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All Journal Jurnal Biologi Tropis International Journal of Community Service Learning Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan Yumary: Jurnal Pengabdian kepada Masyarakat Cendana Medical Journal Journal of Comprehensive Science
Riwu, Magdarita
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A study on the hepatoprotective effect of turmeric (Curcuma longa) extract on the liver histopathology of albino rats induced by sodium diclofenac Hibur, Grasia Intan Praskawati; Amat, Anita Lidesna Shinta; Riwu, Magdarita; Telussa, Arley Sadra
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.209

Abstract

Background: Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), causes significant hepatotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.), rich in curcuminoid antioxidants, may offer hepatoprotection. Objective: To evaluate the hepatoprotective effects of turmeric extract against diclofenac sodium-induced liver injury in rats. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg BW for 7 days), and two treatment groups receiving diclofenac sodium followed by turmeric extract at 100 or 200 mg/kg BW for 14 days. Liver histopathology was assessed using hematoxylin-eosin staining. Data were analyzed descriptively. Results: Turmeric extract attenuated hepatocellular damage in a dose-dependent manner. The 200 mg/kg BW dose completely prevented necrosis, demonstrating superior hepatoprotection compared to 100 mg/kg BW. Conclusion: Turmeric extract exerts hepatoprotective effects against diclofenac-induced liver injury through attenuation of histopathological damage.
Antibacterial Activity Test of Star Fruit Leaf Extract (Averrhoa bilimbi Linn) Against Staphylococcus epidermidis Elsen, Michellin; Rini, Desi Indria; Riwu, Magdarita; Wijaya, Carolin
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11238

Abstract

Staphylococcus epidermidis is a normal flora bacteria on the skin that can cause opportunistic infections. Generally, this infection is treated using antibiotics, but improper use of antibiotics can cause the onset of antibiotic resistance, so the development of natural antibacterial research with plant materials is one of the alternatives to reduce the incidence of resistance. A traditional medicinal plant is the leaves of star fruit (Averrhoa bilimbi Linn). This research aimed to investigate the antibacterial properties of the extract from star fruit leaves on Staphylococcus epidermidis. The type of research used is a true experimental design with a post-test only control group design. The treatment group in this study consisted of concentrations of 100%, 50%, 25%, 12.5%, 6.25%, 3.12%, with a positive control of clindamycin at a dose of 2 μg and a negative control of sterile aquadest which was carried out 3 times for each test group. The antibacterial test method is carried out by the disc diffusion method. The data analysis used is the One Way Anova statistical test. Star fruit leaf extract contains alkaloid compounds, tannins, saponins, flavonoids, and steroids. There is antibacterial activity of star fruit leaf extract against Staphylococcus epidermidis. The inhibition zone was produced at various concentrations of 100% (⌀ 15.14 mm), 50% (⌀ 14.06 mm), 25% (⌀ 13.75 mm), 12.5% (⌀ 12.01 mm), 6.25% (⌀ 10.55 mm), and 3.12% (⌀ 9.03 mm). Starfruit leaf extract has antibacterial activity against Staphylococcus epidermidis.
Activity Test of Anti-Dandruff Shampoo Preparation of Fragrant Pandan Leaf Extract (Pandanus Amaryllifolius Roxb.) Against the fungus Malassezia Furfur Pallo, Arini Aprili; Pakan, Prisca Deviani; Indriarini, Desi; Riwu, Magdarita
Journal of Comprehensive Science Vol. 5 No. 2 (2026): Journal of Comprehensive Science
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v5i2.4022

Abstract

Dandruff is a scalp disorder caused by Malassezia furfur fungus, often treated with anti-dandruff shampoos. However, synthetic active ingredients in such shampoos may cause side effects like scalp irritation, dryness, or allergies. As an alternative, herbal formulations using fragrant pandan leaves (Pandanus amaryllifolius Roxb.), known for their antifungal properties, can be developed. The objective of this study was to determine and analyze the best Fragrant pandan (Pandanus amaryllifolius Roxb.) leaf extract shampoo formulation and its antifungal activity against Malassezia furfur. The type of research conducted was a true experimental study with a Post-Test Only Control Group Design. In this study, there were treatment groups given a shampoo preparation of fragrant pandanus leaf extract at concentrations of 30%, 50%, and 70%, a negative control group of a shampoo base, and a positive control group of a shampoo containing 1% selenium sulfide under the brand name Selsun. The analysis used was the One-Way ANOVA test. The shampoo preparation of fragrant pandanus leaf extract demonstrated antifungal activity against Malassezia furfur, with inhibition zones obtained at a 30% concentration (15.83 mm), 50% concentration (18.68 mm), 70% concentration (21.89 mm), positive control (21.36 mm), and negative control (0 mm). The 70% Fragrant pandan (Pandanus amaryllifolius Roxb.) leaf extract shampoo preparation is the best formulation because it exhibits optimal physical characteristics and produces the greatest inhibition against Malassezia furfur.
Hubungan Letak Hemiparesis Dengan Derajat Depresi Pada Penderita Stroke Non Hemoragik di RSUD Prof. Dr. W. Z. Johannes Kupang Legoh, Christiano Yeheskiel; Louis Wungouw, Herman Pieter; Riwu, Magdarita; Deo, Dwita Anastasia
Journal of Comprehensive Science Vol. 5 No. 3 (2026): Journal of Comprehensive Science
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v5i3.4103

Abstract

Stroke non hemoragik merupakan gangguan neurologis akibat sumbatan aliran darah otak yang sering menimbulkan hemiparesis sebagai gejala sisa. Kondisi kelemahan satu sisi tubuh ini tidak hanya berdampak pada fungsi fisik, tetapi juga berkontribusi terhadap gangguan psikologis seperti depresi. Perbedaan hasil penelitian sebelumnya mengenai kecenderungan depresi berdasarkan letak hemiparesis mendorong dilakukannya penelitian ini. Penelitian ini bertujuan menganalisis hubungan letak hemiparesis dengan derajat depresi pada penderita stroke non hemoragik di RSUD Prof. Dr. W. Z. Johannes Kupang. Penelitian menggunakan desain analitik observasional dengan pendekatan cross sectional terhadap 46 responden yang dipilih secara consecutive sampling. Derajat depresi diukur menggunakan kuesioner Hamilton Depression Rating Scale (HDRS), kemudian dianalisis secara univariat dan bivariat menggunakan uji Koefisien Kontingensi. Hasil penelitian menunjukkan mayoritas responden mengalami depresi derajat sedang (37%). Analisis bivariat menunjukkan terdapat hubungan signifikan antara letak hemiparesis dengan derajat depresi (p=0,009; p<0,05). Disimpulkan bahwa letak hemiparesis berhubungan secara bermakna dengan tingkat keparahan depresi pada pasien stroke non hemoragik, sehingga diperlukan perhatian multidisiplin dalam penanganan aspek fisik dan psikologis pasien.
Peningkatan Kesadaran Stunting Berbasis Edukasi-Demonstrasi Pangan Lokal di Posyandu Tomeko-A Riwu, Magdarita; Patty, Yohana Febriani Putri Peu; Kotta, Jasvidianto Chriza; Kolobani, Matias Nataniel
Yumary: Jurnal Pengabdian kepada Masyarakat Vol 6 No 3 (2026): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i3.5809

Abstract

Purpose: This Community Service Program aimed to enhance awareness of early stunting prevention, promote the use of locally available nutrient-rich foods, and encourage balanced and sustainable dietary practices. Methodology: The program was carried out at Posyandu Tomeko A, East Penfui Village, using a participatory educational approach that combined counselling on the importance of iron intake during pregnancy with demonstrations of processing red spinach into nutritious foods. A 5-point Likert-scale satisfaction questionnaire was administered after the activity, and data were analyzed descriptively. Results: Thirty participants mostly adult women and adolescent girls aged ?21 years took part in the program and showed strong enthusiasm, particularly on risk factors and dietary challenges. Evaluation of 300 responses showed very positive feedback, with 62.3% “Very Satisfied,” 36.0% “Satisfied,” yielding a mean score of 4.61. Overall, the program effectively enhanced participants’ understanding of the importance of iron intake during the first 1,000 days of life in preventing stunting. Conclusions: The counseling program effectively improved community awareness through structured nutrition education, demonstrations of local iron-rich foods, and leaflet distribution. High satisfaction scores indicate that the materials were relevant and well-received. Limitations: No pre–post testing was conducted, the sample was small, and no follow-up assessment occurred. Contributions: The program provides practical guidance for families and posyandu cadres and demonstrates that participatory education can motivate communities to act as agents of change in stunting prevention.
Co-Authors Anderias Umbu Roga Anita Lidesna Shinta Amat Annytha Ina Rohi Detha Arley Sadra Telussa Artawan, I Made Christina Olly Lada Damanik, Efrisca M. Br. Djari, Tesalonica Oryza Sativa Dwita Anastasia Deo Elsen, Michellin Go, Stephannie Felicia Hamidah, Annisa Nur Hibur, Grasia Intan Praskawati Indriarini, Desi Jacob Matheos Ratu Jojor Sihotang Kareri, Dyah Gita Rambu Karolus Tokan, Yohanes Koamesah, S. M. J. Kolobani, Matias Nataniel Kotta, Jasvidianto Chriza Legoh, Christiano Yeheskiel Lenga, Theresia Lama Lokat, Rambu Bangi Louis Wungouw, Herman Pieter Manafe, Derry Tallo Maranatha, Grace Masu, Vinsensius Idelfonsus Fence Muntasir, Muntasir Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pallo, Arini Aprili Pao, Ressa Patricia Patty, Yohana Febriani Putri Peu Ratu, Kristian Rini, Desi Indria Setianingrum, Elisabeth Levina Sari Tallo Manafe, Derri Riskiyanti Tarapanjang, Tiara Rambu Renesia Umbu Datta, Sandra Clarissa Wijaya, Carolin Woda, Rahel Rara Wungouw, Herman Pieter L