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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Pure and Applied Chemistry Sains Natural: Journal of Biology and Chemistry BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Surya Abdimas Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Masyarakat Bangsa JAMAS: Jurnal Abdi Masyarakat Rafflesia Journal of Natural and Applied Sciences (RJNAS) Jurnal Laboratorium Sains Terapan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Notriawan, Doni
Universitas Bengkulu
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Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Aktivitas Antibakteri Ekstrak Daun Mangrove (Rhizophora mucronata) pada Bakteri Helicobacter pylori Penyebab Tukak Lambung Pertiwi, Reza; S, Salprima Yudha; Wibowo, Risky Hadi; Notriawan, Doni; Nasution, Riski Padilah; Azhar, Afra Wafiqah
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.9957

Abstract

Mangrove (Rhizophora mucronata) is a plant that can be used as an antibacterial because it contains several secondary metabolite compounds such as saponins and flavonoids which can inhibit bacterial growth. This research aims to determinehe antibacterial activity of mangrove leaves (Rhizophora mucronata) in inhibiting the growth of Helicobacter pylori bacteria. This research is an in vitro study using the agar dilution method for 2-5 days. The treatment groups consisted of negative, positive (co-trimoxazole), ethanol extract of mangrove leaves (Rhizophora mucronata) with concentrations of6.25%, 12.5%, 25% and 50%. The treatment was carried out by adding the Helicobacter pylori suspension to a petri dish containing agar media. Observations were made to see whether bacteria grew in the media. The data is then analyzed and broken down from the results of calculating the diameter of the inhibition zone. The test results showed that the ethanol extract of mangrove leaves (Rhizophora mucronata) had antibacterial activity in the weak category in inhibiting the growth of Helicobacter pylori bacteria. This antibacterial activity can be caused because mangrove leaves (Rhizophora mucronata) contain secondary metabolite compounds with an antibacterial mechanism of action, so this is in line with the results of this study.
Co-Authors Aanisah Hanuun Aanisah Hanuun Agung Giri Samudra Amelisa Okta Anggita Krisna Pertiwi Aniza, Mifta Violina Azhar, Afra Wafiqah Bekti Widiansyah, Alif Deni Agus Triawan Devianri M Dian Fita Lestari Dian Fita Lestari Dian Handayani Dian Handayani Donna Sagita Mala Donna Sagita Mala Dyah Fitriani Dyah Fitriani Dyah Fitriani Eka Angasa Elvira Yunita Eni Kurniati Eni Kurniati, Eni Ernis, Gustria Fades Br. Gultom Fadhila, Muhammad Adeng Fadila, Muhammad Adeng Febrika Laila Florenza, Widya Gustria Ernis Gustria Ernis Gustria Ernis Gustria Ernis Hanuun, Aanisah Hendri Saputra Hery Haryanto Ida Ayu Suci Ilfanisari, Vinolla Inta Cantika Khodijah, Petri Siti Kurniawati, Noval Lestari, Dian Fita Lestari, Mustika Dewi Mawarti, Siska Mifta Violina Aniza Muhammad Adeng Fadila Muhammad Adeng Fadila Nasution, Riski Padilah Nesbah, Nesbah Noval Kurnia Wati Noval Kurniawati Noval Kurniawati Nurjali, Zavira Nurul Afiatun Hasanah Nurwidiyani, Ria Olin Rafflesia Petri Siti Khodijah Petri Siti Khodijah Prameswari, Florencaya Prameswari Prima Yudha, Sal Ratu, Septika Refpo Rahman Reza Pertiwi Reza Pertiwi Reza Pertiwi Reza Pertiwi Reza Pertiwi Reza Rahmawati Ridho Kurnia Risky Hadi Wibowo Risky Hadi Wibowo SALPRIMA YUDHA S Sella Adesafitri Teja Dwi Sutanto Tenia Desenze Tesa Pebiani Tessa Rianti Malau Triani, Lensi Agus Triawan, Deni Agus Wafa Syahidah Wibowo, Aprillia Devi Wibowo, Risky Hadi Zavira Nurjali