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All Journal Jurnal Bioterdidik: Wahana Ekspresi Ilmiah Bioedukasi: Jurnal Pendidikan Biologi Indonesian Journal of Pharmaceutical Science and Technology Unnes Science Education Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Education and Instruction (JOEAI) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Bioeduca : Journal of Biology Education Science Education and Learning Journal Jurnal Pengabdian Kepada Masyarakat Sosiosaintifik Tamaddun Venn: Journal of Sustainable Innovation on Education, Mathematics and Natural Sciences Abdi Kimia : Jurnal Pengabdian Masyarakat Hayyan Journal Mammiri: Jurnal Pengabdian Masyarakat
Andi Badli Rompegading
Universitas Puangrimaggalatung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Potential of Quercetin Compound from Guava Leaves (Psidium guajava L.) as a Inhibitor COVID-19 Sengka, Rani; Rompegading, Andi Badli; Irfandi, Rizal; Nur, Muhammad; Arafah, Muhammad; Yani, Ahmad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.49666

Abstract

This research is a computer-based experimental study using the molecular docking method of quercetin compounds in the leaves of the guava plant (Psidium guajava L.) against the target protein (receptor), namely Mpro SARS-CoV-2 (PDB ID: 6M2N) using various softwares. consists of Chem Draw Ultra version 7.0, Marvin Sketch, PLANTS, Yasara, Discovery Studio Visualizer 2021, and pkCSM online tool and, protox online tool. This study aims to find out how the potential  of the quercetin compound from the leaves of the guava plant (Psidium guajava L.) has on its ability to inhibit the spread of Covid-19 by molecular docking. Data analysis in this study was carried out based on data obtained from the analysis of pharmacokinetic profiles, physicochemical properties, molecular docking, and predictions of toxicity to compounds that have potential as drug ingredients. Based on the results of molecular docking, it was shown that the quercetin compound has the potential to act as an inhibitor of the Mpro receptor (PDB ID: 6M2N) as evidenced by the docking score obtained which is smaller than the docking score obtained by the original ligand of the target receptor.
Co-Authors Abdul Kadir Ahmad Ghazali Samad Ahmad Rinaldy Ahmad Yani Ahmad Yani ahmad yani Aisyah Gusfira Ambo Upe Andi Alwa Andi Muh. Fathul Andi Wilda Resky Arifuddin, Arman Arisa, Arisa Arman Arifuddin Asriana Asriana Audya Syahra Ayu Lestari Ayu Muliana Bima Sardina Cindy Agustina Darwis Devi Wulandari Ramli Dewi Sartika Dian Ramadhani Fahreza, Muh. Resky Hadarmawandi, Hadarmawandi Hardinal Irfan, Nadia Shazirah Irfandi, Rizal Liska Syam Mirjawanda Mirjawanda Muh. Faqhi S. Muhammad Afdal Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad basriadi Muhammad Basriadi Muhammad Fadryansah Muhammad Fathir Rahmat Muhammad Nasir Muhammad Nasir Muhammad Nasir Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Resky Muhammad Yusri Muhlis, Nur Fadhillah Murniati Safitri Mutmainnah Gani Nasser P, Muhammad Kemal Nirmayanti Syamsuddin Novita darti Nur Fadhillah Muhlis Nur Indah Sari Nur Nur Fisabilianti Nur Rahma R Nur Rahmi Nuramalia Rahma, Besse Nuramalia Rahma Nurhayati Nurhayati Nurul Hikma Fajar Putri Dewi Suci Ramadhani Rahma, Besse Nuramalia Rahmawati Rahmawati Ramadhani, Andi Amaliyah Rani Sengka Reski Hamdiah Ririn Eka Rismawati Rismawati Rizky Arfadilla Rony, Zahara Tussoleha Rosdiana Rosdiana Ruhena Sengka, Rani Sir, Panessai siti zubaedah Sitti Aminah Sudarmianti, Sudarmianti Suharni Sudirman Suriya Satar Surya Satar Syah, Uswah Trywulan Syamsu Rijal Syamsu Rijal Syamsu Rijal Usman, Muhammad Arafah Vitrani Vitrani Widia , Besse Yanti , Hasvika Yanti, Hasvika Yanti, Reski Yetti Anita Yusmarika Zakiah Tantu