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All Journal Pharmaciana: Jurnal Kefarmasian Biolearning Journal Jurnal Abdimasa Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Sehat Indonesia (JUSINDO) Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Science: Indonesian Journal of Science Jurnal Etnofarmasi
Astuti, Ratih Arum
Universitas Pendidikan Muhammadiah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Antioxidant Testing of Solid Soap Preparations Containing Ethanol Extract from California Papaya Leaves (Carica Papaya L.) Gabriela Reyna Rumi; Ratih Arum Astuti; Irwandi, Irwandi
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Air pollution is a global environmental problem that is getting worse due to the mixing of natural atmospheric components with pollutants from human and natural activities. One of the main causes of air pollution in Southwest Papua is the increase in the number of motor vehicles, especially in cities such as Sorong, which also contributes to increased pollutant emissions. One plant that has antioxidant activity is papaya, which contains flavonoids, tannins, and alkaloids. Papaya (Carica papaya L) is a fruit from the Caricaceae family. This study aims to test and determine the antioxidant activity in solid soap preparations and preparation concentrations. This study uses two concentrations, namely 8% and 24%. Positive control used quercetin as a comparison. The results of the study conducted on 8% concentration solid soap preparations showed an IC50 value of 37.77, while 24% concentration preparations showed an IC50 value of 36.81. From the results obtained, it can be concluded that California papaya leaf ethanol extract solid soap preparations have high antioxidant activity When compared to the positive control quercetin, the IC₅₀ value of quercetin is 0.93 ppm, meaning that the positive control quercetin has stronger antioxidant activity.
Antioxidant Activity Test of Peel-off Mask of Ethanol Extract of Kitolod Leaves (Isotoma Longiflora L) Nur Indah Sari; Angga Bayu Budiyanto; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Free radicals are one of the main causes of skin cell damage, resulting in premature aging. Antioxidants play an important role in neutralizing free radicals, thereby maintaining skin health. Kitolod leaves (Isotoma longiflora L.) are known to contain flavonoids, alkaloids, saponins, and polyphenols that have antioxidant potential. This study aims to formulate 70% ethanol extract of kitolod leaves into a peel-off gel mask preparation and evaluate its physical stability and antioxidant activity. The research method is experimental with variations in extract concentration of 5%, 10%, and 15%. Physical evaluation of the formulation included organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and drying time, while antioxidant activity was tested using the DPPH method. The results showed that all formulations met the characteristics of a good peel-off mask preparation and remained stable for 14 days of storage. The antioxidant activity test using the method showed that the IC50 value of kitolod leaf extract was 52.84 ppm, which is classified as strong. Thus, the peel-off gel mask containing kitolod leaf extract has the potential to be developed as a natural cosmetic product with good antioxidant activity.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Lip Balm Ekstrak Etanol Biji Alpukat (Persea americana Mill.) dengan Metode DPPH Syahrani, Anggi; Astuti, Ratih Arum; Budiyanto, Angga Bayu
Jurnal Promotif Preventif Vol 8 No 6 (2025): Desember 2025: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v8i6.2430

Abstract

Antioksidan merupakan senyawa yang mampu menetralkan radikal bebas, yaitu molekul reaktif yang berpotensi menimbulkan kerusakan sel dan memicu stres oksidatif. Biji alpukat (Persea americana Mill.) diketahui mengandung flavonoid, tanin, dan polifenol yang berperan sebagai antioksidan. Penelitian ini bertujuan memformulasikan ekstrak etanol biji alpukat ke dalam sediaan lip balm serta mengkaji sifat fisik dan aktivitas antioksidannya. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 70% dan diformulasikan dalam konsentrasi 2%, 4%, dan 6%. Evaluasi yang dilakukan meliputi uji organoleptik, homogenitas, pH, daya sebar, daya lekat, stabilitas, serta pengujian aktivitas antioksidan dengan metode DPPH pada panjang gelombang 517 nm. Hasil penelitian menunjukkan bahwa seluruh formula memiliki konsistensi semi-solid yang stabil, homogen, pH sekitar 6, serta memenuhi kriteria fisik lip balm tanpa perubahan warna, aroma, atau bentuk selama penyimpanan. Uji aktivitas antioksidan menunjukkan bahwa F1 memiliki aktivitas sangat lemah dengan nilai IC₅₀ (555,64 µg/mL), F2 memiliki aktivitas sedang dengan IC₅₀ (161,32 µg/mL), dan F3 menunjukkan aktivitas kuat dengan IC₅₀ (61,73 µg/mL). Penelitian ini menyimpulkan bahwa ekstrak etanol biji alpukat dapat diformulasikan dengan baik dalam lipbalm, namun aktivitas antioksidannya menurun pada konsentrasi ekstrak yang lebih kecil.
Analgesic Activity Test of Carrot (Daucus carota L.) Peel Extract on White Mice Rahayu, Lintang Kumala; Ratih Arum Astuti; Angga Bayu Budiyanto
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Pain is an unpleasant experience characterized by potential tissue damage. One plant that has the potential to inhibit pain through its chemical compounds, namely flavonoids and alkaloids, is carrot peel (Daucus carota L.). The purpose of this study was to determine the analgesic activity of carrot peel extract in male mice. Carrot peel was extracted using the maceration method with 96% solvent. This study used 15 mice as test animals, which were divided into 5 treatment groups, namely the negative control group (CMC-Na), the positive control group (Sodium Diclofenac), carrot peel extract 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW. The test was conducted using the tail flick method with an analgesia measuring device. The test was conducted using the tail flick method with an analgesia measuring device. The data obtained were then analyzed using a paired sample t-test. The results showed that the three doses of carrot peel ethanol extract, 100 mg/kgBW, 150 mg/kgBW, and 200 mg/kgBW, did not have analgesic activity in male mice.
Antioxidant The Effect of Solvent Variation on Antioxidant Activity in Red Fruit Extract (Pandanus Conoideus Lam) Using UV-Visible Spectrophotometry Liwen Vinesia Bilat Werluka; Ratih Arum Astuti; AM Muslihin
Jurnal EduHealth Vol. 17 No. 01 (2026): Jurnal EduHealt, January-March 2026
Publisher : Sean Institute

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Abstract

This study aims to determine the effect of different solvents on the antioxidant activity of red fruit seed extract (Pandanus conoideus Lam). It was analysed using the DPPH assay and UV–Vis spectrophotometry. Samples were extracted using the maceration method with various solvents, namely 96% ethanol, n-hexane, and ethyl acetate. The yield results showed that ethanol, n-hexane, and ethyl acetate extracts yielded 18%, 12%, and 11%, respectively. Phytochemical screening tests showed that ethanol extracts contained flavonoids, alkaloids, tannins, and saponins. The n-hexane extract contained alkaloids, while the ethyl acetate extract contained alkaloids and saponins. Antioxidant activity was assessed based on the IC₅₀ value of the ethanol extract, which showed antioxidant activity with an IC₅₀ value of 54.67 μg/mL, categorised as a very strong antioxidant. The ethyl acetate extract had an IC₅₀ value of 19.92 μg/mL, categorised as strong, while the n-hexane extract showed the highest IC₅₀ of 9.40 μg/mL, categorised as very strong. These differences indicate that solvent polarity affects the amount and type of bioactive compounds extracted, thereby affecting the ability to capture free radicals. Thus, these results indicate that n-hexane solvent provides the strongest antioxidant activity in red fruit seed extractsc.
ANALISIS KUALITATIF SENYAWA FORMALDEHYDE PADA TAHU PUTIH YANG BEREDAR DI PASAR KABUPATEN DAN PASAR KOTA SORONG Nur Hasana Lamarunga; A.M. Muslihin; Ratih Arum Astuti
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1714

Abstract

Tofu is one of the foods that is very popular with people because it has an economical price and sufficient nutrition, but it does not last long. Formalin is known as a synthetic preservative, but there are still many sellers who add formaldehyde to food, one of which is tofu, in order to extend the shelf life. storage. Formalin should not be added to food, even a small amount because it can cause cancer. The aim of the research is to find out whether the tofu circulating in the Regency market and Sorong City market contains qualitative formaldehyde with chromatophic acid reagent because it effectively binds the formaldehyde so that it is released from the ingredients. The research was carried out. at the UNIMUDA Sorong Integrated Laboratory, using a qualitative method with the addition of chromatogenic acid and sulfuric acid reagents then heated for 15 minutes, if there is a change in color to purple then the sample is declared positive for formalin. A total of 21 tofu samples obtained from 7 markets in Sorong Regency and City did not find formalin compounds.
UJI EFEKTIVITAS DAYA HAMBAT EKSTRAK ETANOL DAUN KASTROLI (Euphorbia Heterophylla, L.) TERHADAP PERTUMBUHAN BAKTERI (Staphylococcus Aureus) Muhammad Raihan Bagaskara; Irwandi Irwandi; Ratih Arum Astuti
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1716

Abstract

Most infections are caused by bacteria. Bacteria that cause infections will continue to increase and will experience resistance, so it is necessary to optimize therapy, one of which is using plants that have antibacterial activity. The use of plants that have antibacterial properties is one treatment that can be used for infections caused by bacteria. One of the medicinal plants that needs to be developed is katroli (Euphorbia Heterophylla, L.). Traditionally, Indonesian people, especially in Eastern Indonesia, use castor oil as a cure for difficulty defecating. This study aims to determine the effectiveness of ethanol extract of castor leaves (Euphorbia Heterophylla, L.) with concentrations of 12.5 mg, 25 mg, 50 mg to inhibit the growth of bacteria (Staphylococcus Aureus). This research is a type of experimental research carried out using the disc diffusion method. The results of this research showed that there was a transparent zone on each paper disc with the concentration of ethanol extract of castor oil (Euphorbia Heterophylla, L.) known to be at a concentration of 50 mg. The diameter of the largest inhibition zone was 11 mm.
EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN MANGROVE (Rhizophora mucronata) TERHADAP PENYEMBUHAN LUKA BAKAR PADA MENCIT JANTAN (Mus Muscullus) Indah Diah Ningrum; Ratih Arum Astuti; Lukman Hardia
JURNAL ETNOFARMASI Vol. 1 No. 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i01.1723

Abstract

Mangrove (Rhizophora mucronata) mengandung flavonoid, saponin dan tanin. Senyawa yang terdapat dalam daun mangrove memiliki aktivitas antiinflamasi, antivirus, dan antimikroba. Berdasarkan senyawa yang dimiliki, mangrove (Rhizophora mucronata) bisa dimanfaatkan sebagai salep untuk luka bakar. Penelitian ini bertujuan untuk menguji sediaan salep ekstrak etanol daun mangrove terhadap penyembuhan luka bakar pada mencit. Proses ekstraksi daun mangrove (Rhizophora mucronata) menggunakan metode maserasi. Pada pengujian sediaan salep dilakukan uji organoleptik, uji homogenitas, uji pH, uji daya sebar dan uji viskositas. Pengujian efektivitas penyembuhan luka bakar menggunakan 5 kelompok yang terdiri dari 4 ekor mencit. Tiap kelompok diberi perlakuan berbeda yaitu K- diberi basis salep, K+ diberi betadin salep, F1 diberi salep konsentrasi 5%, F2 diberi salep konsentrasi 7,5% dan F3 diberi salep konsentrasi 10%. Hasil penelitian menunjukkan bahwa sediaan salep memenuhi syarat standar uji organoleptik, uji homogenitas, uji pH, uji daya sebar dan uji viskositas. Berdasarkan hasil uji luka bakar pada mencit sediaan salep yang paling efektif adalah sediaan dengan
ANALISIS AKTIVITAS ANTIOKSIDAN FRAKSI EKSTRAK DAUN MIMBA (Azadirachta indica A.Juss) DENGAN METODE DPPH A.M. Muslihin; Ratih Arum Astuti; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 1 No. 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i02.1726

Abstract

Telah dilakukan penelitian dengan judul analisis aktivitas antioksidan fraksi ekstrak daun mimba (Azadirachta indica A.Juss) dengan metode DPPH. Tujuan penelitian ini adalah untuk menentukan aktivitas antioksidan fraksi n-heksan, fraksi etil asetat dan fraksi etanol 70% dari ekstrak etanol daun mimba (Azadirachta indica A.Juss) dengan metode DPPH. Daun mimba diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak etanol daun mimba (Azadirachta indica A. Juss) di fraksinasi dengan tiga pelarut yang berbeda kepolaran yaitu n-heksan, etil asetat dan etanol 70%. Masing-masing fraksi diuji aktivitasnya terhadap radikal bebas DPPH dan diukur absorbannya menggunakan spektrofotometer visibel pada panjang gelombang 500 nm. Hasil analisis menunjukan bahwa fraksi n-heksan, fraksi etil asetat dan fraksi etanol 70% daun mimba (Azadirachta indica A. Juss) memiliki aktivitas antioksidan dengan nilai IC50 masing-masing 1420,25 ?g/mL , 642, 75 ?g/mL dan 1007,34 ?g/mL
PENETAPAN KADAR FENOLIK TOTAL EKSTRAK ETANOL 70% PELEPAH PISANG AMBON (Musa paradisiaca Var. Sapientum) DARI KABUPATEN SORONG, PAPUA BARAT Mohammad Usman Nur; Ratih Arum Astuti; Angga Bayu Budiyanto; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 1 No. 02 (2022): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i02.1727

Abstract

Penelitian terkait pemanfaatan limbah sudah banyak dilakukan, salah satunya pelepah pisang ambon. Ekstrak etanol pelepah pisang ambon terbukti memiliki efek farmakologi salah satunya sebagai penyembuh luka. Untuk mengetahui tingkat keamanan dan efektivitas sediaan ekstrak pelepah pisang ambon, maka perlu dilakukan beberapa uji spesifik dan non spesifik sebagai upaya untuk menjaga kualitas mutu. Penelitian ini bertujuan mengetahui parameter spesifik yaitu penetapan kadar total fenol ekstrak etanol pelepah pisang ambon dari Kabupaten Sorong, Papua Barat. Penelitian ini termasuk jenis penelitian non eksperimental. Metode ekstraksi yang digunakan adalah maserasi dengan pelarut etanol 70%. Uji parameter spesifik berupa kadar fenolik total dengan analisis kualitatif menggunakan uji tabung dan uji KLT serta analisis kuantitatif menggunakan Spektrofotometer UV-Vis masing-masing dengan pereaksi Folin-Ciocalteu. Hasil penelitian parameter spesifik ekstrak etanol pelepah pisang ambon dari kabupaten Sorong, Papua Barat adalah sebagai berikut: hasil uji tabung dan uji KLT menunjukkan bahwa ekstrak etanol pelepah pisang ambon mengandung senyawa fenolik, flavonoid, tanin, dan saponin ; hasil penetapan kadar berupa kadar fenolik total sebesar 15,42 ± 0,159 mg GAE/g ekstrak. Parameter standar umum ekstrak tanaman obat berupa parameter spesifik uji kandungan kimia ekstrak pada penelitian ini secara umum telah memenuhi ketentuan yang ditetapkan oleh Farmakope Herbal Indonesia.
Co-Authors A. M. Muslihin A.M.Muslihin Achmad Noerkhaerin Putra AM Muslihin Angga Bayu Budianto Angga Bayu Budianto Angga Bayu Budiyanto Arif Radhika Mentari Assem, Vincentia Santy Bagaskara, Muhammad Raihan Budianto, Angga Bayu Devi Kumala Dewi Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Fadhilah, Windi Nur fania, vikafania Gabriela Reyna Rumi Hardiansyah, La Ode Heni Lutfiyati Iis Wahyuningsih Indah Diah Ningrum Indri Maharani Syahputri Irwandi , Irwandi Irwandi Irwandi Irwandi Irwandi Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Laela Hayu Nurani Lamarunga, Nur Hasana Lanipi, Retna Paricca Lisna Lisna, Lisna Liwen Vinesia Bilat Werluka Lukman Hardia Maria Gloria Yeuyanan Mohammad Usman Nur Muhammad Raihan Bagaskara Nasruddin Nasruddin Ningrum, Indah Diah Nur Hasana Lamarunga Nur Indah Sari Nur ‘Azah Nur, Mohammad Usman Pasulu, Yusran Timang Pratama, Agus Sangka Rahakratat, Ayub M N Rahayu, Lintang Kumala Rahayu, Mellawati Yuningtyas Ratna Wijayatri Retna Paricca Lanipi Rohmania, Siti Rumbewas, Aulia Bella Miranda Salim, Fathiyah Syahrani, Anggi Tunnazilah, Nurhikmah Umpain, Agnes Nesa Wa Ode Suriani Wailegi, Muslika yunus, sri ulan dari Zf, Siti Fatma