Novriani , Erida; Piska , Finna; Meutia , Rena; Neswita, Elfia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.507

Abstract

Hypertension is when blood pressure exceeds normal limits, and it is generally a lifelong condition that requires maintaining stable blood pressure. Every year, the relationship between hypertension and death from heart and blood vessel disease stabilizes. Every year, the link between hypertension and death from heart and blood vessel disease is proven. This research took place from July to September 2023 at H. Adam Malik Hospital, Medan, with 53 patients who met the inclusion criteria. The study aims to assess the level of adherence of hypertensive patients to the use of their medication using the Morisky Medication Adherence Scale questionnaire and to see whether counseling can increase the level of patient compliance. The results of the analysis show that providing counseling has a significant impact on increasing compliance in hypertensive patients at H.Adam Malik General Hospital, Medan, as demonstrated by the Wilcoxon test with p-value < 0.05.
Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Simanjuntak, Nerly Juli Pranita; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4303

Abstract

Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.
Co-Authors Asyrun Alkhairi Lubis Bangar, Roy Indrianto Br Sihite, Rani Marselina Erida Novriani Hasibuan, Fitriah Parmadami Lubis, Graida Tsuraiya Lubis, Razoki Meutia , Rena Meutia, Rena Muhammad Yunus Nainggolan , Intan Natalia , Astriani Ndruru, Masiria Ndruru, Titi Marlina Neswita, Elfia Novriani , Erida Novriani, Erida nurasni, nurasni Piska , Finna Puput, Puput Virgia Ningrum Razoki Razoki, Razoki Reh Malem br Karo Rosidah Saragih, Maria Lady Sinulingga, Enjellika Yemina Br. Sipayung, Sry Anita Siregar, Nurhakiki Vera Estefania Kaban Yuandani