Article Per Year (5 Year)
p-Index From 2021 - 2026
5.267
P-Index
This Author published in this journals
All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) LINK Jurnal Kesehatan Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmiah Universitas Batanghari Jambi Holistik Jurnal Kesehatan Jurnal Kreativitas PKM Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Jurnal Hilirisasi IPTEKS (JHI) NERS Jurnal Keperawatan JIK- JURNAL ILMU KESEHATAN PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Perawat Indonesia Majalah Kedokteran Andalas International Journal of Agricultural Sciences Real in Nursing Journal Jurnal Keperawatan Widya Gantari Indonesia Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Ners Journal of Telenursing (JOTING) Jurnal Pengabdian Masyarakat Multidisiplin Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks JAPI: Jurnal Akses Pengabdian Indonesia NERS Jurnal Keperawatan
Susmiati Susmiati
Fakultas Keperawatan Universitas Andalas, Jl. Limau Manis, Padang, 25163, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 53 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Kesehatan

 1 
Analysis of Allele Frequency Distribution Apoliprotein E Gene in Patients With Down Syndrome Trisomy 21 Malinda Meinapuri; Arni Amir; Eva Chundrayetti; efrida efrida; Susmiati Susmiati
Jurnal Kesehatan - STIKes Prima Nusantara Vol 15 No 1 (2024): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v15i1.1171

Abstract

Background: Down syndrome is a global health problem of particular concern because people with Down syndrome have a wide variety of clinical disorders and are one of the causes of mental retardation and serious physical growth disorders.Down syndrome can occur at all socioeconomic, ethnic and demographic levels. The incidence of Down Syndrome will increase as the mother's age increases at the time of pregnancy and the incidence varies in different populations: 1 in 319 to 1 in 1000 live births. Each year, an estimated 3,000 to 5,000 children are born with Down syndrome. The APOE gene is located in the long arm (q) of chromosome 19 at position 13.2 (19q13.2). The APOE gene consists of four exons and three introns, a total of 3597 base pairs. In melanocyte cells APOE gene expression can be regulated by MITF. APOE is a form of polymorphic, which translates into three gene alleles: normal: allele ?3 and dysfunctional: allele ?2 and allele ?4.  The polymorphism of the APOE gene had a strong effect on the level of allele production, a high concentration of APOE indicated that the production of ?4 allele was increased and a low concentration of APOE was associated with the production of ?2 allelePurpose:To Analyze of Allele Frequency Distribution Apoliprotein E Gene  in Patients With Down Syndrome Trisomy  21Methods: This research is an analitic observasional study with a comparative  study design. The sample used was the result of DNA extraction patients with Down's Syndrome Trisomy 21 as many as 33 samples and 33 controls stored in the Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang, Indonesia. The next step is to examine the APOE gene polymorphisms using PCR and sequencing techniques.Results: Samples of Down syndrome patients had variations in the distribution of alleles, where alleles ?4 and ?2 were found even though the allele frequency ?3 was still the highest allele frequency. Meanwhile, in the samples representing the normal control population, ?3 and ?2 alleles were found and no ?4 allele was found. Although the allele is not associated with Down Syndrome, Down Syndrome sufferers have a 2.26 times greater risk for e2 and e4 alleles than e3.Conclusion: There was a difference in the frequency distribution pattern of the APOE gene allele in patients with Down Trisomy Syndrome 21 compared to the control. 
Co-Authors ADEP JUNIKA Afriani Sandra Aisya Rahmadhanty Amir, Arni Arif, Yulastri Arza, Putri Aulia Asrawati Asrawati Asrawati Nurdin Avit Suchitra Dally Rahman Darmawidyawati Darmawidyawati Delta Apriani Deswita Deswita Deswita Dewi Dewi Dewi Murni Dewi Murni Dorisnita Dorisnita Dorisnita Dorisnita Dwi Apriadi efrida efrida Elmi Elmi Emil Huraini Emil Huriani Endang Purwati Endriani Gusni Esi Afrianti Eva Chundrayetti Evasari, Diana Febby Irianti Deski Finny Fitry Yani Fitri Dona Fitri Harmawati Fitri Mailani Fitriana Fitriana Fitriatul Munnawarroh Gusni, Endriani Hafifatul A Rahmy Hafifatul Auliya Rahmy Hamelda Fajri Weirpa Hamzah Hamzah Hanni Oktavia Rahayu Hanny Hafiar Hanny Oktavia Rahayu Helmaizar Helmaizar Helmizar HENDRIA PUTRA Heppi Sasmita Hurriya Alzahra Hurriya Alzahra Ilfa Khairina Lenggogeni, Devia Putri Leni Merdawati Lestari, Nanda Wilda Lili Fajria Maisa, Esthika Ariany Malinda Meinapuri Masni Hayati Mawaddah Mawaddah, Mawaddah Meicy Astuti Melba, Restu Arahman Meri Neharta Miftah Huljanah Monika Trijuli Astuti Muliantino, Mulyanti Roberto Mustika, Hevy Muthamainah Muthamainah Muthmainnah Muthmainnah Neherta, Meri Nelwati Nelwati Nelwati, Nelwati Nice Rachmawati Nopita, Yanti Nur Indrawaty Liepoto Nur Indrawaty Lipoeto Oktarina, Elvi Puteri Nabilla Puteri, Zifriyanthi Minanda Putri, Nelvi Kurnia Putri, Zifriyanthi Minanda Rahmi Muthia Rahmiwati Rani Wahyuni Reni Prima Gusty Restu Sakinah Restu Sakinah Riyena, Vilda Roza Armayuni Serly Suryana Sidaria, Sidaria Solly Aryza Sovia Susianty Sri Wahyuningsih Sri Wahyuningsih Testcia Arifin Testcia Arifin Virtuous Setyaka Widia Wati Wisdia Lola Erwinda Wisdia Lola Erwinda Wisdia Lola Erwinda Yanti Puspita Sari Yevri Zulfiqar Yosdedrison Yosdedrison Yuanita Ananda Yulastri Arif Yulastri Yulastri Zifrianthi Minanda Putri Zifrianti Minanda Putri Zifriyanthi Minanda Putri Zifriyanthi Zifriyanthi Zifriyanthi Zifriyanthi Zifriyanti Minanda Putri