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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Edu Masda Journal Edu Dharma Journal: Jurnal penelitian dan pengabdian masyarakat Pharmaceutical Science Journal
Agung Dewantoro
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Decision Sciences, Operations Research & Management Medicine & Pharmacology Nursing Public Health

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UJI EFEKTIVITAS SERUM EKSTRAK DAUN KELOR (Moringa oleifera L.) SEBAGAI ANTIJERAWAT Staphylococcus aureus Dewi, Bheta Sari; Werawati, Ayu; Hasanah, Uswatun; Sayyidah, Sayyidah; Dewantoro, Agung; Saputra, Aldi
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.281

Abstract

                                                       ABSTRACTAcne is among the most prevalent dermatological issues caused by the bacterium Staphylococcus aureus. Moringa leaf extract (Moringa oleifera L.) is known to contain bioactive compounds such as flavonoids, tannins, and alkaloids, which serve as anti-acne agents. This research seeks to assess the efficacy of a serum formulated with moringa leaf extract in inhibiting the growth of acne-causing Staphylococcus aureus. The extraction of moringa leaves was carried out using the maceration technique with 96% ethanol serving as the solvent. The extract was then formulated into a serum preparation with concentrations of 4%, 7%, and 10%, using Clindamycin as the positive control and the serum base as the negative control. The antibacterial efficacy was evaluated through the agar well diffusion technique to determine the inhibition zone against Staphylococcus aureus. Each treatment was conducted in triplicate. Additionally, the physical stability of the serum was assessed, covering organoleptic characteristics, homogeneity, pH, spreadability, and adhesion. The findings revealed that moringa leaf extract exhibited inhibitory effects on the growth of Staphylococcus aureus, as evidenced by the presence of inhibition zones. The inhibition zone diameters were 14.21 mm at 4% concentration, 17.30 mm at 7%, and 19.20 mm at 10%. In comparison, the positive control showed a diameter of 30.78 mm, while the negative control showed no inhibition (0 mm). This research suggests that serum formulated with moringa leaf extract holds promise as an effective topical solution for treating acne.                                                  ABSTRAKJerawat ialah satu diantara masalah kulit yang umum disebabkan oleh bakteri Staphylococcus aureus. Ekstrak daun kelor (Moringa oleifera L.) dikenal punya senyawa bioaktif seperti flavonoid, tanin, dan alkaloid sebagai agen antijerawat. Kajian ini memiliki tujuan guna melakukan uji efektivitas serum berbahan dasar ekstrak daun kelor dalam menghambat pertumbuhan bakteri jerawat Staphylococcus aureus. Ekstrak daun kelor diperoleh lewat metode maserasi dengan pelarut etanol 96%. Ekstrak ini kemudian diformulasi ke sediaan serum dengan konsentrasi 4%, 7%, dan 10% serta digunakan Clindamycin sebagai kontrol positif dan basis serum menjadi kontrol negatif. Uji aktivitas antibakteri memakai metode difusi sumuran agar, guna mengukur zona hambat pada Staphylococcus aureus. Perlakuan diulang sebanyak 3 kali. Stabilitas fisik serum juga diuji meliputi organoleptis, homogenitas, pH, daya sebar dan daya lekat. Hasilnya diperoleh bahwa ekstrak daun kelor mempunyai kemampuan menghambat pertumbuhan Staphylococcus aureus bisa diamati dengan adanya zona hambat yang dibentuk. Diameter zona hambat di konsentrasi 4% senilai 14,21 mm, konsentrasi 7% sebesar 17,30 mm, konsentrasi 10% senilai 19,20 mm, kontrol positif senilai 30,78 mm, dan kontrol negatif sebesar 0 mm. Kajian ini memberi indikasi jika serum ekstrak daun kelor punya potensi jadi sediaan topikal yang efektif bagi pengobatan jerawat.
PROFIL PRESEPAN OBAT PADA PASIEN PEMBESARAN PROSTAT JINAK ATAU BPH (BENIGN PROSTATIC HYPERPLASIA) TAMSULOSIN DAN DUTASTERIDE DI INSTALASI RAWAT JALAN RUMAH SAKIT “X” CIPUTAT PERIODE OKTOBER-DESEMBER 2024 Dewantoro, Agung; Dewi, Bheta Sari; Rahajeng, Suny Koswara
PHRASE (Pharmaceutical Science) Journal Vol 5, No 1 (2025): Vol 5 No 1 : Pharmaceutical Science Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i1.1003

Abstract

Benign prostatic hyperplasia (BPH) is a term used in histopathology to describe the presence of enlarged stromal and epithelial cells in the prostate gland.  In essence, BPH mostly affects elderly men whose testes are still capable of making testosterone. According to earlier research, using dutasteride and tamsulosin together may have greater therapeutic results for BPH and significantly lower the chance that symptoms may worsen. Purpose:  The objective of this study was to identify salient features of Tamsulosin and Dutasteride prescriptions for benign prostatic enlargement (BPH) at Ciputat "X" Hospital's outpatient clinic from October to December 2024.. Methods: This research method is descriptive, the data is taken restropectively, namely research that looks back, meaning data collection from medical records of outpatients with BPH diagnoses. Results: This study showed that, 101 samples of BPH patients were obtained, the most BPH patients occurred at the age of 56-65 (47.5%), the most work status was self-employed (44.6%), the mosttypes oftherapy were combination therapy oftamsulosin with dutasteride (56.4%), α1-blocker drug classes that got a percentage (100%), the most length of therapy was 1 month (98.0%), and other groups of drugs prescribed Antibiotics (37.5%).
Profil Peresepan Obat Pada Ibu Hamil Di Rumah Sakit X Tangerang Selatan Januari – Maret 2023 Susanti, Debi; Dewantoro, Agung; Nurlela, Nurlela; Adha, Muhammad Zulfikar; Susilowatie, Oni
Edu Masda Journal Vol 9, No 2 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i2.270

Abstract

                                                    ABSTRACTPregnancy is a natural physiological condition that is prepared by women of reproductive age to ensure a safe process. In 2017, Indonesia reported a maternal mortality rate of 359 cases per 100,000 live births, with most cases caused by complications such as postpartum hemorrhage, anemia, and hypertension. To address health issues during pregnancy, medication use is often necessary. However, since many drugs can enter the fetal bloodstream, it is important to consider their safety for fetal development. The aim of this study is to evaluate the drug prescribing profile for pregnant women who received care at Hospital X, South Tangerang, from January to March 2023. The aspects examined include patient characteristics, therapeutic categories, types of prescribed medications, frequency of drug prescriptions, and the classification of drug safety based on their risk levels during pregnancy. This research used a descriptive and retrospective design, based on the analysis of 210 patient medical records. The study results showed that most respondents were in the early adulthood age group (26.0–35.0 years), with 141 patients (67.14%). Additionally, the majority of pregnancies were in the first trimester (1.0–12.0 weeks), with 110 patients (52.38%). In terms of therapy, 20 therapeutic categories were identified, comprising a total of 63 types of medications, with vitamins and minerals being the most commonly used group, totaling 22 types (34.92%). The highest frequency of prescriptions was also found in the vitamins and minerals group, with 289 prescriptions (65.83%) out of 439 total prescriptions. According to the FDA safety classification, the majority of drugs prescribed to pregnant women fell into Category A, indicating a high level of safety for use during pregnancy.                                             ABSTRAKKehamilan adalah kondisi fisiologis alami yang dipersiapkan oleh wanita usia subur agar berlangsung aman. Tahun 2017 di Indonesia, Angka kematian ibu sebesar 359 kasus untuk setiap 100.000 kelahiran hidup, sebagian besar disebabkan komplikasi seperti perdarahan pasca persalinan, anemia dan hipertensi. Dalam menghadapi masalah kesehatan selama kehamilan, penggunaan obat sering kali diperlukan. Namun, banyak obat masuk kedalam aliran darah janin, penting untuk mempertimbangkan keamanan obat terhadap perkembangan janin. Evaluasi profil peresepan obat pada ibu hamil yang mendapatkan pelayanan di Rumah Sakit X, Tangerang Selatan, bulan Januari hingga Maret 2023 merupakan tujuan penelitian ini. Aspek yang dikaji karakteristik pasien, kategori terapi, jenis obat yang diresepkan, frekuensi penulisan obat dalam resep, serta klasifikasi keamanan obat berdasarkan tingkat risikonya terhadap kehamilan. Desain penelitian menggunakan deskriptif, secara retrospektif. Berdasarkan analisis terhadap 210 data rekam medis pasien. Hasil studi menunjukkan sebagian besar responden berada dalam kelompok usia awal dewasa (26,0–35,0 tahun), yaitu sebanyak 141,0 pasien (67,14.%). Sementara itu, mayoritas umur kehamilan berada pada trimester ke-1 (1,0–12,0 minggu) sebanyak 110 pasien (52,38%). Dari segi terapi, ditemukan 20 kelompok terapi obat dengan total 63 jenis obat, di mana kelas vitamin dan mineral menjadi yang paling banyak digunakan, yakni 22 jenis (34,92%). Frekuensi peresepan tertinggi terdapat pada kelompok terapi vitamin dan mineral, dengan jumlah 289 penulisan resep (65,83%) dari total 439 penulisan. Berdasarkan klasifikasi keamanan menurut FDA, mayoritas obat yang diberikan kepada ibu hamil tergolong kategori A, yang menunjukkan tingkat keamanan selama kehamilan.
Co-Authors Ahmad Fadhila Ahmad Sopian Andriyani Rahmah Fahriati Anggraini Karditiawati Aulia, Gina Ayu Werawati Bachtiar, Wahyu Bheta Sari Dewi Dony Mahendra Febrial Hikmah Galih Pratiwi, Rekiyan Tuhu Imansari, Aulia Nadya Rizki Kuncoro, Daviet Dwi Luciana Luciana Melda Yunisa Mochammad Imron Awalludin Muhammad Zulfikar Adha Novita Rahmadhani Nur Hasanah Nur Sakinah Nurina, Sheima Sukmaria Nurlela Nurlela Nurwulan Adi Ismaya Priono, Fransiskus Agus Puji Rahayu RIRIS ANDRIATI Rohmatudzakiyyah, Mia Saputra, Aldi Sayyidah Sayyidah Sayyidah, Sayyidah Setianti Haryani Sheila Meitania Utami Suny Koswara Rahajeng Susanti, Debi Susilowatie, Oni Uswatun Hasanah Wilapangga, Anjas Yazid, Ricky Chaerul