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All Journal Pharmaciana: Jurnal Kefarmasian Biolearning Journal Jurnal Abdimasa Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Sehat Indonesia (JUSINDO) Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Science: Indonesian Journal of Science Jurnal Etnofarmasi
Astuti, Ratih Arum
Universitas Pendidikan Muhammadiah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : Jurnal EduHealth

 1 
Anti-Inflammatory Activity Test of Ointment Preparations of Nutmeg Leaf Extract from Fak-Fak (Myristica argentea Warb) Against Burns in Male Wistar White Rats Maria Gloria Yeuyanan; Ratih Arum Astuti; A.M. Muslihin
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

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The fak-fak nutmeg plant (Myristica argentea Warb) is one type of spice plant native to Indonesia originating from fak-fak City. This nutmeg is included in the Myristicaceae family which can have secondary metabolite compounds in the form of alkaloids, tannins, flavonoids, saponins, and phenolics which have biological activity as an anti-inflammatory burn. This study aims to determine the anti-inflammatory activity and concentration of effective preparations. This study used test animals consisting of 15 male white rats which were divided into 5 groups, namely group I negative control (ointment base), group II positive control (bioplacenton) group III ointment extract of nutmeg leaves from fak-fak concentration 2%, group IV ointment extract of nutmeg leaves from fak-fak concentration 6% and group V ointment extract of nutmeg leaves from fak-fak concentration 10%. From the results of the research that has been done, the ointment preparation with 2% extract concentration shows inflammation healing activity against rats with wound shrinkage (0.676), ointment with 6% extract concentration (0.374) and for ointment with 10% extract concentration (0.313) while in the positive group shows inflammation healing activity with wound shrinkage (0.508) and negative group (0.755). From the results obtained, it can be concluded that the ointment preparation of nutmeg leaf extract from fak-fak (Myristica argentea Warb) is effective in healing inflammation, the most effective ointment preparation is an ointment preparation with 10% extract concentration.
Potential Antianemia Activity of Cokelat Seaweed Extract (Sargassum Duplicatum) on Mencit (Mus Musculus) Injured With NaNO2 Umpain, Agnes Nesa; Lukman Hardia; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

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Seaweed is one of the leading commodities that is rich in nutrients and bioactive compounds that have potential for human health. The content contained in brown seaweed can be used as a therapy in increasing hemoglobin levels in anemia problems. The purpose of this study was to see the potential antianemia activity of brown seaweed extract (Sargassum duplicatum) against white mice (Mus musculus) and what dose can increase hemoglobin levels in mice. This research method is an experimental method with the Hb stick method carried out on 20 white mice, which were divided into 5 groups, namely the positive control group (blood supplement tablets), negative control group NaCMC 1%, treatment group 1 dose of 21 mg / kgBB, treatment group 2 dose 42 mg / kgBB, and treatment group 3 doisis 84 mg / kgBB. Testing the potential antianemia activity of brown seaweed was carried out on mice that had been induced with NaNo 2and then given a dose of extract treatment. The data were analyzed statistically using paired-sample t-test analysis to analyze the effectiveness of the treatment indicated by the difference in the average before and average after treatment. The results of the study Hemoglobin (Hb) g/dl levels on day 1 to day 15 showed a very significant increase in hemoglobin where the parameters of the dose group were close to the normal condition of the positive control group (blood supplement tablets), namely group 3 dose of 84 mg/KgBB, so it can be concluded that brown seaweed extract (Sargassum duplicatum) in group 3 dose of 84 mg/KgBB has potential antianemia activity comparable to the positive control dose (blood supplement tablets).
Antioxidant Testing of Solid Soap Preparations Containing Ethanol Extract from California Papaya Leaves (Carica Papaya L.) Gabriela Reyna Rumi; Ratih Arum Astuti; Irwandi, Irwandi
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Air pollution is a global environmental problem that is getting worse due to the mixing of natural atmospheric components with pollutants from human and natural activities. One of the main causes of air pollution in Southwest Papua is the increase in the number of motor vehicles, especially in cities such as Sorong, which also contributes to increased pollutant emissions. One plant that has antioxidant activity is papaya, which contains flavonoids, tannins, and alkaloids. Papaya (Carica papaya L) is a fruit from the Caricaceae family. This study aims to test and determine the antioxidant activity in solid soap preparations and preparation concentrations. This study uses two concentrations, namely 8% and 24%. Positive control used quercetin as a comparison. The results of the study conducted on 8% concentration solid soap preparations showed an IC50 value of 37.77, while 24% concentration preparations showed an IC50 value of 36.81. From the results obtained, it can be concluded that California papaya leaf ethanol extract solid soap preparations have high antioxidant activity When compared to the positive control quercetin, the IC₅₀ value of quercetin is 0.93 ppm, meaning that the positive control quercetin has stronger antioxidant activity.
Antioxidant Activity Test of Peel-off Mask of Ethanol Extract of Kitolod Leaves (Isotoma Longiflora L) Nur Indah Sari; Angga Bayu Budiyanto; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Free radicals are one of the main causes of skin cell damage, resulting in premature aging. Antioxidants play an important role in neutralizing free radicals, thereby maintaining skin health. Kitolod leaves (Isotoma longiflora L.) are known to contain flavonoids, alkaloids, saponins, and polyphenols that have antioxidant potential. This study aims to formulate 70% ethanol extract of kitolod leaves into a peel-off gel mask preparation and evaluate its physical stability and antioxidant activity. The research method is experimental with variations in extract concentration of 5%, 10%, and 15%. Physical evaluation of the formulation included organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and drying time, while antioxidant activity was tested using the DPPH method. The results showed that all formulations met the characteristics of a good peel-off mask preparation and remained stable for 14 days of storage. The antioxidant activity test using the method showed that the IC50 value of kitolod leaf extract was 52.84 ppm, which is classified as strong. Thus, the peel-off gel mask containing kitolod leaf extract has the potential to be developed as a natural cosmetic product with good antioxidant activity.
Analgesic Activity Test of Carrot (Daucus carota L.) Peel Extract on White Mice Rahayu, Lintang Kumala; Ratih Arum Astuti; Angga Bayu Budiyanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Pain is an unpleasant experience characterized by potential tissue damage. One plant that has the potential to inhibit pain through its chemical compounds, namely flavonoids and alkaloids, is carrot peel (Daucus carota L.). The purpose of this study was to determine the analgesic activity of carrot peel extract in male mice. Carrot peel was extracted using the maceration method with 96% solvent. This study used 15 mice as test animals, which were divided into 5 treatment groups, namely the negative control group (CMC-Na), the positive control group (Sodium Diclofenac), carrot peel extract 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW. The test was conducted using the tail flick method with an analgesia measuring device. The test was conducted using the tail flick method with an analgesia measuring device. The data obtained were then analyzed using a paired sample t-test. The results showed that the three doses of carrot peel ethanol extract, 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW, did not have analgesic activity in male mice.
Antioxidant The Effect of Solvent Variation on Antioxidant Activity in Red Fruit Extract (Pandanus Conoideus Lam) Using UV-Visible Spectrophotometry Liwen Vinesia Bilat Werluka; Ratih Arum Astuti; AM Muslihin
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

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This study aims to determine the effect of different solvents on the antioxidant activity of red fruit seed extract (Pandanus conoideus Lam). It was analysed using the DPPH assay and UV–Vis spectrophotometry. Samples were extracted using the maceration method with various solvents, namely 96% ethanol, n-hexane, and ethyl acetate. The yield results showed that ethanol, n-hexane, and ethyl acetate extracts yielded 18%, 12%, and 11%, respectively. Phytochemical screening tests showed that ethanol extracts contained flavonoids, alkaloids, tannins, and saponins. The n-hexane extract contained alkaloids, while the ethyl acetate extract contained alkaloids and saponins. Antioxidant activity was assessed based on the IC₅₀ value of the ethanol extract, which showed antioxidant activity with an IC₅₀ value of 54.67 μg/mL, categorised as a very strong antioxidant. The ethyl acetate extract had an IC₅₀ value of 19.92 μg/mL, categorised as strong, while the n-hexane extract showed the highest IC₅₀ of 9.40 μg/mL, categorised as very strong. These differences indicate that solvent polarity affects the amount and type of bioactive compounds extracted, thereby affecting the ability to capture free radicals. Thus, these results indicate that n-hexane solvent provides the strongest antioxidant activity in red fruit seed extractsc.
Co-Authors A. M. Muslihin A.M.Muslihin Achmad Noerkhaerin Putra AM Muslihin Angga Bayu Budianto Angga Bayu Budianto Angga Bayu Budiyanto Arif Radhika Mentari Assem, Vincentia Santy Bagaskara, Muhammad Raihan Budianto, Angga Bayu Devi Kumala Dewi Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Fadhilah, Windi Nur fania, vikafania Gabriela Reyna Rumi Hardiansyah, La Ode Heni Lutfiyati Iis Wahyuningsih Indah Diah Ningrum Indri Maharani Syahputri Irwandi , Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Laela Hayu Nurani Lamarunga, Nur Hasana Lanipi, Retna Paricca Lisna Lisna, Lisna Liwen Vinesia Bilat Werluka Lukman Hardia Maria Gloria Yeuyanan Mohammad Usman Nur Muhammad Raihan Bagaskara Nasruddin Nasruddin Ningrum, Indah Diah Nur Hasana Lamarunga Nur Indah Sari Nur ‘Azah Nur, Mohammad Usman Pasulu, Yusran Timang Pratama, Agus Sangka Rahakratat, Ayub M N Rahayu, Lintang Kumala Rahayu, Mellawati Yuningtyas Ratna Wijayatri Retna Paricca Lanipi Rohmania, Siti Rumbewas, Aulia Bella Miranda Salim, Fathiyah Syahrani, Anggi Tunnazilah, Nurhikmah Umpain, Agnes Nesa Wa Ode Suriani Wailegi, Muslika Zf, Siti Fatma