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Astuti, Ratih Arum
Universitas Pendidikan Muhammadiah Sorong
Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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ANALISIS AKTIVITAS ANTIOKSIDAN FRAKSI EKSTRAK DAUN MIMBA (Azadirachta indica A.Juss) DENGAN METODE DPPH Muslihin, A.M.; Astuti, Ratih Arum; Irwandi, Irwandi
JURNAL ETNOFARMASI Vol 1 No 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

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Abstract

Telah dilakukan penelitian dengan judul analisis aktivitas antioksidan fraksi ekstrak daun mimba (Azadirachta indica A.Juss) dengan metode DPPH. Tujuan penelitian ini adalah untuk menentukan aktivitas antioksidan fraksi n-heksan, fraksi etil asetat dan fraksi etanol 70% dari ekstrak etanol daun mimba (Azadirachta indica A.Juss) dengan metode DPPH. Daun mimba diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak etanol daun mimba (Azadirachta indica A. Juss) di fraksinasi dengan tiga pelarut yang berbeda kepolaran yaitu n-heksan, etil asetat dan etanol 70%. Masing-masing fraksi diuji aktivitasnya terhadap radikal bebas DPPH dan diukur absorbannya menggunakan spektrofotometer visibel pada panjang gelombang 500 nm. Hasil analisis menunjukan bahwa fraksi n-heksan, fraksi etil asetat dan fraksi etanol 70% daun mimba (Azadirachta indica A. Juss) memiliki aktivitas antioksidan dengan nilai IC50 masing-masing 1420,25 μg/mL , 642, 75 μg/mL dan 1007,34 μg/mL
EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN MANGROVE (Rhizophora mucronata) TERHADAP PENYEMBUHAN LUKA BAKAR PADA MENCIT JANTAN (Mus Muscullus) Ningrum, Indah Diah; Astuti, Ratih Arum; Hardia, Lukman
JURNAL ETNOFARMASI Vol 1 No 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

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Mangrove (Rhizophora mucronata) mengandung flavonoid, saponin dan tanin. Senyawa yang terdapat dalam daun mangrove memiliki aktivitas antiinflamasi, antivirus, dan antimikroba. Berdasarkan senyawa yang dimiliki, mangrove (Rhizophora mucronata) bisa dimanfaatkan sebagai salep untuk luka bakar. Penelitian ini bertujuan untuk menguji sediaan salep ekstrak etanol daun mangrove terhadap penyembuhan luka bakar pada mencit. Proses ekstraksi daun mangrove (Rhizophora mucronata) menggunakan metode maserasi. Pada pengujian sediaan salep dilakukan uji organoleptik, uji homogenitas, uji pH, uji daya sebar dan uji viskositas. Pengujian efektivitas penyembuhan luka bakar menggunakan 5 kelompok yang terdiri dari 4 ekor mencit. Tiap kelompok diberi perlakuan berbeda yaitu K- diberi basis salep, K+ diberi betadin salep, F1 diberi salep konsentrasi 5%, F2 diberi salep konsentrasi 7,5% dan F3 diberi salep konsentrasi 10%. Hasil penelitian menunjukkan bahwa sediaan salep memenuhi syarat standar uji organoleptik, uji homogenitas, uji pH, uji daya sebar dan uji viskositas. Berdasarkan hasil uji luka bakar pada mencit sediaan salep yang paling efektif adalah sediaan dengan
UJI EFEKTIVITAS DAYA HAMBAT EKSTRAK ETANOL DAUN KASTROLI (Euphorbia Heterophylla, L.) TERHADAP PERTUMBUHAN BAKTERI (Staphylococcus Aureus) Bagaskara, Muhammad Raihan; Irwandi, Irwandi; Astuti, Ratih Arum
JURNAL ETNOFARMASI Vol 2 No 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

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Abstract

Most infections are caused by bacteria. Bacteria that cause infections will continue to increase and will experience resistance, so it is necessary to optimize therapy, one of which is using plants that have antibacterial activity. The use of plants that have antibacterial properties is one treatment that can be used for infections caused by bacteria. One of the medicinal plants that needs to be developed is katroli (Euphorbia Heterophylla, L.). Traditionally, Indonesian people, especially in Eastern Indonesia, use castor oil as a cure for difficulty defecating. This study aims to determine the effectiveness of ethanol extract of castor leaves (Euphorbia Heterophylla, L.) with concentrations of 12.5 mg, 25 mg, 50 mg to inhibit the growth of bacteria (Staphylococcus Aureus). This research is a type of experimental research carried out using the disc diffusion method. The results of this research showed that there was a transparent zone on each paper disc with the concentration of ethanol extract of castor oil (Euphorbia Heterophylla, L.) known to be at a concentration of 50 mg. The diameter of the largest inhibition zone was 11 mm.
ANALISIS KUALITATIF SENYAWA FORMALDEHYDE PADA TAHU PUTIH YANG BEREDAR DI PASAR KABUPATEN DAN PASAR KOTA SORONG Lamarunga, Nur Hasana; Muslihin, A.M.; Astuti, Ratih Arum
JURNAL ETNOFARMASI Vol 2 No 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

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Abstract

Tofu is one of the foods that is very popular with people because it has an economical price and sufficient nutrition, but it does not last long. Formalin is known as a synthetic preservative, but there are still many sellers who add formaldehyde to food, one of which is tofu, in order to extend the shelf life. storage. Formalin should not be added to food, even a small amount because it can cause cancer. The aim of the research is to find out whether the tofu circulating in the Regency market and Sorong City market contains qualitative formaldehyde with chromatophic acid reagent because it effectively binds the formaldehyde so that it is released from the ingredients. The research was carried out. at the UNIMUDA Sorong Integrated Laboratory, using a qualitative method with the addition of chromatogenic acid and sulfuric acid reagents then heated for 15 minutes, if there is a change in color to purple then the sample is declared positive for formalin. A total of 21 tofu samples obtained from 7 markets in Sorong Regency and City did not find formalin compounds.
EVALUATION OF THE LEVEL OF PATIENT SATISFACTION WITH PHARMACY SERVICES AT Dr. J.P. WANANE, SORONG DISTRICT Pasulu, Yusran Timang; Budiyanto, Angga Bayu; Astuti, Ratih Arum
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 7 No. 2 (2023): Volume 7, Nomor 2, December 2023
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v7i2.30113

Abstract

At this time, the level of public awareness about the importance of health is increasing. This is especially true in providing more and more health services. And quality of service is also needed to ensure satisfaction with health services, one of which is pharmacy. increases and does not cause disappointment for consumers. This research used a sample of 100 respondents. The research was carried out with a descriptive quantitative design by collecting data through observation data and questionnaires, totaling 10 questions representing 5 aspects. All data obtained and collected in this research were primary data. In this research the variable is focused on the level of satisfaction. Satisfaction is seen from 5 dimensional aspects, namely the empathy dimension, reliability dimension, facility dimension, confidence dimension and responsiveness dimension. The results of the first question related to the reliability dimension aspect were 68.2% and 75.6%. The second question related to the empathy dimension aspect received a score of 68.6% and 75.6%, while the third question related to the responsiveness dimension aspect received a score of 77.4% and 73. % The fourth question related to the dimension of confidence received a score of 64% and 78.2% and the fifth question regarding the aspect of the facility dimension received a score of 77.8% and 67.4%
TESTING THE ANTIHYPERGLYCEMIC POTENTIAL OF THE ETHANOL EXTRACT OF PAPUAN ANTS' NESTS (Myrmecodia pendans) ON MENCIT (Mus musculus) fania, vikafania; Hardia, Lukman; Astuti, Ratih Arum
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 7 No. 2 (2023): Volume 7, Nomor 2, December 2023
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v7i2.31654

Abstract

The use of synthetic drugs has potential pose a risk of complications in sufferers of hyperglycemia. WHO recommends the use of traditional medicine to prevent & treat chronic diseases. The problem formulation includes the effectiveness of the original Papuan EESS test in treating hyperglycemia in mice, with a comparison of results at doses of 100.8 mg/kgBB, 50.4 mg/kgBB, and 25.2 mg/kgBB. This research aims to prove effectiveness of native Papuan EESS in treating hyperglycemia with mice & compare the effectiveness at different doses. The research uses an experimental laboratory design. Male mice aged 2 – 3 months with body weight of 20 – 30 grams, divided into five groups: control + glibenclamide 13.39 mg/kgBW, control - NaCMC 1%, native Papuan EESS treatment dose 100.8 mg/kgBW, 50.4 mg/kgBB, and 25.2 mg/kgBB. Alloxan 4.54 mg/kgBW was administered to create hyperglycemia in mice. Extraction used the maceration method with 70% ethanol solvent. The research results showed that EESS suspension was effective in treating hyperglycemia. The dose of 100.8 mg/kgBB had an average decrease in blood sugar of 122.17 mg/dL, higher than the dose of 50.4 mg/kgBB (decrease of 155.00 mg/dL) and 25.2 mg/kgBB (decrease 200.33mg/dL). In the control group, control + with 13.39 mg/kgBW glibenclamide showed a greater reduction (121.87 mg/dL) than control - with 1% NaCMC (205.83 mg/dL reduction). EESS is native to Papua antihyperglycemia is effective in mice with hyperglycemia. Comparison of the effectiveness of EESS doses showed a significant difference in response.
ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT Areca catechu L. Stalk USING THE DPPH METHOD Tunnazilah, Nurhikmah; Arum Astuti, Ratih; Hardia, Lukman
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1667

Abstract

A monocotyledonous plant from the wild palm group, the areca nut (Areca actechu L.), has numerous health advantages. Most people in Sorong City empirically cure illnesses with areca nut medication. Using the DPPH (2,2 diphenyl-1-picrylhydrazyl) technique, the secondary metabolite chemicals and antioxidant activity were determined. The areca palm stalks were extracted using a maceration method with a 96% ethanol filter. The IC50 value was used to test for antioxidants using UV-Vis spectrophotometry. Phytochemical analysis revealed that the areca stem extract contained tannins, alkaloids, steroids, and flavonoids.The results of the antioxidant activity test of areca nut stalk extract showed that the IC50 value in replication 1 was 32.66µg/mL, replication 2 was 32.88µg/mL, and replication 3 was 32.84 µg/mL. Conclusion: Ethanol extract of areca stalk (Areca catechu L.) has secondary metabolite compounds and antioxidant activity with an average IC50 value of mean ± SD = 32,79 ± 0,114. Keywords: antioxidants, dpph method, Areca catechu L.
Anti-Inflammatory Activity Test of Ointment Preparations of Nutmeg Leaf Extract from Fak-Fak (Myristica argentea Warb) Against Burns in Male Wistar White Rats Maria Gloria Yeuyanan; Ratih Arum Astuti; A.M. Muslihin
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

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Abstract

The fak-fak nutmeg plant (Myristica argentea Warb) is one type of spice plant native to Indonesia originating from fak-fak City. This nutmeg is included in the Myristicaceae family which can have secondary metabolite compounds in the form of alkaloids, tannins, flavonoids, saponins, and phenolics which have biological activity as an anti-inflammatory burn. This study aims to determine the anti-inflammatory activity and concentration of effective preparations. This study used test animals consisting of 15 male white rats which were divided into 5 groups, namely group I negative control (ointment base), group II positive control (bioplacenton) group III ointment extract of nutmeg leaves from fak-fak concentration 2%, group IV ointment extract of nutmeg leaves from fak-fak concentration 6% and group V ointment extract of nutmeg leaves from fak-fak concentration 10%. From the results of the research that has been done, the ointment preparation with 2% extract concentration shows inflammation healing activity against rats with wound shrinkage (0.676), ointment with 6% extract concentration (0.374) and for ointment with 10% extract concentration (0.313) while in the positive group shows inflammation healing activity with wound shrinkage (0.508) and negative group (0.755). From the results obtained, it can be concluded that the ointment preparation of nutmeg leaf extract from fak-fak (Myristica argentea Warb) is effective in healing inflammation, the most effective ointment preparation is an ointment preparation with 10% extract concentration.
Potential Antianemia Activity of Cokelat Seaweed Extract (Sargassum Duplicatum) on Mencit (Mus Musculus) Injured With NaNO2 Umpain, Agnes Nesa; Lukman Hardia; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

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Abstract

Seaweed is one of the leading commodities that is rich in nutrients and bioactive compounds that have potential for human health. The content contained in brown seaweed can be used as a therapy in increasing hemoglobin levels in anemia problems. The purpose of this study was to see the potential antianemia activity of brown seaweed extract (Sargassum duplicatum) against white mice (Mus musculus) and what dose can increase hemoglobin levels in mice. This research method is an experimental method with the Hb stick method carried out on 20 white mice, which were divided into 5 groups, namely the positive control group (blood supplement tablets), negative control group NaCMC 1%, treatment group 1 dose of 21 mg / kgBB, treatment group 2 dose 42 mg / kgBB, and treatment group 3 doisis 84 mg / kgBB. Testing the potential antianemia activity of brown seaweed was carried out on mice that had been induced with NaNo 2and then given a dose of extract treatment. The data were analyzed statistically using paired-sample t-test analysis to analyze the effectiveness of the treatment indicated by the difference in the average before and average after treatment. The results of the study Hemoglobin (Hb) g/dl levels on day 1 to day 15 showed a very significant increase in hemoglobin where the parameters of the dose group were close to the normal condition of the positive control group (blood supplement tablets), namely group 3 dose of 84 mg/KgBB, so it can be concluded that brown seaweed extract (Sargassum duplicatum) in group 3 dose of 84 mg/KgBB has potential antianemia activity comparable to the positive control dose (blood supplement tablets).
UJI AKTIVITAS ANALGESIK EKSTRAK ANALGESIK DAUN PALIASA (KLEINHOVIA HOSPITA L.) TERHADAP MENCIT PUTIH (MUS MUSCULUS) Salim, Fathiyah; Budiyanto, Angga Bayu; Astuti, Ratih Arum
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45754

Abstract

Nyeri adalah kondisi terhadap tubuh akibat adanya kerusakan jaringan yang menimbulkan peradangan bahkan menyebabkan kerusakan kronik yang dapat memicu kerusakan pada organ tubuh manusia, sehingga dapat dikatakan bahwa nyeri merupakan suatu respon penanda bahwa terjadi kerusakan jaringan pada tubuh manusia. Analgesik merupakan obat yang dapat menekan/menghilangkan rasa sakit yang diesebabkan oleh berbagai rangsangan tubuh. Penelitian ini bertujuan untuk mengetahui aktivitas analgesik dari ekstrak etanol daun paliasa dengan menggunakan metode tail flick. Serbuk simplisia daun paliasa diekstraksi menggunakan pelarut etanol dengan cara maserasi. Hewan uji yang digunakan pada penelitian ini adalah mencit putih sebanyak 25 ekor yang kemudian dibagi menjadi 5 kelompok, yaitu kelompok KP (Ibuprofen), kelompok KN (Na CMC), kelompok ekstrak etanol daun paliasa KD1 125 mg/KgBB, KD2 250 mg/KgBB dan kelompok KD3 500 mg/KgBB. Data yang diperoleh kemudian dianalisa dengan uji ANOVA, dan uji paired samples test selanjutnya digunakan uji LSD untuk mengetahui perbedaan setiap kelompok. Hasil penelitian menunjukkan bahwa ekstrak daun paliasa (K. hospita L.) pada kelompok KD1 125 mg/KgBB, KD2 250 mg/KgBB, dan KD3 500 mg/KgBB memiliki aktivitas analgesik yang mengalami perbedaan makna. Kesimpulan yang didapat dari penelitian ini adalah ekstrak daun paliasa (K. hospita L.) pada KD1 125 mg/KgBB, KD2 250 mg/KgBB dan KD3 500 mg/KgBB memiliki aktivitas analgesik tetapi tidak lebih baik daripada KP (Ibuprofen).
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Angga Bayu Budiyanto Arif Radhika Mentari Assem, Vincentia Santy Bagaskara, Muhammad Raihan Budianto, Angga Bayu Devi Kumala Dewi Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Fadhilah, Windi Nur fania, vikafania Gabriela Reyna Rumi Hardiansyah, La Ode Heni Lutfiyati Iis Wahyuningsih Irwandi , Irwandi Irwandi Irwandi Irwandi Irwandi Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Laela Hayu Nurani Lamarunga, Nur Hasana Lanipi, Retna Paricca Lisna Lisna, Lisna Lukman Hardia Maria Gloria Yeuyanan Nasruddin Nasruddin Ningrum, Indah Diah Nur Indah Sari Nur, Mohammad Usman Pasulu, Yusran Timang Pratama, Agus Sangka Rahakratat, Ayub M N Rahayu, Mellawati Yuningtyas Ratna Wijayatri Rohmania, Siti Rumbewas, Aulia Bella Miranda Salim, Fathiyah Tunnazilah, Nurhikmah Umpain, Agnes Nesa Wa Ode Suriani Wailegi, Muslika Zf, Siti Fatma